N-Methylguanosine (BioDeep_00000408660)

Main id: BioDeep_00000017758

 

PANOMIX_OTCML-2023


代谢物信息卡片


N(2)-Methylguanosine

化学式: C11H15N5O5 (297.10731400000003)
中文名称: 2-甲鳥苷
谱图信息: 最多检出来源 Bos taurus(endogenous) 66.67%

分子结构信息

SMILES: CNC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO)O)O
InChI: InChI=1S/C11H15N5O5/c1-12-11-14-8-5(9(20)15-11)13-3-16(8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15,20)/t4-,6-,7-,10-/m1/s1

描述信息

CONFIDENCE standard compound; INTERNAL_ID 319
N2-methylguanosine is a modified nucleoside that occurs at several specific locations in many tRNA's.
N2-methylguanosine is a modified nucleoside that occurs at several specific locations in many tRNA's.

同义名列表

6 个代谢物同义名

N(2)-Methylguanosine; N-Methyl-guanosine; N-Methylguanosine; 7-Methylguanosine; 2-Methylguanosine; N2-Methylguanosine



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Alexander P Walker, Haitian Fan, Jeremy R Keown, Michael L Knight, Jonathan M Grimes, Ervin Fodor. The SARS-CoV-2 RNA polymerase is a viral RNA capping enzyme. Nucleic acids research. 2021 12; 49(22):13019-13030. doi: 10.1093/nar/gkab1160. [PMID: 34850141]
  • Yuan Wang, Shaofang Li, Yonghui Zhao, Chenjiang You, Brandon Le, Zhizhong Gong, Beixin Mo, Yiji Xia, Xuemei Chen. NAD+-capped RNAs are widespread in the Arabidopsis transcriptome and can probably be translated. Proceedings of the National Academy of Sciences of the United States of America. 2019 06; 116(24):12094-12102. doi: 10.1073/pnas.1903682116. [PMID: 31142655]
  • Barbara Bobrowska-Korczak, Paulina Gątarek, Angelina Rosiak, Joanna Giebułtowicz, Joanna Kałużna-Czaplińska. Reduced levels of modified nucleosides in the urine of autistic children. Preliminary studies. Analytical biochemistry. 2019 04; 571(?):62-67. doi: 10.1016/j.ab.2019.02.009. [PMID: 30771338]
  • Encarnación Rodríguez-Gonzalo, Leticia Herrero-Herrero, Diego García-Gómez. Development, validation and application of a fast analytical methodology for the simultaneous determination of DNA- and RNA-derived urinary nucleosides by liquid chromatography coupled to tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Apr; 1019(?):132-9. doi: 10.1016/j.jchromb.2015.10.044. [PMID: 26565068]
  • Aleksandra Krstulja, Coralie De Schutter, Patrick Favetta, Panagiotis Manesiotis, Luigi A Agrofoglio. Artificial receptors for the extraction of nucleoside metabolite 7-methylguanosine from aqueous media made by molecular imprinting. Journal of chromatography. A. 2014 Oct; 1365(?):12-8. doi: 10.1016/j.chroma.2014.08.086. [PMID: 25218630]
  • Ryan M Patrick, Laura K Mayberry, Grace Choy, Lauren E Woodard, Joceline S Liu, Allyson White, Rebecca A Mullen, Toug M Tanavin, Christopher A Latz, Karen S Browning. Two Arabidopsis loci encode novel eukaryotic initiation factor 4E isoforms that are functionally distinct from the conserved plant eukaryotic initiation factor 4E. Plant physiology. 2014 Apr; 164(4):1820-30. doi: 10.1104/pp.113.227785. [PMID: 24501003]
  • Tiantian Gu, Hongjuan He, Yan Zhang, Zhengbin Han, Guangyuan Hou, Tiebo Zeng, Qi Liu, Qiong Wu. Trmt112 gene expression in mouse embryonic development. Acta histochemica et cytochemica. 2012 Apr; 45(2):113-9. doi: 10.1267/ahc.11047. [PMID: 22685353]
  • Danijel Djukovic, Hamid R Baniasadi, Ravi Kc, Zane Hammoud, Daniel Raftery. Targeted serum metabolite profiling of nucleosides in esophageal adenocarcinoma. Rapid communications in mass spectrometry : RCM. 2010 Oct; 24(20):3057-62. doi: 10.1002/rcm.4739. [PMID: 20872639]
  • Peng Chen, Gunilla Jäger, Bo Zheng. Transfer RNA modifications and genes for modifying enzymes in Arabidopsis thaliana. BMC plant biology. 2010 Sep; 10(?):201. doi: 10.1186/1471-2229-10-201. [PMID: 20836892]
