Diacetyldichlorofluorescein (BioDeep_00000173660)
human metabolite blood metabolite
代谢物信息卡片
6-(acetyloxy)-2,7-dichloro-3-oxo-3H-spiro[2-benzofuran-1,9-xanthene]-3-yl acetate
化学式: C24H14Cl2O7 (484.0117)
中文名称: 2′,7′-二氯荧光素二乙酸酯
谱图信息:
最多检出来源 Homo sapiens(blood) 19.23%
分子结构信息
SMILES: CC(=O)OC1=C(C=C2C(=C1)OC3=CC(=C(C=C3C24C5=CC=CC=C5C(=O)O4)Cl)OC(=O)C)Cl
InChI: InChI=1S/C24H14Cl2O7/c1-11(27)30-21-9-19-15(7-17(21)25)24(14-6-4-3-5-13(14)23(29)33-24)16-8-18(26)22(31-12(2)28)10-20(16)32-19/h3-10H,1-2H3
描述信息
D004396 - Coloring Agents > D005456 - Fluorescent Dyes > D005452 - Fluoresceins
同义名列表
13 个代谢物同义名
6-(acetyloxy)-2,7-dichloro-3-oxo-3H-spiro[2-benzofuran-1,9-xanthene]-3-yl acetate; 6-(acetyloxy)-2,7-dichloro-3-oxospiro[2-benzofuran-1,9-xanthene]-3-yl acetate; Leukodiacetyl-2,7-dichlorofluorescein; 2,7-Dichlorofluorescein diacetate; 2,7-Dichlorofluorescin diacetate; Diacetyldichlorofluorescein; 2,7-Difluorofluorescein; Leuco-DCF diacetate; DCFH-DA; DCFDA; 2',7'-Dichlorofluorescein diacetate; 2',7'-Dichlorofluorescin diacetate; 2',7'-Difluorofluorescein
数据库引用编号
分类词条
相关代谢途径
Reactome()
BioCyc()
PlantCyc()
代谢反应
个相关的代谢反应过程信息。
Reactome()
BioCyc()
WikiPathways()
Plant Reactome()
INOH()
PlantCyc()
COVID-19 Disease Map()
PathBank()
PharmGKB()
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
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Blood cells, molecules & diseases.
2024 Jan; 106(?):102827. doi:
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Scientific reports.
2023 12; 13(1):21344. doi:
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Journal of inorganic biochemistry.
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PloS one.
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Life sciences.
2012 Jun; 90(25-26):968-74. doi:
10.1016/j.lfs.2012.04.043. [PMID: 22634580] - Michele Hinerasky da Silva, Edovando José Flores da Rosa, Nélson Rodrigues de Carvalho, Fernando Dobrachinski, João Batista Teixeira da Rocha, Jose L Mauriz, Javier González-Gallego, Félix Alexandre Antunes Soares. Acute brain damage induced by acetaminophen in mice: effect of diphenyl diselenide on oxidative stress and mitochondrial dysfunction.
Neurotoxicity research.
2012 Apr; 21(3):334-44. doi:
10.1007/s12640-011-9288-1. [PMID: 22081409] - Jin-Lian Li, Qiao-Yun Wang, Hai-Yun Luan, Ze-Chun Kang, Chun-Bo Wang. Effects of L-carnitine against oxidative stress in human hepatocytes: involvement of peroxisome proliferator-activated receptor alpha.
Journal of biomedical science.
2012 Mar; 19(?):32. doi:
10.1186/1423-0127-19-32. [PMID: 22435679] - Wei Ding, Lei Yang, Minmin Zhang, Yong Gu. Reactive oxygen species-mediated endoplasmic reticulum stress contributes to aldosterone-induced apoptosis in tubular epithelial cells.
Biochemical and biophysical research communications.
2012 Feb; 418(3):451-6. doi:
10.1016/j.bbrc.2012.01.037. [PMID: 22281495] - I A Naydov, M M Mubarakshina, B N Ivanov. Formation kinetics and H2O2 distribution in chloroplasts and protoplasts of photosynthetic leaf cells of higher plants under illumination.
