Coptisine (BioDeep_00000230824)
Secondary id: BioDeep_00000230034, BioDeep_00000395862
PANOMIX_OTCML-2023
代谢物信息卡片
5,7,17,19-tetraoxa-13-azoniahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-1(13),2,4(8),9,14,16(20),21,23-octaene;chloride
化学式: C19H14NO4+.Cl- (355.0611314000001)
中文名称: 盐酸黄连碱
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 2.22%
分子结构信息
SMILES: C1(C(CC[N+]2=C1C=C(C=C3)C(C4=C3OCO4)=C2)=C5)=CC6=C5OCO6.[Cl-]
InChI: /p-1
描述信息
Coptisine chloride is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM. Coptisine chloride is a potent H1N1 neuraminidase (NA-1) inhibitor with an IC50 of 104.6?μg/mL and can be used for influenza A (H1N1) infection.
Coptisine chloride is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM. Coptisine chloride is a potent H1N1 neuraminidase (NA-1) inhibitor with an IC50 of 104.6?μg/mL and can be used for influenza A (H1N1) infection.
同义名列表
24 个代谢物同义名
5,7,17,19-tetraoxa-13-azoniahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-1(13),2,4(8),9,14,16(20),21,23-octaene;chloride; 6,7-Dihydro-2H,10H-[1,3]dioxolo[4,5-g][1,3]dioxolo[7,8]isoquinolino[3,2-a]isoquinolin-5-ium chloride; 6,7-dihydro-[1,3]dioxolo[4,5:7,8]isoquinolino[3,2-a][1,3]dioxolo[4,5-g]isoquinolin-5-ium chloride; Bis[1,3]benzodioxolo[5,6-a:4,5-g]quinolizinium, 6,7-dihydro-, chloride (1:1); Berbinium, 7,8,13,13a-tetradehydro-2,3:9,10-bis(methylenedioxy)-, chloride; Berbinium,8,13,13a-tetradehydro-2,3:9,10-bis(methylenedioxy)-, chloride; Bis(1,3)benzodioxolo(5,6-a:4,5-g)quinolizinium, 6,7-dihydro-, chloride; Bis[1,3]benzodioxolo[5,6-a:4,5-g]quinolizinium, 6,7-dihydro-, chloride; 6,7-Dihydro-bis[1,3]benzodioxolo[5,6-a:4,5-g]quinolizinium Chloride; 7,8,13,13a-tetradehydro-2,3-9,10-bis(methylenedioxy)berbinium; Bis[1,6-a:4,5-g]quinolizinium, 6,7-dihydro-, chloride; Bis(methylenedioxy)protoberberine chloride; Coptisine chloride, analytical standard; Coptisine Chloride, >=98\\% (HPLC); Coptisine chloride, HPLC Grade; Coptisine hydrochloride; Coptisine (chloride); Coptisine, chloride; Coptisine chloride; Coptisine-chloride; Coptisin Chloride; UNII-4RSB8UY88E; 4RSB8UY88E; Coptisine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Fangqiu Xu, Chuyu Shen, Shuoyang Zhang, Yingli Liu, Di Liu, Yu Kuang, Ruiru Li, Cuicui Wang, Xiaoyan Cai, Maohua Shi, Youjun Xiao. Coptisine inhibits aggressive and proliferative actions of fibroblast like synoviocytes and exerts a therapeutic potential for rheumatoid arthritis.
International immunopharmacology.
2024 Jan; 128(?):111433. doi:
10.1016/j.intimp.2023.111433. [PMID: 38181676] - Chih-Hsin Lin, Yih-Ru Wu, Chih-Ying Chao, Kuo-Hsuan Chang, Chiung-Mei Chen, Wan-Ling Chen, Pei-Ning Yang, Guey-Jen Lee-Chen. Protective Effects of Coptis chinensis Rhizome Extract and Its Constituents (Berberine, Coptisine, and Palmatine) against α-Synuclein Neurotoxicity in Dopaminergic SH-SY5Y Cells.
Biological & pharmaceutical bulletin.
2024; 47(4):827-839. doi:
10.1248/bpb.b23-00758. [PMID: 38599826] - Qiang Lu, Ying Tang, Shuang Luo, Qihai Gong, Cailan Li. Coptisine, the Characteristic Constituent from Coptis chinensis, Exhibits Significant Therapeutic Potential in Treating Cancers, Metabolic and Inflammatory Diseases.
The American journal of Chinese medicine.
