Tauroursodeoxycholic acid (BioDeep_00000265463)

Main id: BioDeep_00000017905

 

natural product PANOMIX_OTCML-2023 Bile acids


代谢物信息卡片


Tauroursodeoxycholic acid

化学式: C26H45NO6S (499.2967)
中文名称: 牛磺脱氧胆酸二水合物
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C
InChI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20+,21+,22+,24+,25+,26-/m1/s1

描述信息

C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C61074 - Serine/Threonine Kinase Inhibitor
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent
D005765 - Gastrointestinal Agents > D002756 - Cholagogues and Choleretics
D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D005765 - Gastrointestinal Agents > D002793 - Cholic Acids
Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.
Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

同义名列表

5 个代谢物同义名

Tauroursodeoxycholic acid; TUDCA; UR 906; Tauroursodeoxycholate; Tauroursodeoxycholic acid



数据库引用编号

34 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Aliya Ayaz, Abdul Jalal, Zhou Qian, Khalid Ali Khan, Liwang Liu, Chunmei Hu, Ying Li, Xilin Hou. Investigating the effects of tauroursodeoxycholic acid (TUDCA) in mitigating endoplasmic reticulum stress and cellular responses in Pak choi. Physiologia plantarum. 2024 Mar; 176(2):e14246. doi: 10.1111/ppl.14246. [PMID: 38467573]
  • Yanbo Chang, Xuejing Li, Jinping Jiang, Lanlan Gui, Linfei Wan, Xiangxiang Zhou, Linchuan Liao, Kexin Li, Ke Lan. Separation of bile acid isomer plays a pivotal role in bioequivalence evaluation of ursodeoxycholic acid. Journal of pharmaceutical and biomedical analysis. 2024 Feb; 239(?):115882. doi: 10.1016/j.jpba.2023.115882. [PMID: 38071766]
  • Qiuyue Wang, Wen Li, Xiaozhuo Zhang, Shuet Ling Chung, Jinling Dai, Zhu Jin. Tauroursodeoxycholic acid protects Schwann cells from high glucose-induced cytotoxicity by targeting NLRP3 to regulate cell migration and pyroptosis. Biotechnology and applied biochemistry. 2024 Feb; 71(1):28-37. doi: 10.1002/bab.2518. [PMID: 37749820]
  • Na Cui, Wensen Zhang, Fazhi Su, Zhihong Zhang, Weijie Qiao, Yanping Sun, Bingyou Yang, Haixue Kuang, Qiuhong Wang. Metabolomics and Lipidomics Study Unveils the Impact of Tauroursodeoxycholic Acid on Hyperlipidemic Mice. Molecules (Basel, Switzerland). 2023 Aug; 28(17):. doi: 10.3390/molecules28176352. [PMID: 37687178]
  • Kelu Lei, Minghao Yuan, Sihui Li, Qiang Zhou, Meifeng Li, Dafu Zeng, Yiping Guo, Li Guo. Performance evaluation of E-nose and E-tongue combined with machine learning for qualitative and quantitative assessment of bear bile powder. Analytical and bioanalytical chemistry. 2023 Jul; 415(17):3503-3513. doi: 10.1007/s00216-023-04740-5. [PMID: 37199792]
  • Himanshu Sankrityayan, Vishwadeep Shelke, Ajinath Kale, Anil Bhanudas Gaikwad. Evaluating the potential of tauroursodeoxycholic acid as add-on therapy in amelioration of streptozotocin-induced diabetic kidney disease. European journal of pharmacology. 2023 Mar; 942(?):175528. doi: 10.1016/j.ejphar.2023.175528. [PMID: 36690052]
