Chlorotrianisene (BioDeep_00000033214)

 

Secondary id: BioDeep_00000014998

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


1-[1-chloro-2,2-bis(4-methoxyphenyl)ethenyl]-4-methoxybenzene

化学式: C23H21ClO3 (380.11791460000006)
中文名称: 氯烯雌醚
谱图信息: 最多检出来源 Homo sapiens(blood) 9.52%

分子结构信息

SMILES: COC1=CC=C(C=C1)C(=C(C2=CC=C(C=C2)OC)Cl)C3=CC=C(C=C3)OC
InChI: InChI=1S/C23H21ClO3/c1-25-19-10-4-16(5-11-19)22(17-6-12-20(26-2)13-7-17)23(24)18-8-14-21(27-3)15-9-18/h4-15H,1-3H3

描述信息

Chlorotrianisene is only found in individuals that have used or taken this drug. It is a powerful synthetic, non-steroidal estrogen.Chlorotrianisene binds to the estrogen receptor on various estrogen receptor bearing cells. Target cells include cells in the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03C - Estrogens > G03CA - Natural and semisynthetic estrogens, plain
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D004967 - Estrogens
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen
D000970 - Antineoplastic Agents

同义名列表

15 个代谢物同义名

1-[1-chloro-2,2-bis(4-methoxyphenyl)ethenyl]-4-methoxybenzene; Chlortrianisoestrolum; Chloortrianisestrol; Chlortrianisestrol; Chlorotrianisenum; Chlorotrianisine; Chlortrianisenum; Chlorotrianisene; Chlortrianisene; Chlorotrianizen; Clorotrianiseno; Chlortrianizen; Chlortrianisen; Chlorestrolo; TACE



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • S J Song. [Bone metabolism in postmenopausal women and after estrogen treatment]. Zhonghua fu chan ke za zhi. 1993 Feb; 28(2):79-81, 122. doi: NULL. [PMID: 8344086]
  • M J Juedes, D Kupfer. Role of P-450c in the formation of a reactive intermediate of chlorotrianisene (TACE) by hepatic microsomes from methylcholanthrene-treated rats. Drug metabolism and disposition: the biological fate of chemicals. 1990 Mar; 18(2):131-7. doi: NULL. [PMID: 1971562]
  • S Baba, G Janetschek, K Pollow, K Hahn, G H Jacobi. The effects of chlorotrianisene (Tace) of kinetics of 3H-testosterone metabolism in patients with carcinoma of the prostate. British journal of urology. 1982 Aug; 54(4):393-8. doi: 10.1111/j.1464-410x.1982.tb08952.x. [PMID: 6810984]
  • A Morales, B Pujari. The choice of estrogen preparations in the treatment of prostatic cancer. Canadian Medical Association journal. 1975 Nov; 113(9):865-7. doi: NULL. [PMID: 1182631]
  • W H Utian, G Begg, A I Vinik, M Paul, L Shuman. Effect of bromocriptine and chlorotrianisene on inhibition of lactation and serum prolactin. A comparative double-blind study. British journal of obstetrics and gynaecology. 1975 Sep; 82(9):755-9. doi: 10.1111/j.1471-0528.1975.tb00718.x. [PMID: 1101946]
  • F A Klepikov, S G Genes, S S Popova. [Functional state of the adrenal cortex in cancer and adenoma of the prostate in the process of estrogen therapy]. Urologiia i nefrologiia. 1972 Nov; 37(6):38-42. doi: NULL. [PMID: 4124660]
  • H Wolf. Hormonal alteration of efficiency of conversion of tryptophan to urinary metabolites of niacin in man. The American journal of clinical nutrition. 1971 Jul; 24(7):792-9. doi: 10.1093/ajcn/24.7.792. [PMID: 4326365]
  • M Kontturi, E Sotaniemi. Effect of estrogen on the serum cholesterol and triglyceride levels of prostatic cancer patients. The Journal of urology. 1971 Jun; 105(6):847-9. doi: 10.1016/s0022-5347(17)61644-6. [PMID: 4997080]
  • H Wolf, R R Brown, P O Madsen. The effect of estrogens on pyridoxal phosphate dependent enzymes in patients with cancer of the prostate. The Journal of urology. 1971 Mar; 105(3):415-22. doi: 10.1016/s0022-5347(17)61540-4. [PMID: 5549790]
  • H Wolf, R R Brown, J M Price, P O Madsen. Studies on tryptophan metabolism in male subjects treated with female sex hormones. The Journal of clinical endocrinology and metabolism. 1970 Oct; 31(4):397-408. doi: 10.1210/jcem-31-4-397. [PMID: 4195194]
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  • H Wolf, R R Brown, J M Price, P O Madsen. Effect of hormones on the biosynthesis of nicotinic acid from tryptophan in man. The Journal of clinical endocrinology and metabolism. 1970 Mar; 30(3):380-5. doi: 10.1210/jcem-30-3-380. [PMID: 4312796]
  • M Kontturi, E Sotaniemi. Effect of oestrogen on liver function of prostatic cancer patients. British medical journal. 1969 Oct; 4(5677):204-5. doi: 10.1136/bmj.4.5677.204. [PMID: 5349302]
  • R R Brown, D P Rose, J M Price, H Wolf. Tryptophan metabolism as affected by anovulatory agents. Annals of the New York Academy of Sciences. 1969 Sep; 166(1):44-56. doi: 10.1111/j.1749-6632.1969.tb46372.x. [PMID: 4243378]
  • W H Pearlman, O Crépy, M Murphy. Testosterone-binding levels in the serum of women during the normal menstrual cycle, pregnancy, and the post-partum period. The Journal of clinical endocrinology and metabolism. 1967 Jul; 27(7):1012-8. doi: 10.1210/jcem-27-7-1012. [PMID: 6028274]
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  • J M Price, N Yess, R R Brown, A M Johnson. Tryptophan metabolism. A hitherto unreported abnormality occurring in a family. Archives of dermatology. 1967 May; 95(5):462-72. doi: 10.1001/archderm.95.5.462. [PMID: 6023698]
  • E Waldschmidt-Leitz, L Keller, I Kohl. [On the problem of transference of the resistance effect occuring after irradiation. II. Radioresistance in goats after irradiation]. Strahlentherapie. 1967 Mar; 132(3):454-62. doi: NULL. [PMID: 4172509]
  • D Charles, J A Loraine, E T Bell, R A Harkness. Further observations on the induction of ovulation with clomiphene. Fertility and sterility. 1966 May; 17(3):351-62. doi: 10.1016/s0015-0282(16)35946-5. [PMID: 4952093]
  • P W Copeman, D J Cripps, R Summerly. Cutaneous hepatic porphyria and oestrogens. British medical journal. 1966 Feb; 1(5485):461-3. doi: 10.1136/bmj.1.5485.461. [PMID: 5902684]
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