2Z6NA534YE (BioDeep_00000396505)

Main id: BioDeep_00000403293

 

PANOMIX_OTCML-2023


代谢物信息卡片


[(2S)-2-[(2-benzamido-3-phenylpropanoyl)amino]-3-phenylpropyl] acetate

化学式: C27H28N2O4 (444.20489680000003)
中文名称: 金色酰胺醇酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)OCC(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C3=CC=CC=C3
InChI: InChI=1S/C27H28N2O4/c1-20(30)33-19-24(17-21-11-5-2-6-12-21)28-27(32)25(18-22-13-7-3-8-14-22)29-26(31)23-15-9-4-10-16-23/h2-16,24-25H,17-19H2,1H3,(H,28,32)(H,29,31)/t24-,25?/m0/s1

描述信息

Aurantiamide acetate is a member of amphetamines.
Aurantiamide acetate is a natural product found in Pteris multifida, Orthosiphon aristatus, and other organisms with data available.
Aurantiamide acetate (TMC-58A) is a selective and orally active cathepsin inhibitor isolated from?Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of ?inflammatory?diseases[1][2].
Aurantiamide acetate (TMC-58A) is a selective and orally active cathepsin inhibitor isolated from?Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of ?inflammatory?diseases[1][2].

同义名列表

12 个代谢物同义名

[(2S)-2-[(2-benzamido-3-phenylpropanoyl)amino]-3-phenylpropyl] acetate; N-benzoyl-1-phenylalanyl-1-phenylalaninol acetate; N-Benzoyl-L-phenylalanyl-L-phenylalinol acetate; 6.N-Benzoylphenylalanylphenylalinol acetate; N-benzoylphenylalanylphenylalinol acetate; N-benzoyl-Phe-Phe-ol-acetate; Asperglaucide, Lyciumamide; Aurantiamide acetate; UNII-2Z6NA534YE; asperglaucide; lyciumamide; 2Z6NA534YE



