1'-hydroxytriazolam (BioDeep_00000018389)

 

Secondary id: BioDeep_00000408832

human metabolite Endogenous blood metabolite Chemicals and Drugs


代谢物信息卡片


[12-chloro-9-(2-chlorophenyl)-2,4,5,8-tetraazatricyclo[8.4.0.0²,⁶]tetradeca-1(10),3,5,8,11,13-hexaen-3-yl]methanol

化学式: C17H12Cl2N4O (358.0388122)
中文名称: Α-羟基三唑仑
谱图信息: 最多检出来源 Homo sapiens(blood) 2.2%

分子结构信息

SMILES: C1C2=NN=C(N2C3=C(C=C(C=C3)Cl)C(=N1)C4=CC=CC=C4Cl)CO
InChI: InChI=1S/C17H12Cl2N4O/c18-10-5-6-14-12(7-10)17(11-3-1-2-4-13(11)19)20-8-15-21-22-16(9-24)23(14)15/h1-7,24H,8-9H2

描述信息

1-hydroxytriazolam is a metabolite of triazolam. Triazolam (marketed in English-speaking countries under the brand names Apo-Triazo, Halcion, Hypam, and Trilam) is a benzodiazepine drug. It possesses pharmacological properties similar to that of other benzodiazepines, but it is generally only used as a sedative to treat severe insomnia. In addition to the hypnotic properties triazolam possesses, amnesic, anxiolytic, sedative, anticonvulsant and muscle relaxant properties are also present. (Wikipedia)

同义名列表

7 个代谢物同义名

[12-chloro-9-(2-chlorophenyl)-2,4,5,8-tetraazatricyclo[8.4.0.0²,⁶]tetradeca-1(10),3,5,8,11,13-hexaen-3-yl]methanol; N-Desmethyltoremifene, (e)-isomer; 1-Hydroxymethyltriazolam; alpha-Hydroxytriazolam; N-Demethyltoremifene; 1-hydroxytriazolam; α-Hydroxytriazolam



