Remerin (BioDeep_00000395556)

 

Secondary id: BioDeep_00000019005

PANOMIX_OTCML-2023


代谢物信息卡片


11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.0^{2,6}.0^{8,20}.0^{14,19}]icosa-1(20),2(6),7,14,16,18-hexaene

化学式: C18H17NO2 (279.1259)
中文名称: 莲碱, 阿朴雷因
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 22.94%

分子结构信息

SMILES: CN1CCC(C2=C3C4=CC=CC=C4C[C@@]12[H])=CC5=C3OCO5
InChI: InChI=1S/C18H17NO2/c1-19-7-6-12-9-15-18(21-10-20-15)17-13-5-3-2-4-11(13)8-14(19)16(12)17/h2-5,9,14H,6-8,10H2,1H3

描述信息

Remerin is an isoquinoline alkaloid.
Roemerine is a natural product found in Cryptocarya angulata, Stephania abyssinica, and other organisms with data available.
Origin: Plant; Formula(Parent): C18H17NO2; Bottle Name:Remerine hydrochloride; PRIME Parent Name:Remerine; PRIME in-house No.:V0353; SubCategory_DNP: Isoquinoline alkaloids, Aporphine alkaloids
Roemerine, an aporphine alkaloid, isolated from the leaves of Fibraurea recisa Pierre, functions by interacting with P-glycoprotein. Roemerine reverses the multidrug-resistance phenotype with cultured cells[1].
Roemerine, an aporphine alkaloid, isolated from the leaves of Fibraurea recisa Pierre, functions by interacting with P-glycoprotein. Roemerine reverses the multidrug-resistance phenotype with cultured cells[1].

同义名列表

24 个代谢物同义名

(12R)-11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.02,6.08,20.014,19]icosa-1(20),2(6),7,14,16,18-hexaene; (R)-7-Methyl-6,7,7a,8-tetrahydro-5H-[1,3]dioxolo[4,5:4,5]benzo[1,2,3-de]benzo[g]quinoline; 5H-Benzo(g)-1,3-benzodioxolo(6,5,4-de)quinoline, 6,7,7a,8-tetrahydro-7-methyl-, (7aR)-; (7aR)-7-Methyl-6,7,7a,8-tetrahydro-5H-benzo(g)-1,3-benzodioxolo(6,5,4-de)quinoline; 7-Methyl-6,7,7a,8-tetrahydro-5H-[1,3]benzodioxolo[6,5,4-de]benzo[g]quinoline #; 6a-beta-Aporphine, 1,2-(methylenedioxy)-; roemerine hydrochloride, (R)-isomer; JCTYWRARKVGOBK-CQSZACIVSA-N; roemerine, (S)-isomer; Remerine (alkaloid); (-)-roemerine; (-)-Aporheine; Roemerine-HBr; l-Roemerine; Aporheine; Roemerine; Roemerin; aporeine; Remerin; 11-methyl-3,5-dioxa-11-azapentacyclo[10.7.1.0^{2,6}.0^{8,20}.0^{14,19}]icosa-1(20),2(6),7,14,16,18-hexaene; 1,2-(Methylenedioxy)-6a-beta-aporphine; (R)-Roemerine; (-)-Remerine; Remerine



