Umanopterin (BioDeep_00000027661)
Main id: BioDeep_00000027657
human metabolite PANOMIX_OTCML-2023 Endogenous BioNovoGene_Lab2019
代谢物信息卡片
2-amino-6-[(1R,2R)-1,2,3-trihydroxypropyl]-4,8-dihydropteridin-4-one
化学式: C9H11N5O4 (253.0811)
中文名称: 新蝶呤, 新喋呤
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C(N=C2C(=O)NC(=NC2=N1)N)C(C(CO)O)O
InChI: InChI=1S/C9H11N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h1,4,6,15-17H,2H2,(H3,10,11,13,14,18)/t4-,6-/m1/s1
描述信息
Umanopterin is a pteridine derivative. It is identified in body fluids. An elevated level of umanopterin is associated with immune system activation, malignant diseases, allograft rejection, and viral infections. (http://www.online-medical-dictionary.org/) [HMDB]
Umanopterin is a pteridine derivative. It is identified in body fluids. An elevated level of umanopterin is associated with immune system activation, malignant diseases, allograft rejection, and viral infections (http://www.online-medical-dictionary.org/).
Neopterin (D-(+)-Neopterin), a catabolic product of guanosine triphosphate (GTM), serves as a marker of cellular immune system activation.
同义名列表
20 个代谢物同义名
2-amino-6-[(1R,2R)-1,2,3-trihydroxypropyl]-4,8-dihydropteridin-4-one; 2-Amino-6-[(1R,2R)-1,2,3-trihydroxypropyl]-4(3H)-pteridinone; 2-amino-6-[(1R,2R)-1,2,3-trihydroxypropyl]-8H-pteridin-4-one; 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone; D-6-(Threo-1’,2’,3’-trihydroxypropyl)pterin; D-6-(Threo-1,2,3-trihydroxypropyl)pterin; Neopterin, (erythro-D)-isomer; Neopterin, (threo-D)-isomer; Neopterin, (r*, r*)-isomer; 6-D-Threo-monapterin; D-erythro-Neopterin; D-Threo-monapterin; D-Threo-neopterin; D-(-)-Monapterin; D-Monapterin; Umanopterin; Monapterin; neopterin; D-(+)-Neopterin; Neopterin
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:179056
- PubChem: 135460965
- HMDB: HMDB0000877
- DrugBank: DB02385
- MeSH: Neopterin
- foodb: FDB022295
- chemspider: 392507
- CAS: 10162-32-0
- CAS: 2009-64-5
- medchemexpress: HY-W040055
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-901
- KEGG: C05926
- PubChem: 8214
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 5908 - Tetrahymena pyriformis: 10.1002/1522-2675(20010418)84:4<918::AID-HLCA918>3.0.CO;2-M
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Amir Kiani, Daniel Elieh-Ali-Komi, Fariborz Bahrehmand, Shayan Mostafaei, Asad Vaisi-Raygani, Hosein Baniamerian, Farank Aghaz, Maryam Tanhapour, Ebrahim Shakiba, Zohreh Rahimi, Tayebeh Pourmotabbed. Association of angiotensin-converting enzyme (ACE) I/D variation with biochemical parameters and oxidative stress markers in systemic lupus erythematosus patients in west of Iran.
Molecular biology reports.
2023 Aug; ?(?):. doi:
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International journal of molecular sciences.
2023 Jun; 24(12):. doi:
10.3390/ijms241210188. [PMID: 37373334] - Xiaodan Fu, Zhemin Liu, Rong Li, Junyi Yin, Han Sun, Changliang Zhu, Qing Kong, Haijin Mou, Shaoping Nie. Amelioration of hydrolyzed guar gum on high-fat diet-induced obesity: Integrated hepatic transcriptome and metabolome.
Carbohydrate polymers.
2022 Dec; 297(?):120051. doi:
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The Journal of nutrition.
2022 07; 152(7):1792-1800. doi:
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AIDS research and human retroviruses.
2022 06; 38(6):441-450. doi:
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Clinical biochemistry.
2022 Jun; 104(?):1-12. doi:
10.1016/j.clinbiochem.2022.03.002. [PMID: 35307400] - Gaidaa M Dogheim, Ibtsam Khairat, Gamal A Omran, Sahar M El-Haggar, Ahmed M El Amrawy, Rehab H Werida. Clinical comparative study assessing the effect of ivabradine on neopterin and NT-Pro BNP against standard treatment in chronic heart failure patients.
European journal of clinical pharmacology.
2022 Jun; 78(6):943-954. doi:
10.1007/s00228-022-03290-6. [PMID: 35238960] - Arvid Edén, Anna Grahn, Daniel Bremell, Anahit Aghvanyan, Pradeepthi Bathala, Dietmar Fuchs, Johanna Gostner, Lars Hagberg, Nelly Kanberg, Sunsanee Kanjananimmanont, Magnus Lindh, Salvia Misaghian, Staffan Nilsson, Michael Schöll, George Sigal, Erika Stentoft, Marie Studahl, Aylin Yilmaz, Mingyue Wang, Martin Stengelin, Henrik Zetterberg, Magnus Gisslén. Viral Antigen and Inflammatory Biomarkers in Cerebrospinal Fluid in Patients With COVID-19 Infection and Neurologic Symptoms Compared With Control Participants Without Infection or Neurologic Symptoms.