  • Guochao Song, Fengyi Weng, Bin Zou, Jing Zhao, Jingyi Jin, Dongming Yan, Kai Huang, Xing Sun, Cheng-Hai Liu, Yi-Yang Hu, Yue Li, Furong Qiu. Potential therapeutic action of Tauroursodeoxycholic acid against cholestatic liver injury via hepatic Fxr/Nrf2 and CHOP-DR5-caspase-8 pathway. Clinical science (London, England : 1979). 2023 Feb; ?(?):. doi: 10.1042/cs20220674. [PMID: 36795945]
  • Jing Zhao, Guochao Song, Fengyi Weng, Yue Li, Bin Zou, Jingyi Jin, Dongming Yan, Xin Sun, Chenghai Liu, Fu-Rong Qiu. The choleretic role of TUDCA exacerbates ANIT-induced cholestatic liver injury through the FXR/BSEP pathway. Journal of applied toxicology : JAT. 2023 Feb; ?(?):. doi: 10.1002/jat.4446. [PMID: 36787806]
  • Xiaolu Zhou, Yaling Li, Ren Mu, Chuanming Wang, Yuyan Song, Caibi Zhou, Xin Mei. Duyun compound green tea extracts regulate bile acid metabolism on mice induced by high-fat diet. The British journal of nutrition. 2022 Oct; ?(?):1-9. doi: 10.1017/s0007114522003166. [PMID: 36210537]
  • Dongqin Wei, Yizhou Li, Meng Che, Chaowei Li, Qiong Wu, Chao Sun. Melatonin relieves hepatic lipid dysmetabolism caused by aging via modifying the secondary bile acid pattern of gut microbes. Cellular and molecular life sciences : CMLS. 2022 Sep; 79(10):527. doi: 10.1007/s00018-022-04412-0. [PMID: 36151409]
  • Duygu Elif Yilmaz, Karin Kirschner, Hasan Demirci, Nina Himmerkus, Sebastian Bachmann, Kerim Mutig. Immunosuppressive calcineurin inhibitor cyclosporine A induces proapoptotic endoplasmic reticulum stress in renal tubular cells. The Journal of biological chemistry. 2022 03; 298(3):101589. doi: 10.1016/j.jbc.2022.101589. [PMID: 35033536]
  • Siyu Wu, Lorenzo Romero-Ramírez, Jörg Mey. Taurolithocholic acid but not tauroursodeoxycholic acid rescues phagocytosis activity of bone marrow-derived macrophages under inflammatory stress. Journal of cellular physiology. 2022 02; 237(2):1455-1470. doi: 10.1002/jcp.30619. [PMID: 34705285]
  • Yong Wu, Huan Yang, Sujuan Xu, Ming Cheng, Jie Gu, Weichen Zhang, Shaojun Liu, Minmin Zhang. AIM2 inflammasome contributes to aldosterone-induced renal injury via endoplasmic reticulum stress. Clinical science (London, England : 1979). 2022 01; 136(1):103-120. doi: 10.1042/cs20211075. [PMID: 34935888]
  • Min Yao, Gan Li, Long-Yun Zhou, Zhong Zheng, Yue-Li Sun, Shu-Fen Liu, Yong-Jun Wang, Xue-Jun Cui. Shikonin inhibits neuronal apoptosis via regulating endoplasmic reticulum stress in the rat model of double-level chronic cervical cord compression. Cell biology and toxicology. 2022 Jan; ?(?):. doi: 10.1007/s10565-021-09648-3. [PMID: 35028790]
  • Ya Zhang, Jian Liu, Genxiang Mao, Jihui Zuo, Shijun Li, Yue Yang, Ronald W Thring, Mingjiang Wu, Haibin Tong. Sargassum fusiforme fucoidan alleviates diet-induced insulin resistance by inhibiting colon-derived ceramide biosynthesis. Food & function. 2021 Sep; 12(18):8440-8453. doi: 10.1039/d1fo01272j. [PMID: 34374401]
