(R)-Mahanine (BioDeep_00000019878)

Secondary id: BioDeep_00000395549, BioDeep_00000622227

human metabolite PANOMIX_OTCML-2023 natural product

代谢物信息卡片

3,5-dimethyl-3-(4-methylpent-3-en-1-yl)-3H,11H-pyrano[3,2-a]carbazol-9-ol

化学式: C23H25NO2 (347.1885)
中文名称: MAHANINE
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 81.54%

分子结构信息

SMILES: CC(C)=CCCC1(C)C=Cc2c(c(C)cc3c2[nH]c2cc(O)ccc23)O1
InChI: InChI=1S/C23H25NO2/c1-14(2)6-5-10-23(4)11-9-18-21-19(12-15(3)22(18)26-23)17-8-7-16(25)13-20(17)24-21/h6-9,11-13,24-25H,5,10H2,1-4H3

描述信息

(R)-Mahanine is found in herbs and spices. (R)-Mahanine is an alkaloid from the leaves of Murraya koenigii (curry leaf tree).
Alkaloid from the leaves of Murraya koenigii (curry leaf tree). (R)-Mahanine is found in herbs and spices.

同义名列表

6 个代谢物同义名

3,5-dimethyl-3-(4-methylpent-3-en-1-yl)-3H,11H-pyrano[3,2-a]carbazol-9-ol; 3,5-dimethyl-3-(4-methylpent-3-en-1-yl)-11H-pyrano[3,2-a]carbazol-9-ol; bisisomahanine; (R)-Mahanine; Isomahanine; mahanine

数据库引用编号

8 个数据库交叉引用编号

PubChem: 375151
HMDB: HMDB0038837
ChEMBL: CHEMBL496633
foodb: FDB018272
chemspider: 332794
CAS: 28360-49-8
PMhub: MS000033403
LOTUS: LTS0102420

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

22 个相关的物种来源信息

2478535 - Bergera: LTS0102420
2759 - Eukaryota: LTS0102420
9606 - Homo sapiens: -
3398 - Magnoliopsida: LTS0102420
68549 - Micromelum: LTS0102420
68550 - Micromelum minutum: 10.1021/JF025564W
68550 - Micromelum minutum: LTS0102420
43710 - Murraya: LTS0102420
1224773 - Murraya euchrestifolia: 10.1016/0031-9422(91)85313-O
1224773 - Murraya euchrestifolia: 10.1016/0031-9422(95)00447-F
1224773 - Murraya euchrestifolia: 10.1021/NP000020E
1224773 - Murraya euchrestifolia: LTS0102420
159030 - Murraya koenigii: 10.1016/0031-9422(92)83651-E
159030 - Murraya koenigii: 10.1021/JF010621R
159030 - Murraya koenigii: 10.1021/JF9805808
159030 - Murraya koenigii: 10.1248/CPB.41.2096
159030 - Murraya koenigii: 10.3390/MOLECULES16119651
159030 - Murraya koenigii: LTS0102420
23513 - Rutaceae: LTS0102420
35493 - Streptophyta: LTS0102420
58023 - Tracheophyta: LTS0102420
33090 - Viridiplantae: LTS0102420

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表

文献列表

Eswara Murali Satyavarapu, Prasun Kumar Sinha, Chitra Mandal. Preclinical Development of Mahanine-Enriched Fraction from Indian Spice Murraya koenigii for the Management of Cancer: Efficacy, Temperature/pH stability, Pharmacokinetics, Acute and Chronic Toxicity (14-180 Days) Studies. BioMed research international. 2020; 2020(?):4638132. doi: 10.1155/2020/4638132. [PMID: 32851075]
Nattakarn Nooron, Anan Athipornchai, Apichart Suksamrarn, Anchalee Chiabchalard. Mahanine enhances the glucose-lowering mechanisms in skeletal muscle and adipocyte cells. Biochemical and biophysical research communications. 2017 12; 494(1-2):101-106. doi: 10.1016/j.bbrc.2017.10.075. [PMID: 29050941]
Thilahgavani Nagappan, Thirukanthan Chandra Segaran, Mohd Effendy Abdul Wahid, Perumal Ramasamy, Charles S Vairappan. Efficacy of carbazole alkaloids, essential oil and extract of Murraya koenigii in enhancing subcutaneous wound healing in rats. Molecules (Basel, Switzerland). 2012 Dec; 17(12):14449-63. doi: 10.3390/molecules171214449. [PMID: 23519245]
M Itoigawa, Y Kashiwada, C Ito, H Furukawa, Y Tachibana, K F Bastow, K H Lee. Antitumor agents. 203. Carbazole alkaloid murrayaquinone A and related synthetic carbazolequinones as cytotoxic agents. Journal of natural products. 2000 Jul; 63(7):893-7. doi: 10.1021/np000020e. [PMID: 10924160]