2,4-Dihydroxybenzoic acid (BioDeep_00000017757)

 

Secondary id: BioDeep_00000615797, BioDeep_00000863145, BioDeep_00001871345

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


beta-Resorcylic acid, monosodium salt

化学式: C7H6O4 (154.0266076)
中文名称: 2,4-二羟基苯甲酸
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 3.85%

分子结构信息

SMILES: C1=CC(=C(C=C1O)O)C(=O)O
InChI: InChI=1S/C7H6O4/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,8-9H,(H,10,11)

描述信息

2,4-Dihydroxybenzoic acid is found in alcoholic beverages. 2,4-Dihydroxybenzoic acid is found in avocado, beer, wine and coffee. 2,4-Dihydroxybenzoic acid is a food flavour ingredient and flavour modifie
Found in avocado, beer, wine and coffee. Food flavour ingredient and flavour modifier
2,4-Dihydroxybenzoic acid is a degradation product of cyaniding glycoside from tart cheeries in cell culture.
2,4-Dihydroxybenzoic acid is a degradation product of cyaniding glycoside from tart cheeries in cell culture.

同义名列表

25 个代谢物同义名

beta-Resorcylic acid, monosodium salt; beta-Resorcylic acid, sodium salt; beta-Resorcylic acid, lead salt; Resorcinol-4-carboxylic acid; 2,4-Dihydroxy-benzoic acid; 2,4-dihydroxybenzoic acid; 24-Dihydroxy-benzoic acid; 24-Dihydroxybenzoic acid; P-Hydroxysalicylic acid; 4-Hydroxysalicylic acid; beta-Resorcinolic acid; b-Resorcylic acid, 8ci; Resorcylic acid, beta; 24-Dihydroxy-benzoate; 2,4-Dihydroxybenzoate; beta-Resorcylic acid; 24-Dihydroxybenzoate; 4-Carboxyresorcinol; β-resorcylic acid; b-resorcylic acid; beta-Resorcylate; b-Resorcylate; β-resorcylate; FEMA 3798; 2,4-DHBA