  • Qifan Lu, Zhaoyan Jiang, Qihan Wang, Hai Hu, Gang Zhao. The effect of Tauroursodeoxycholic acid (TUDCA) and gut microbiota on murine gallbladder stone formation. Annals of hepatology. 2021 Jul; 23(?):100289. doi: 10.1016/j.aohep.2020.100289. [PMID: 33217585]
  • Cong Liang, Xiao-Hong Zhou, Pi-Min Gong, Hai-Yue Niu, Lin-Zheng Lyu, Yi-Fan Wu, Xue Han, Lan-Wei Zhang. Lactiplantibacillus plantarum H-87 prevents high-fat diet-induced obesity by regulating bile acid metabolism in C57BL/6J mice. Food & function. 2021 May; 12(10):4315-4324. doi: 10.1039/d1fo00260k. [PMID: 34031676]
  • Lucas Zangerolamo, Jean F Vettorazzi, Lucas R O Rosa, Everardo M Carneiro, Helena C L Barbosa. The bile acid TUDCA and neurodegenerative disorders: An overview. Life sciences. 2021 May; 272(?):119252. doi: 10.1016/j.lfs.2021.119252. [PMID: 33636170]
  • Julien Allard, Simon Bucher, Julie Massart, Pierre-Jean Ferron, Dounia Le Guillou, Roxane Loyant, Yoann Daniel, Youenn Launay, Nelly Buron, Karima Begriche, Annie Borgne-Sanchez, Bernard Fromenty. Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell biology and toxicology. 2021 04; 37(2):151-175. doi: 10.1007/s10565-020-09537-1. [PMID: 32535746]
  • Avinash K Persaud, Sreenath Nair, Md Fazlur Rahman, Radhika Raj, Brenna Weadick, Debasis Nayak, Craig McElroy, Muruganandan Shanmugam, Sue Knoblaugh, Xiaolin Cheng, Rajgopal Govindarajan. Facilitative lysosomal transport of bile acids alleviates ER stress in mouse hematopoietic precursors. Nature communications. 2021 02; 12(1):1248. doi: 10.1038/s41467-021-21451-6. [PMID: 33623001]
  • Holden W Hemingway, Amy M Moore, Albert H Olivencia-Yurvati, Steven A Romero. Effect of endoplasmic reticulum stress on endothelial ischemia-reperfusion injury in humans. American journal of physiology. Regulatory, integrative and comparative physiology. 2020 12; 319(6):R666-R672. doi: 10.1152/ajpregu.00257.2020. [PMID: 33074709]
  • Iván L Csanaky, Andrew J Lickteig, Youcai Zhang, Curtis D Klaassen. Effects of patent ductus venosus on bile acid homeostasis in aryl hydrocarbon receptor (AhR)-null mice. Toxicology and applied pharmacology. 2020 09; 403(?):115136. doi: 10.1016/j.taap.2020.115136. [PMID: 32679164]
  • Sabrina Paganoni, Eric A Macklin, Suzanne Hendrix, James D Berry, Michael A Elliott, Samuel Maiser, Chafic Karam, James B Caress, Margaret A Owegi, Adam Quick, James Wymer, Stephen A Goutman, Daragh Heitzman, Terry Heiman-Patterson, Carlayne E Jackson, Colin Quinn, Jeffrey D Rothstein, Edward J Kasarskis, Jonathan Katz, Liberty Jenkins, Shafeeq Ladha, Timothy M Miller, Stephen N Scelsa, Tuan H Vu, Christina N Fournier, Jonathan D Glass, Kristin M Johnson, Andrea Swenson, Namita A Goyal, Gary L Pattee, Patricia L Andres, Suma Babu, Marianne Chase, Derek Dagostino, Samuel P Dickson, Noel Ellison, Meghan Hall, Kent Hendrix, Gale Kittle, Michelle McGovern, Joseph Ostrow, Lindsay Pothier, Rebecca Randall, Jeremy M Shefner, Alexander V Sherman, Eric Tustison, Prasha Vigneswaran, Jason Walker, Hong Yu, James Chan, Janet Wittes, Joshua Cohen, Justin Klee, Kent Leslie, Rudolph E Tanzi, Walter Gilbert, Patrick D Yeramian, David Schoenfeld, Merit E Cudkowicz. Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis. The New England journal of medicine. 2020 09; 383(10):919-930. doi: 10.1056/nejmoa1916945. [PMID: 32877582]