2023 Nov; ?(?):1-36. doi:
10.1142/s0192415x2350091x. [PMID: 37930333] - Junjie Zhang, Ao Qi, Lulu Liu, Chun Cai, Hui Xu. Gas Chromatography-Mass Spectrometry-Based Cerebrospinal Fluid Metabolomics to Reveal the Protection of Coptisine against Transient Focal Cerebral Ischemia-Reperfusion Injury via Anti-Inflammation and Antioxidant.
Molecules (Basel, Switzerland).
2023 Aug; 28(17):. doi:
10.3390/molecules28176350. [PMID: 37687175] - Kuangyang Yang, Qian Xie, Jiaxin Liao, Na Zhao, Jianhui Liang, Ben Liu, Jianhai Chen, Wenxiang Cheng, Xueling Bai, Peng Zhang, Qian Liu, Bing Song, Junyi Danny Wang, Fanghao Zheng, Chun Hu, Lichu Liu, Lei Chen, Yan Wang. Shang-Ke-Huang-Shui and coptisine alleviate osteoarthritis in the knee of monosodium iodoacetate-induced rats through inhibiting CXCR4 signaling.
Journal of ethnopharmacology.
2023 Jul; 311(?):116476. doi:
10.1016/j.jep.2023.116476. [PMID: 37031825] - Ming-Feng He, Jian-Hui Liang, Yan-Ni Shen, Chao-Wei Zhang, Kuang-Yang Yang, Li-Chu Liu, Qian Xie, Chun Hu, Xun Song, Yan Wang. Coptisine Inhibits Influenza Virus Replication by Upregulating p21.
Molecules (Basel, Switzerland).
2023 Jul; 28(14):. doi:
10.3390/molecules28145398. [PMID: 37513270] - Yingxin Chen, Xiaotong Huang, Lu Li, Junxian Wu, Yongqi Guo, Yachao Yao, Lihua Zhou. Paper mill sludge-based carbon quantum dots as a specifically ratiometric fluorescent probe for the sensitive and selective detection of coptisine.
Luminescence : the journal of biological and chemical luminescence.
2022 Jul; 37(7):1078-1086. doi:
10.1002/bio.4260. [PMID: 35441456] - Yue He, Xiaoyin Zhang, Ming Li, Nan Zheng, Shengguo Zhao, Jiaqi Wang. Coptisine: A natural plant inhibitor of ruminal bacterial urease screened by molecular docking.
The Science of the total environment.
2022 Feb; 808(?):151946. doi:
10.1016/j.scitotenv.2021.151946. [PMID: 34843773] - Lan Xie, Shanshan Feng, Xiaoling Zhang, Wenlong Zhao, Juan Feng, Chengmei Ma, Ruijun Wang, Weifang Song, Jing Cheng. Biological Response Profiling Reveals the Functional Differences of Main Alkaloids in Rhizoma Coptidis.
Molecules (Basel, Switzerland).
2021 Dec; 26(23):. doi:
10.3390/molecules26237389. [PMID: 34885971] - Xueshan Wen, Xing Zhang, Shulan Qu, Xugang Chen, Cheng Liu, Yifu Yang. Coptisine induces G2/M arrest in esophageal cancer cell via the inhibition of p38/ERK1/2/claudin-2 signaling pathway.
Die Pharmazie.
2021 05; 76(5):202-207. doi:
10.1691/ph.2021.1353. [PMID: 33964993] - Yongfu Wang, Jingjing Liu, Ziwei Huang, Yucui Li, Yuanyuan Liang, Chaodan Luo, Chen Ni, Jianhui Xie, Ziren Su, Jiannan Chen, Cailan Li. Coptisine ameliorates DSS-induced ulcerative colitis via improving intestinal barrier dysfunction and suppressing inflammatory response.
European journal of pharmacology.
2021 Apr; 896(?):173912. doi:
10.1016/j.ejphar.2021.173912. [PMID: 33508280] - Wei Ren, Fuchun Nan, Shumu Li, Sijin Yang, Jiechao Ge, Zhenwen Zhao. Red Emissive Carbon Dots Prepared from Polymers as an Efficient Nanocarrier for Coptisine Delivery in vivo and in vitro.
ChemMedChem.
2021 02; 16(4):646-653. doi:
10.1002/cmdc.202000420. [PMID: 32959534] - Shengmei Sun, Pengfei Wang. Coptisine alleviates ischemia/reperfusion-induced myocardial damage by regulating apoptosis-related proteins.
Tissue & cell.