Biochemistry. Biokhimiia.
2012 Feb; 77(2):143-51. doi:
10.1134/s0006297912020046. [PMID: 22348473] - Jianghai Liu, Timothy Chun-Ping Mak, Ali Banigesh, Kaushik Desai, Rui Wang, Lingyun Wu. Aldolase B knockdown prevents high glucose-induced methylglyoxal overproduction and cellular dysfunction in endothelial cells.
PloS one.
2012; 7(7):e41495. doi:
10.1371/journal.pone.0041495. [PMID: 22911800] - Paola Brun, Paola Brun, Maria Vono, Paola Venier, Elena Tarricone, Velika Deligianni, Emilio Martines, Matteo Zuin, Silvia Spagnolo, Roberto Cavazzana, Romilda Cardin, Ignazio Castagliuolo, Alvise La Gloria Valerio, Andrea Leonardi. Disinfection of ocular cells and tissues by atmospheric-pressure cold plasma.
PloS one.
2012; 7(3):e33245. doi:
10.1371/journal.pone.0033245. [PMID: 22432007] - Jong-Jer Lee, Chang-Chun Hsiao, I-Hui Yang, Ming-Huei Chou, Chia-Lin Wu, Yin-Chu Wei, Chih-Hsin Chen, Jiin-Haur Chuang. High-mobility group box 1 protein is implicated in advanced glycation end products-induced vascular endothelial growth factor A production in the rat retinal ganglion cell line RGC-5.
Molecular vision.
2012; 18(?):838-50. doi:
NULL. [PMID: 22511847] - Eun Hui Bae, Sunghee Cho, Soo Yeon Joo, Seong Kwon Ma, Suhn Hee Kim, Jongun Lee, Soo Wan Kim. 4-Hydroxy-2-hexenal-induced apoptosis in human renal proximal tubular epithelial cells.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2011 Dec; 26(12):3866-73. doi:
10.1093/ndt/gfr386. [PMID: 21771752] - Mohamed Anwar Bin-Umer, John E McLaughlin, Debaleena Basu, Susan McCormick, Nilgun E Tumer. Trichothecene mycotoxins inhibit mitochondrial translation--implication for the mechanism of toxicity.
Toxins.
2011 12; 3(12):1484-501. doi:
10.3390/toxins3121484. [PMID: 22295173] - Anat Elmann, Sharon Mordechay, Hilla Erlank, Alona Telerman, Miriam Rindner, Rivka Ofir. Anti-neuroinflammatory effects of the extract of Achillea fragrantissima.
BMC complementary and alternative medicine.
2011 Oct; 11(?):98. doi:
10.1186/1472-6882-11-98. [PMID: 22018032] - Seung Kim, Se-Eun Park, Kumar Sapkota, Myung-Kon Kim, Sung-Jun Kim. Leaf extract of Rhus verniciflua Stokes protects dopaminergic neuronal cells in a rotenone model of Parkinson's disease.
The Journal of pharmacy and pharmacology.
2011 Oct; 63(10):1358-67. doi:
10.1111/j.2042-7158.2011.01342.x. [PMID: 21899552] - Dongwu Liu, Zhiwei Chen, Peiguo Shi, Xue Wang, Weiwei Cai. Analysis of reactive oxygen species in the guard cell of wheat stoma with confocal microscope.
Microscopy research and technique.
2011 Sep; 74(9):795-8. doi:
10.1002/jemt.20957. [PMID: 23939665] - James M Brimson, Tewin Tencomnao. Rhinacanthus nasutus protects cultured neuronal cells against hypoxia induced cell death.
Molecules (Basel, Switzerland).
