10-Methyl-9-(10-methyl-1H-acridin-9-yl)-1H-acridine (BioDeep_00000183530)

   

human metabolite blood metabolite


代谢物信息卡片


10,10'-dimethyl-1H,1'H,10H,10'H-9,9'-biacridine

  化学式: C28H24N2 (388.1939)
中文名称:
  谱图信息: 最多检出来源 Homo sapiens(blood) 86.53%

分子结构信息

SMILES: CN1C2=CC=CCC2=C(C2=CC=CC=C12)C1=C2CC=CC=C2N(C)C2=CC=CC=C12
InChI: InChI=1S/C28H24N2/c1-29-23-15-7-3-11-19(23)27(20-12-4-8-16-24(20)29)28-21-13-5-9-17-25(21)30(2)26-18-10-6-14-22(26)28/h3-11,13,15-18H,12,14H2,1-2H3



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Stephanie W Watts, Samantha Shaw, Robert Burnett, Anne M Dorrance. Indoleamine 2,3-diooxygenase in periaortic fat: mechanisms of inhibition of contraction. American journal of physiology. Heart and circulatory physiology. 2011 Oct; 301(4):H1236-47. doi: 10.1152/ajpheart.00384.2011. [PMID: 21841011]
  • T V Zhidkova, E V Proskurnina, E A Parfenov, Yu A Vladimirov. Determination of superoxide dismutase and SOD-mimetic activities by a chemical system: Co2/H2O2/lucigenin. Analytical and bioanalytical chemistry. 2011 Jul; 401(1):381-6. doi: 10.1007/s00216-011-5070-8. [PMID: 21573844]
  • Juozas Žilinskas, Jonas Žekonis, Gediminas Žekonis, Renata Šadzevičienė, Marija Sapragonienė, Justina Navickaitė, Ingrida Barzdžiukaitė. Inhibition of peripheral blood neutrophil oxidative burst in periodontitis patients with a homeopathic medication Traumeel S. Medical science monitor : international medical journal of experimental and clinical research. 2011 May; 17(5):CR284-91. doi: 10.12659/msm.881769. [PMID: 21525811]
  • Stephen J Moore, Matthew G Fisher, Masafumi Yano, Christine C Tong, Philip A Gale. A dual host approach to transmembrane transport of salts. Chemical communications (Cambridge, England). 2011 Jan; 47(2):689-91. doi: 10.1039/c0cc04430j. [PMID: 21103515]
  • Gulgun Tahan, Hakan Akin, Fatih Aydogan, Saime Sezgin Ramadan, Ozlem Yapicier, Orhan Tarcin, Hafize Uzun, Veysel Tahan, Kagan Zengin. Melatonin ameliorates liver fibrosis induced by bile-duct ligation in rats. Canadian journal of surgery. Journal canadien de chirurgie. 2010 Oct; 53(5):313-8. doi: NULL. [PMID: 20858375]
  • E A Shkapova, L M Kurtasova, A A Savchenko. Lucigenin- and luminol-dependent chemiluminescence of blood neutrophils in patients with renal cancer. Bulletin of experimental biology and medicine. 2010 Aug; 149(2):239-41. doi: 10.1007/s10517-010-0916-1. [PMID: 21113500]
  • Yu A Vladimirov, E V Proskurnina. Free radicals and cell chemiluminescence. Biochemistry. Biokhimiia. 2009 Dec; 74(13):1545-66. doi: 10.1134/s0006297909130082. [PMID: 20210708]
  • Jing Yang, Pascale H Lane, Jennifer S Pollock, Pamela K Carmines. PKC-dependent superoxide production by the renal medullary thick ascending limb from diabetic rats. American journal of physiology. Renal physiology. 2009 Nov; 297(5):F1220-8. doi: 10.1152/ajprenal.00314.2009. [PMID: 19741016]
  • Arata Kojima, Takashi Umeda, Kazuo Saito, Yoshikazu Ookubo, Junya Sato, Shigeyuki Nakaji, Masashi Matsuzaka, Makoto Yaegaki, Motoki Ohnishi, Maki Miyazawa, Ippei Takahashi. Effects of 2.5-hour sumo training on serum opsonic activity. Luminescence : the journal of biological and chemical luminescence. 2009 Jul; 24(4):224-9. doi: 10.1002/bio.1104. [PMID: 19253272]
  • Melissa Li, Xiaoling Dai, Stephanie Watts, David Kreulen, Gregory Fink. Increased superoxide levels in ganglia and sympathoexcitation are involved in sarafotoxin 6c-induced hypertension. American journal of physiology. Regulatory, integrative and comparative physiology. 2008 Nov; 295(5):R1546-54. doi: 10.1152/ajpregu.00783.2007. [PMID: 18768769]
