5-demethylsinensetin (BioDeep_00000397005)
Secondary id: BioDeep_00000266141
PANOMIX_OTCML-2023 Volatile Flavor Compounds
代谢物信息卡片
化学式: C19H18O7 (358.10524780000003)
中文名称: 5-去甲基甜橙黄酮, 5-羟基-3',4',6,7-四甲氧基黄酮, 5-羟基-3'，4'，6,7-四甲氧基黄酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1(OC)=CC2OC(C3C=C(OC)C(OC)=CC=3)=CC(=O)C=2C(O)=C1OC
InChI: InChI=1S/C19H18O7/c1-22-12-6-5-10(7-14(12)23-2)13-8-11(20)17-15(26-13)9-16(24-3)19(25-4)18(17)21/h5-9,21H,1-4H3
描述信息
5-Hydroxy-3,4,6,7-tetramethoxyflavone is a natural product found in Achillea santolina, Chromolaena odorata, and other organisms with data available.
See also: Tangerine peel (part of).
5-desmethylsinensetin, isolated from Artemisia princeps , possesses antiprotozoal activity. 5-desmethylsinensetin shows IC50 values of 0.4 μg/mL on T. cruzi epimastigotes and 75.1 μg/mL on trypomastigotes, respectively[1].
5-desmethylsinensetin, isolated from Artemisia princeps , possesses antiprotozoal activity. 5-desmethylsinensetin shows IC50 values of 0.4 μg/mL on T. cruzi epimastigotes and 75.1 μg/mL on trypomastigotes, respectively[1].
同义名列表
18 个代谢物同义名
4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7-dimethoxy-; 2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7-dimethoxy-4H-chromen-4-one #; 2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7-dimethoxy-4H-chromen-4-one; 2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7-dimethoxy-chromen-4-one; 2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7-dimethoxychromen-4-one; 6-Hydroxyluteolin 6,7,3,4-tetramethyl ether; 5-Hydroxy-6,7,3,4-tetramethoxyflavone; 5-Hydroxy-3,4,6,7-tetramethoxyflavone; QEWSAPKRFOFQIU-UHFFFAOYSA-N; 5-Desmethylsinensetin; 3-O-methyl-eupatorin; 5-demethylsinensetin; 3-O-METHYLEUPATORIN; UNII-MRF3C7FE9G; SANTAFLAVONE; MRF3C7FE9G; HTMF; 5-Hydroxy-3',4',6,7-tetramethoxyflavone
数据库引用编号
8 个数据库交叉引用编号
- PubChem: 152430
- LipidMAPS: LMPK12111243
- MeSH: 5-hydroxy-3,4,6,7-tetramethoxyflavone
- ChemIDplus: 0021763804
- CAS: 21763-80-4
- medchemexpress: HY-N7632
- LOTUS: LTS0032351
- wikidata: Q83046487
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Panagiota Papapetrou, Kyriakos Dimitriadis, Vasiliki Galani, Vasiliki Zoi, Maria Giannakopoulou, Vasiliki A Papathanasopoulou, Chrissa Sioka, Pericles Tsekeris, Athanassios P Kyritsis, Diamanto Lazari, George A Alexiou. Antitumor activity of 5-hydroxy-3',4',6,7-tetramethoxyflavone in glioblastoma cell lines and its antagonism with radiotherapy.
Biomolecular concepts.
2024 Jan; 15(1):. doi:
10.1515/bmc-2022-0039. [PMID: 38345457] - Akram Taleghani, Seyed Ahmad Emami, Zahra Tayarani-Najaran. Artemisia: a promising plant for the treatment of cancer.
Bioorganic & medicinal chemistry.
2020 01; 28(1):115180. doi:
10.1016/j.bmc.2019.115180. [PMID: 31784199] - Prashant Joshi, Vinay R Sonawane, Ibidapo S Williams, Glen J P McCann, Linda Gatchie, Rajni Sharma, Naresh Satti, Bhabatosh Chaudhuri, Sandip B Bharate. Identification of karanjin isolated from the Indian beech tree as a potent CYP1 enzyme inhibitor with cellular efficacy via screening of a natural product repository.
MedChemComm.
2018 Feb; 9(2):371-382. doi:
10.1039/c7md00388a. [PMID: 30108931] - Amer Tarawneh, Francisco León, Sara Pettaway, Khaled M Elokely, Michael L Klein, Janet Lambert, Arsala Mansoor, Stephen J Cutler. Flavonoids from Perovskia atriplicifolia and Their in Vitro Displacement of the Respective Radioligands for Human Opioid and Cannabinoid Receptors.
Journal of natural products.
2015 Jun; 78(6):1461-5. doi:
10.1021/acs.jnatprod.5b00218. [PMID: 26035635] - Kaan Polatoğlu, Omer Cem Karakoç, Fatih Demirci, Ayhan Gökçe, Nezhun Gören. Chemistry and biological activities of Tanacetum chiliophyllum var. oligocephalum extracts.
Journal of AOAC International.
2013 Nov; 96(6):1222-7. doi:
10.5740/jaoacint.sgepolatoglu. [PMID: 24645497] - Hai-Yan Zhao, Li Yang, Jian Wei, Ming Huang, Jian-Guo Jiang. Bioactivity evaluations of ingredients extracted from the flowers of Citrus aurantium L. var. amara Engl.
Food chemistry.
2012 Dec; 135(4):2175-81. doi:
10.1016/j.foodchem.2012.07.018. [PMID: 22980787] - Shiming Li, Min-Hsiung Pan, Ching-Shu Lai, Chih-Yu Lo, Slavik Dushenkov, Chi-Tang Ho. Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines.
Bioorganic & medicinal chemistry.
2007 May; 15(10):3381-9. doi:
10.1016/j.bmc.2007.03.021. [PMID: 17391969] - Masateru Ono, Hiroaki Morinaga, Chikako Masuoka, Tsuyoshi Ikeda, Masafumi Okawa, Junei Kinjo, Toshihiro Nohara. New Bisabolane-Type Sesquiterpenes from the Aerial Parts of Lippia dulcis.
Chemical & pharmaceutical bulletin.
2005 Sep; 53(9):1175-7. doi:
10.1248/cpb.53.1175. [PMID: 16141591] - Jeong-Min Seo, Hyun-Mi Kang, Kwang-Hee Son, Jong Han Kim, Chang Woo Lee, Hwan Mook Kim, Soo-Ik Chang, Byoung-Mog Kwon. Antitumor activity of flavones isolated from Artemisia argyi.
Planta medica.
2003 Mar; 69(3):218-22. doi:
10.1055/s-2003-38486. [PMID: 12677524] - F Z Ren, X H Luan, Y M Zhao, H H Qu. [Studies on flavonoids from leaves of Callicarpa bodinieri Levl].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2001 Dec; 26(12):841-4. doi:
". [PMID: 12776333] - R X Tan, H Lu, J L Wolfender, T T Yu, W F Zheng, L Yang, S Gafner, K Hostettmann. Mono- and sesquiterpenes and antifungal constituents from Artemisia species.
Planta medica.
1999 Feb; 65(1):64-7. doi:
10.1055/s-1999-13965. [PMID: 10083848] - C M Wu. [The chemical constituents of Artemisia species (III). Isolation and identification of the lipophilic constituents from Artemisia argyi].
Zhong yao tong bao (Beijing, China : 1981).
1985 Jan; 10(1):31-2. doi:
". [PMID: 3157475] - D G Kingston, M M Rao, W V Zucker. Plant anticancer agents. IX. Constituents of Hyptis tomentosa.
Journal of natural products.
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10.1021/np50005a010. [PMID: 521819]