Senegin (BioDeep_00000230411)

 

Secondary id: BioDeep_00000230819

PANOMIX_OTCML-2023


代谢物信息卡片


(2S,3R,4S,4aR,6aR,8aR,12aS,13S,14aR,14bR)-13-(chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4,4a,5,6,6a,7,8,9,10,11,12,12a,13,14,14a,14b-octadecahydropicene-4,8a(1H)-dicarboxylic acid

化学式: C30H45O6Cl (536.2905)
中文名称: 远志皂苷元
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 92.86%

分子结构信息

SMILES: CC1(CCC2(CCC3=C(C2C1)C(CC4C3(CCC5C4(CC(C(C5(C)C(=O)O)O)O)C)C)CCl)C(=O)O)C
InChI: InChI=1S/C30H45ClO6/c1-26(2)10-11-30(25(36)37)9-6-17-22(18(30)13-26)16(15-31)12-21-27(17,3)8-7-20-28(21,4)14-19(32)23(33)29(20,5)24(34)35/h16,18-21,23,32-33H,6-15H2,1-5H3,(H,34,35)(H,36,37)/t16-,18+,19+,20-,21+,23+,27+,28+,29+,30-/m1/s1

描述信息

Senegenin is a 12alpha-hydroxy steroid.
Tenuigenin is a natural product found in Polygala senega with data available.
Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting NF-κB activation. Tenuigenin has anti-inflammatory effect[1].
Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting NF-κB activation. Tenuigenin has anti-inflammatory effect[1].

同义名列表

17 个代谢物同义名

(2S,3R,4S,4aR,6aR,8aR,12aS,13S,14aR,14bR)-13-(chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4,4a,5,6,6a,7,8,9,10,11,12,12a,13,14,14a,14b-octadecahydropicene-4,8a(1H)-dicarboxylic acid; (2S,3R,4S,4AR,6AR,8AS,12AS,13S,14AR,14BR)-13-(CHLOROMETHYL)-2,3-DIHYDROXY-4,6A,11,11,14B-PENTAMETHYL-2,3,4A,5,6,7,8,9,10,12,12A,13,14,14A-TETRADECAHYDRO-1H-PICENE-4,8A-DICARBOXYLIC ACID; 27-Norolean-13-ene-23,28-dioic acid, 12-(chloromethyl)-2,3-dihydroxy-, (2.beta.,3.beta.,4.alpha.,12.alpha.)-; 27-Norolean-13-ene-23,28-dioic acid, 12-(chloromethyl)-2,3-dihydroxy-, (2beta,3beta,4alpha,12alpha)-; 12-(CHLOROMETHYL)-2.BETA.,3.BETA.-DIHYDROXY-27-NOROLEAN-13-ENE-23,28-DIOIC ACID; 27-Noro-13-ene-23,28-dioic acid, 12-(chloromethyl)-2-beta,3-beta-dihydroxy-; 3-10-00-02482 (Beilstein Handbook Reference); 12-(Chloromethyl)-2b,3b-dihydroxy-27; Senegenin, >=98\\% (HPLC); Senegenin(Tenuigenin); UNII-06S1QH951L; Tenuifolic acid; SENEGENIN [MI]; Tenuigenin; 06S1QH951L; Senegenin; Senegin



