Ipodate (BioDeep_00000180093)
Secondary id: BioDeep_00000012069
human metabolite blood metabolite Volatile Flavor Compounds
代谢物信息卡片
3-(3-{[(dimethylamino)methylidene]amino}-2,4,6-triiodophenyl)propanoic acid
化学式: C12H13I3N2O2 (597.8111288000001)
中文名称: 胆影脒
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)C=NC1=C(C=C(C(=C1I)CCC(=O)O)I)I
InChI: InChI=1S/C12H13I3N2O2/c1-17(2)6-16-12-9(14)5-8(13)7(11(12)15)3-4-10(18)19/h5-6H,3-4H2,1-2H3,(H,18,19)
描述信息
同义名列表
22 个代谢物同义名
3-(3-{[(dimethylamino)methylidene]amino}-2,4,6-triiodophenyl)propanoic acid; 3-[[(dimethylamino)methylene]amino]-3-(2,4,6-triiodophenyl)propionic acid; 3-(3-(Dimethylaminomethylideneamino)-2,4,6-triiodophenyl)propanoic acid; Iopodate, calcium; Calcium iopodate; Iopodate, sodium; Ipodate, calcium; Ipodate, sodium; Sodium, ipodate; Sodium iopodate; Calcium ipodate; Ipodate sodium; Sodium ipodate; Solu biloptin; Solu-biloptin; SoluBiloptin; IPODic acid; Biloptin; Iopodate; Bilimin; IPODATE; Iopodic acid
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:81496
- KEGG: C18093
- PubChem: 5241
- HMDB: HMDB0253566
- DrugBank: DB09333
- ChEMBL: CHEMBL3306201
- ChEMBL: CHEMBL1201243
- MeSH: Ipodate
- CAS: 1221-56-3
- CAS: 5587-89-3
- PubChem: 96024310
- NIKKAJI: J8.011J
- KNApSAcK: 81496
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- E J Limonard, P H Bisschop, E Fliers, E J Nieveen van Dijkum. Thyroid function after subtotal thyroidectomy in patients with Graves' hyperthyroidism.
TheScientificWorldJournal.
2012; 2012(?):548796. doi:
10.1100/2012/548796. [PMID: 22448136] - Ömer Tarım. Thyroid hormones and growth in health and disease.
Journal of clinical research in pediatric endocrinology.
2011; 3(2):51-5. doi:
10.4274/jcrpe.v3i2.11. [PMID: 21750631] - Peter Laurberg, Henrik Vestergaard, Soren Nielsen, Stig E Christensen, Torben Seefeldt, Kjeld Helleberg, Klaus M Pedersen. Sources of circulating 3,5,3'-triiodothyronine in hyperthyroidism estimated after blocking of type 1 and type 2 iodothyronine deiodinases.
The Journal of clinical endocrinology and metabolism.
2007 Jun; 92(6):2149-56. doi:
10.1210/jc.2007-0178. [PMID: 17389703] - J C Fontanilla, A B Schneider, D H Sarne. The use of oral radiographic contrast agents in the management of hyperthyroidism.
Thyroid : official journal of the American Thyroid Association.
2001 Jun; 11(6):561-7. doi:
10.1089/105072501750302868. [PMID: 11442003] - M Braga, D S Cooper. Clinical review 129: Oral cholecystographic agents and the thyroid.
The Journal of clinical endocrinology and metabolism.
2001 May; 86(5):1853-60. doi:
10.1210/jcem.86.5.7484. [PMID: 11344170] - S M Tomaski, E M Mahoney, L P Burgess, K B Raines, M Bornemann. Sodium ipodate (oragrafin) in the preoperative preparation of Graves' hyperthyroidism.
The Laryngoscope.
1997 Aug; 107(8):1066-70. doi:
10.1097/00005537-199708000-00012. [PMID: 9261010] - L A Murray, M E Peterson. Ipodate treatment of hyperthyroidism in cats.
Journal of the American Veterinary Medical Association.
1997 Jul; 211(1):63-7. doi:
NULL. [PMID: 9215413] - I J Chopra, A J van Herle, S G Korenman, S Viosca, S Younai. Use of sodium ipodate in management of hyperthyroidism in subacute thyroiditis.