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

43 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Omer Bayazeid, Emirhan Nemutlu, Cemil Can Eylem, Mert İlhan, Esra Küpeli-Akkol, Hande Karahan, Pelin Kelicen-Uğur, Tayfun Ersoz, Funda N Yalçın. Neuroactivity of the naturally occurring aporphine alkaloid, roemerine. Natural product research. 2021 Dec; 35(24):6147-6152. doi: 10.1080/14786419.2020.1830395. [PMID: 33025828]
  • Renren Bai, Chuansheng Yao, Zhichao Zhong, Jiamin Ge, Ziqiang Bai, Xiangyang Ye, Tian Xie, Yuanyuan Xie. Discovery of natural anti-inflammatory alkaloids: Potential leads for the drug discovery for the treatment of inflammation. European journal of medicinal chemistry. 2021 Mar; 213(?):113165. doi: 10.1016/j.ejmech.2021.113165. [PMID: 33454546]
  • Fatma Gizem Avci, Basak Atas, Cemile Selin Aksoy, Eldin Kurpejovic, Gizem Gulsoy Toplan, Caglayan Gurer, Maxime Guillerminet, Cedric Orelle, Jean-Michel Jault, Berna Sariyar Akbulut. Repurposing bioactive aporphine alkaloids as efflux pump inhibitors. Fitoterapia. 2019 Nov; 139(?):104371. doi: 10.1016/j.fitote.2019.104371. [PMID: 31629051]
  • Omer Bayazeid, Cemil Can Eylem, Tuba Reçber, Funda Nuray Yalçın, Sedef Kır, Emirhan Nemutlu. An LC-ESI-MS/MS method for the simultaneous determination of pronuciferine and roemerine in some Papaver species. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Oct; 1096(?):223-227. doi: 10.1016/j.jchromb.2018.08.020. [PMID: 30189375]
  • Fatma Gizem Avci, Nihat Alpagu Sayar, Berna Sariyar Akbulut. An OMIC approach to elaborate the antibacterial mechanisms of different alkaloids. Phytochemistry. 2018 May; 149(?):123-131. doi: 10.1016/j.phytochem.2017.12.023. [PMID: 29494814]
  • Nan Wu, Huihui Xie, Yingtong Fang, Yuanyuan Liu, Xingjun Xi, Qiao Chu, Genlai Dong, Tao Lan, Yun Wei. Isolation and purification of alkaloids from lotus leaves by ionic-liquid-modified high-speed countercurrent chromatography. Journal of separation science. 2018 Jan; 41(2):571-577. doi: 10.1002/jssc.201700851. [PMID: 29087605]
  • Dilara Ayyildiz, Kazim Yalcin Arga, Fatma Gizem Avci, Fatma Ece Altinisik, Caglayan Gurer, Gizem Gulsoy Toplan, Dilek Kazan, Katharina Wozny, Britta Brügger, Bulent Mertoglu, Berna Sariyar Akbulut. Transcriptomic analysis displays the effect of (-)-roemerine on the motility and nutrient uptake in Escherichia coli. Current genetics. 2017 Aug; 63(4):709-722. doi: 10.1007/s00294-016-0673-4. [PMID: 28013396]
  • Chhavarath Dary, Sok-Siya Bun, Gaëtan Herbette, Fathi Mabrouki, Hot Bun, Sothea Kim, Florian Jabbour, Sovanmoly Hul, Béatrice Baghdikian, Evelyne Ollivier. Chemical profiling of the tuber of Stephania cambodica Gagnep. (Menispermaceae) and analytical control by UHPLC-DAD. Natural product research. 2017 Apr; 31(7):802-809. doi: 10.1080/14786419.2016.1247077. [PMID: 27976592]
  • Hong-Bin Ma, Zhong-Shi Tian, Shi-Liang Gui, Wei-Guo Cui, Wei Li. [Anti-prostate cancer effect of roemerine: An experimental study]. Zhonghua nan ke xue = National journal of andrology. 2017 Jan; 23(1):27-33. doi: NULL. [PMID: 29658233]
  • Chaoyu Ma, Faya Du, Lan Yan, Gonghao He, Jianchang He, Chengying Wang, Gaoxiong Rao, Yuanying Jiang, Guili Xu. Potent Activities of Roemerine against Candida albicans and the Underlying Mechanisms. Molecules (Basel, Switzerland). 2015 Sep; 20(10):17913-28. doi: 10.3390/molecules201017913. [PMID: 26426004]
  • Nilay Budeyri Gokgoz, Berna Sariyar Akbulut. Proteomics Evidence for the Activity of the Putative Antibacterial Plant Alkaloid (-)-Roemerine: Mainstreaming Omics-Guided Drug Discovery. Omics : a journal of integrative biology. 2015 Aug; 19(8):478-89. doi: 10.1089/omi.2015.0056. [PMID: 26230533]
  • Sunjun Yin, Gaoxiong Rao, Jin Wang, Liyang Luo, Gonghao He, Chengying Wang, Chaoyu Ma, Xiaoxing Luo, Zheng Hou, Guili Xu. Roemerine Improves the Survival Rate of Septicemic BALB/c Mice by Increasing the Cell Membrane Permeability of Staphylococcus aureus. PloS one. 2015; 10(11):e0143863. doi: 10.1371/journal.pone.0143863. [PMID: 26606133]
  • Yue-Qiong Liu, Gong-Hao He, Hong-Liang Li, Jiang-Chang He, En-Fu Feng, Lan Bai, Cheng-Ying Wang, Gui-Li Xu. Plasma pharmacokinetics and tissue distribution study of roemerine in rats by liquid chromatography with tandem mass spectrometry (LC-MS/MS). Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Oct; 969(?):249-55. doi: 10.1016/j.jchromb.2014.08.031. [PMID: 25195027]
  • Zhenjia Zheng, Minglin Wang, Daijie Wang, Wenjuan Duan, Xiao Wang, Chengchao Zheng. Preparative separation of alkaloids from Nelumbo nucifera leaves by conventional and pH-zone-refining counter-current chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Jun; 878(19):1647-51. doi: 10.1016/j.jchromb.2010.04.020. [PMID: 20451476]