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mengqian Lu, Yifan Zhao, Yingying Feng, Xiaoyan Tang, Wei Zhao, Keke Yu, Yuting Pan, Qiang Wang, Jilai Cui, Mengting Zhang, Jieyang Jin, Jingming Wang, Mingyue Zhao, Wilfried Schwab, Chuankui Song. 2,4-Dihydroxybenzoic Acid, a Novel SA Derivative, Controls Plant Immunity via UGT95B17-Mediated Glucosylation: A Case Study in Camellia Sinensis. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023 Dec; ?(?):e2307051. doi: 10.1002/advs.202307051. [PMID: 38063804]
  • Divek V T Nair, Shijinaraj Manjankattil, Claire Peichel, Wayne Martin, Annie M Donoghue, Kumar Venkitanarayanan, Anup Kollanoor Johny. Effect of plant-derived antimicrobials, eugenol, carvacrol, and β-resorcylic acid against Salmonella on organic chicken wings and carcasses. Poultry science. 2023 Jun; 102(10):102886. doi: 10.1016/j.psj.2023.102886. [PMID: 37517363]
  • Shiho Sato, Ferry Ferdiansyah Sofian, Wataru Suehiro, Desi Harneti, Rani Maharani, Unang Supratman, Fajar Fauzi Abdullah, Supriatno Salam, Takuya Koseki, Yoshihito Shiono. β-Resorcylic Acid Derivatives, with Their Phytotoxic Activities, from the Endophytic Fungus Lasiodiplodia theobromae in the Mangrove Plant Xylocarpus granatum. Chemistry & biodiversity. 2021 Mar; 18(3):e2000928. doi: 10.1002/cbdv.202000928. [PMID: 33555653]
  • Congwei Li, Pengfei Du, Meilin Zhou, Liuxin Yang, Haoyue Zhang, Jing Wang, Caiqin Yang. Spectroscopic Methodology and Molecular Docking Studies on Changes in Binding Interaction of Felodipine with Bovine Serum Albumin Induced by Cocrystallization with β-Resorcylic Acid. Chemical & pharmaceutical bulletin. 2020; 68(10):946-953. doi: 10.1248/cpb.c20-00212. [PMID: 32999146]
  • Miroslav Novakovic, Iris Djordjevic, Nina Todorovic, Snezana Trifunovic, Boban Andjelkovic, Boris Mandic, Milka Jadranin, Ivan Vuckovic, Vlatka Vajs, Slobodan Milosavljevic, Vele Tesevic. New aurone epoxide and auronolignan from the heartwood of Cotinus coggygria Scop. Natural product research. 2019 Oct; 33(19):2837-2844. doi: 10.1080/14786419.2018.1508141. [PMID: 30513208]
  • A Vulić, T Lešić, N Kudumija, T Mikuš, J Pleadin. Resorcylic Acid Lactones in Urine Samples of Croatian Farm Animals. Journal of analytical toxicology. 2019 Mar; 43(2):126-133. doi: 10.1093/jat/bky069. [PMID: 30295910]
  • Kathleen O'Connor, Madeleine Morrissette, Philip Strandwitz, Meghan Ghiglieri, Mariaelena Caboni, Haiyan Liu, Christina Khoo, Anthony D'Onofrio, Kim Lewis. Cranberry extracts promote growth of Bacteroidaceae and decrease abundance of Enterobacteriaceae in a human gut simulator model. PloS one. 2019; 14(11):e0224836. doi: 10.1371/journal.pone.0224836. [PMID: 31714906]
  • Godwin U Ebiloma, Teresa Díaz Ayuga, Emmanuel O Balogun, Lucía Abad Gil, Anne Donachie, Marcel Kaiser, Tomás Herraiz, Daniel K Inaoka, Tomoo Shiba, Shigeharu Harada, Kiyoshi Kita, Harry P de Koning, Christophe Dardonville. Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense. European journal of medicinal chemistry. 2018 Apr; 150(?):385-402. doi: 10.1016/j.ejmech.2018.02.075. [PMID: 29544150]
  • Liangxiong Xu, Ping Wu, Jinghua Xue, Istvan Molnar, Xiaoyi Wei. Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species. Journal of natural products. 2017 08; 80(8):2215-2223. doi: 10.1021/acs.jnatprod.7b00066. [PMID: 28749671]
  • Sangeetha Ananda Baskaran, Anup Kollanoor-Johny, Meera Surendran Nair, Kumar Venkitanarayanan. Efficacy of Plant-Derived Antimicrobials in Controlling Enterohemorrhagic Escherichia coli Virulence In Vitro. Journal of food protection. 2016 11; 79(11):1965-1970. doi: 10.4315/0362-028x.jfp-16-104. [PMID: 28221905]