2020 Oct; 66(?):101392. doi:
10.1016/j.tice.2020.101392. [PMID: 32933715] - Nana Wen, Lu Xue, Yongle Yang, Shunbo Shi, Qing-Hua Liu, Congli Cai, Jinhua Shen. Coptisine, a protoberberine alkaloid, relaxes mouse airway smooth muscle via blockade of VDLCCs and NSCCs.
Bioscience reports.
2020 02; 40(2):. doi:
10.1042/bsr20190534. [PMID: 32095824] - Jiajia Zhai, Zeping Li, Huifeng Zhang, Louyan Ma, Zhengquan Ma, Yi Zhang, Jian Zou, Mo Li, Li Ma, Xiaomiao Li. Coptisine ameliorates renal injury in diabetic rats through the activation of Nrf2 signaling pathway.
Naunyn-Schmiedeberg's archives of pharmacology.
2020 01; 393(1):57-65. doi:
10.1007/s00210-019-01710-6. [PMID: 31420722] - Xiang-Peng Kong, Etta Y L Liu, Zhi-Cong Chen, Miranda Li Xu, Anna X D Yu, Qi-Yun Wu, Ying-Jie Xia, Ran Duan, Tina T X Dong, Karl W K Tsim. Synergistic Inhibition of Acetylcholinesterase by Alkaloids Derived from Stephaniae Tetrandrae Radix, Coptidis Rhizoma and Phellodendri Chinensis Cortex.
Molecules (Basel, Switzerland).
2019 Dec; 24(24):. doi:
10.3390/molecules24244567. [PMID: 31847089] - Jiasi Wu, Yu Luo, Donghang Deng, Siyu Su, Sheng Li, Li Xiang, Yingfan Hu, Ping Wang, Xianli Meng. Coptisine from Coptis chinensis exerts diverse beneficial properties: A concise review.
Journal of cellular and molecular medicine.
2019 12; 23(12):7946-7960. doi:
10.1111/jcmm.14725. [PMID: 31622015] - Li-Li Shi, Wei-Hua Jia, Li Zhang, Chun-Yang Xu, Xi Chen, Lin Yin, Nuo-Qi Wang, Lian-Hua Fang, Gui-Fen Qiang, Xiu-Ying Yang, Guan-Hua Du. Glucose consumption assay discovers coptisine with beneficial effect on diabetic mice.
European journal of pharmacology.
2019 Sep; 859(?):172523. doi:
10.1016/j.ejphar.2019.172523. [PMID: 31279667] - Lan Gao, Hans-Joachim Schmitz, Karl-Heinz Merz, Dieter Schrenk. Characterization of the cytotoxicity of selected Chelidonium alkaloids in rat hepatocytes.
Toxicology letters.
2019 Sep; 311(?):91-97. doi:
10.1016/j.toxlet.2019.04.031. [PMID: 31054355] - Thomas Kopp, Mona Abdel-Tawab, Martin Khoeiklang, Boris Mizaikoff. Development of a Selective Adsorbing Material for Binding of Pyrrolizidine Alkaloids in Herbal Extracts, Based on Molecular Group Imprinting.
Planta medica.
2019 Sep; 85(13):1107-1113. doi:
10.1055/a-0961-2658. [PMID: 31382302] - Jiasi Wu, Yu Luo, Qing Jiang, Sheng Li, Wenge Huang, Li Xiang, Deming Liu, Yingfan Hu, Ping Wang, Xiaoxia Lu, Guolin Zhang, Fei Wang, Xianli Meng. Coptisine from Coptis chinensis blocks NLRP3 inflammasome activation by inhibiting caspase-1.
Pharmacological research.
2019 09; 147(?):104348. doi:
10.1016/j.phrs.2019.104348. [PMID: 31336157] - Zhong-Min Zhao, Xiao-Fei Shang, Raymond Kobla Lawoe, Ying-Qian Liu, Rui Zhou, Yu Sun, Yin-Fang Yan, Jun-Cai Li, Guan-Zhou Yang, Cheng-Jie Yang. Anti-phytopathogenic activity and the possible mechanisms of action of isoquinoline alkaloid sanguinarine.
Pesticide biochemistry and physiology.
2019 Sep; 159(?):51-58. doi:
10.1016/j.pestbp.2019.05.015. [PMID: 31400784] - Cuiting Wu, Xin Wang, Ming Xu, Youping Liu, Xin Di. Intracellular Accumulation as an Indicator of Cytotoxicity to Screen Hepatotoxic Components of Chelidonium majus L. by LC-MS/MS.