  • W S Koko, M Ahmed Mesaik, S Yousaf, M Galal, M Iqbal Choudhary. In vitro immunomodulating properties of selected Sudanese medicinal plants. Journal of ethnopharmacology. 2008 Jun; 118(1):26-34. doi: 10.1016/j.jep.2008.03.007. [PMID: 18440170]
  • Hale Z Toklu, Tugba Tunali Akbay, Ayliz Velioglu-Ogunc, Feriha Ercan, Nursal Gedik, Meral Keyer-Uysal, Goksel Sener. Silymarin, the antioxidant component of Silybum marianum, prevents sepsis-induced acute lung and brain injury. The Journal of surgical research. 2008 Apr; 145(2):214-22. doi: 10.1016/j.jss.2007.03.072. [PMID: 17950327]
  • H Benbarek, G Deby-Dupont, C Deby, D Serteyn. Direct stimulation of the oxidative activity of isolated equine neutrophils by TNF-alpha and IL-1beta. Veterinary immunology and immunopathology. 2008 Jan; 121(1-2):101-6. doi: 10.1016/j.vetimm.2007.09.006. [PMID: 18006077]
  • Gediminas Zekonis, Jonas Zekonis, Renata Sadzeviciene, Genovaite Simoniene, Egidijus Kevelaitis. Effect of Perilla frutescens aqueous extract on free radical production by human neutrophil leukocytes. Medicina (Kaunas, Lithuania). 2008; 44(9):699-705. doi: 10.3390/medicina44090090. [PMID: 18971608]
  • Radu Iliescu, Valeria E Cucchiarelli, Licy L Yanes, Joshua W Iles, Jane F Reckelhoff. Impact of androgen-induced oxidative stress on hypertension in male SHR. American journal of physiology. Regulatory, integrative and comparative physiology. 2007 Feb; 292(2):R731-5. doi: 10.1152/ajpregu.00353.2006. [PMID: 16971373]
  • Ender Dulundu, Yahya Ozel, Umit Topaloglu, Ozer Sehirli, Feriha Ercan, Nursal Gedik, Goksel Sener. Alpha-lipoic acid protects against hepatic ischemia-reperfusion injury in rats. Pharmacology. 2007; 79(3):163-70. doi: 10.1159/000098953. [PMID: 17259747]
  • Göksel Sener, Halil Tuğtepe, Meral Yüksel, Sule Cetinel, Nursal Gedik, Berrak C Yeğen. Resveratrol improves ischemia/reperfusion-induced oxidative renal injury in rats. Archives of medical research. 2006 Oct; 37(7):822-9. doi: 10.1016/j.arcmed.2006.04.003. [PMID: 16971220]
  • Katsuaki Takahashi, Tatsuya Komaru, Satoru Takeda, Morihiko Takeda, Ryoji Koshida, Masaharu Nakayama, Yasunori Kokusho, Yuki Kawakami, Nobuhiro Yamaguchi, Teruo Miyazawa, Hiroaki Shimokawa, Kunio Shirato. gamma-tocopherol, but not alpha-tocopherol, potently inhibits neointimal formation induced by vascular injury in insulin resistant rats. Journal of molecular and cellular cardiology. 2006 Sep; 41(3):544-54. doi: 10.1016/j.yjmcc.2006.06.010. [PMID: 16876819]
  • E L Pavlova, V M Savov. Chemiluminescent in vitro estimation of the inhibitory constants of antioxidants ascorbic and uric acids in Fenton's reaction in urine. Biochemistry. Biokhimiia. 2006 Aug; 71(8):861-3. doi: 10.1134/s0006297906080062. [PMID: 16978148]
  • Mark A Baker, R John Aitken. Reactive oxygen species in spermatozoa: methods for monitoring and significance for the origins of genetic disease and infertility. Reproductive biology and endocrinology : RB&E. 2005 Nov; 3(?):67. doi: 10.1186/1477-7827-3-67. [PMID: 16313680]
  • Göksel Sener, Emre Sener, Ozer Sehirli, Ayliz Velioğlu Oğünç, Sule Cetinel, Nursal Gedik, Abdullah Sakarcan. Ginkgo biloba extract ameliorates ischemia reperfusion-induced renal injury in rats. Pharmacological research. 2005 Sep; 52(3):216-22. doi: 10.1016/j.phrs.2005.03.006. [PMID: 15896977]
  • V A Kosolapov, A A Spasov, V A Anisimova. [Study of antiradical activity of new compounds by chemiluminescence]. Biomeditsinskaia khimiia. 2005 May; 51(3):287-94. doi: ". [PMID: 16104391]
  • Licy Yanes, Damian Romero, Radu Iliescu, Valeria E Cucchiarelli, Lourdes A Fortepiani, Francisco Santacruz, William Bell, Huimin Zhang, Jane F Reckelhoff. Systemic arterial pressure response to two weeks of Tempol therapy in SHR: involvement of NO, the RAS, and oxidative stress. American journal of physiology. Regulatory, integrative and comparative physiology. 2005 Apr; 288(4):R903-8. doi: 10.1152/ajpregu.00530.2004. [PMID: 15604302]