  • Nicola Gray, Lee A Gethings, Robert S Plumb, Ian D Wilson. UHPLC-MS-Based Lipidomic and Metabonomic Investigation of the Metabolic Phenotypes of Wild Type and Hepatic CYP Reductase Null (HRN) Mice. Journal of pharmaceutical and biomedical analysis. 2020 Jul; 186(?):113318. doi: 10.1016/j.jpba.2020.113318. [PMID: 32380354]
  • Sebastiano Masuri, Enzo Cadoni, Maria Grazia Cabiddu, Francesco Isaia, Maria Giovanna Demuru, Lukáš Moráň, David Buček, Petr Vaňhara, Josef Havel, Tiziana Pivetta. The first copper(ii) complex with 1,10-phenanthroline and salubrinal with interesting biochemical properties. Metallomics : integrated biometal science. 2020 06; 12(6):891-901. doi: 10.1039/d0mt00006j. [PMID: 32337526]
  • Timothy W Olsen, Roy B Dyer, Fukutaro Mano, Jeffrey H Boatright, Micah A Chrenek, Daniel Paley, Kathy Wabner, Jenn Schmit, Ju Byung Chae, Jana T Sellers, Ravinder J Singh, Timothy S Wiedmann. Drug Tissue Distribution of TUDCA From a Biodegradable Suprachoroidal Implant versus Intravitreal or Systemic Delivery in the Pig Model. Translational vision science & technology. 2020 05; 9(6):11. doi: 10.1167/tvst.9.6.11. [PMID: 32821508]
  • Runbin Sun, Dan Xu, Qingli Wei, Bangling Zhang, Jiye Aa, Guangji Wang, Yuan Xie. Silybin ameliorates hepatic lipid accumulation and modulates global metabolism in an NAFLD mouse model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Mar; 123(?):109721. doi: 10.1016/j.biopha.2019.109721. [PMID: 31865143]
  • Silei Sun, Bing Zhao, Mengzhi Qi, Yi Yao, Lili Xu, Ran Ji, Weiwei Chen, Jinlong Wang, Shunwei Huang, Li Ma, Ying Chen, Zhitao Yang, Huiqiu Sheng, Jian Fei, Erzhen Chen, Enqiang Mao. TUDCA Ameliorates Liver Injury Via Activation of SIRT1-FXR Signaling in a Rat Hemorrhagic Shock Model. Shock (Augusta, Ga.). 2020 02; 53(2):217-222. doi: 10.1097/shk.0000000000001351. [PMID: 30998645]
  • Jeenat Ferdous Urmi, Hiroaki Itoh, Keiko Muramatsu-Kato, Yukiko Kohmura-Kobayashi, Natsuyo Hariya, Divyanu Jain, Naoaki Tamura, Toshiyuki Uchida, Kazunao Suzuki, Yoshihiro Ogawa, Nobuaki Shiraki, Kazuki Mochizuki, Takeo Kubota, Naohiro Kanayama. Plasticity of histone modifications around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis. Scientific reports. 2019 11; 9(1):17100. doi: 10.1038/s41598-019-52943-7. [PMID: 31745102]
  • David Peter Obert, Alexander Karl Wolpert, Sebastian Korff. Modulation of Endoplasmic Reticulum Stress Influences Ischemia-Reperfusion Injury After Hemorrhagic Shock. Shock (Augusta, Ga.). 2019 11; 52(5):e76-e84. doi: 10.1097/shk.0000000000001298. [PMID: 30499877]