2011 Jul; 16(8):6322-38. doi:
10.3390/molecules16086322. [PMID: 21792150] - Carolina Gonçalves Fernandes, Clarissa Günther Borges, Bianca Seminotti, Alexandre Umpierrez Amaral, Lisiane Aurélio Knebel, Paula Eichler, Anderson Büker de Oliveira, Guilhian Leipnitz, Moacir Wajner. Experimental evidence that methylmalonic acid provokes oxidative damage and compromises antioxidant defenses in nerve terminal and striatum of young rats.
Cellular and molecular neurobiology.
2011 Jul; 31(5):775-85. doi:
10.1007/s10571-011-9675-4. [PMID: 21424830] - Sergio González-Pérez, Jorge Gutiérrez, Francisco García-García, Daniel Osuna, Joaquín Dopazo, Óscar Lorenzo, José L Revuelta, Juan B Arellano. Early transcriptional defense responses in Arabidopsis cell suspension culture under high-light conditions.
Plant physiology.
2011 Jul; 156(3):1439-56. doi:
10.1104/pp.111.177766. [PMID: 21531897] - Guan-wen Mo, Shao-xi Cai, Hai-jin Zhao, Wen-jun Li, Wan-cheng Tong, Lai-yu Liu. [Effect of toluene diisocyanate on reactive oxygen species production and permeability of human bronchial epithelial cells in vitro].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2011 Feb; 31(2):239-43. doi:
NULL. [PMID: 21354901] - Ji-Sook Lee, Eun Ju Yang, Chi-Young Yun, Dong-Hee Kim, In Sik Kim. Suppressive effect of Petasites japonicus extract on ovalbumin-induced airway inflammation in an asthmatic mouse model.
Journal of ethnopharmacology.
2011 Jan; 133(2):551-7. doi:
10.1016/j.jep.2010.10.038. [PMID: 21029770] - Nguyen Xuan Nhiem, Ki Cheon Kim, Areum-Daseul Kim, Jin Won Hyun, Hee Kyoung Kang, Phan Van Kiem, Chau Van Minh, Vu Kim Thu, Bui Huu Tai, Jeong Ah Kim, Young Ho Kim. Phenylpropanoids from the leaves of Acanthopanax koreanum and their antioxidant activity.
Journal of Asian natural products research.
2011 Jan; 13(1):56-61. doi:
10.1080/10286020.2010.525743. [PMID: 21253950] - Quan Liu, Yanqing Li, Li Hu, Dehui Wang. Lycium barbarum polysaccharides attenuate cisplatin-induced hair cell loss in rat cochlear organotypic cultures.
International journal of molecular sciences.
2011; 12(12):8982-92. doi:
10.3390/ijms12128982. [PMID: 22272115] - Mariana C Loya, Karla S Brammer, Chulmin Choi, Li-Han Chen, Sungho Jin. Plasma-induced nanopillars on bare metal coronary stent surface for enhanced endothelialization.
Acta biomaterialia.
2010 Dec; 6(12):4589-95. doi:
10.1016/j.actbio.2010.07.007. [PMID: 20624494] - Giuseppe Meca, Maria José Ruiz, Monica Fernandez-Franzón, Alberto Ritieni, Jordi Manes. Isolation, purification, LC-MS/MS characterization and reactive oxygen species induced by fumonisin B1 in VERO cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2010 Oct; 48(10):2891-7. doi:
10.1016/j.fct.2010.07.023. [PMID: 20655973] - Joe F Lo, Elly Sinkala, David T Eddington. Oxygen gradients for open well cellular cultures via microfluidic substrates.
Lab on a chip.
2010 Sep; 10(18):2394-401. doi:
10.1039/c004660d. [PMID: 20559583] - Ki Sung Kang, Yujing Wen, Noriko Yamabe, Masayuki Fukui, Stephanie C Bishop, Bao Ting Zhu. Dual beneficial effects of (-)-epigallocatechin-3-gallate on levodopa methylation and hippocampal neurodegeneration: in vitro and in vivo studies.
PloS one.