The Journal of clinical endocrinology and metabolism.
1995 Jul; 80(7):2178-80. doi:
10.1210/jcem.80.7.7608275. [PMID: 7608275] - E Roti, E Gardini, R Minelli, L Bianconi, L E Braverman. Sodium ipodate and methimazole in the long-term treatment of hyperthyroid Graves' disease.
Metabolism: clinical and experimental.
1993 Apr; 42(4):403-8. doi:
10.1016/0026-0495(93)90094-5. [PMID: 8487661] - F Santini, I J Chopra. A radioimmunoassay of rat type I iodothyronine 5'-monodeiodinase.
Endocrinology.
1992 Dec; 131(6):2521-6. doi:
10.1210/endo.131.6.1446594. [PMID: 1446594] - J H Hays, C Eil, R C Smallridge. Sodium ipodate increases triiodothyronine action in vivo.
Journal of endocrinological investigation.
1992 Jul; 15(7):507-12. doi:
10.1007/bf03348793. [PMID: 1332995] - S Y Wu, W S Huang, D Polk, W H Florsheim, W L Green, D A Fisher. Identification of thyroxine-sulfate (T4S) in human serum and amniotic fluid by a novel T4S radioimmunoassay.
Thyroid : official journal of the American Thyroid Association.
1992; 2(2):101-5. doi:
10.1089/thy.1992.2.101. [PMID: 1525576] - E Martino, S Balzano, L Bartalena, A Loviselli, V Sica, L Petrini, L Grasso, M Piga, L E Braverman. Therapy of Graves' disease with sodium ipodate is associated with a high recurrence rate of hyperthyroidism.
Journal of endocrinological investigation.
1991 Nov; 14(10):847-51. doi:
10.1007/bf03347940. [PMID: 1687043] - D C Shen, S Y Wu, I J Chopra, L R Shian, W Florsheim, D H Solomon. Further studies on the long-term treatment of Graves' hyperthyroidism with ipodate: assessment of a minimal effective dose.
Thyroid : official journal of the American Thyroid Association.
1991; 1(2):143-6. doi:
10.1089/thy.1991.1.143. [PMID: 1822359] - M B Dratman, F L Crutchfield. Thyroxine, triiodothyronine, and reverse triiodothyronine processing in the cerebellum: autoradiographic studies in adult rats.
Endocrinology.
1989 Sep; 125(3):1723-33. doi:
10.1210/endo-125-3-1723. [PMID: 2759043] - N Bagchi, T R Brown, S K Banerjee. Comparison of the effects of amiodarone and ipodate on the rat heart.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
1989 Apr; 21(4):182-4. doi:
10.1055/s-2007-1009186. [PMID: 2753467] - A Berghout, W M Wiersinga, W H Brummelkamp. Sodium ipodate in the preparation of Graves' hyperthyroid patients for thyroidectomy.
Hormone research.
1989; 31(5-6):256-60. doi:
10.1159/000181127. [PMID: 2613192] - N Kamel, A R Uysal, S Koloğlu, G Erdoğan, M Senel, H Polat. Sodium ipodate in the treatment of toxic diffuse goiter. Short-term and long-term effects on thyrotoxicosis.
Endocrinologie.
1988 Apr; 26(2):99-105. doi:
NULL. [PMID: 3413443] - E Roti, G Robuschi, E Gardini, M Montermini, M Salvi, A Manfredi, A Gnudi, L E Braverman. Comparison of methimazole, methimazole and sodium ipodate, and methimazole and saturated solution of potassium iodide in the early treatment of hyperthyroid Graves' disease.
Clinical endocrinology.
1988 Mar; 28(3):305-14. doi:
10.1111/j.1365-2265.1988.tb01217.x. [PMID: 3168311] - G Brabant, A Brabant, U Ranft, K Ocran, J Köhrle, R D Hesch, A von zur Mühlen. Circadian and pulsatile thyrotropin secretion in euthyroid man under the influence of thyroid hormone and glucocorticoid administration.
The Journal of clinical endocrinology and metabolism.
