Gamma-Glutamylvaline (BioDeep_00000018627)

 

Secondary id: BioDeep_00000398065, BioDeep_00000403024

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


(2S)-2-amino-4-{[(1S)-1-carboxy-2-methylpropyl]carbamoyl}butanoic acid

化学式: C10H18N2O5 (246.12156579999998)
中文名称: γ-谷氨酰缬氨酸
谱图信息: 最多检出来源 Homo sapiens(feces) 0.26%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

Gamma-Glutamylvaline. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/gamma-glutamylvaline (retrieved 2024-11-10) (BioDeep RN: BioDeep_00000018627). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC(C)C(C(=O)O)NC(=O)CCC(C(=O)O)N
InChI: InChI=1S/C10H18N2O5/c1-5(2)8(10(16)17)12-7(13)4-3-6(11)9(14)15/h5-6,8H,3-4,11H2,1-2H3,(H,12,13)(H,14,15)(H,16,17)

描述信息

gamma-Glutamylvaline is a dipeptide composed of gamma-glutamate and valine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. gamma-Glutamylvaline belongs to the family of N-acyl-alpha amino acids and derivatives. These are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. It is found in urine (PMID: 3782411).
γ-Glutamylvaline is an activator of CaSR with anti-inflammatory activity. γ-Glutamylvaline inhibits TNF-α-induced proinflammatory cytokine production and increases Wnt5a expression. γ-Glutamylvaline activates calcium-sensing receptor pathways in adipocytes of 3T3-L1 mice and prevents low-grade chronic inflammation[1].

同义名列表

25 个代谢物同义名

(2S)-2-amino-4-{[(1S)-1-carboxy-2-methylpropyl]carbamoyl}butanoic acid; N-gamma-L-Glutamyl-L-valine; N-L-gamma-Glutamyl-L-valine; gamma-l-glutamyl-l-valine; L-gamma-Glutamyl-L-valine; N-L-gamma-Glutamylvaline; N-Γ-L-glutamyl-L-valine; N-L-Γ-glutamyl-L-valine; N-gamma-Glutamylvaline; L-Γ-glutamyl-L-valine; Γ-L-glutamyl-L-valine; N-L-Γ-glutamylvaline; gamma-Glutamylvaline; N-Γ-glutamylvaline; L-gamma-Glu-L-val; gamma-L-Glu-L-val; Γ-glutamylvaline; g-Glutamylvaline; L-g-Glu-L-val; Γ-L-glu-L-val; L-Γ-glu-L-val; gamma-Glu-val; Γ-glu-val; g-Glu-val; gamma-Glutamyl-valine



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • MacKenzie E Chee, Kaustav Majumder, Yoshinori Mine. Intervention of Dietary Dipeptide Gamma-l-Glutamyl-l-Valine (γ-EV) Ameliorates Inflammatory Response in a Mouse Model of LPS-Induced Sepsis. Journal of agricultural and food chemistry. 2017 Jul; 65(29):5953-5960. doi: 10.1021/acs.jafc.7b02109. [PMID: 28691814]