JAMA network open.
2022 05; 5(5):e2213253. doi:
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Journal of acquired immune deficiency syndromes (1999).
2022 05; 90(1):106-114. doi:
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Journal for immunotherapy of cancer.
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BMC gastroenterology.
2022 Apr; 22(1):172. doi:
10.1186/s12876-022-02255-4. [PMID: 35395735] - Rowan Saloner, Natalie Savini, Scott L Letendre, David J Moore, Jessica L Montoya. Neopterin Relates to Lifetime Depression in Older Adults With HIV on Suppressive Antiretroviral Therapy.
Journal of acquired immune deficiency syndromes (1999).
2022 04; 89(4):454-461. doi:
10.1097/qai.0000000000002883. [PMID: 35202052] - Meltem Yıldız Kayaoğlu, Gözde Girgin, Ismail Solmaz, Terken Baydar, Banu Anlar. Urine neopterin in childhood acute demyelinating diseases: Potential for differential diagnosis.
Multiple sclerosis and related disorders.
2022 Mar; 59(?):103662. doi:
10.1016/j.msard.2022.103662. [PMID: 35149394] - Daniel R Ambruso, Natalie J Briones, Angelina F Baroffio, John R Murphy, Alexander D Tran, Katherine Gowan, Bridget Sanford, Michael Ellison, Kenneth L Jones. In vivo interferon-gamma induced changes in gene expression dramatically alter neutrophil phenotype.
PloS one.
2022; 17(2):e0263370. doi:
10.1371/journal.pone.0263370. [PMID: 35113934] - Katinka Nordheim Alme, Arve Ulvik, Torunn Askim, Jörg Assmus, Tom Eirik Mollnes, Mala Naik, Halvor Næss, Ingvild Saltvedt, Per-Magne Ueland, Anne-Brita Knapskog. Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke.
BMC neurology.
2021 Dec; 21(1):476. doi:
10.1186/s12883-021-02498-w. [PMID: 34879833] - Kazuhisa Ikemoto, Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Toshiharu Nagatsu, Kazunao Kondo. Salivary neopterin and related pterins: their comparison to those in plasma and changes in individuals.
Journal of biochemistry.
2021 Dec; 170(4):559-567. doi:
10.1093/jb/mvab076. [PMID: 34181024] - Songul Unuvar, Rauf Melekoglu, Nese B Turkmen, Ercan Yilmaz, Seyma Yasar, Hande Yuce. Comparison of preoperative serum neopterin, periostin, indoleamine 2,3-dioxygenase, YKL-40, and tenascin-C levels with current tumor markers for early-stage endometrial cancer.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.
2021 Dec; 155(3):417-424. doi:
10.1002/ijgo.13666. [PMID: 33660848] - Hayder M Al-Kuraishy, Ali I Al-Gareeb, Khalid J Alzahrani, Natália Cruz-Martins, Gaber El-Saber Batiha. The potential role of neopterin in Covid-19: a new perspective.
Molecular and cellular biochemistry.
2021 Nov; 476(11):4161-4166. doi:
10.1007/s11010-021-04232-z. [PMID: 34319496] - Josefina Robertson, Arvid Edén, Kristina Nyström, Lars Hagberg, Aylin Yilmaz, Johanna M Gostner, Dietmar Fuchs, Staffan Nilsson, Kaj Blennow, Henrik Zetterberg, Magnus Gisslén. Increased immune activation and signs of neuronal injury in HIV-negative people on preexposure prophylaxis.
AIDS (London, England).
2021 11; 35(13):2129-2136. doi:
10.1097/qad.0000000000002980. [PMID: 34115648] - Carolina Rosadas, Henrik Zetterberg, Amanda Heslegrave, Jana Haddow, Mina Borisova, Graham P Taylor. Neurofilament Light in CSF and Plasma Is a Marker of Neuronal Damage in HTLV-1-Associated Myelopathy and Correlates With Neuroinflammation.
Neurology(R) neuroimmunology & neuroinflammation.
2021 11; 8(6):. doi:
10.1212/nxi.0000000000001090. [PMID: 34611039] - Lin-Lie Meng, Li Cao. Serum neopterin levels and their role in the prognosis of patients with ischemic stroke: A systematic review and meta-analysis.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia.
2021 Oct; 92(?):55-60. doi:
10.1016/j.jocn.2021.07.033. [PMID: 34509262] - Halina Baran, Markus Draxler, Carina Kronsteiner, Berthold Kepplinger. Increase of Kynurenic Acid after Encephalomyocarditis Virus Infection and Its Significances.
Neuro-Signals.
2021 09; 29(1):24-34. doi:
10.33594/000000434. [PMID: 34590795] - Anita Helland, Marianne Bratlie, Ingrid V Hagen, Øivind Midttun, Harald Sveier, Gunnar Mellgren, Per Magne Ueland, Oddrun A Gudbrandsen. Effect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial.
European journal of nutrition.
2021 Sep; 60(6):3237-3248. doi:
10.1007/s00394-021-02497-0. [PMID: 33576844] - Esther Uwimaana, Bernard S Bagaya, Barbara Castelnuovo, David P Kateete, Anguzu Godwin, Noah Kiwanuka, Christopher C Whalen, Moses L Joloba. Heme oxygenase-1 and neopterin plasma/serum levels and their role in diagnosing active and latent TB among HIV/TB co-infected patients: a cross sectional study.
