Wilforine (BioDeep_00000185009)
Main id: BioDeep_00000230673
human metabolite PANOMIX_OTCML-2023 blood metabolite
代谢物信息卡片
化学式: C43H49NO18 (867.2949494)
中文名称: 雷公藤次碱
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(OCC(C1OC(C)=O)(C(C(OC(C2=CC=CC=C2)=O)C3OC(C4C)=O)OC(C)=O)C(OC(C)(COC(C5=CC=CN=C5CC4)=O)C6C1OC(C)=O)(C3(O)C)C6OC(C)=O)=O
InChI: InChI=1S/C43H49NO18/c1-21-16-17-29-28(15-12-18-44-29)39(52)55-19-40(7)30-31(56-23(3)46)35(58-25(5)48)42(20-54-22(2)45)36(59-26(6)49)32(60-38(51)27-13-10-9-11-14-27)34(61-37(21)50)41(8,53)43(42,62-40)33(30)57-24(4)47/h9-15,18,21,30-36,53H,16-17,19-20H2,1-8H3
描述信息
Wilforine is a sesquiterpene pyridine alkaloid; important bioactive compound in T. wilfordii plants, and is effective in treating idiopathic pulmonary fibrosis.
Wilforine is a sesquiterpene pyridine alkaloid; important bioactive compound in T. wilfordii plants, and is effective in treating idiopathic pulmonary fibrosis.
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相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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3 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yurong Huang, Yanhui Peng, Hui Li, Chen Li, Yajie Wu, Xiaomei Wang, Jun Chang, Chenggui Miao. Wilforine inhibits rheumatoid arthritis pathology through the Wnt11/β-catenin signaling pathway axis.
Arthritis research & therapy.
2023 Dec; 25(1):243. doi:
10.1186/s13075-023-03224-2. [PMID: 38098062] - Jieru Chen, Yuanping Xue, Xiaoyu Shuai, Chunxu Ni, Zihui Fang, Ling Ye, Mei Hong. Effect of major components of Tripterygium wilfordii Hook. f on the uptake function of organic anion transporting polypeptide 1B1.
Toxicology and applied pharmacology.
2022 01; 435(?):115848. doi:
10.1016/j.taap.2021.115848. [PMID: 34958783] - Xiao-Peng Lu, Jia-Huan Liu, Xiang-Yun Fu, Feng-Jin Wang, Hua Wu, Hua Weng, Zhi-Qing Ma. Effects of RNAi-mediated plasma membrane calcium transporting ATPase and inositol 1,4,5-trisphosphate receptor gene silencing on the susceptibility of Mythimna separata to wilforine.
Ecotoxicology and environmental safety.
2021 Dec; 227(?):112909. doi:
10.1016/j.ecoenv.2021.112909. [PMID: 34673414] - Shujie Ma, Ting Ma, Meiru Ren, Hai Li, Zhiqing Ma. Insecticidal action of the botanical insecticide wilforine on Mythimna separata (Walker) related with the changes of ryanodine receptor expression.
Ecotoxicology and environmental safety.
2021 Apr; 213(?):112025. doi:
10.1016/j.ecoenv.2021.112025. [PMID: 33578098] - Ying-Tzu Chang, Yu-Chao Lin, Lijuan Sun, Wei-Chieh Liao, Charles C N Wang, Che-Yi Chou, Susan L Morris-Natschke, Kuo-Hsiung Lee, Chin-Chuan Hung. Wilforine resensitizes multidrug resistant cancer cells via competitive inhibition of P-glycoprotein.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2020 Jun; 71(?):153239. doi:
10.1016/j.phymed.2020.153239. [PMID: 32447245] - Shujie Ma, Jiahuan Liu, Xiaopeng Lu, Xing Zhang, Zhiqing Ma. Effect of Wilforine on the Calcium Signaling Pathway in Mythimna separata Walker Myocytes Using the Calcium Imaging Technique.
Journal of agricultural and food chemistry.
2019 Dec; 67(49):13751-13757. doi:
10.1021/acs.jafc.9b05592. [PMID: 31721577] - Xue Gao, Xi Du, Lijun An, Yangyang Wang, Lili Wang, Zengguang Wu, Cong Huang, Xin He. Wilforine, the Q-marker and PK-maker of Tripterygium glycosides tablet: Based on preparation quantitative analysis and PK-PD study.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Feb; 54(?):357-364. doi:
10.1016/j.phymed.2018.03.031. [PMID: 30318152] - Guo-Peng Miao, Juan Han, Ji-Feng Zhang, Chuan-Shu Zhu, Xing Zhang. A MDR transporter contributes to the different extracellular production of sesquiterpene pyridine alkaloids between adventitious root and hairy root liquid cultures of Tripterygium wilfordii Hook.f.
Plant molecular biology.
2017 Sep; 95(1-2):51-62. doi:
10.1007/s11103-017-0634-4. [PMID: 28733871] - Meng-Xiang Su, Min Song, Bin Di, Tai-jun Hang. Application of a sensitive and specific LC-MS/MS method for determination of wilforine from Tripterygium wilfordii Hook. F. in rat plasma for a bioavailability study.
Biomedical chromatography : BMC.
2015 Jul; 29(7):1042-7. doi:
10.1002/bmc.3390. [PMID: 25425175] - Chuanshu Zhu, Guopeng Miao, Jia Guo, Yanbo Huo, Xing Zhang, Jiahua Xie, Juntao Feng. Establishment of Tripterygium wilfordii Hook. f. Hairy root culture and optimization of its culture conditions for the production of triptolide and wilforine.
Journal of microbiology and biotechnology.
2014 Jun; 24(6):823-34. doi:
10.4014/jmb.1402.02045. [PMID: 24651642] - Mei-qiang Cai, Xiao-hong Chen, Shi-wei He, Xiao-kun OuYang, Mi-cong Jin. Determination of four pyridine alkaloids from Tripterygium wilfordii Hook. f. in human plasma by high-performance liquid chromatography coupled with mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Nov; 879(30):3516-22. doi:
10.1016/j.jchromb.2011.09.034. [PMID: 21982911] - Haoyu Ye, Svetlana Ignatova, Houding Luo, Yanfang Li, Aihua Peng, Lijuan Chen, Ian Sutherland. Preparative separation of a terpenoid and alkaloids from Tripterygium wilfordii Hook. f. using high-performance counter-current chromatography. Comparison of various elution and operating strategies.
Journal of chromatography. A.
2008 Dec; 1213(2):145-53. doi:
10.1016/j.chroma.2008.09.116. [PMID: 18976997]