Azacyclonol (BioDeep_00000176341)

   

human metabolite blood metabolite


代谢物信息卡片


diphenyl(piperidin-4-yl)methanol

  化学式: C18H21NO (267.1623)
中文名称: α-(4-哌啶基)二苯甲醇
  谱图信息: 最多检出来源 Mus musculus(blood) 100%

分子结构信息

SMILES: C1CNCCC1C(C2=CC=CC=C2)(C3=CC=CC=C3)O
InChI: InChI=1S/C18H21NO/c20-18(15-7-3-1-4-8-15,16-9-5-2-6-10-16)17-11-13-19-14-12-17/h1-10,17,19-20H,11-14H2


描述信息

C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
Azacyclonol (γ-pipradol), a metabolite of Terfenadine, is a central depressant agent. Azacyclonol is a ganglion-blocking agent. Azacyclonol can be used to diminish psychoses-induced hallucinations[1][2][3].

同义名列表

66 个代谢物同义名

diphenyl(piperidin-4-yl)methanol; Azacyclonol hydrochloride; gamma-Pipradol; Azacyclonol; g-Pipradol; γ-pipradol; Ataractan; Psychosan; Frenquel; Calmeran; Frenoton; UNII-2MMR990PEM; .alpha.-(4-Piperidyl)benzhydrol; .alpha.,.alpha.-Diphenyl-4-piperidinemethanol; .gamma.-Pipradol; |A inverted exclamation mark,|A inverted exclamation mark-Diphenyl-4-piperidinemethanol; |A-(4-Piperidyl)benzhydrol; 2MMR990PEM; 4-(diphenylhydroxymethyl) piperidine; 4-(Diphenylhydroxymethyl)piperidine; 4-(hydroxy-diphenyl-methyl)-piperidine; 4-(hydroxydiphenylmethyl)piperidine; 4-Piperidinemethanol, .alpha.,.alpha.-diphenyl-; 4-Piperidinemethanol, alpha,alpha-diphenyl-; 5-21-04-00072 (Beilstein Handbook Reference); a-(4-Piperidyl)benzhydrol; alpha-(4-Piperidyl)benzhydrol; alpha, alpha-diphenyl-4-piperidinemethanol; alpha,alpha -diphenyl-4-piperidine-methanol; alpha,alpha -diphenyl-4-piperidinemethanol; alpha,alpha-Diphenyl-4-piperidinemethanol; alpha,alpha-diphenyl-4-piperidinomethanol; azaciclonol; Azaciclonolo; Azaciclonolo [DCIT]; Azacyclonol (alpha,alpha-Diphenyl-4-piperidinomethanol); Azacyclonol [INN:BAN]; AZACYCLONOL [INN]; AZACYCLONOL [MI]; AZACYCLONOL [WHO-DD]; Azacyclonolum; Azacyclonolum (INN-Latin); Azacyclonolum [INN-Latin]; Azacyklonol; BPBio1_000052; diphenyl 4-piperidyl carbinol; Diphenyl-4-piperidylmethanol; Diphenyl-piperidin-4-yl-methanol; Diphenyl(4-piperidinyl)methanol; Diphenyl(4-piperidinyl)methanol #; Diphenyl(piperidin-4-yl)methanol (Azacyclonol); FEXOFENADINE HYDROCHLORIDE IMPURITY E [EP IMPURITY]; IDI1_012420; Maybridge3_001033; MER 17; Oprea1_114075; Oprea1_848733; Prestwick_84; Prestwick0_000093; Prestwick1_000093; Prestwick2_000093; Prestwick3_000093; TERFENADINE IMPURITY I (EP IMPURITY); TERFENADINE IMPURITY I [EP IMPURITY]; Tox21_110399; Tox21_110399_1



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Ujjwala Karmacharya, Prakash Chaudhary, Dongchul Lim, Sadan Dahal, Bhuwan Prasad Awasthi, Hee Dong Park, Jung-Ae Kim, Byeong-Seon Jeong. Synthesis and anticancer evaluation of 6-azacyclonol-2,4,6-trimethylpyridin-3-ol derivatives: M3 muscarinic acetylcholine receptor-mediated anticancer activity of a cyclohexyl derivative in androgen-refractory prostate cancer. Bioorganic chemistry. 2021 05; 110(?):104805. doi: 10.1016/j.bioorg.2021.104805. [PMID: 33725508]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Girum L Lemma, Zaiqi Wang, Mitchell A Hamman, Narjis A Zaheer, J Christopher Gorski, Stephen D Hall. The effect of short- and long-term administration of verapamil on the disposition of cytochrome P450 3A and P-glycoprotein substrates. Clinical pharmacology and therapeutics. 2006 Mar; 79(3):218-30. doi: 10.1016/j.clpt.2005.11.001. [PMID: 16513446]
  • M A Hamman, M A Bruce, B D Haehner-Daniels, S D Hall. The effect of rifampin administration on the disposition of fexofenadine. Clinical pharmacology and therapeutics. 2001 Mar; 69(3):114-21. doi: 10.1067/mcp.2001.113697. [PMID: 11240975]
  • J Martens. Determination of the terfenadine metabolite azacyclonol in human serum using gas chromatography-mass spectrometry. Journal of chromatography. B, Biomedical applications. 1996 Apr; 678(2):349-53. doi: 10.1016/0378-4347(95)00561-7. [PMID: 8738042]
  • S Surapaneni, S K Khalil. A preliminary pharmacokinetic study of the enantiomers of the terfenadine acid metabolite in humans. Chirality. 1994; 6(6):479-83. doi: 10.1002/chir.530060606. [PMID: 7946974]
  • J J Kuhlman, B Levine, K L Klette, J Magluilo, K S Kalasinsky, M L Smith. Measurement of azacyclonol in urine and serum of humans following terfenadine (Seldane) administration using gas chromatography-mass spectrometry. Journal of chromatography. 1992 Jul; 578(2):207-13. doi: 10.1016/0378-4347(92)80418-p. [PMID: 1400799]
  • J F BERRY, W L MAGEE, R J ROSSITER. Effect of chlorpromazine and azacyclonol on the labelling of phosphatides in brain slices. Biochimica et biophysica acta. 1956 Aug; 21(2):408-9. doi: 10.1016/0006-3002(56)90045-2. [PMID: 13363943]