1987 Jul; 65(1):83-8. doi:
10.1210/jcem-65-1-83. [PMID: 3584402] - V S Lim, D C Zavala, M J Flanigan, R M Freeman. Blunted peripheral tissue responsiveness to thyroid hormone in uremic patients.
Kidney international.
1987 Mar; 31(3):808-14. doi:
10.1038/ki.1987.70. [PMID: 3573541] - B A Karpman, B Rapoport, S Filetti, D A Fisher. Treatment of neonatal hyperthyroidism due to Graves' disease with sodium ipodate.
The Journal of clinical endocrinology and metabolism.
1987 Jan; 64(1):119-23. doi:
10.1210/jcem-64-1-119. [PMID: 3782427] - N Boye. Thyroxine monodeiodination in normal human kidney tissue in vitro.
Acta endocrinologica.
1986 Aug; 112(4):536-40. doi:
10.1530/acta.0.1120536. [PMID: 3751464] - G Robuschi, A Manfredi, M Salvi, E Gardini, M Montermini, L d'Amato, E Borciani, L Negrotti, A Gnudi, E Roti. Effect of sodium ipodate and iodide on free T4 and free T3 concentrations in patients with Graves' disease.
Journal of endocrinological investigation.
1986 Aug; 9(4):287-91. doi:
10.1007/bf03346928. [PMID: 3537101] - D G Cyr, J G Eales. The effects of sodium ipodate (ORAgrafin) on thyroid function in rainbow trout, Salmo gairdneri.
General and comparative endocrinology.
1986 Jul; 63(1):86-92. doi:
10.1016/0016-6480(86)90185-1. [PMID: 3770448] - J V Felicetta, R Czanko, M J Huber-Smith, D S McCann. Cholecystographic agents and sulfobromophthalein inhibit the binding of L-thyroxine to plasma membranes of rat hepatocytes.
Endocrinology.
1986 Jun; 118(6):2500-4. doi:
10.1210/endo-118-6-2500. [PMID: 3698921] - V S Lim, D C Zavala, M J Flanigan, R M Freeman. Basal oxygen uptake: a new technique for an old test.
The Journal of clinical endocrinology and metabolism.
1986 May; 62(5):863-8. doi:
10.1210/jcem-62-5-863. [PMID: 3958124] - D C Shen, S Y Wu, I J Chopra, H W Huang, L R Shian, T Y Bian, C Y Jeng, D H Solomon. Long term treatment of Graves' hyperthyroidism with sodium ipodate.
The Journal of clinical endocrinology and metabolism.
1985 Oct; 61(4):723-7. doi:
10.1210/jcem-61-4-723. [PMID: 3928675] - V S Lim, M J Flanigan, D C Zavala, R M Freeman. Protective adaptation of low serum triiodothyronine in patients with chronic renal failure.
Kidney international.
1985 Sep; 28(3):541-9. doi:
10.1038/ki.1985.162. [PMID: 3934453] - A N Yusufi, N Murayama, M J Keller, T P Dousa. Modulatory effect of thyroid hormones on uptake of phosphate and other solutes across luminal brush border membrane of kidney cortex.
Endocrinology.
1985 Jun; 116(6):2438-49. doi:
10.1210/endo-116-6-2438. [PMID: 2986951] - E Roti, G Robuschi, A Manfredi, L D'Amato, E Gardini, M Salvi, M Montermini, A L Barlli, A Gnudi, L E Braverman. Comparative effects of sodium ipodate and iodide on serum thyroid hormone concentrations in patients with Graves' disease.
Clinical endocrinology.
1985 Apr; 22(4):489-96. doi:
10.1111/j.1365-2265.1985.tb00148.x. [PMID: 3838710] - G Schaison, P Thomopoulos, D Leguillouzic, G Thomas, M Moatti. Effects of sodium ipodate and propylthiouracil in athyreotic human subjects, role of triiodothyronine and pituitary thyroxine monodeiodination in thyrotrophin regulation.
Acta endocrinologica.
1984 Jul; 106(3):338-45. doi:
10.1530/acta.0.1060338. [PMID: 6741399] - P Laurberg, N Boye. Propylthiouracil, ipodate, dexamethasone and periods of fasting induce different variations in serum rT3 in dogs.
Metabolism: clinical and experimental.