BMC infectious diseases.
2021 Jul; 21(1):711. doi:
10.1186/s12879-021-06370-7. [PMID: 34315412] - Sabri Ekin, Abdullah Sivrikaya, Turan Akdağ, Sema Yilmaz, Semral Gülcemal. Elevated levels of neopterin and pentraxin 3 in patients with rheumatoid arthritis.
Hormone molecular biology and clinical investigation.
2021 Jul; 42(4):419-423. doi:
10.1515/hmbci-2021-0012. [PMID: 34303320] - Hekma Saad Farghaly, Kotb Abbass Metwalley, Duaa Mohamed Raafat, Ghada Mohamed Saied, Magda Farghali Gabri, Magdy Algowhary. Association between vascular endothelial dysfunction and the inflammatory marker neopterin in patients with classic congenital adrenal hyperplasia.
Atherosclerosis.
2021 07; 328(?):38-43. doi:
10.1016/j.atherosclerosis.2021.05.017. [PMID: 34091068] - Katja Schmitz, Sandra Trautmann, Lisa Hahnefeld, Caroline Fischer, Yannick Schreiber, Annett Wilken-Schmitz, Robert Gurke, Robert Brunkhorst, Ernst R Werner, Katrin Watschinger, Sabine Wicker, Dominique Thomas, Gerd Geisslinger, Irmgard Tegeder. Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.
2021 07; 18(3):1862-1879. doi:
10.1007/s13311-021-01043-4. [PMID: 33844153] - Jacob D Negrey, Verena Behringer, Kevin E Langergraber, Tobias Deschner. Urinary neopterin of wild chimpanzees indicates that cell-mediated immune activity varies by age, sex, and female reproductive status.
Scientific reports.
2021 04; 11(1):9298. doi:
10.1038/s41598-021-88401-6. [PMID: 33927233] - Riska Habriel Ruslie, Darmadi Darmadi, Gontar Alamsyah Siregar. Vascular Endothelial Growth Factor (VEGF) and Neopterin Levels in Children with Steroid-sensitive and Steroid-resistant Nephrotic Syndrome.
Medical archives (Sarajevo, Bosnia and Herzegovina).
2021 Apr; 75(2):133-137. doi:
10.5455/medarh.2021.75.133-137. [PMID: 34219873] - Takuya Watanabe. Neopterin derivatives - a novel therapeutic target rather than biomarker for atherosclerosis and related diseases.
VASA. Zeitschrift fur Gefasskrankheiten.
2021 Apr; 50(3):165-173. doi:
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The international journal of biochemistry & cell biology.
2021 04; 133(?):105918. doi:
10.1016/j.biocel.2021.105918. [PMID: 33421634] - Hasan Selcuk Ozger, Murat Dizbay, Seref Kerem Corbacioglu, Pinar Aysert, Zehra Demirbas, Ozlem Guzel Tunccan, Kenan Hizel, Gulendam Bozdayi, Kayhan Caglar. The prognostic role of neopterin in COVID-19 patients.
Journal of medical virology.
2021 03; 93(3):1520-1525. doi:
10.1002/jmv.26472. [PMID: 32860465] - Sheela S Sinharoy, Heather E Reese, Ira Praharaj, Howard H Chang, Thomas Clasen. Effects of a combined water and sanitation intervention on biomarkers of child environmental enteric dysfunction and associations with height-for-age z-score: A matched cohort study in rural Odisha, India.
PLoS neglected tropical diseases.
2021 03; 15(3):e0009198. doi:
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Psychiatry research.
2021 03; 297(?):113745. doi:
10.1016/j.psychres.2021.113745. [PMID: 33524773] - Brian J Koos, Jeffrey A Gornbein. Early pregnancy metabolites predict gestational diabetes mellitus: implications for fetal programming.
American journal of obstetrics and gynecology.
2021 02; 224(2):215.e1-215.e7. doi:
10.1016/j.ajog.2020.07.050. [PMID: 32739399] - Felix Grabherr, Maria Effenberger, Alisa Pedrini, Lisa Mayr, Julian Schwärzler, Simon Reider, Barbara Enrich, Gernot Fritsche, Sophie Wildner, Rosa Bellmann-Weiler, Günter Weiss, Sabine Scholl-Bürgi, Thomas Müller, Alexander Moschen, Timon E Adolph, Herbert Tilg. Increased Fecal Neopterin Parallels Gastrointestinal Symptoms in COVID-19.
Clinical and translational gastroenterology.
2021 01; 12(1):e00293. doi:
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International journal of molecular sciences.
2021 Jan; 22(2):. doi:
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Rheumatology (Oxford, England).
2021 01; 60(1):231-238. doi:
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Frontiers in immunology.
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Frontiers in cellular and infection microbiology.
2021; 11(?):709893. doi:
10.3389/fcimb.2021.709893. [PMID: 34497777] - Okan Zenger, Burcu Eren, Pırıl Arısoy, Sibel Özdaş, Gözde Baydemir Peşint. Determination of Neopterin as a Prognostic Indicator Using Neopterin-Imprinted Cryogel Membranes.