Molecules (Basel, Switzerland).
2019 Jun; 24(13):. doi:
10.3390/molecules24132410. [PMID: 31261913] - Yingfan Hu, Li Wang, Li Xiang, Jiasi Wu, Wen'ge Huang, Chensi Xu, Xianli Meng, Ping Wang. Pharmacokinetic-Pharmacodynamic Modeling for Coptisine Challenge of Inflammation in LPS-Stimulated Rats.
Scientific reports.
2019 02; 9(1):1450. doi:
10.1038/s41598-018-38164-4. [PMID: 30723253] - Bing Han, Pu Jiang, Heshan Xu, Wuyang Liu, Jian Zhang, Siqi Wu, Liangyu Liu, Wenyu Ma, Xuegang Li, Xiaoli Ye. 8-Cetylcoptisine, a new coptisine derivative, induces mitochondria-dependent apoptosis and G0/G1 cell cycle arrest in human A549 cells.
Chemico-biological interactions.
2019 Feb; 299(?):27-36. doi:
10.1016/j.cbi.2018.11.005. [PMID: 30472432] - Cailan Li, Ping Huang, Kambo Wong, Yifei Xu, Lihua Tan, Hanbin Chen, Qiang Lu, Chaodan Luo, Chunlai Tam, Lixiang Zhu, Ziren Su, Jianhui Xie. Coptisine-induced inhibition of Helicobacter pylori: elucidation of specific mechanisms by probing urease active site and its maturation process.
Journal of enzyme inhibition and medicinal chemistry.
2018 Dec; 33(1):1362-1375. doi:
10.1080/14756366.2018.1501044. [PMID: 30191728] - Shuilian Fu, Saihong Ni, Danni Wang, Tie Hong. Coptisine Suppresses Mast Cell Degranulation and Ovalbumin-Induced Allergic Rhinitis.
Molecules (Basel, Switzerland).
2018 Nov; 23(11):. doi:
10.3390/molecules23113039. [PMID: 30469322] - Bing Han, Pu Jiang, Zhaoxing Li, Yang Yu, Tao Huang, Xiaoli Ye, Xuegang Li. Coptisine-induced apoptosis in human colon cancer cells (HCT-116) is mediated by PI3K/Akt and mitochondrial-associated apoptotic pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2018 Sep; 48(?):152-160. doi:
10.1016/j.phymed.2017.12.027. [PMID: 30195873] - Xinyu Zhao, Yan Wang, Lu Zheng, Chengpeng Sun, Chao Wang, Haijian Cong, Ting Xiang, Lin Zhang, Houli Zhang, Sa Deng, Baojing Zhang, Bin Wu, Xiaokui Huo. Comparative pharmacokinetics study of five alkaloids in rat plasma and related compound-herb interactions mechanism after oral administration of Shuanghua Baihe tablets.
Natural product research.
2018 Sep; 32(17):2031-2036. doi:
10.1080/14786419.2017.1365075. [PMID: 28871816] - Fang-Ni Chai, Wen-Yu Ma, Jian Zhang, He-Shan Xu, Yuan-Feng Li, Qi-De Zhou, Xue-Gang Li, Xiao-Li Ye. Coptisine from Rhizoma coptidis exerts an anti-cancer effect on hepatocellular carcinoma by up-regulating miR-122.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jul; 103(?):1002-1011. doi:
10.1016/j.biopha.2018.04.052. [PMID: 29710498] - Li Lang, Qian Hu, Jingyuan Wang, Zehui Liu, Jin Huang, Weiqiang Lu, Ying Huang. Coptisine, a natural alkaloid from Coptidis Rhizoma, inhibits plasmodium falciparum dihydroorotate dehydrogenase.
Chemical biology & drug design.
2018 07; 92(1):1324-1332. doi:
10.1111/cbdd.13197. [PMID: 29582555] - Xiaoling Gu, Yang Jin, Fang Dong, Yueqing Cai, Zhengyi You, Junhui You, Liying Zhang, Shuhu Du. Toward rapid analysis, forecast and discovery of bioactive compounds from herbs by jointly using thin layer chromatography and ratiometric surface-enhanced Raman spectroscopy technique.
Journal of pharmaceutical and biomedical analysis.