  • Yoshie Arai, Bogyu Choi, Byoung Ju Kim, Wongyu Rim, Sunghyun Park, Hyoeun Park, Jinsung Ahn, Soo-Hong Lee. Tauroursodeoxycholic acid (TUDCA) counters osteoarthritis by regulating intracellular cholesterol levels and membrane fluidity of degenerated chondrocytes. Biomaterials science. 2019 Aug; 7(8):3178-3189. doi: 10.1039/c9bm00426b. [PMID: 31143889]
  • Yiwei Zhu, Yuan Guan, Juan J Loor, Xueying Sha, Danielle N Coleman, Cai Zhang, Xiliang Du, Zhen Shi, Xiaobing Li, Zhe Wang, Guowen Liu, Xinwei Li. Fatty acid-induced endoplasmic reticulum stress promoted lipid accumulation in calf hepatocytes, and endoplasmic reticulum stress existed in the liver of severe fatty liver cows. Journal of dairy science. 2019 Aug; 102(8):7359-7370. doi: 10.3168/jds.2018-16015. [PMID: 31155263]
  • Raji Lenin, Peter G Nagy, Kumar Abhiram Jha, Rajashekhar Gangaraju. GRP78 translocation to the cell surface and O-GlcNAcylation of VE-Cadherin contribute to ER stress-mediated endothelial permeability. Scientific reports. 2019 07; 9(1):10783. doi: 10.1038/s41598-019-47246-w. [PMID: 31346222]
  • Jody Groenendyk, Alison Robinson, Qian Wang, Miao Hu, Jingfeng Tang, Xing-Zhen Chen, Michael Mengel, R Todd Alexander, Luis B Agellon, Marek Michalak. Tauroursodeoxycholic acid attenuates cyclosporine-induced renal fibrogenesis in the mouse model. Biochimica et biophysica acta. General subjects. 2019 07; 1863(7):1210-1216. doi: 10.1016/j.bbagen.2019.04.016. [PMID: 31028822]
  • Qi Zhou, Wenjia Guo, Yanan Jia, Jiancheng Xu. Effect of 4-Phenylbutyric Acid and Tauroursodeoxycholic Acid on Magnesium and Calcium Metabolism in Streptozocin-Induced Type 1 Diabetic Mice. Biological trace element research. 2019 Jun; 189(2):501-510. doi: 10.1007/s12011-018-1494-8. [PMID: 30171596]
  • Xing Yu, Tanchun Wang, Meichen Zhu, Liting Zhang, Fengzhi Zhang, Enen Jing, Yongzhe Ren, Zhiqiang Wang, Zeyu Xin, Tongbao Lin. Transcriptome and physiological analyses for revealing genes involved in wheat response to endoplasmic reticulum stress. BMC plant biology. 2019 May; 19(1):193. doi: 10.1186/s12870-019-1798-7. [PMID: 31072347]
  • Shijin Tang, Yinping Pan, Deshuai Lou, Shunlin Ji, Liancai Zhu, Jun Tan, Na Qi, Qiong Yang, Zhi Zhang, Biling Yang, Wenyan Zhao, Bochu Wang. Structural and functional characterization of a novel acidophilic 7α-hydroxysteroid dehydrogenase. Protein science : a publication of the Protein Society. 2019 05; 28(5):910-919. doi: 10.1002/pro.3599. [PMID: 30839141]
  • Carmen De Miguel, Randee Sedaka, Malgorzata Kasztan, Jeremie M Lever, Michelle Sonnenberger, Andrew Abad, Chunhua Jin, Pamela K Carmines, David M Pollock, Jennifer S Pollock. Tauroursodeoxycholic acid (TUDCA) abolishes chronic high salt-induced renal injury and inflammation. Acta physiologica (Oxford, England). 2019 05; 226(1):e13227. doi: 10.1111/apha.13227. [PMID: 30501003]
  • Yeo Min Yoon, SangMin Kim, Yong-Seok Han, Chul Won Yun, Jun Hee Lee, Hyunjin Noh, Sang Hun Lee. TUDCA-treated chronic kidney disease-derived hMSCs improve therapeutic efficacy in ischemic disease via PrPC. Redox biology. 2019 04; 22(?):101144. doi: 10.1016/j.redox.2019.101144. [PMID: 30785084]
