Viniferin-alpha (BioDeep_00000229403)
Main id: BioDeep_00000020598
human metabolite PANOMIX_OTCML-2023
代谢物信息卡片
(2R,3R,10R,11R,18S,19S)-3,11,19-tris(4-hydroxyphenyl)-4,12,20-trioxaheptacyclo[16.6.1.1^{2,5}.1^{10,13}.0^{21,25}.0^{9,27}.0^{17,26}]heptacosa-1(24),5(27),6,8,13(26),14,16,21(25),22-nonaene-7,15,23-triol
化学式: C42H30O9 (678.188973)
中文名称: ALFA-葡萄素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC=C1C2C3C4=C5C(C(OC5=CC(=C4)O)C6=CC=C(C=C6)O)C7=C8C(C(OC8=CC(=C7)O)C9=CC=C(C=C9)O)C1=C3C(=CC(=C1)O)O2)O
InChI: InChI=1S/C42H30O9/c43-22-7-1-19(2-8-22)40-37-28-13-25(46)17-32-35(28)39(42(50-32)21-5-11-24(45)12-6-21)30-15-27(48)18-33-36(30)38(29-14-26(47)16-31(49-40)34(29)37)41(51-33)20-3-9-23(44)10-4-20/h1-18,37-48H/t37-,38-,39+,40+,41+,42-/m1/s1
描述信息
α-Viniferin is an anti-inflammatory compound from Caragana chamlagu root[1].
同义名列表
7 个代谢物同义名
(2R,3R,10R,11R,18S,19S)-3,11,19-tris(4-hydroxyphenyl)-4,12,20-trioxaheptacyclo[16.6.1.1^{2,5}.1^{10,13}.0^{21,25}.0^{9,27}.0^{17,26}]heptacosa-1(24),5(27),6,8,13(26),14,16,21(25),22-nonaene-7,15,23-triol; (+)-Α-viniferin; alpha-Viniferin; (+)-a-Viniferin; Viniferin-alpha; α-Viniferin; a-Viniferin
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:66359
- PubChem: 196402
- HMDB: HMDB0304750
- ChEMBL: CHEMBL443463
- Wikipedia: Alpha-Viniferin
- foodb: FDB097392
- chemspider: 170167
- CAS: 62218-13-7
- medchemexpress: HY-N2854
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yingying Shi, Dongdong Zhang, Shupei Li, Xiuxiu Xuan, Liuqiang Zhang, Yiming Li, Fujiang Guo. Inhibitors of BRD4 protein from the roots of Astilbe grandis stapf ex E.H. Wilson.
Natural product research.
2021 Jun; 35(12):2044-2050. doi:
10.1080/14786419.2019.1655414. [PMID: 31437007] - Md Abdur Rahim, Hoonhee Seo, Sukyung Kim, Yoon Kyoung Jeong, Hanieh Tajdozian, Mijung Kim, Saebim Lee, Ho-Yeon Song. A Clinical Trial to Evaluate the Efficacy of α-Viniferin in Staphylococcus aureus - Specific Decolonization without Depleting the Normal Microbiota of Nares.
Polish journal of microbiology.
2021 Mar; 70(1):117-130. doi:
10.33073/pjm-2021-011. [PMID: 33815533] - Young-Rak Cho, Eun-Kyung Ahn, Young Jin Park, Kyuhee Park, Seong-Su Hong, Dong-Wan Seo, Joa Sub Oh. A novel role for α-viniferin in suppressing angiogenesis by blocking the VEGFR-2/p70S6K signaling pathway.
Phytotherapy research : PTR.
2020 Oct; 34(10):2697-2705. doi:
10.1002/ptr.6706. [PMID: 32400050] - Yuqi Fan, Lulu Zhao, Xuhua Huang, Qi Jia, Wei Wang, Mengyuan Gao, Xiaohua Jia, Yanxu Chang, Huizi Ouyang, Jun He. Pharmacokinetic and bioavailability studies of α-viniferin after intravenous and oral administration to rats.
Journal of pharmaceutical and biomedical analysis.
2020 Sep; 188(?):113376. doi:
10.1016/j.jpba.2020.113376. [PMID: 32502955] - Cheong-Yong Yun, Seon Mi Ko, Yong Pyo Choi, Beom Joon Kim, Jungno Lee, Jae Mun Kim, Ju Yeon Kim, Jin Yong Song, Song-Hee Kim, Bang Yeon Hwang, Jin Tae Hong, Sang-Bae Han, Youngsoo Kim. α-Viniferin Improves Facial Hyperpigmentation via Accelerating Feedback Termination of cAMP/PKA-Signaled Phosphorylation Circuit in Facultative Melanogenesis.
Theranostics.
2018; 8(7):2031-2043. doi:
10.7150/thno.24385. [PMID: 29556371] - Hoonhee Seo, Mijung Kim, Sukyung Kim, Hafij Al Mahmud, Md Imtiazul Islam, Kung-Woo Nam, Myoung-Lae Cho, Hyun-Sook Kwon, Ho-Yeon Song. In vitro activity of alpha-viniferin isolated from the roots of Carex humilis against Mycobacterium tuberculosis.
Pulmonary pharmacology & therapeutics.
2017 Oct; 46(?):41-47. doi:
10.1016/j.pupt.2017.08.003. [PMID: 28782713] - Florian Schuck, Ulrich Schmitt, Sven Reinhardt, Christian Freese, Ik-Soo Lee, Eckhard Thines, Thomas Efferth, Kristina Endres. Extract of Caragana sinica as a potential therapeutic option for increasing alpha-secretase gene expression.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2015 Oct; 22(11):1027-36. doi:
10.1016/j.phymed.2015.08.001. [PMID: 26407945] - Bikash Ranjan Giri, Bishnupada Roy. Resveratrol- and α-viniferin-induced alterations of acetylcholinesterase and nitric oxide synthase in Raillietina echinobothrida.