Methods in molecular biology (Clifton, N.J.).
2021; 2359(?):171-181. doi:
10.1007/978-1-0716-1629-1_15. [PMID: 34410669] - S Mrakic-Sposta, M Gussoni, C Dellanoce, M Marzorati, M Montorsi, L Rasica, L Pratali, G D'Angelo, M Martinelli, L Bastiani, L Di Natale, A Vezzoli. Effects of acute and sub-acute hypobaric hypoxia on oxidative stress: a field study in the Alps.
European journal of applied physiology.
2021 Jan; 121(1):297-306. doi:
10.1007/s00421-020-04527-x. [PMID: 33057877] - Gregory Baxter-Parker, Lloyd Roffe, Elena Moltchanova, Jay Jefferies, Siddarth Raajasekar, Gary Hooper, Steven P Gieseg. Urinary neopterin and total neopterin measurements allow monitoring of oxidative stress and inflammation levels of knee and hip arthroplasty patients.
PloS one.
2021; 16(8):e0256072. doi:
10.1371/journal.pone.0256072. [PMID: 34403444] - Yan-Ping Wang, Ting Wei, Xiao Ma, Xiao-Liang Zhu, Long-Fei Ren, Lei Zhang, Fang-Hui Ding, Xun Li, Hai-Ping Wang, Zhong-Tian Bai, Ke-Xiang Zhu, Long Miao, Jun Yan, Wen-Ce Zhou, Wen-Bo Meng, Yu-Qin Liu. Effect of Helicobacter Pylori on Plasma Metabolic Phenotype in Patients With Gastric Cancer.
Cancer control : journal of the Moffitt Cancer Center.
2021 Jan; 28(?):10732748211041881. doi:
10.1177/10732748211041881. [PMID: 34569311] - Josefina Robertson, Johanna M Gostner, Staffan Nilsson, Lars-Magnus Andersson, Dietmar Fuchs, Magnus Gisslen. Serum neopterin levels in relation to mild and severe COVID-19.
BMC infectious diseases.
2020 Dec; 20(1):942. doi:
10.1186/s12879-020-05671-7. [PMID: 33302893] - Wael El-Deeb, Mahmoud Fayez, Ibrahim Elsohaby, Hermine V Mkrtchyan, Abdulrahman Alhaider. Changes in blood biomarkers in Arabian horses with Clostridium difficile-induced enterocolitis.
Comparative immunology, microbiology and infectious diseases.
2020 Dec; 73(?):101525. doi:
10.1016/j.cimid.2020.101525. [PMID: 32877870] - Fathia M Khattab, Mai A Samir. Assessment of neopterin level and severity in lichen planus patients treated with narrow-band ultraviolet B.
Journal of cosmetic dermatology.
2020 Dec; 19(12):3389-3392. doi:
10.1111/jocd.13417. [PMID: 32530076] - Alireza Hejrati, Mahdi Taghadosi, Reza Alizadeh-Navaei, Shahnaz Hosseinzadeh, Davood Bashash, Mozhgan Esmaili, Parisa Zafari. Neopterin serum level does not reflect the disease activity in rheumatoid arthritis: A systematic review and meta-analysis.
IUBMB life.
2020 12; 72(12):2563-2571. doi:
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Journal of neurology.
2020 Dec; 267(12):3609-3616. doi:
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Nutrients.
2020 Oct; 12(11):. doi:
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Scientific reports.
2020 10; 10(1):17025. doi:
10.1038/s41598-020-74183-w. [PMID: 33046801] - Guy-Marino Hinnouho, K Ryan Wessells, Maxwell A Barffour, Somphou Sayasone, Charles D Arnold, Sengchanh Kounnavong, Sonja Y Hess. Impact of Different Strategies for Delivering Supplemental Zinc on Selected Fecal Markers of Environmental Enteric Dysfunction among Young Laotian Children: A Randomized Controlled Trial.
The American journal of tropical medicine and hygiene.
2020 10; 103(4):1416-1426. doi:
10.4269/ajtmh.20-0106. [PMID: 32618258] - Bing Sun, Linda Abadjian, Alexander Monto, Heather Freasier, Lynn Pulliam. Hepatitis C Virus Cure in Human Immunodeficiency Virus Coinfection Dampens Inflammation and Improves Cognition Through Multiple Mechanisms.
The Journal of infectious diseases.
2020 07; 222(3):396-406. doi:
10.1093/infdis/jiaa109. [PMID: 32157304] - Roman Dąbrowski, Anna Wdowiak, Marek Szczubiał, Leszek Krakowski, Piotr Brodzki, Mariola Bochniarz, Asta Tvarijonaviciute. Changes in interferon-gamma and neopterin in female dogs undergoing ovariohysterectomy as elective spay or as treatment of pyometra.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.
2020 Jul; 84(3):230-234. doi:
NULL. [PMID: 32801459] - Jamie Perin, Vanessa Burrowes, Mathieu Almeida, Shahnawaz Ahmed, Rashidul Haque, Tahmina Parvin, Shwapon Biswas, Ishrat J Azmi, Sazzadul Islam Bhuyian, Kaisar A Talukder, Abu G Faruque, O Colin Stine, Christine Marie George. A Retrospective Case-Control Study of the Relationship between the Gut Microbiota, Enteropathy, and Child Growth.