  • Yingpeng Xu, Li Yang, Shujuan Zhao, Zhengtao Wang. Large-scale production of tauroursodeoxycholic acid products through fermentation optimization of engineered Escherichia coli cell factory. Microbial cell factories. 2019 Feb; 18(1):34. doi: 10.1186/s12934-019-1076-2. [PMID: 30736766]
  • Sevtap Han, Nur Banu Bal, Gökhan Sadi, Suzan Emel Usanmaz, Merve Matilda Tuglu, Mecit Orhan Uludag, Emine Demirel-Yilmaz. Inhibition of endoplasmic reticulum stress protected DOCA-salt hypertension-induced vascular dysfunction. Vascular pharmacology. 2019 02; 113(?):38-46. doi: 10.1016/j.vph.2018.11.004. [PMID: 30458302]
  • Hangqi Luo, Changzuan Zhou, Jufang Chi, Sunlei Pan, Hui Lin, Feidan Gao, Tingjuan Ni, Liping Meng, Jie Zhang, Chengjian Jiang, Zheng Ji, Haitao Lv, Hangyuan Guo. The Role of Tauroursodeoxycholic Acid on Dedifferentiation of Vascular Smooth Muscle Cells by Modulation of Endoplasmic Reticulum Stress and as an Oral Drug Inhibiting In-Stent Restenosis. Cardiovascular drugs and therapy. 2019 02; 33(1):25-33. doi: 10.1007/s10557-018-6844-4. [PMID: 30663009]
  • Jun Hee Lee, Yeo Min Yoon, Sang Hun Lee. TUDCA-Treated Mesenchymal Stem Cells Protect against ER Stress in the Hippocampus of a Murine Chronic Kidney Disease Model. International journal of molecular sciences. 2019 Jan; 20(3):. doi: 10.3390/ijms20030613. [PMID: 30708974]
  • Talha Rashid, Ivan Nemazanyy, Cecilia Paolini, Takashi Tatsuta, Paul Crespin, Delphine de Villeneuve, Susanne Brodesser, Paule Benit, Pierre Rustin, Martin A Baraibar, Onnik Agbulut, Anne Olivier, Feliciano Protasi, Thomas Langer, Roman Chrast, Pascale de Lonlay, Helene de Foucauld, Bert Blaauw, Mario Pende. Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone-responsive myopathy. The EMBO journal. 2019 01; 38(1):. doi: 10.15252/embj.201899576. [PMID: 30420558]
  • Alejandra Daruich, Emilie Picard, Jeffrey H Boatright, Francine Behar-Cohen. Review: The bile acids urso- and tauroursodeoxycholic acid as neuroprotective therapies in retinal disease. Molecular vision. 2019; 25(?):610-624. doi: ". [PMID: 31700226]
  • K-Y Bian, H-F Jin, W Sun, Y-J Sun. DCA can improve the ACI-induced neurological impairment through negative regulation of Nrf2 signaling pathway. European review for medical and pharmacological sciences. 2019 Jan; 23(1):343-351. doi: 10.26355/eurrev_201901_16782. [PMID: 30657576]
  • Zhi Jian Chen, Jia Xing Chen, Li Kang Wu, Bi Yun Li, Ya Feng Tian, Min Xian, Zi Pei Huang, Ri An Yu. Induction of Endoplasmic Reticulum Stress by Cadmium and Its Regulation on Nrf2 Signaling Pathway in Kidneys of Rats. Biomedical and environmental sciences : BES. 2019 Jan; 32(1):1-10. doi: 10.3967/bes2019.001. [PMID: 30696534]
  • Xinxin Pang, Yage Zhang, Xiujie Shi, Dongyang Li, Jiarui Han. ERp44 depletion exacerbates ER stress and aggravates diabetic nephropathy in db/db mice. Biochemical and biophysical research communications. 2018 10; 504(4):921-926. doi: 10.1016/j.bbrc.2018.09.037. [PMID: 30224065]