2018 May; 153(?):9-15. doi:
10.1016/j.jpba.2018.02.016. [PMID: 29459236] - Tian-Jin Wu, Jun Lu, Hui Ni, Ping Li, Yan Jiang, Hui-Jun Li. Construction of an optimized method for quality evaluation and species discrimination of Coptidis Rhizoma by ion-pair high performance liquid chromatography combined with response surface methodology.
Journal of pharmaceutical and biomedical analysis.
2018 May; 153(?):152-157. doi:
10.1016/j.jpba.2018.02.019. [PMID: 29494887] - Chaodan Luo, Hanbin Chen, Yongfu Wang, Guosheng Lin, Cailan Li, Lihua Tan, Ziren Su, Xiaoping Lai, Jianhui Xie, Huifang Zeng. Protective effect of coptisine free base on indomethacin-induced gastric ulcers in rats: Characterization of potential molecular mechanisms.
Life sciences.
2018 Jan; 193(?):47-56. doi:
10.1016/j.lfs.2017.12.004. [PMID: 29223540] - Han-Bin Chen, Chao-Dan Luo, Jia-Li Liang, Zhen-Biao Zhang, Guo-Sheng Lin, Jia-Zhen Wu, Cai-Lan Li, Li-Hua Tan, Xiao-Bo Yang, Zi-Ren Su, Jian-Hui Xie, Hui-Fang Zeng. Anti-inflammatory activity of coptisine free base in mice through inhibition of NF-κB and MAPK signaling pathways.
European journal of pharmacology.
2017 Sep; 811(?):222-231. doi:
10.1016/j.ejphar.2017.06.027. [PMID: 28648405] - Min Feng, Shu-Zhen Kong, Zhen-Xu Wang, Kai He, Zong-Yao Zou, Yin-Ran Hu, Hang Ma, Xue-Gang Li, Xiao-Li Ye. The protective effect of coptisine on experimental atherosclerosis ApoE-/- mice is mediated by MAPK/NF-κB-dependent pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Sep; 93(?):721-729. doi:
10.1016/j.biopha.2017.07.002. [PMID: 28700976] - Yahui Wang, Qiangli Wang, Lu Zhang, Zunli Ke, Yuanyuan Zhao, Dongshan Wang, Hui Chen, Xi Jiang, Ming Gu, Shengjie Fan, Cheng Huang. Coptisine protects cardiomyocyte against hypoxia/reoxygenation-induced damage via inhibition of autophagy.
Biochemical and biophysical research communications.
2017 08; 490(2):231-238. doi:
10.1016/j.bbrc.2017.06.027. [PMID: 28606475] - Yu Yan, Huifang Zhang, Zhihui Zhang, Junke Song, Yucai Chen, Xiaobo Wang, Yangyang He, Hailin Qin, Lianhua Fang, Guanhua Du. Pharmacokinetics and tissue distribution of coptisine in rats after oral administration by liquid chromatography-mass spectrometry.
Biomedical chromatography : BMC.
2017 Jul; 31(7):. doi:
10.1002/bmc.3918. [PMID: 27957743] - Jie Liang, Fuxue Chen, Fu Gu, Xin Liu, Feng Li, Dongshu Du. Expression and functional activity of bitter taste receptors in primary renal tubular epithelial cells and M-1 cells.
Molecular and cellular biochemistry.
2017 Apr; 428(1-2):193-202. doi:
10.1007/s11010-016-2929-1. [PMID: 28236092] - Tao Huang, Yubo Xiao, Lin Yi, Ling Li, Meimei Wang, Cheng Tian, Hang Ma, Kai He, Yue Wang, Bing Han, Xiaoli Ye, Xuegang Li. Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo.
Scientific reports.
2017 02; 7(?):38524. doi:
10.1038/srep38524. [PMID: 28165459] - Yu Jin Kim, Hye-Sun Lim, Yoonju Kim, Jun Lee, Bu-Yeo Kim, Soo-Jin Jeong. Neuroprotective Effect of Corydalis ternata Extract and Its Phytochemical Quantitative Analysis.
Chemical & pharmaceutical bulletin.
2017; 65(9):826-832. doi:
10.1248/cpb.c17-00300. [PMID: 28867709] - Yin-Ran Hu, Hang Ma, Zong-Yao Zou, Kai He, Yu-Bo Xiao, Yue Wang, Min Feng, Xiao-Li Ye, Xue-Gang Li. Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Jan; 85(?):313-322. doi:
10.1016/j.biopha.2016.11.031. [PMID: 27903425] - Jiasi Wu, Hai Zhang, Boyang Hu, Lijuan Yang, Ping Wang, Fei Wang, Xianli Meng. Coptisine from Coptis chinensis inhibits production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells.