Parasitology research.
2015 Oct; 114(10):3775-81. doi:
10.1007/s00436-015-4607-8. [PMID: 26141435] - Bishnupada Roy, Bikash R Giri. α-Viniferin-Induced Structural and Functional Alterations in Raillietina echinobothrida, a Poultry Tapeworm.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada.
2015 Apr; 21(2):377-84. doi:
10.1017/s1431927614014603. [PMID: 25592142] - Matharage Gayani Dilshara, Kyoung-Tae Lee, Hee Ju Kim, Hak-Ju Lee, Yung Hyun Choi, Chang-Min Lee, Lark Kyun Kim, Gi-Young Kim. Anti-inflammatory mechanism of α-viniferin regulates lipopolysaccharide-induced release of proinflammatory mediators in BV2 microglial cells.
Cellular immunology.
2014 Jul; 290(1):21-9. doi:
10.1016/j.cellimm.2014.04.009. [PMID: 24859013] - L Giovannelli, M Innocenti, A R Santamaria, E Bigagli, G Pasqua, N Mulinacci. Antitumoural activity of viniferin-enriched extracts from Vitis vinifera L. cell cultures.
Natural product research.
2014; 28(22):2006-16. doi:
10.1080/14786419.2014.924935. [PMID: 24949881] - N K N A Zawawi, N Ahmat, M Z Mazatulikhma, R M Shafiq, N H Wahid, A S Sufian. Bioactive oligostilbenoids from Shorea maxwelliana King and their chemotaxonomic significance.
Natural product research.
2013; 27(17):1589-93. doi:
10.1080/14786419.2012.730047. [PMID: 23035830] - Tong Yan, Ting Wang, Wei Wei, Nan Jiang, Yan Hua Qin, Ren Xiang Tan, Hui Ming Ge. Polyphenolic acetylcholinesterase inhibitors from Hopea chinensis.
Planta medica.
2012 Jun; 78(10):1015-9. doi:
10.1055/s-0031-1298623. [PMID: 22628156] - Toshio Morikawa, Saowanee Chaipech, Hisashi Matsuda, Makoto Hamao, Yohei Umeda, Hiroki Sato, Haruka Tamura, Haruka Kon'i, Kiyofumi Ninomiya, Masayuki Yoshikawa, Yutana Pongpiriyadacha, Takao Hayakawa, Osamu Muraoka. Antidiabetogenic oligostilbenoids and 3-ethyl-4-phenyl-3,4-dihydroisocoumarins from the bark of Shorea roxburghii.
Bioorganic & medicinal chemistry.
2012 Jan; 20(2):832-40. doi:
10.1016/j.bmc.2011.11.067. [PMID: 22209731] - Qinghao Jin, Xiang Hua Han, Seong Su Hong, Chul Lee, Sanggil Choe, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang. Antioxidative oligostilbenes from Caragana sinica.
Bioorganic & medicinal chemistry letters.
2012 Jan; 22(2):973-6. doi:
10.1016/j.bmcl.2011.12.012. [PMID: 22209460] - Hui Ming Ge, Bo Huang, Shu Hua Tan, Da Hua Shi, Yong Chun Song, Ren Xiang Tan. Bioactive oligostilbenoids from the stem bark of Hopea exalata.
Journal of natural products.
2006 Dec; 69(12):1800-2. doi:
10.1021/np060242y. [PMID: 17190464] - Na Shu, Hong Zhou, Hongqing Huang, Changqi Hu. Quantitative determination of stilbene oligomers in Jin Que-gen collected from different regions by a HPLC method.
Chemical & pharmaceutical bulletin.
2006 Jun; 54(6):878-81. doi:
10.1248/cpb.54.878. [PMID: 16755062] - Na Shu, Hong Zhou, Changqi Hu. Simultaneous determination of the contents of three stilbene oligomers in Caragana sinica collected in different seasons using an improved HPLC method.
Biological & pharmaceutical bulletin.
2006 Apr; 29(4):608-12. doi:
10.1248/bpb.29.608. [PMID: 16595888] - Shizuo Toda, Yoshiaki Shirataki. Inhibitory effects of stilbenes in Sophora moorcroftiana BENTH ex BAKER on copper ion-induced protein oxidative modification of mouse brain homogenate in vitro.
Phytotherapy research : PTR.
2005 Jan; 19(1):72-4. doi:
10.1002/ptr.1425. [PMID: 15798998] - Jae Yeong Lee, Joong-Hyun Kim, Seong Soo Kang, Chun Sik Bae, Seok Hwa Choi. The effects of alpha-viniferin on adjuvant-induced arthritis in rats.
The American journal of Chinese medicine.
2004; 32(4):521-30. doi:
10.1142/s0192415x04002168. [PMID: 15481642] - Sang Hyun Sung, So Young Kang, Ki Yong Lee, Mi Jung Park, Jeong Hun Kim, Jong Hee Park, Young Chul Kim, Jinwoong Kim, Young Choong Kim. (+)-Alpha-viniferin, a stilbene trimer from Caragana chamlague, inhibits acetylcholinesterase.
Biological & pharmaceutical bulletin.
2002 Jan; 25(1):125-7. doi:
10.1248/bpb.25.125. [PMID: 11824541] - S H Lee, N H Shin, S H Kang, J S Park, S R Chung, K R Min, Y Kim. Alpha-viniferin: a prostaglandin H2 synthase inhibitor from root of Carex humilis.
Planta medica.
1998 Apr; 64(3):204-7. doi:
10.1055/s-2006-957409. [PMID: 9581514]