The American journal of tropical medicine and hygiene.
2020 07; 103(1):520-527. doi:
10.4269/ajtmh.19-0761. [PMID: 32431271] - Indu Dhar, Sumia Siddique, Eva R Pedersen, Gard F T Svingen, Vegard Lysne, Thomas Olsen, Dennis W Nilsen, Jan Erik Nordrehaug, Øivind Midttun, Per M Ueland, Grethe S Tell, Ottar K Nygård. Lipid parameters and vitamin A modify cardiovascular risk prediction by plasma neopterin.
Heart (British Cardiac Society).
2020 07; 106(14):1073-1079. doi:
10.1136/heartjnl-2019-316165. [PMID: 32398245] - Fikret Akyurek, Fatma Tuncez Akyurek. Investigation of pregnancy associated plasma protein-A and neopterin levels in Behçet's patients.
Dermatologic therapy.
2020 07; 33(4):e13443. doi:
10.1111/dth.13443. [PMID: 32307820] - Alessandro Di Stefano, Chiara Alcantarini, Cristiana Atzori, Filippo Lipani, Daniele Imperiale, Elisa Burdino, Sabrina Audagnotto, Lorenzo Mighetto, Maria Grazia Milia, Giovanni Di Perri, Andrea Calcagno. Cerebrospinal fluid biomarkers in patients with central nervous system infections: a retrospective study.
CNS spectrums.
2020 06; 25(3):402-408. doi:
10.1017/s1092852919000981. [PMID: 31130152] - Joyce Y Huang, Tricia L Larose, Hung N Luu, Renwei Wang, Anouar Fanidi, Karine Alcala, Victoria L Stevens, Stephanie J Weinstein, Demetrius Albanes, Neil E Caporaso, Mark P Purdue, Regina G Ziegler, Neal D Freedman, Qing Lan, Ross L Prentice, Mary Pettinger, Cynthia A Thomson, Qiuyin Cai, Jie Wu, William J Blot, Xiao-Ou Shu, Wei Zheng, Alan A Arslan, Anne Zeleniuch-Jacquotte, Loïc Le Marchand, Lynn R Wilkens, Christopher A Haiman, Xuehong Zhang, Meir J Stampfer, Jiali Han, Graham G Giles, Allison M Hodge, Gianluca Severi, Mikael Johansson, Kjell Grankvist, Arnulf Langhammer, Kristian Hveem, Yong-Bing Xiang, Hong-Lan Li, Yu-Tang Gao, Kala Visvanathan, Per M Ueland, Øivind Midttun, Arve Ulvi, Julie E Buring, I-Min Lee, Howard D Sesso, J Michael Gaziano, Jonas Manjer, Caroline Relton, Woon-Puay Koh, Paul Brennan, Mattias Johansson, Jian-Min Yuan. Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3).
International journal of cancer.
2020 05; 146(9):2394-2405. doi:
10.1002/ijc.32555. [PMID: 31276202] - Wael El-Deeb, Ibrahim Elsohaby, Mahmoud Fayez, Hermine V Mkrtchyan, Dalia El-Etriby, Magdy ElGioushy. Use of procalcitonin, neopterin, haptoglobin, serum amyloid A and proinflammatory cytokines in diagnosis and prognosis of bovine respiratory disease in feedlot calves under field conditions.
Acta tropica.
2020 Apr; 204(?):105336. doi:
10.1016/j.actatropica.2020.105336. [PMID: 31926143] - Kadriye Erkan, Mete K Bozkurt, Hasibe Artaç, Hülya Özdemir, Ali Ünlü, Emine N Korucu, Çağdaş Elsürer. The role of regulatory T cells in allergic rhinitis and their correlation with IL-10, IL-17 and neopterin levels in serum and nasal lavage fluid.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery.
2020 Apr; 277(4):1109-1114. doi:
10.1007/s00405-020-05811-4. [PMID: 31993765] - Momoka Kamada, Tsuneaki Kenzaka. Effectiveness of Profiling Serum IL-18 and Neopterin in Diagnosis of Adult-Onset Still's Disease Complicated by Pulmonary Tuberculosis: A Case Report.
The Tohoku journal of experimental medicine.
2020 04; 250(4):201-206. doi:
10.1620/tjem.250.201. [PMID: 32238618] - Q-L Peng, Y-M Zhang, L Liang, X Liu, L-F Ye, H-B Yang, L Zhang, X-M Shu, X Lu, G-C Wang. A high level of serum neopterin is associated with rapidly progressive interstitial lung disease and reduced survival in dermatomyositis.
Clinical and experimental immunology.
2020 03; 199(3):314-325. doi:
10.1111/cei.13404. [PMID: 31797350] - Simon Geisler, Simon D Lytton, Nguyen Linh Toan, Trinh Huu Nghia, Nguyen Minh Nam, Hoang Vu Hung, Nguyen Thai Son, Do Tuan Anh, Hoang Tien Tuyen, Tran Viet Tien, Do Quyet, Hoang Van Tong, Nghiem Xuan Hoan, Le Huu Song, Srinivas Reddy Pallerla, Johanna M Gostner, Dietmar Fuchs, Thirumalaisamy P Velavan. Neopterin levels and Kyn/Trp ratios were significantly increased in dengue virus patients and subsequently decreased after recovery.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2020 Feb; 91(?):162-168. doi:
10.1016/j.ijid.2019.12.005. [PMID: 31821895] - Marco Gelpi, Per Magne Ueland, Marius Trøseid, Amanda Mocroft, Anne-Mette Lebech, Henrik Ullum, Øivind Midttun, Jens Lundgren, Susanne D Nielsen. Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus.