  • Hyeree Moon, Min Suk Rhee. Synergism between carvacrol or thymol increases the antimicrobial efficacy of soy sauce with no sensory impact. International journal of food microbiology. 2016 Jan; 217(?):35-41. doi: 10.1016/j.ijfoodmicro.2015.10.009. [PMID: 26490647]
  • Jikun Li, Xinxin Feng, Wei Zhu, Nikita Oskolkov, Tianhui Zhou, Boo Kyung Kim, Noman Baig, Michael T McMahon, Eric Oldfield. Chemical Exchange Saturation Transfer (CEST) Agents: Quantum Chemistry and MRI. Chemistry (Weinheim an der Bergstrasse, Germany). 2016 Jan; 22(1):264-71. doi: 10.1002/chem.201503942. [PMID: 26616530]
  • Syeda Sohaila Naz, Muhammad Raza Shah, Nazar Ul Islam, Ajmal Khan, Samina Nazir, Sara Qaisar, Syed Sartaj Alam. Synthesis and bioactivities of silver nanoparticles capped with 5-amino-β-resorcylic acid hydrochloride dihydrate. Journal of nanobiotechnology. 2014 Sep; 12(?):34. doi: 10.1186/s12951-014-0034-8. [PMID: 25201390]
  • Myeong Hyeon Park, In Sook Kim, Sun-A Kim, Chun-Soo Na, Cheol Yi Hong, Mi-Sook Dong, Hye Hyun Yoo. Inhibitory effect of Rhus verniciflua Stokes extract on human aromatase activity; butin is its major bioactive component. Bioorganic & medicinal chemistry letters. 2014 Apr; 24(7):1730-3. doi: 10.1016/j.bmcl.2014.02.039. [PMID: 24630560]
  • Sangeetha Ananda Baskaran, Abhinav Upadhyay, Anup Kollanoor-Johny, Indu Upadhyaya, Shankumar Mooyottu, Mary Anne Roshni Amalaradjou, David Schreiber, Kumar Venkitanarayanan. Efficacy of plant-derived antimicrobials as antimicrobial wash treatments for reducing enterohemorrhagic Escherichia coli O157:H7 on apples. Journal of food science. 2013 Sep; 78(9):M1399-404. doi: 10.1111/1750-3841.12174. [PMID: 24024692]
  • Sangeetha Ananda Baskaran, Varunkumar Bhattaram, Indu Upadhyaya, Abhinav Upadhyay, Anup Kollanoor-Johny, David Schreiber, Kumar Venkitanarayanan. Inactivation of Escherichia coli O157:H7 on cattle hides by caprylic acid and β-resorcylic acid. Journal of food protection. 2013 Feb; 76(2):318-22. doi: 10.4315/0362-028x.jfp-12-248. [PMID: 23433381]
  • Ge Bai, Xueli Cao, Hong Zhang, Junfeng Xiang, Hong Ren, Li Tan, Yalin Tang. Direct screening of G-quadruplex ligands from Kalopanax septemlobus (Thunb.) Koidz extract by high performance liquid chromatography. Journal of chromatography. A. 2011 Sep; 1218(37):6433-8. doi: 10.1016/j.chroma.2011.07.028. [PMID: 21835418]
  • Anup Kollanoor Johny, Thomas Hoagland, Kumar Venkitanarayanan. Effect of subinhibitory concentrations of plant-derived molecules in increasing the sensitivity of multidrug-resistant Salmonella enterica serovar Typhimurium DT104 to antibiotics. Foodborne pathogens and disease. 2010 Oct; 7(10):1165-70. doi: 10.1089/fpd.2009.0527. [PMID: 20618084]
  • Susana Tárraga, Purificación Lisón, María Pilar López-Gresa, Cristina Torres, Ismael Rodrigo, José María Bellés, Vicente Conejero. Molecular cloning and characterization of a novel tomato xylosyltransferase specific for gentisic acid. Journal of experimental botany. 2010 Oct; 61(15):4325-38. doi: 10.1093/jxb/erq234. [PMID: 20729481]
  • Prontipa Nokthai, Vannajan Sanghiran Lee, Lalida Shank. Molecular modeling of peroxidase and polyphenol oxidase: substrate specificity and active site comparison. International journal of molecular sciences. 2010 Sep; 11(9):3266-76. doi: 10.3390/ijms11093266. [PMID: 20957092]