  • Hyo-Jin Park, Dong Gil Lee, Jung Bae Seong, Hyun-Shik Lee, Oh-Shin Kwon, Beom Sik Kang, Jeen-Woo Park, Sang-Rae Lee, Dong-Seok Lee. Peroxiredoxin I maintains luteal function by regulating unfolded protein response. Reproductive biology and endocrinology : RB&E. 2018 Aug; 16(1):79. doi: 10.1186/s12958-018-0396-0. [PMID: 30111318]
  • Dibyendu K Panda, Xiuying Bai, Yves Sabbagh, Yan Zhang, Hans-Christian Zaun, Angeliki Karellis, Antonis E Koromilas, Mark L Lipman, Andrew C Karaplis. Defective interplay between mTORC1 activity and endoplasmic reticulum stress-unfolded protein response in uremic vascular calcification. American journal of physiology. Renal physiology. 2018 06; 314(6):F1046-F1061. doi: 10.1152/ajprenal.00350.2017. [PMID: 29357413]
  • Yu Gu, Fei Huang, Yanling Wang, Chaojin Chen, Shan Wu, Shaoli Zhou, Ziqing Hei, Dongdong Yuan. Connexin32 plays a crucial role in ROS-mediated endoplasmic reticulum stress apoptosis signaling pathway in ischemia reperfusion-induced acute kidney injury. Journal of translational medicine. 2018 05; 16(1):117. doi: 10.1186/s12967-018-1493-8. [PMID: 29728112]
  • Weijun Wang, Jinfang Zhao, Wenfang Gui, Dan Sun, Haijiang Dai, Li Xiao, Huikuan Chu, Fan Du, Qingjing Zhu, Bernd Schnabl, Kai Huang, Ling Yang, Xiaohua Hou. Tauroursodeoxycholic acid inhibits intestinal inflammation and barrier disruption in mice with non-alcoholic fatty liver disease. British journal of pharmacology. 2018 02; 175(3):469-484. doi: 10.1111/bph.14095. [PMID: 29139555]
  • Ying Yang, Xianglin Tang, Feiran Hao, Zengchun Ma, Yuguang Wang, Lili Wang, Yue Gao. Bavachin Induces Apoptosis through Mitochondrial Regulated ER Stress Pathway in HepG2 Cells. Biological & pharmaceutical bulletin. 2018 Feb; 41(2):198-207. doi: 10.1248/bpb.b17-00672. [PMID: 29187671]
  • Seung Pil Yun, Yeo Min Yoon, Jun Hee Lee, Minjee Kook, Yong-Seok Han, Seo Kyung Jung, Sang Hun Lee. Tauroursodeoxycholic Acid Protects against the Effects of P-Cresol-Induced Reactive Oxygen Species via the Expression of Cellular Prion Protein. International journal of molecular sciences. 2018 Jan; 19(2):. doi: 10.3390/ijms19020352. [PMID: 29370069]
  • Ying Zhang, Pengxiang Qu, Xiaonan Ma, Fang Qiao, Yefei Ma, Suzhu Qing, Yong Zhang, Yongsheng Wang, Wei Cui. Tauroursodeoxycholic acid (TUDCA) alleviates endoplasmic reticulum stress of nuclear donor cells under serum starvation. PloS one. 2018; 13(5):e0196785. doi: 10.1371/journal.pone.0196785. [PMID: 29718981]
  • Yan Sun, Dai Zhang, Xiaoli Liu, Xuesong Li, Fang Liu, Yi Yu, Shuo Jia, Yujie Zhou, Yingxin Zhao. Endoplasmic Reticulum Stress Affects Lipid Metabolism in Atherosclerosis Via CHOP Activation and Over-Expression of miR-33. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 48(5):1995-2010. doi: 10.1159/000492522. [PMID: 30092598]
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