1984 Apr; 33(4):323-5. doi:
10.1016/0026-0495(84)90191-4. [PMID: 6708815] - G Limido. [Problems related to the radiographic study of the biliary tract using oral or intravenous contrast media. Main side effects and biochemical changes induced by the administration of contrast media].
Minerva dietologica e gastroenterologica.
1984 Jan; 30(1):9-15. doi:
NULL. [PMID: 6374500] - E Arteaga, J M López, J A Rodríguez, P Michaud, G López. Effect of the combination of dexamethasone and sodium ipodate on serum thyroid hormones in Graves' disease.
Clinical endocrinology.
1983 Nov; 19(5):619-27. doi:
10.1111/j.1365-2265.1983.tb00040.x. [PMID: 6688973] - P B Sogol, J M Hershman, A W Reed, W H Dillmann. The effects of amiodarone on serum thyroid hormones and hepatic thyroxine 5'-monodeiodination in rats.
Endocrinology.
1983 Oct; 113(4):1464-9. doi:
10.1210/endo-113-4-1464. [PMID: 6617581] - K D Burman, R C Smallridge, J R Burge, D Carlson, L Wartofsky. Ipodate restores the fasting-induced decrement in thyrotropin secretion.
The Journal of clinical endocrinology and metabolism.
1983 Sep; 57(3):597-602. doi:
10.1210/jcem-57-3-597. [PMID: 6409917] - J V Felicetta, W L Green, M J Huber-Smith. Effects of cholecystographic agents and sulfobromophthalein on binding of thyroid hormones to serum proteins.
The Journal of clinical endocrinology and metabolism.
1983 Jul; 57(1):207-12. doi:
10.1210/jcem-57-1-207. [PMID: 6853679] - B Grubeck-Loebenstein, H Vierhapper, W Waldhäusl. Increased plasma concentrations of thyrotropin in healthy subjects during three weeks peroral administration of a small dose of ipodate.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
1983 Apr; 15(4):205-6. doi:
10.1055/s-2007-1018672. [PMID: 6407950] - G C Borst, C Eil, K D Burman. Euthyroid hyperthyroxinemia.
Annals of internal medicine.
1983 Mar; 98(3):366-78. doi:
10.7326/0003-4819-98-3-366. [PMID: 6187257] - A Pernet, D G Johnston, J M Burrin, H Orskov, K G Alberti. Transient triiodothyronine deficiency. Absence of effect on basal or adrenaline-stimulated carbohydrate and lipid metabolism in man.
Diabete & metabolisme.
1982 Mar; 8(1):41-6. doi:
. [PMID: 7047251] - I J Chopra. Triiodothyronines in health and disease.
Monographs on endocrinology.
1981; 18(?):1-14, 58. doi:
10.1007/978-3-642-81548-5. [PMID: 6164917] - J R Amberg, W M Thompson, L Golberger, S Williamson, R Alexander, M Bates. Factors in the intestinal absorption of oral cholecystopaques.
Investigative radiology.
1980 Nov; 15(6 Suppl):S136-41. doi:
10.1097/00004424-198011001-00029. [PMID: 7203915] - J V Felicetta, W L Green, W B Nelp. Inhibition of hepatic binding of thyroxine by cholecystographic agents.
The Journal of clinical investigation.
1980 May; 65(5):1032-40. doi:
10.1172/jci109755. [PMID: 7364937] - C G Beng, M L Wellby, R G Symons, S Stuart, J Marshall. The effects of iopodate on the serum iodothyronine pattern in normal subjects.
Acta endocrinologica.
1980 Feb; 93(2):175-8. doi:
10.1530/acta.0.0930175. [PMID: 7376789] - S Y Wu, I J Chopra, D H Solomon, D E Johnson. The effect of repeated administration of ipodate (Oragrafin) in hyperthyroidism.
The Journal of clinical endocrinology and metabolism.
1978 Dec; 47(6):1358-62. doi:
10.1210/jcem-47-6-1358. [PMID: 263735] - S Y Wu, I J Chopra, D H Solomon, L R Bennett. Changes in circulating iodothyronines in euthyroid and hyperthyroid subjects given ipodate (Oragrafin), an agent for oral cholecystography.