2010 Aug; 5(8):e11951. doi:
10.1371/journal.pone.0011951. [PMID: 20700524] - R Bertelli, A Trivelli, A Magnasco, M Cioni, M Bodria, A Carrea, G Montobbio, G Barbano, G M Ghiggeri. Failure of regulation results in an amplified oxidation burst by neutrophils in children with primary nephrotic syndrome.
Clinical and experimental immunology.
2010 Jul; 161(1):151-8. doi:
10.1111/j.1365-2249.2010.04160.x. [PMID: 20491793] - Jung-Ae Kim, Chang-Suk Kong, Se-Kwon Kim. Effect of Sargassum thunbergii on ROS mediated oxidative damage and identification of polyunsaturated fatty acid components.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2010 May; 48(5):1243-9. doi:
10.1016/j.fct.2010.02.017. [PMID: 20171254] - Xiaoli Wei, Wei Guo, Shuhong Wu, Li Wang, Peng Huang, Jinsong Liu, Bingliang Fang. Oxidative stress in NSC-741909-induced apoptosis of cancer cells.
Journal of translational medicine.
2010 Apr; 8(?):37. doi:
10.1186/1479-5876-8-37. [PMID: 20398386] - G R Huff, W E Huff, M B Farnell, N C Rath, F Solis de Los Santos, A M Donoghue. Bacterial clearance, heterophil function, and hematological parameters of transport-stressed turkey poults supplemented with dietary yeast extract.
Poultry science.
2010 Mar; 89(3):447-56. doi:
10.3382/ps.2009-00328. [PMID: 20181859] - Jung-Ran Noh, Gil-Tae Gang, Yong-Hoon Kim, Keum-Jin Yang, Chul-Ho Lee, O-Su Na, Gi-Ju Kim, Won-Keun Oh, Young-Don Lee. Desalinated underground seawater of Jeju Island (Korea) improves lipid metabolism in mice fed diets containing high fat and increases antioxidant potential in t-BHP treated HepG2 cells.
Nutrition research and practice.
2010 Feb; 4(1):3-10. doi:
10.4162/nrp.2010.4.1.3. [PMID: 20198202] - Seungjeong Song, Sang Won Kang, Chulhee Choi. Trichostatin A enhances proliferation and migration of vascular smooth muscle cells by downregulating thioredoxin 1.
Cardiovascular research.
2010 Jan; 85(1):241-9. doi:
10.1093/cvr/cvp263. [PMID: 19633316] - Niranjani Jambunathan. Determination and detection of reactive oxygen species (ROS), lipid peroxidation, and electrolyte leakage in plants.
Methods in molecular biology (Clifton, N.J.).
2010; 639(?):292-8. doi:
10.1007/978-1-60761-702-0_18. [PMID: 20387054] - A Chaveiro, F Moreira da Silva. Effect of oestrous cycle on the oxidative burst activity of blood polymorphonuclear leucocytes in cows.
Reproduction in domestic animals = Zuchthygiene.
2009 Dec; 44(6):900-6. doi:
10.1111/j.1439-0531.2008.01114.x. [PMID: 19000223] - Jing Yan, Yuewen Gong, Yi-Min She, Guqi Wang, Michael S Roberts, Frank J Burczynski. Molecular mechanism of recombinant liver fatty acid binding protein's antioxidant activity.
Journal of lipid research.
2009 Dec; 50(12):2445-54. doi:
10.1194/jlr.m900177-jlr200. [PMID: 19474456] - Samiran Bandyopadhyay, Sudipto Ganguly, Goutam Mandal, Rupashree Sen, Piu Saha, Monoj Kumar Ghosh, Mihir Sarkar, Mitali Chatterjee. Cytotoxicity of Senecio in macrophages is mediated via its induction of oxidative stress.
Research in veterinary science.
2009 Aug; 87(1):85-90. doi:
10.1016/j.rvsc.2008.12.007. [PMID: 19195669] - Kim Anker Kristiansen, Poul Erik Jensen, Ian Max Møller, Alexander Schulz. Monitoring reactive oxygen species formation and localisation in living cells by use of the fluorescent probe CM-H(2)DCFDA and confocal laser microscopy.