  • Yvonne O'Dowd, Fathi Driss, Pham My-Chan Dang, Carole Elbim, Marie-Anne Gougerot-Pocidalo, Catherine Pasquier, Jamel El-Benna. Antioxidant effect of hydroxytyrosol, a polyphenol from olive oil: scavenging of hydrogen peroxide but not superoxide anion produced by human neutrophils. Biochemical pharmacology. 2004 Nov; 68(10):2003-8. doi: 10.1016/j.bcp.2004.06.023. [PMID: 15476671]
  • R John Aitken, Angela L Ryan, Mark A Baker, Eileen A McLaughlin. Redox activity associated with the maturation and capacitation of mammalian spermatozoa. Free radical biology & medicine. 2004 Apr; 36(8):994-1010. doi: 10.1016/j.freeradbiomed.2004.01.017. [PMID: 15059640]
  • Martina Pavelkova, Lukas Kubala. Luminol-, isoluminol- and lucigenin-enhanced chemiluminescence of rat blood phagocytes stimulated with different activators. Luminescence : the journal of biological and chemical luminescence. 2004 Jan; 19(1):37-42. doi: 10.1002/bio.754. [PMID: 14981645]
  • R J Aitken, A L Ryan, B J Curry, M A Baker. Multiple forms of redox activity in populations of human spermatozoa. Molecular human reproduction. 2003 Nov; 9(11):645-61. doi: 10.1093/molehr/gag086. [PMID: 14561808]
  • Daisuke Saito, Shigeyuki Nakaji, Takashi Umeda, Shigeyoshi Kurakake, Kazuma Danjo, Tadashi Shimoyama, Kazuo Sugawara. Effects of long-distance running on serum opsonic activity measured by chemiluminescence. Luminescence : the journal of biological and chemical luminescence. 2003 Mar; 18(2):122-4. doi: 10.1002/bio.438. [PMID: 12687633]
  • Chih-Jui Lo, Jaung-Geng Lin, Jon-Son Kuo, Sun-Yin Chiang, Shu-Chao Chen, En-Tzu Liao, Ching-Liang Hsieh. Effect of salvia miltiorrhiza bunge on cerebral infarct in ischemia-reperfusion injured rats. The American journal of Chinese medicine. 2003; 31(2):191-200. doi: 10.1142/s0192415x03000916. [PMID: 12856858]
  • Seikou Ohta, Shigeyuki Nakaji, Katsuhiko Suzuki, Manabu Totsuka, Takashi Umeda, Kazuo Sugawara. Depressed humoral immunity after weight reduction in competitive judoists. Luminescence : the journal of biological and chemical luminescence. 2002 May; 17(3):150-7. doi: 10.1002/bio.686. [PMID: 12164364]
  • E Van den Worm, C J Beukelman, A J Van den Berg, B H Kroes, R P Labadie, H Van Dijk. Effects of methoxylation of apocynin and analogs on the inhibition of reactive oxygen species production by stimulated human neutrophils. European journal of pharmacology. 2001 Dec; 433(2-3):225-30. doi: 10.1016/s0014-2999(01)01516-3. [PMID: 11755156]
  • S K Ozel, M Yüksel, G Haklar, C U Durakbaşa , T E Dagli, A O Aktan . Nitric oxide and endothelin relationship in intestinal ischemia/reperfusion injury (II). Prostaglandins, leukotrienes, and essential fatty acids. 2001 Apr; 64(4-5):253-7. doi: 10.1054/plef.2001.0268. [PMID: 11418020]
  • F R Ochsendorf, C Goy, J Fuchs, W Mörke, H A Beschmann, H J Brömme. Lucigenin chemiluminescence in human seminal plasma. Free radical research. 2001 Feb; 34(2):153-65. doi: 10.1080/10715760100300141. [PMID: 11264892]
  • P Olinga, I H Hof, M T Merema, M Smit, M H de Jager, P J Swart, M J Slooff, D K Meijer, G M Groothuis. The applicability of rat and human liver slices to the study of mechanisms of hepatic drug uptake. Journal of pharmacological and toxicological methods. 2001 Jan; 45(1):55-63. doi: 10.1016/s1056-8719(01)00127-7. [PMID: 11489665]
  • M Kist, J Horst, G Steidten. [Salmonella freiburg: a new salmonella-serotype (3,10:1,Z13:1,2) (author's transl)]. Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie. 1979 Mar; 243(1):28-30. doi: NULL. [PMID: 442879]


Loading...