  • Liangxiong Xu, Zhengxiang He, Jinghua Xue, Xiaoping Chen, Xiaoyi Wei. beta-Resorcylic acid lactones from a Paecilomyces fungus. Journal of natural products. 2010 May; 73(5):885-9. doi: 10.1021/np900853n. [PMID: 20429578]
  • Markus A Queisser, Dachun Yao, Sven Geisler, Hans-Peter Hammes, Günter Lochnit, Erwin D Schleicher, Michael Brownlee, Klaus T Preissner. Hyperglycemia impairs proteasome function by methylglyoxal. Diabetes. 2010 Mar; 59(3):670-8. doi: 10.2337/db08-1565. [PMID: 20009088]
  • Wendy R Russell, Lorraine Scobbie, Garry G Duthie, Andrew Chesson. Inhibition of 15-lipoxygenase-catalysed oxygenation of arachidonic acid by substituted benzoic acids. Bioorganic & medicinal chemistry. 2008 Apr; 16(8):4589-93. doi: 10.1016/j.bmc.2008.02.041. [PMID: 18314336]
  • Chao-Bin Xue, Li Zhang, Wan-Chun Luo, Xian-Ye Xie, Lin Jiang, Ting Xiao. 3D-QSAR and molecular docking studies of benzaldehyde thiosemicarbazone, benzaldehyde, benzoic acid, and their derivatives as phenoloxidase inhibitors. Bioorganic & medicinal chemistry. 2007 Mar; 15(5):2006-15. doi: 10.1016/j.bmc.2006.12.038. [PMID: 17258462]
  • Zhen Yi, Maoxin Zhang, Bing Ling, Di Xu, Jingzhong Ye. [Inhibitory effects of Lantana camera and its contained phenolic compounds in Eichhornia crassipes growth]. Ying yong sheng tai xue bao = The journal of applied ecology. 2006 Sep; 17(9):1637-40. doi: ". [PMID: 17147172]
  • M H Blokland, S S Sterk, R W Stephany, F M Launay, D G Kennedy, L A van Ginkel. Determination of resorcylic acid lactones in biological samples by GC-MS. Discrimination between illegal use and contamination with fusarium toxins. Analytical and bioanalytical chemistry. 2006 Mar; 384(5):1221-7. doi: 10.1007/s00216-005-0274-4. [PMID: 16416095]
  • Mendel Friedman, Robert Buick, Christopher T Elliott. Antibacterial activities of naturally occurring compounds against antibiotic-resistant Bacillus cereus vegetative cells and spores, Escherichia coli, and Staphylococcus aureus. Journal of food protection. 2004 Aug; 67(8):1774-8. doi: 10.4315/0362-028x-67.8.1774. [PMID: 15330549]
  • Barton J Bradbury, Piotr Bartyzel, Teodoro S Kaufman, Marcelo J Nieto, Robert D Sindelar, Susanne M Scesney, Bruce R Gaumond, Henry C Marsh. Synthesis and complement inhibitory activity of B/C/D-ring analogues of the fungal metabolite 6,7-diformyl-3',4',4a',5',6',7',8',8a'-octahydro-4,6',7'-trihydroxy- 2',5',5',8a'-tetramethylspiro[1'(2'H)-naphthalene-2(3H)-benzofuran]. Journal of medicinal chemistry. 2003 Jun; 46(13):2697-705. doi: 10.1021/jm0204284. [PMID: 12801233]
  • K Róna, K Ary. Determination of calcium dobesilate in human plasma using ion-pairing extraction and high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications. 2001 May; 755(1-2):245-51. doi: 10.1016/s0378-4347(01)00114-1. [PMID: 11393710]
  • H S Yun-Choi, J H Kim, J R Lee. Potential inhibitors of platelet aggregation from plant sources, III. Journal of natural products. 1987 Nov; 50(6):1059-64. doi: 10.1021/np50054a008. [PMID: 3127544]
  • V Hanfeld, G Wagner. [Synthesis of phenol-antigen conjugates by reacting N-hydroxysuccinimidic esters of hydroxybenzoic acids with human serum albumin and bovine gamma globulin]. Die Pharmazie. 1982 Jul; 37(7):479-80. doi: 10.1002/chin.198250292. [PMID: 6182571]
  • R A Scherrer, S M Howard. Use of distribution coefficients in quantitative structure-activity relationships. Journal of medicinal chemistry. 1977 Jan; 20(1):53-8. doi: 10.1021/jm00211a010. [PMID: 13215]