The Journal of clinical endocrinology and metabolism.
1978 Apr; 46(4):691-7. doi:
10.1210/jcem-46-4-691. [PMID: 582597] - I Kippen, J R Klinenberg. Effects of drugs on the uptake of uric acid by separated renal tubules of the rabbit.
Advances in experimental medicine and biology.
1977; 76B(?):114-6. doi:
10.1007/978-1-4684-3285-5_16. [PMID: 855739] - R N Berk, P M Loeb. Pharmacology and physiology of the biliary radiographic contrast materials.
Seminars in roentgenology.
1976 Jul; 11(3):147-56. doi:
10.1016/0037-198x(76)90043-2. [PMID: 133461] - H Bockslaff, A Brase, H Haindl, G Körber. [The effect of contrast media containing iodine on selected in vitro thyroid test procedures (author's transl)].
MMW, Munchener medizinische Wochenschrift.
1976 Jan; 118(1):1-6. doi:
NULL. [PMID: 55963] - A E Postlethwaite, W N Kelley. Radiocontrast agents and aspirin.
JAMA.
1972 Mar; 219(11):1479. doi:
10.1001/jama.1972.03190370069027. [PMID: 5066914] - T J Daymond. Cholecystography and renal failure.
Lancet (London, England).
1971 Sep; 2(7723):549-50. doi:
10.1016/s0140-6736(71)90474-0. [PMID: 4105699] - A E Postlethwaite, W N Kelley. Uricosuric effect of radiocontrast agents. A study in man of four commonly used preparations.
Annals of internal medicine.
1971 Jun; 74(6):845-52. doi:
10.7326/0003-4819-74-6-845. [PMID: 5580635] - W N Kelley. Uricosuria and x-ray contrast agents.
The New England journal of medicine.
1971 Apr; 284(17):975-6. doi:
10.1056/nejm197104292841712. [PMID: 5573284] - G H Mudge. Uricosuric action of cholecystographic agents. A possible factor in nephrotoxicity.
The New England journal of medicine.
1971 Apr; 284(17):929-33. doi:
10.1056/nejm197104292841701. [PMID: 5551801] - G H Mudge, W O Berndt, A Saunders, B Beattie. Renal transport of diatrizoate in the rabbit, dog, and rat.
Nephron.
1971; 8(2):156-72. doi:
10.1159/000179916. [PMID: 5119527] - G H Mudge, W O Brndt, D N Wade. Inhibition of p-aminohippurate transport by cholegraphic agents.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1971 Jan; 136(1):309-12. doi:
10.3181/00379727-136-35254. [PMID: 5540631] - R Ködding, H L Krüskemper. [Reaction of endogenous and exogenous iodine compounds in the serum with a basic ion exchanger].
Zeitschrift fur klinische Chemie und klinische Biochemie.
1970 Jul; 8(4):425-30. doi:
NULL. [PMID: 4194809] - J M Janbroers, J C Sanders, H P Til, V J Feron, A P De Groot. Toxicologic and pharmacologic properties of iocetamic acid, a new oral cholecystographic agent.
Toxicology and applied pharmacology.
1969 Mar; 14(2):232-41. doi:
10.1016/0041-008x(69)90103-3. [PMID: 5772846] - B R Harrow, O P Winslow. Renal toxicity following oral cholecystography with oragrafin (ipodate calcium).
Radiology.
1966 Oct; 87(4):721-4. doi:
10.1148/87.4.721. [PMID: 5923766] - J G TEPLICK, R M MYERSON, F J SANEN. ACUTE RENAL FAILURE FOLLOWING ORAL CHOLECYSTOGRAPHY.
Acta radiologica: diagnosis.
1965 Jul; 3(?):353-69. doi:
10.1177/028418516500300408. [PMID: 14328214] - H E FINK, W J ROENIGK, G P WILSON. AN EXPERIMENTAL INVESTIGATION OF THE NEPHROTOXIC EFFECTS OF ORAL CHOLECYSTOGRAPHIC AGENTS.
The American journal of the medical sciences.
1964 Feb; 247(?):201-16. doi:
10.1097/00000441-196402000-00010. [PMID: 14124710]