The Journal of infectious diseases.
2020 01; 221(3):419-427. doi:
10.1093/infdis/jiz465. [PMID: 31538186] - Nicole Thompson González, Emily Otali, Zarin Machanda, Martin N Muller, Richard Wrangham, Melissa Emery Thompson. Urinary markers of oxidative stress respond to infection and late-life in wild chimpanzees.
PloS one.
2020; 15(9):e0238066. doi:
10.1371/journal.pone.0238066. [PMID: 32916689] - Thomas A Premeaux, Shireen Javandel, Kalei R J Hosaka, Meredith Greene, Nicholas Therrien, Isabel E Allen, Michael J Corley, Victor G Valcour, Lishomwa C Ndhlovu. Associations Between Plasma Immunomodulatory and Inflammatory Mediators With VACS Index Scores Among Older HIV-Infected Adults on Antiretroviral Therapy.
Frontiers in immunology.
2020; 11(?):1321. doi:
10.3389/fimmu.2020.01321. [PMID: 32695109] - Yu E Shilov, I I Miroshnichenko. [Neopterin as a potential biomarker in neuropsychiatry].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.
2020; 120(10):125-129. doi:
10.17116/jnevro2020120101125. [PMID: 33244968] - Charlotte M Stuart, Elina Zotova, Grielof Koster, Aravinthan Varatharaj, Grace Richardson, Faye R Cornick, Mark Weal, Tracey A Newman, Anthony D Postle, Ian Galea. High-Throughput Urinary Neopterin-to-Creatinine Ratio Monitoring of Systemic Inflammation.
The journal of applied laboratory medicine.
2020 01; 5(1):101-113. doi:
10.1373/jalm.2019.030007. [PMID: 31704895] - Suna Sabuncuoğlu, Yeşim Öztaş, Ahmet Yalcinkaya, Selma Ünal, Terken Baydar, Gözde Girgin. The increased neopterin content in turkish pediatric patients with sickle cell anemia.
Annals of hematology.
2020 Jan; 99(1):41-47. doi:
10.1007/s00277-019-03817-5. [PMID: 31760485] - Virginie Prendki, Astrid Malézieux-Picard, Leire Azurmendi, Jean-Charles Sanchez, Nicolas Vuilleumier, Sebastian Carballo, Xavier Roux, Jean-Luc Reny, Dina Zekry, Jérôme Stirnemann, Nicolas Garin. Accuracy of C-reactive protein, procalcitonin, serum amyloid A and neopterin for low-dose CT-scan confirmed pneumonia in elderly patients: A prospective cohort study.
PloS one.
2020; 15(9):e0239606. doi:
10.1371/journal.pone.0239606. [PMID: 32997689] - Alaa Eid, Sawsan Khoja, Shareefa AlGhamdi, Hadeil Alsufiani, Faten Alzeben, Nasim Alhejaili, Haythum O Tayeb, Frank I Tarazi. Vitamin D supplementation ameliorates severity of generalized anxiety disorder (GAD).
Metabolic brain disease.
2019 12; 34(6):1781-1786. doi:
10.1007/s11011-019-00486-1. [PMID: 31478182] - Simona Mrakic-Sposta, Alessandra Vezzoli, Alex Rizzato, Cinzia Della Noce, Sandro Malacrida, Michela Montorsi, Matteo Paganini, Pasqua Cancellara, Gerardo Bosco. Oxidative stress assessment in breath-hold diving.
European journal of applied physiology.
2019 Dec; 119(11-12):2449-2456. doi:
10.1007/s00421-019-04224-4. [PMID: 31520216] - Alex Pizzini, Katharina Kurz, Janine Santifaller, Christoph Tschurtschenthaler, Igor Theurl, Dietmar Fuchs, Günter Weiss, Rosa Bellmann-Weiler. Assessment of neopterin and indoleamine 2,3-dioxygenase activity in patients with seasonal influenza: A pilot study.
Influenza and other respiratory viruses.
2019 11; 13(6):603-609. doi:
10.1111/irv.12677. [PMID: 31489989] - Maiko Takakura, Masaki Shimizu, Hitoshi Irabu, Naoto Sakumura, Natsumi Inoue, Mao Mizuta, Yasuo Nakagishi, Akihiro Yachie. Comparison of serum biomarkers for the diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis.
Clinical immunology (Orlando, Fla.).
2019 11; 208(?):108252. doi:
10.1016/j.clim.2019.108252. [PMID: 31449879] - Ahmet Omma, Seda Colak, Sevinc Can Sandikci, Cigdem Yucel, Abdulsamet Erden, Erdim Sertoglu, Taner Ozgurtas. Serum neopterin and ischemia modified albumin levels are associated with the disease activity of adult immunoglobulin A vasculitis (Henoch-Schönlein purpura).
International journal of rheumatic diseases.