European journal of pharmacology.
2016 Jun; 780(?):106-14. doi:
10.1016/j.ejphar.2016.03.037. [PMID: 27018392] - Liping Li, Siyuan Sun, Yayun Weng, Feifeng Song, Sisi Zhou, Mengru Bai, Hui Zhou, Su Zeng, Huidi Jiang. Interaction of six protoberberine alkaloids with human organic cation transporters 1, 2 and 3.
Xenobiotica; the fate of foreign compounds in biological systems.
2016; 46(2):175-83. doi:
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Journal of pharmaceutical and biomedical analysis.
2015 Nov; 115(?):339-44. doi:
10.1016/j.jpba.2015.07.034. [PMID: 26263062] - Zong-Yao Zou, Yin-Ran Hu, Hang Ma, Yan-Zhi Wang, Kai He, Shuang Xia, Hao Wu, Dong-Fang Xue, Xue-Gang Li, Xiao-Li Ye. Coptisine attenuates obesity-related inflammation through LPS/TLR-4-mediated signaling pathway in Syrian golden hamsters.
Fitoterapia.
2015 Sep; 105(?):139-46. doi:
10.1016/j.fitote.2015.06.005. [PMID: 26073947] - Chang-Seob Seo, Ohn Soon Kim, Jung-Hoon Kim, Hyeun-Kyoo Shin. Simultaneous quantification and antiatherosclerosis effect of the traditional Korean medicine, Hwangryunhaedok-tang.
BMC complementary and alternative medicine.
2015 Apr; 15(?):108. doi:
10.1186/s12906-015-0632-5. [PMID: 25880755] - Jana Paulsen, Mahdi Yahyazadeh, Sophie Hänsel, Maik Kleinwächter, Kerstin Ibrom, Dirk Selmar. 13,14-dihydrocoptisine--the genuine alkaloid from Chelidonium majus.
Phytochemistry.
2015 Mar; 111(?):149-53. doi:
10.1016/j.phytochem.2015.01.006. [PMID: 25666130] - Kai He, Xiaoli Ye, Hao Wu, YanZhi Wang, Zongyao Zou, Na Ning, Yinran Hu, Biao Chen, Xuedong Fang, Xuegang Li. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters.
Lipids.
2015 Feb; 50(2):185-94. doi:
10.1007/s11745-014-3983-7. [PMID: 25547428] - Yan Li, Chang-Feng Li, Li-Ming Du, Jian-Xia Feng, Hai-Long Liu, Yun-Long Fu. A competitive strategy based on cucurbit[7]uril supramolecular interaction for simple and sensitive detection of dibucaine.
Talanta.
2015 Jan; 132(?):653-7. doi:
10.1016/j.talanta.2014.09.005. [PMID: 25476359] - Dan Yu, Bang-Bao Tao, Yun-Yun Yang, Li-Sha Du, Shuang-Shuang Yang, Xiao-Jie He, Yu-Wen Zhu, Jun-Kai Yan, Qing Yang. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD.
2015; 43(1):291-302. doi:
10.3233/jad-140414. [PMID: 25079795] - Jin Su, Qing Miao, Peipei Miao, Yuanyuan Zhao, Yuanyuan Zhang, Ning Chen, Yujie Zhang, Shuangcheng Ma. Pharmacokinetics and Brain Distribution and Metabolite Identification of Coptisine, a Protoberberine Alkaloid with Therapeutic Potential for CNS Disorders, in Rats.
Biological & pharmaceutical bulletin.
2015; 38(10):1518-28. doi:
10.1248/bpb.b15-00293. [PMID: 26228628] - Le-Le Zhang, Li-Na Ma, Dan Yan, Cong-En Zhang, Dan Gao, Yin Xiong, Fei-Ya Sheng, Xiao-Ping Dong, Xiao-He Xiao. Dynamic monitoring of the cytotoxic effects of protoberberine alkaloids from Rhizoma Coptidis on HepG2 cells using the xCELLigence system.
Chinese journal of natural medicines.
2014 Jun; 12(6):428-35. doi:
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Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2014 Mar; 37(3):395-7. doi:
". [PMID: 25174101] - Zhao-Tang Ma, Xiu-Wei Yang, Ying Zhang, Jian-Xun Liu. Pharmacochemistry and integrated pharmacokinetics of six alkaloids after oral administration of huang-lian-jie-du-tang decoction.
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