Physiologia plantarum.
2009 Aug; 136(4):369-83. doi:
10.1111/j.1399-3054.2009.01243.x. [PMID: 19493304] - Bin Li, Gil-Saeng Jeong, Dae-Gill Kang, Ho-Sub Lee, Youn-Chul Kim. Cytoprotective effects of lindenenyl acetate isolated from Lindera strychnifolia on mouse hippocampal HT22 cells.
European journal of pharmacology.
2009 Jul; 614(1-3):58-65. doi:
10.1016/j.ejphar.2009.04.056. [PMID: 19447102] - Cheng-Ri Zhao, Takashi Ikka, Yoshiharu Sawaki, Yuriko Kobayashi, Yuji Suzuki, Takashi Hibino, Shigeru Sato, Nozomu Sakurai, Daisuke Shibata, Hiroyuki Koyama. Comparative transcriptomic characterization of aluminum, sodium chloride, cadmium and copper rhizotoxicities in Arabidopsis thaliana.
BMC plant biology.
2009 Mar; 9(?):32. doi:
10.1186/1471-2229-9-32. [PMID: 19309492] - Feng Bao, Christopher S Bailey, Kevin R Gurr, Stewart I Bailey, M Patricia Rosas-Arellano, Gregory A Dekaban, Lynne C Weaver. Increased oxidative activity in human blood neutrophils and monocytes after spinal cord injury.
Experimental neurology.
2009 Feb; 215(2):308-16. doi:
10.1016/j.expneurol.2008.10.022. [PMID: 19056384] - Alejandra Espinosa, Alejandra García, Steffen Härtel, Cecilia Hidalgo, Enrique Jaimovich. NADPH oxidase and hydrogen peroxide mediate insulin-induced calcium increase in skeletal muscle cells.
The Journal of biological chemistry.
2009 Jan; 284(4):2568-75. doi:
10.1074/jbc.m804249200. [PMID: 19028699] - Ana Paula Beskow, Carolina Gonçalves Fernandes, Guilhian Leipnitz, Lucila de Bortoli da Silva, Bianca Seminotti, Alexandre U Amaral, Angela T S Wyse, Clóvis M D Wannmacher, Carmen R Vargas, Carlos S Dutra-Filho, Moacir Wajner. Influence of ketone bodies on oxidative stress parameters in brain of developing rats in vitro.
Metabolic brain disease.
2008 Dec; 23(4):411-25. doi:
10.1007/s11011-008-9108-3. [PMID: 18777091] - Ilhan Onaran, Sevide Sencan, Halil Demirtaş, Birsen Aydemir, Turgut Ulutin, Murat Okutan. Toxic-dose warfarin-induced apoptosis and its enhancement by gamma ionizing radiation in leukemia K562 and HL-60 cells is not mediated by induction of oxidative stress.
Naunyn-Schmiedeberg's archives of pharmacology.
2008 Nov; 378(5):471-81. doi:
10.1007/s00210-008-0306-7. [PMID: 18568337] - Yoshimi Nakajima, Yuta Inokuchi, Masamitsu Shimazawa, Kazumasa Otsubo, Takashi Ishibashi, Hideaki Hara. Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in-vitro and in mice in-vivo.
The Journal of pharmacy and pharmacology.
2008 Oct; 60(10):1365-74. doi:
10.1211/jpp/60.10.0013. [PMID: 18812030] - Joydeep Das, Jyotirmoy Ghosh, Prasenjit Manna, Parames C Sil. Taurine provides antioxidant defense against NaF-induced cytotoxicity in murine hepatocytes.
Pathophysiology : the official journal of the International Society for Pathophysiology.
2008 Oct; 15(3):181-90. doi:
10.1016/j.pathophys.2008.06.002. [PMID: 18676123]
