Ubiquinol-6 (BioDeep_00000032545)
Secondary id: BioDeep_00001872283
human metabolite Endogenous
代谢物信息卡片
化学式: C39H60O4 (592.449136)
中文名称:
谱图信息:
最多检出来源 Bos taurus(endogenous) 7.41%
分子结构信息
SMILES: CC(=CCC/C(=C/CC/C(=C/CC/C(=C/CC/C(=C/CC/C(=C/Cc1c(C)c(c(c(c1O)OC)OC)O)/C)/C)/C)/C)/C)C
InChI: InChI=1S/C39H60O4/c1-28(2)16-11-17-29(3)18-12-19-30(4)20-13-21-31(5)22-14-23-32(6)24-15-25-33(7)26-27-35-34(8)36(40)38(42-9)39(43-10)37(35)41/h16,18,20,22,24,26,40-41H,11-15,17,19,21,23,25,27H2,1-10H3/b29-18+,30-20+,31-22+,32-24+,33-26+
描述信息
UbUbiquinone(Q) is an essential, lipid soluble, redox component of the mitochondrial respiratory chain. Much evidence suggests that ubiquinol (QH2) functions as an effective antioxidant in a number of membrane and biological systems by preventing peroxidative damage to lipids. It has been proposed that superoxide dismutase (SOD) may protect QH2 from autoxidation by acting either directly as a superoxide−semiquinone oxidoreductase or indirectly by scavenging superoxide. (Biochemistry, 1996, 35 (21), pp 6595 - 6603) [HMDB]
UbUbiquinone(Q) is an essential, lipid soluble, redox component of the mitochondrial respiratory chain. Much evidence suggests that ubiquinol (QH2) functions as an effective antioxidant in a number of membrane and biological systems by preventing peroxidative damage to lipids. It has been proposed that superoxide dismutase (SOD) may protect QH2 from autoxidation by acting either directly as a superoxide−semiquinone oxidoreductase or indirectly by scavenging superoxide. (Biochemistry, 1996, 35 (21), pp 6595 - 6603).
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:52970
- PubChem: 5813154
- HMDB: HMDB0012299
- foodb: FDB028922
- chemspider: 4710167
- CAS: 5677-58-7
- RefMet: Ubiquinol-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
18 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(14)
- glycerophosphodiester degradation:
sn-glycerol 3-phosphate + ubiquinone-6 ⟶ DHAP + ubiquinol - NAD/NADP-NADH/NADPH mitochondrial interconversion:
ATP + NAD+ ⟶ ADP + H+ + NADP+ - aerobic respiration (cytochrome c):
succinate + ubiquinone-6 ⟶ fumarate + ubiquinol - aerobic respiration (linear view):
succinate + ubiquinone-6 ⟶ fumarate + ubiquinol - glycerol degradation I:
ATP + glycerol ⟶ sn-glycerol 3-phosphate + ADP + H+ - glycerol-3-phosphate shuttle:
sn-glycerol 3-phosphate + NAD+ ⟶ DHAP + H+ + NADH - ubiquinone-6 biosynthesis (eukaryotic):
3-hexaprenyl-4-hydroxy-5-methoxybenzoate + H+ ⟶ 2-hexaprenyl-6-methoxyphenol + CO2 - superpathway of ubiquinol-6 biosynthesis (eukaryotic):
3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H+ ⟶ 2-hexaprenyl-6-methoxyphenol + CO2 - ubiquinol-6 biosynthesis from 4-hydroxybenzoate (eukaryotic):
3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H+ ⟶ 2-hexaprenyl-6-methoxyphenol + CO2 - ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast):
3-demethylubiquinol-6 + SAM ⟶ H+ + SAH + ubiquinol - ubiquinol-6 bypass biosynthesis (eukaryotic):
3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H+ ⟶ 2-hexaprenyl-6-methoxyphenol + CO2 - ubiquinol-6 bypass biosynthesis:
3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + SAM ⟶ 3-methoxy-4-hydroxy-5-all-trans-hexaprenylbenzoate + H+ + SAH - ubiquinol-6 biosynthesis (eukaryotic):
3-hexaprenyl-4-hydroxybenzoate + H+ + NADPH + O2 ⟶ 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NADP+ - ubiquinol-6 biosynthesis (eukaryotic):
3-hexaprenyl-4-hydroxybenzoate + H+ + NADPH + O2 ⟶ 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + NADP+
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(4)
- Methylglyoxal Degradation I:
Glutathione + Pyruvaldehyde ⟶ S-Lactoylglutathione - Methylglyoxal Degradation I:
Glutathione + Pyruvaldehyde ⟶ S-Lactoylglutathione - TCA cycle (ubiquinol-6):
Citric acid ⟶ Water + cis-Aconitic acid - TCA Cycle (Ubiquinol-6):
Water + cis-Aconitic acid ⟶ D-threo-Isocitric acid
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ulrika Forsman, Mats Sjöberg, Mikael Turunen, Pavel J Sindelar. 4-Nitrobenzoate inhibits coenzyme Q biosynthesis in mammalian cell cultures.
Nature chemical biology.
2010 Jul; 6(7):515-7. doi:
10.1038/nchembio.372. [PMID: 20526342]