4-Hydroxyestrone (BioDeep_00000026379)
Main id: BioDeep_00000637483
human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite
代谢物信息卡片
化学式: C18H22O3 (286.1569)
中文名称: 4-羟雌甾酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4O)O
InChI: InChI=1S/C18H22O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,19,21H,2-3,5,7-9H2,1H3/t11?,12?,14?,18-/m1/s1
描述信息
4-Hydroxyestrone is metabolite originating from 17beta-estradiol, and is reported as carcinogenic and have ability to initiate cancer.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
A human metabolite taken as a putative food compound of mammalian origin [HMDB]
4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity[1].
同义名列表
11 个代谢物同义名
(15R)-5,6-dihydroxy-15-methyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-2(7),3,5-trien-14-one; 3,4-Dihydroxy-estra-1,3,5(10)-trien-17-one; 3,4-dihydroxy-1,3,5(10)-estratrien-17-one; 3,4-Dihydroxyestra-1,3,5(10)-trien-17-one; Estra-1,3,5(10)-triene-3,4-diol-17-one; 1,3,5(10)-Estratriene-3,4-diol-17-one; 4-Hydroxy catechol estrogen; 4-hydroxyestrone; SCHEMBL13123039; 4OHEs; 4-OHE1
数据库引用编号
8 个数据库交叉引用编号
- PubChem: 53477797
- HMDB: HMDB0005895
- Wikipedia: 4-Hydroxyestrone
- foodb: FDB023786
- CAS: 3131-23-5
- PMhub: MS000220432
- RefMet: 4-Hydroxyestrone
- medchemexpress: HY-W009300
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Hongge Wang, Ming-Jie Hou, Lixi Liao, Peng Li, Tongxiang Chen, Pan Wang, Bao Ting Zhu. Strong Protection by 4-Hydroxyestrone against Erastin-Induced Ferroptotic Cell Death in Estrogen Receptor-Negative Human Breast Cancer Cells: Evidence for Protein Disulfide Isomerase as a Mechanistic Target for Protection.
Biochemistry.
2024 Apr; 63(8):984-999. doi:
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Hormones & cancer.
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Bulletin of experimental biology and medicine.
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The Prostate.
2006 Oct; 66(14):1565-71. doi:
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The Journal of endocrinology.
2004 Oct; 183(1):91-9. doi:
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Biochemistry.
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. [PMID: 15157104] - Xia Xu, Regina G Ziegler, David J Waterhouse, Joseph E Saavedra, Larry K Keefer. Stable isotope dilution high-performance liquid chromatography-electrospray ionization mass spectrometry method for endogenous 2- and 4-hydroxyestrones in human urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
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The Journal of clinical endocrinology and metabolism.
1999 Nov; 84(11):3914-8. doi:
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1998 Sep; 45(1):52-7. doi:
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. [PMID: 9848110] - B T Zhu, Q D Bui, J Weisz, J G Liehr. Conversion of estrone to 2- and 4-hydroxyestrone by hamster kidney and liver microsomes: implications for the mechanism of estrogen-induced carcinogenesis.
Endocrinology.
1994 Nov; 135(5):1772-9. doi:
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Acta endocrinologica.
1981 Jun; 97(2):251-7. doi:
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