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Heping Zhang, Wei Zhou, Jianling Li, Zhaohui Qiu, Xiaotong Wang, Hui Xu, Huadong Wang, Daxiang Lu, Renbin Qi. Senegenin Rescues PC12 Cells with Oxidative Damage Through Inhibition of Ferroptosis. Molecular neurobiology. 2022 Nov; 59(11):6983-6992. doi: 10.1007/s12035-022-03014-y. [PMID: 36068400]
  • Yihong Tian, Yongmei Qi, Hui Cai, Mengchen Xu, Yingmei Zhang. Senegenin alleviates Aβ1-42 induced cell damage through triggering mitophagy. Journal of ethnopharmacology. 2022 Sep; 295(?):115409. doi: 10.1016/j.jep.2022.115409. [PMID: 35640739]
  • Jiamei Lin, Shengqiang Wang, Yunlin Feng, Weihong Zhao, Weilu Zhao, Foquan Luo, Namin Feng. Propofol exposure during early gestation impairs learning and memory in rat offspring by inhibiting the acetylation of histone. Journal of cellular and molecular medicine. 2018 05; 22(5):2600-2611. doi: 10.1111/jcmm.13524. [PMID: 29461008]
  • Ruichun Jia, Haogang Zhang, Wenjing Zhang, Hong Zhao, Caijun Zha, Yanhong Liu. Protective effects of tenuigenin on lipopolysaccharide and d-galactosamine-induced acute liver injury. Microbial pathogenesis. 2017 Nov; 112(?):83-88. doi: 10.1016/j.micpath.2017.09.051. [PMID: 28958948]
  • Haiyan Fu, Zhansheng Hu, Xingwei Di, Qiuhong Zhang, Rongbin Zhou, Hongyang Du. Tenuigenin exhibits protective effects against LPS-induced acute kidney injury via inhibiting TLR4/NF-κB signaling pathway. European journal of pharmacology. 2016 11; 791(?):229-234. doi: 10.1016/j.ejphar.2016.08.013. [PMID: 27546562]
  • Xiao-Qing Zhu, Xue-Min Li, Yan-Dong Zhao, Xi-Luan Ji, Yan-Ping Wang, Yong-Mei Fu, Hua-Dong Wang, Da-Xiang Lu, Ren-Bin Qi. Effects of Senegenin against hypoxia/reoxygenation-induced injury in PC12 cells. Chinese journal of integrative medicine. 2016 May; 22(5):353-61. doi: 10.1007/s11655-015-2091-8. [PMID: 26759162]
  • Chun-Hong Liu, Wei-Dong Zhang, Jian-Jie Wang, Shan-Dan Feng. Senegenin Ameliorate Acute Lung Injury Through Reduction of Oxidative Stress and Inhibition of Inflammation in Cecal Ligation and Puncture-Induced Sepsis Rats. Inflammation. 2016 Apr; 39(2):900-6. doi: 10.1007/s10753-016-0322-6. [PMID: 26945584]
  • Robert Jesky, Hailong Chen. The neuritogenic and neuroprotective potential of senegenin against Aβ-induced neurotoxicity in PC 12 cells. BMC complementary and alternative medicine. 2016 Jan; 16(?):26. doi: 10.1186/s12906-016-1006-3. [PMID: 26803813]
  • Xuemin Li, Yandong Zhao, Panhong Liu, Xiaoqing Zhu, Minyi Chen, Huadong Wang, Daxiang Lu, Renbin Qi. Senegenin Inhibits Hypoxia/Reoxygenation-Induced Neuronal Apoptosis by Upregulating RhoGDIα. Molecular neurobiology. 2015 Dec; 52(3):1561-1571. doi: 10.1007/s12035-014-8948-6. [PMID: 25367882]
  • Qin Chen, Yi-Qing Chen, Hai-Yan Ye, Jain-Qi Yu, Qi-Quan Shi, Yan Huang. [The mechanism of tenuigenin for eliminating waste product accumulation in cerebral neurons of Alzheimer's disease rats via ubiquitin-proteasome pathway]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2015 Mar; 35(3):327-32. doi: ". [PMID: 25951639]
  • Jun-ni Huang, Chun-yang Wang, Xiu-li Wang, Bo-zhi Wu, Xing-yang Gu, Wen-xiao Liu, Liang-wei Gong, Peng Xiao, Chu-hua Li. Tenuigenin treatment improves behavioral Y-maze learning by enhancing synaptic plasticity in mice. Behavioural brain research. 2013 Jun; 246(?):111-5. doi: 10.1016/j.bbr.2013.03.001. [PMID: 23499702]
  • Yujing Chen, Xiaobo Huang, Wenqiang Chen, Ningqun Wang, Lin Li. Tenuigenin promotes proliferation and differentiation of hippocampal neural stem cells. Neurochemical research. 2012 Apr; 37(4):771-7. doi: 10.1007/s11064-011-0671-3. [PMID: 22179853]
  • Weibin Xie, Yan Yang, Xiaoping Gu, Yaguo Zheng, Yu-e Sun, Ying Liang, Jinhua Bo, Zhengliang Ma. Senegenin attenuates hepatic ischemia-reperfusion induced cognitive dysfunction by increasing hippocampal NR2B expression in rats. PloS one. 2012; 7(9):e45575. doi: 10.1371/journal.pone.0045575. [PMID: 23029109]
  • Yu-Jing Chen, Xiao-Bo Huang, Zong-Xin Li, Lin-Lin Yin, Wen-Qiang Chen, Lin Li. Tenuigenin protects cultured hippocampal neurons against methylglyoxal-induced neurotoxicity. European journal of pharmacology. 2010 Oct; 645(1-3):1-8. doi: 10.1016/j.ejphar.2010.06.034. [PMID: 20609361]
  • J Lv, H Jia, Y Jiang, Y Ruan, Z Liu, W Yue, K Beyreuther, P Tu, D Zhang. Tenuifolin, an extract derived from tenuigenin, inhibits amyloid-beta secretion in vitro. Acta physiologica (Oxford, England). 2009 Aug; 196(4):419-25. doi: 10.1111/j.1748-1716.2009.01961.x. [PMID: 19208093]