  • Yongqing Jiang, Yinfa Ma. A fast capillary electrophoresis method for separation and quantification of modified nucleosides in urinary samples. Analytical chemistry. 2009 Aug; 81(15):6474-80. doi: 10.1021/ac901216n. [PMID: 19552424]
  • Kei Iida, Hailing Jin, Jian-Kang Zhu. Bioinformatics analysis suggests base modifications of tRNAs and miRNAs in Arabidopsis thaliana. BMC genomics. 2009 Apr; 10(?):155. doi: 10.1186/1471-2164-10-155. [PMID: 19358740]
  • A Seidel, S Brunner, P Seidel, G I Fritz, O Herbarth. Modified nucleosides: an accurate tumour marker for clinical diagnosis of cancer, early detection and therapy control. British journal of cancer. 2006 Jun; 94(11):1726-33. doi: 10.1038/sj.bjc.6603164. [PMID: 16685264]
  • Yoshitaka Takano, Naoyuki Takayanagi, Hiroyuki Hori, Yoshiho Ikeuchi, Tsutomu Suzuki, Akiko Kimura, Tetsuro Okuno. A gene involved in modifying transfer RNA is required for fungal pathogenicity and stress tolerance of Colletotrichum lagenarium. Molecular microbiology. 2006 Apr; 60(1):81-92. doi: 10.1111/j.1365-2958.2006.05080.x. [PMID: 16556222]
  • Karolina L Tkaczuk, Agnieszka Obarska, Janusz M Bujnicki. Molecular phylogenetics and comparative modeling of HEN1, a methyltransferase involved in plant microRNA biogenesis. BMC evolutionary biology. 2006 Jan; 6(?):6. doi: 10.1186/1471-2148-6-6. [PMID: 16433904]
  • Mateen A Khan, Dixie J Goss. Translation initiation factor (eIF) 4B affects the rates of binding of the mRNA m7G cap analogue to wheat germ eIFiso4F and eIFiso4F.PABP. Biochemistry. 2005 Mar; 44(11):4510-6. doi: 10.1021/bi047298g. [PMID: 15766281]
  • Lan Zhang, Yu He, Yiting Chen, Ping Tong, Guonan Chen. [Simultaneous determination of 7-methylguanosine and mitomycin C by capillary electrophoresis with amperometric detection]. Se pu = Chinese journal of chromatography. 2005 Mar; 23(2):138-41. doi: NULL. [PMID: 16013555]
  • Vanessa Niot-Mansart, Arbana Muhamedi, Jean-Pierre Arnould. A competitive ELISA detecting 7-methylguanosine adduct induced by N-nitrosodimethylamine exposure. Human & experimental toxicology. 2005 Feb; 24(2):89-94. doi: 10.1191/0960327105ht501oa. [PMID: 15850283]
  • M R Jacobson, T Pederson. A 7-methylguanosine cap commits U3 and U8 small nuclear RNAs to the nucleolar localization pathway. Nucleic acids research. 1998 Feb; 26(3):756-60. doi: 10.1093/nar/26.3.756. [PMID: 9443967]
  • J G Tebib, C Reynaud, J P Cedoz, M C Letroublon, A Niveleau. Relationship between urinary excretion of modified nucleosides and rheumatoid arthritis process. British journal of rheumatology. 1997 Sep; 36(9):990-5. doi: 10.1093/rheumatology/36.9.990. [PMID: 9376997]
  • K Tang, S L Allman, R B Jones, C H Chen, S Araghi. Laser mass spectrometry of oligonucleotides with isomer matrices. Rapid communications in mass spectrometry : RCM. 1993 Jun; 7(6):435-9. doi: 10.1002/rcm.1290070606. [PMID: 8329766]
  • G D Foster, P R Mills. Cell-free translation of American hop latent virus RNA. Virus genes. 1991 Oct; 5(4):327-34. doi: 10.1007/bf00271531. [PMID: 1796552]
  • D D Dunigan, M Zaitlin. Capping of tobacco mosaic virus RNA. Analysis of viral-coded guanylyltransferase-like activity. The Journal of biological chemistry. 1990 May; 265(14):7779-86. doi: 10.1016/s0021-9258(19)38996-3. [PMID: 2159456]
  • E Schlimme, K S Boos, M Weise. [Selective characterisation of N1-methyladenosine and N7-methylguanosine in urine (author's transl)]. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie. 1981 Feb; 19(2):55-60. doi: . [PMID: 7217895]
  • A M Krstulovic, R A Hartwick, P R Brown. High performance liquid chromatographic determination of serum UV profiles of normal subjects and patients with breast cancer and benign fibrocystic changes. Clinica chimica acta; international journal of clinical chemistry. 1979 Oct; 97(2-3):159-70. doi: 10.1016/0009-8981(79)90412-1. [PMID: 487602]