2019 Oct; 22(10):1920-1925. doi:
10.1111/1756-185x.13673. [PMID: 31411385] - Aki Nishioka, Shinichiro Tsunoda, Takeo Abe, Takahiro Yoshikawa, Miki Takata, Masayasu Kitano, Kiyoshi Matsui, Ran Nakashima, Yuji Hosono, Koichiro Ohmura, Tsuneyo Mimori, Hajime Sano. Serum neopterin as well as ferritin, soluble interleukin-2 receptor, KL-6 and anti-MDA5 antibody titer provide markers of the response to therapy in patients with interstitial lung disease complicating anti-MDA5 antibody-positive dermatomyositis.
Modern rheumatology.
2019 Sep; 29(5):814-820. doi:
10.1080/14397595.2018.1548918. [PMID: 30449228] - Betty Lanyero, Benedikte Grenov, Nicolette N Barungi, Hanifa Namusoke, Kim F Michaelsen, Ezekiel Mupere, Christian Mølgaard, Pingping Jiang, Hanne Frøkiær, Maria Wiese, Musemma K Muhammed, Hannah Pesu, Dennis S Nielsen, Henrik Friis, Maren Jh Rytter, Vibeke B Christensen. Correlates of Gut Function in Children Hospitalized for Severe Acute Malnutrition, a Cross-sectional Study in Uganda.
Journal of pediatric gastroenterology and nutrition.
2019 09; 69(3):292-298. doi:
10.1097/mpg.0000000000002381. [PMID: 31169661] - Bianca Thomas, Priyesh Bipath, Margaretha Viljoen. Comparison between plasma neopterin and the urine neopterin:creatinine ratio as inflammatory biomarkers.
African health sciences.
2019 Sep; 19(3):2407-2413. doi:
10.4314/ahs.v19i3.14. [PMID: 32127811] - Şerafettin Demir, Hüseyin Ede, Mehmet Kaplan, Fethi Yavuz, Ceyhun Yücel, İbrahim Halil Kurt. Neopterin as a novel marker; well correlated with mortality and morbidity in patients with advanced systolic heart failure.
Acta cardiologica.
2019 Jun; 74(3):216-221. doi:
10.1080/00015385.2018.1478266. [PMID: 29914304] - Débora da Luz Scheffer, Karina Ghisoni, Aderbal Silva Aguiar, Alexandra Latini. Moderate running exercise prevents excessive immune system activation.
Physiology & behavior.
2019 05; 204(?):248-255. doi:
10.1016/j.physbeh.2019.02.023. [PMID: 30794851] - Ufuk Kutluana, Ayse Guldem Kilciler, Soycan Mizrak, Utku Dilli. Can neopterin be a useful immune biomarker for differentiating gastric intestinal metaplasia and gastric atrophy from non-atrophic non-metaplastic chronic gastritis?.
Gastroenterologia y hepatologia.
2019 May; 42(5):289-295. doi:
10.1016/j.gastrohep.2019.01.005. [PMID: 30795853] - Kinga Musiał, Danuta Zwolińska. New markers of cell migration and inflammation in children with chronic kidney disease.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2019 May; 24(3):295-302. doi:
10.1080/1354750x.2018.1556341. [PMID: 30516070] - Fatih Dal, Yusuf Cicek, Salih Pekmezci, Bekir Kocazeybek, Hrisi Bahar Tokman, Dildar Konukoglu, Osman Şimşek, Zeynep Taner, Serhat Sirekbasan, Server Sezgin Uludağ. Role of Alvarado score and biological indicators of C-reactive protein, procalicitonin and neopterin in diagnosis of acute appendicitis.
Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES.
2019 May; 25(3):229-237. doi:
10.5505/tjtes.2018.57362. [PMID: 31135946] - Nasrin Iranshahi, Shirin Assar, Seyed Mojtaba Amiri, Parisa Zafari, Adel Fekri, Mahdi Taghadosi. Decreased Gene Expression of Epstein-Barr Virus-Induced Gene 3 (EBI-3) may Contribute to the Pathogenesis of Rheumatoid Arthritis.
Immunological investigations.
2019 May; 48(4):367-377. doi:
10.1080/08820139.2018.1549066. [PMID: 30513021] - Luke Whiley, Leanne C Nye, Isobelle Grant, Nick Andreas, Katie E Chappell, Magali H Sarafian, Ravi Misra, Robert S Plumb, Matthew R Lewis, Jeremy K Nicholson, Elaine Holmes, Jonathan R Swann, Ian D Wilson. Ultrahigh-Performance Liquid Chromatography Tandem Mass Spectrometry with Electrospray Ionization Quantification of Tryptophan Metabolites and Markers of Gut Health in Serum and Plasma-Application to Clinical and Epidemiology Cohorts.
Analytical chemistry.
2019 04; 91(8):5207-5216. doi:
10.1021/acs.analchem.8b05884. [PMID: 30848589] - Thomas A Premeaux, Michelle L D'Antoni, Mohamed Abdel-Mohsen, Satish K Pillai, Kalpana J Kallianpur, Beau K Nakamoto, Melissa Agsalda-Garcia, Bruce Shiramizu, Cecilia M Shikuma, Magnus Gisslén, Richard W Price, Victor Valcour, Lishomwa C Ndhlovu. Elevated cerebrospinal fluid Galectin-9 is associated with central nervous system immune activation and poor cognitive performance in older HIV-infected individuals.