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Yu-Dong Jeong, Min Kyung Kim, Sung Ill Suh, Moon Kyo In, Jin Young Kim, Ki-Jung Paeng. Rapid determination of benzodiazepines, zolpidem and their metabolites in urine using direct injection liquid chromatography-tandem mass spectrometry. Forensic science international. 2015 Dec; 257(?):84-92. doi: 10.1016/j.forsciint.2015.07.043. [PMID: 26282513]
  • Masaru Terada, Tatsuo Shinozuka, Chika Hasegawa, Einosuke Tanaka, Makiko Hayashida, Youkichi Ohno, Kunihiko Kurosaki. Analysis of quazepam and its metabolites in human urine by gas chromatography-mass spectrometry: application to a forensic case. Forensic science international. 2013 Apr; 227(1-3):95-9. doi: 10.1016/j.forsciint.2012.11.017. [PMID: 23290298]
  • Akira Namera, Ryosuke Makita, Tatsuro Saruwatari, Aiko Hatano, Hiroaki Shiraishi, Masataka Nagao. Acute intoxication caused by overdose of flunitrazepam and triazolam: high concentration of metabolites detected at autopsy examination. The American journal of forensic medicine and pathology. 2012 Dec; 33(4):293-6. doi: 10.1097/paf.0b013e31820f1514. [PMID: 21372658]
  • Stephanie J Marin, Mark Roberts, Michelle Wood, Gwendolyn A McMillin. Sensitive UPLC-MS-MS assay for 21 benzodiazepine drugs and metabolites, zolpidem and zopiclone in serum or plasma. Journal of analytical toxicology. 2012 Sep; 36(7):472-6. doi: 10.1093/jat/bks059. [PMID: 22833647]
  • S Stybe Johansen, R Dahl-Sørensen. A drug rape case involving triazolam detected in hair and urine. International journal of legal medicine. 2012 Jul; 126(4):637-43. doi: 10.1007/s00414-011-0654-6. [PMID: 22160334]
  • Ryh-Nan Pan, Cheng-Huei Hsiong, Pei-Wei Huang, Wei-Shiuan Tsai, Wen-Yi Li, Li-Heng Pao. Simultaneous quantification of triazolam and its metabolites in human urine by liquid chromatography-tandem mass spectrometry. Journal of analytical toxicology. 2011 Apr; 35(3):170-5. doi: 10.1093/anatox/35.3.170. [PMID: 21439153]
  • Stephanie J Marin, Gwendolyn A McMillin. LC-MS/MS analysis of 13 benzodiazepines and metabolites in urine, serum, plasma, and meconium. Methods in molecular biology (Clifton, N.J.). 2010; 603(?):89-105. doi: 10.1007/978-1-60761-459-3_9. [PMID: 20077062]
  • Bruce A Goldberger, Chris W Chronister, Michele L Merves. Quantitation of benzodiazepines in blood and urine using gas chromatography-mass spectrometry (GC-MS). Methods in molecular biology (Clifton, N.J.). 2010; 603(?):75-87. doi: 10.1007/978-1-60761-459-3_8. [PMID: 20077061]
  • Dora Farkas, Lauren E Oleson, Yanli Zhao, Jerold S Harmatz, Miguel A Zinny, Michael H Court, David J Greenblatt. Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450-3A activity: comparison with grapefruit juice. Journal of clinical pharmacology. 2007 Mar; 47(3):286-94. doi: 10.1177/0091270006298359. [PMID: 17322140]
  • Kenji Tsujikawa, Kenji Kuwayama, Hajime Miyaguchi, Tatsuyuki Kanamori, Yuko Iwata, Hiroyuki Inoue, Tohru Kishi. Urinary excretion profiles of two major triazolam metabolites, alpha-hydroxytriazolam and 4-hydroxytriazolam. Journal of analytical toxicology. 2005 May; 29(4):240-3. doi: 10.1093/jat/29.4.240. [PMID: 15975253]
  • Dong-Liang Lin, Tsun-Ying Huang, Hsiu-Chuan Liu, Rea-Ming Yin. Urinary excretion of alpha-hydroxytriazolam following a single dose of halcion. Journal of analytical toxicology. 2005 Mar; 29(2):118-23. doi: 10.1093/jat/29.2.118. [PMID: 15902980]
  • Zhaolin Jiang, Yu Zhu, Jiayi Tan, Limei Xing, Lijuan Yao, Qing Zhang, Guoying Tao. [Determination of alpha-hydroxytrizolam and alpha hydroxyaplrazolam from urine by acetylation derivatization using gas chromatography electron capture detection]. Se pu = Chinese journal of chromatography. 2004 Nov; 22(6):664. doi: NULL. [PMID: 15807132]
  • Fumio Moriya, Yoshiaki Hashimoto. A case of fatal triazolam overdose. Legal medicine (Tokyo, Japan). 2003 Mar; 5 Suppl 1(?):S91-5. doi: 10.1016/s1344-6223(02)00074-3. [PMID: 12935561]
  • A D Fraser, W Bryan, A F Isner. Urinary screening for alpha-OH triazolam by FPIA and EIA with confirmation by GC/MS. Journal of analytical toxicology. 1992 Nov; 16(6):347-50. doi: 10.1093/jat/16.6.347. [PMID: 1293398]
  • P H Dickson, W Markus, J McKernan, H C Nipper. Urinalysis of alpha-hydroxyalprazolam, alpha-hydroxytriazolam, and other benzodiazepine compounds by GC/EIMS. Journal of analytical toxicology. 1992 Mar; 16(2):67-71. doi: 10.1093/jat/16.2.67. [PMID: 1501466]
  • W J Adams, P A Bombardt, R A Code. Absorption of triazolam from pelleted drug-diet mixtures by the mouse: quantitation of alpha-hydroxytriazolam in urine. Journal of pharmaceutical sciences. 1983 Oct; 72(10):1185-9. doi: 10.1002/jps.2600721020. [PMID: 6139470]
  • P Coassolo, C Aubert, J P Cano. Simultaneous assay of triazolam and its main hydroxy metabolite in plasma and urine by capillary gas chromatography. Journal of chromatography. 1983 May; 274(?):161-70. doi: 10.1016/s0378-4347(00)84419-9. [PMID: 6135700]
  • O Dehlin, G Björnson, L Börjesson, L Abrahamsson, R B Smith. Pharmacokinetics of triazolam in geriatric patients. European journal of clinical pharmacology. 1983; 25(1):91-4. doi: 10.1007/bf00544022. [PMID: 6137388]
  • F S Eberts, Y Philopoulos, L M Reineke, R W Vliek. Triazolam disposition. Clinical pharmacology and therapeutics. 1981 Jan; 29(1):81-93. doi: 10.1038/clpt.1981.14. [PMID: 6109586]