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Acharya Balkrishna, Sudeep Verma, M Priya Rani, Pardeep Nain, Anurag Varshney. Exploring the potential of Mustard (Brassica spp.) seeds through 'Kolhu' traditional method of extraction and novel identification of an anti-cancer dipeptide, Aurantiamide acetate (Asperglaucide) on ultra-performance liquid chromatography-mass spectrometry coupled with quadrupole time-of-flight (UPLC/MS-QToF) analytical platform. Food chemistry. 2024 Jul; 446(?):138870. doi: 10.1016/j.foodchem.2024.138870. [PMID: 38430771]
  • Huihai Yang, Man-Kit Cheung, Grace Gar-Lee Yue, Ping-Chung Leung, Chun-Kwok Wong, Clara Bik-San Lau. Integrated Network Pharmacology Analysis and In Vitro Validation Revealed the Potential Active Components and Underlying Mechanistic Pathways of Herba Patriniae in Colorectal Cancer. Molecules (Basel, Switzerland). 2021 Oct; 26(19):. doi: 10.3390/molecules26196032. [PMID: 34641576]
  • Beixian Zhou, Zifeng Yang, Qitong Feng, Xiaoli Liang, Jing Li, Mark Zanin, Zhihong Jiang, Nanshan Zhong. Aurantiamide acetate from baphicacanthus cusia root exhibits anti-inflammatory and anti-viral effects via inhibition of the NF-κB signaling pathway in Influenza A virus-infected cells. Journal of ethnopharmacology. 2017 Mar; 199(?):60-67. doi: 10.1016/j.jep.2017.01.038. [PMID: 28119097]
  • X B Liu, B X Yang, L Zhang, Y Z Lu, M H Gong, J K Tian. An in vivo and in vitro assessment of the anti-inflammatory, antinociceptive, and immunomodulatory activities of Clematis terniflora DC. extract, participation of aurantiamide acetate. Journal of ethnopharmacology. 2015 Jul; 169(?):287-94. doi: 10.1016/j.jep.2015.04.009. [PMID: 25910534]
  • Yi Yang, Li-hui Zhang, Bing-xian Yang, Jin-kui Tian, Lin Zhang. Aurantiamide acetate suppresses the growth of malignant gliomas in vitro and in vivo by inhibiting autophagic flux. Journal of cellular and molecular medicine. 2015 May; 19(5):1055-64. doi: 10.1111/jcmm.12498. [PMID: 25704599]
  • Kuan-Chung Chen, Mao-Feng Sun, Calvin Yu-Chian Chen. In Silico Investigation of Potential PARP-1 Inhibitors from Traditional Chinese Medicine. Evidence-based complementary and alternative medicine : eCAM. 2014; 2014(?):917605. doi: 10.1155/2014/917605. [PMID: 24876881]
  • Clayton Q Alves, Luciano S Lima, Jorge M David, Marcos V B Lima, Juceni P David, Fernanda W M Lima, Kelly C M C Pedroza, Luciano P Queiroz. In vitro acetylcholinesterase activity of peptide derivatives isolated from two species of Leguminosae. Pharmaceutical biology. 2013 Jul; 51(7):936-9. doi: 10.3109/13880209.2013.770536. [PMID: 23570522]
  • Jules Lobe Songue, Kouam, Etienne Dongo, Theophile Ngando Mpondo, Robert L White. Chemical constituents from stem bark and roots of Clausena anisata. Molecules (Basel, Switzerland). 2012 Nov; 17(11):13673-86. doi: 10.3390/molecules171113673. [PMID: 23169265]
  • Fan Cheng, Yuan Zhou, Kun Zou, Jun Wu. [Studies on the chemical constituents of the fruit of Xylocarpus granatum]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2009 Aug; 32(8):1220-3. doi: ". [PMID: 19960941]
  • Cai-Fang Wang, Rao-Rao Li, Lan-Lan Huang, Li-Qun Zhong, Si-Tong Yuan. [Studies on chemical constituents of Daphne genkwa]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2009 Apr; 32(4):508-11. doi: . [PMID: 19645232]
  • Wei-Hua Huang, You-Bin Li, Jian-Qin Jiang. [Chemical constituents from Hedyotis diffusa]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2008 Mar; 33(5):524-6. doi: ". [PMID: 18536374]
  • Li-sheng Wang, Xue-min Ma, Ya-jian Guo, Han-dong Sun, Jie-ming Zou. [Study on the chemical constituents from Picria fel-tarrae]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2004 Feb; 29(2):149-52. doi: ". [PMID: 15719682]
  • M Kaya, T Wada, S Kawaguchi, S Nagoya, T Yamashita, Y Abe, H Hiraga, K Isu, M Shindoh, F Higashino, F Okada, M Tada, S Yamawaki, S Ishii. Increased pre-therapeutic serum vascular endothelial growth factor in patients with early clinical relapse of osteosarcoma. British journal of cancer. 2002 Mar; 86(6):864-9. doi: 10.1038/sj.bjc.6600201. [PMID: 11953816]
  • S Ducki, J A Hadfield, X Zhang, N J Lawrence, A T McGown. Isolation of aurantiamide acetate from Arisaema erubescens. Planta medica. 1996 Jun; 62(3):277-8. doi: 10.1055/s-2006-957878. [PMID: 8693046]
  • M Noguchi, K Mochida, T Shingu, M Kozuka, K Fujitani. [The constituents of the Chinese drug 'ti-ku-'pi'. I. Isolation and constitution of lyciumamide, a new dipeptide]. Chemical & pharmaceutical bulletin. 1984 Sep; 32(9):3584-7. doi: 10.1248/cpb.32.3584. [PMID: 6525652]
  • J H Holmes, I Kanfer, H Zwarenstein. Effect of benzodiazepine derivatives on human blood cholinesterase in vitro. Research communications in chemical pathology and pharmacology. 1978 Aug; 21(2):367-70. doi: . [PMID: 29327]
  • N Miki, M Nagano, K Kuriyama. Catalase activates cerebral granylate cyclase in the presence of sodium azide. Biochemical and biophysical research communications. 1976 Oct; 72(3):952-9. doi: 10.1016/s0006-291x(76)80224-0. [PMID: 10917]