Journal of neurovirology.
2019 04; 25(2):150-161. doi:
10.1007/s13365-018-0696-3. [PMID: 30478799] - Tomasz W Kaminski, Krystyna Pawlak, Malgorzata Karbowska, Beata Znorko, Adrian L Mor, Michal Mysliwiec, Dariusz Pawlak. The impact of antihypertensive pharmacotherapy on interplay between protein-bound uremic toxin (indoxyl sulfate) and markers of inflammation in patients with chronic kidney disease.
International urology and nephrology.
2019 Mar; 51(3):491-502. doi:
10.1007/s11255-018-02064-3. [PMID: 30617956] - Pei-Zhong Bao, Jun Ye, Lian-Shu Han, Wen-Juan Qiu, Hui-Wen Zhang, Yong-Guo Yu, Jian-Guo Wang, Xue-Fan Gu. Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia.
World journal of pediatrics : WJP.
2019 Feb; 15(1):66-71. doi:
10.1007/s12519-018-0202-2. [PMID: 30443829] - Xiao Yang, Huang Huang, Qing Lu, Shao-Hong Chen, Feng Wang, Ou-Ping Huang, Bin Hu, Bi-Cheng Yang. High-throughput polymer tip-electrospray ionization mass spectrometry for enhanced detection of neopterin and biopterin in clinical urine samples.
Journal of mass spectrometry : JMS.
2019 Feb; 54(2):189-194. doi:
10.1002/jms.4322. [PMID: 30597687] - Linn Hermansson, Aylin Yilmaz, Markus Axelsson, Kaj Blennow, Dietmar Fuchs, Lars Hagberg, Jan Lycke, Henrik Zetterberg, Magnus Gisslén. Cerebrospinal fluid levels of glial marker YKL-40 strongly associated with axonal injury in HIV infection.
Journal of neuroinflammation.
2019 Jan; 16(1):16. doi:
10.1186/s12974-019-1404-9. [PMID: 30678707] - Gregory Baxter-Parker, Lloyd Roffe, Sean Cross, Chris Frampton, Gary J Hooper, Steven P Gieseg. Knee replacement surgery significantly elevates the urinary inflammatory biomarkers neopterin and 7,8-dihydroneopterin.
Clinical biochemistry.
2019 Jan; 63(?):39-45. doi:
10.1016/j.clinbiochem.2018.11.002. [PMID: 30399370] - Stein-Erik Hafstad Solvang, Jan Erik Nordrehaug, Grethe S Tell, Ottar Nygård, Adrian McCann, Per Magne Ueland, Øivind Midttun, Klaus Meyer, Christian A Vedeler, Dag Aarsland, Helga Refsum, A David Smith, Lasse Melvaer Giil. The kynurenine pathway and cognitive performance in community-dwelling older adults. The Hordaland Health Study.
Brain, behavior, and immunity.
2019 01; 75(?):155-162. doi:
10.1016/j.bbi.2018.10.003. [PMID: 30675874] - Angelique Egberts, Robert J Osse, Durk Fekkes, Joke H M Tulen, Tischa J M van der Cammen, Francesco U S Mattace-Raso. Differences in potential biomarkers of delirium between acutely ill medical and elective cardiac surgery patients.
Clinical interventions in aging.
2019; 14(?):271-281. doi:
10.2147/cia.s193605. [PMID: 30799917] - Marwan Al-Nimer, Rawa Ratha, Taha Mahwi. Utility of Tetrahydrobiopterin Pathway in the Assessment of Diabetic Foot Ulcer: Significant and Complex Interrelations.
Journal of diabetes research.
2019; 2019(?):3426878. doi:
10.1155/2019/3426878. [PMID: 31828160] - Therese Löhrich, Verena Behringer, Roman M Wittig, Tobias Deschner, Fabian H Leendertz. The Use of Neopterin as a Noninvasive Marker in Monitoring Diseases in Wild Chimpanzees.
EcoHealth.
2018 12; 15(4):792-803. doi:
10.1007/s10393-018-1357-y. [PMID: 30117002] - M Szczubiał, R Dabrowski, W Łopuszyński, M Bochniarz, M Krawczyk. Changes in serum neopterin and C-reactive protein concentrations in female dogs with mammary gland tumours.
Polish journal of veterinary sciences.
2018 Dec; 21(4):691-696. doi:
10.24425/124307. [PMID: 30605283] - Else Quist-Paulsen, Pål Aukrust, Anne-Marte Bakken Kran, Oona Dunlop, Vidar Ormaasen, Birgitte Stiksrud, Øivind Midttun, Thor Ueland, Per Magne Ueland, Tom Eirik Mollnes, Anne Ma Dyrhol-Riise. High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections.
Journal of neuroinflammation.
2018 Nov; 15(1):327. doi:
10.1186/s12974-018-1366-3. [PMID: 30470234] - Vasilios Pergialiotis, Nikoleta Karampetsou, Panagiotis Zoumpourlis, Nikolaos Papantoniou, Nikolaos Thomakos, Georgios Daskalakis. Serum neopterin levels in women with preeclampsia: a systematic review.
Hypertension in pregnancy.
2018 Nov; 37(4):220-226. doi:
10.1080/10641955.2018.1526300. [PMID: 30301383]
