Phthalide (BioDeep_00000017714)
Secondary id: BioDeep_00000869535
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
1,3-Dihydrobenzo[C]furan-2-one;2-Benzofuran-1(3H)-one;2-Hydroxymethylbenzoic acid, gamma-lactone;Phthalolactone
化学式: C8H6O2 (134.0367776)
中文名称: 苯酞
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 0.93%
分子结构信息
SMILES: C1C2=CC=CC=C2C(=O)O1
InChI: InChI=1S/C8H6O2/c9-8-7-4-2-1-3-6(7)5-10-8/h1-4H,5H2
描述信息
2-benzofuran-1(3H)-one is a gamma-lactone that is 1,3-dihydro-2-benzofuran in which the hydrogens at position 1 are replaced by an oxo group. It is a gamma-lactone and a member of 2-benzofurans.
Phthalide is a natural product found in Ligusticum striatum, Angelica sinensis, and Ligusticum chuanxiong with data available.
Phthalide is used as a food additive [EAFUS] ("EAFUS: Everything Added to Food in the United States. [http://www.eafus.com/]")
It is used as a food additive .
Phthalide is a promising chemical scaffold with a potent anti-inflammatory efficacy. Phthalide can be used to synthesize a variety of phthalide derivatives including anti-inflammatory agent, antimicrobial, antioxidant[1][2][3].
Phthalide is a promising chemical scaffold with a potent anti-inflammatory efficacy. Phthalide can be used to synthesize a variety of phthalide derivatives including anti-inflammatory agent, antimicrobial, antioxidant[1][2][3].
同义名列表
42 个代谢物同义名
1,3-Dihydrobenzo[C]furan-2-one;2-Benzofuran-1(3H)-one;2-Hydroxymethylbenzoic acid, gamma-lactone;Phthalolactone; 2-Hydroxymethylbenzoic acid, laquo gammaRaquo -lactone; InChI=1/C8H6O2/c9-8-7-4-2-1-3-6(7)5-10-8/h1-4H,5H; 2-Hydroxymethylbenzoic acid, .gamma.-lactone; 5-17-10-00007 (Beilstein Handbook Reference); 2-Hydroxymethylbenzoic acid, gamma-lactone; 2-Hydroxymethylbenzoic acid, γ-lactone; 2-Hydroxymethylbenzoic acid, g-lactone; 2-Hydroxymethylbenzoate, gamma-lactone; 2-Hydroxymethylbenzoate, g-lactone; 2-Hydroxymethylbenzoate, γ-lactone; 3-Butylidene-7-hydroxyphthalide; 3-oxo-1,3-dihydro-isobenzofuran; 1,3-dihydro-2-benzofuran-1-one; Phthalide, analytical standard; 1(3H)-Isobenzofuranone-1-11C; Butylphthalide Impurity 4; isobenzofuran-1 (3H)-one; CHLORTALIDONE IMPURITY 7; 2-Benzofuran-1(3H)-one #; 2-benzofuran-1(3 H)-one; Isobenzofuran-1(3H)-one; 1(3H)-Isobenzofuranone; 3H-isobenzofuran-1-one; 2-Benzofuran-1(3H)-one; 1H-Isobenzofuran-3-one; 3H-2-benzofuran-1-one; (3H)-isobenzofuranone; isobenzofuran-1-one; 1-Isobenzofuranone; PHTHALIDE [FHFI]; Isobenzofuranone; UNII-8VV922U86J; Phthalide, 98\\%; Phthalolactone; 1-Phthalanone; Tox21_303762; CAS-87-41-2; Phthalanone; 8VV922U86J; Phthalide; AI3-05785
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:38085
- PubChem: 6885
- HMDB: HMDB0032469
- ChEMBL: CHEMBL2391738
- Wikipedia: Phthalide
- MeSH: phthalide
- ChemIDplus: 0000087412
- KNApSAcK: C00014972
- foodb: FDB010076
- chemspider: 6621
- CAS: 591234-45-6
- CAS: 87-41-2
- medchemexpress: HY-W015820
- PMhub: MS000094415
- RefMet: Phthalide
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 2689076 - Ligusticum chuanxiong: 10.1093/CHROMSCI/41.8.428
- 1508160 - Ligusticum striatum: 10.1093/CHROMSCI/41.8.428
- 33090 - Plants: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Toshio Morikawa, Naoki Inoue, Saya Yamamoto, Miyuki Shiotani, Yoshiaki Manse, Kiyofumi Ninomiya. Alkylphthalides with intracellular triglyceride metabolism-promoting activity from the rhizomes of Cnidium officinale Makino.
Journal of natural medicines.
2024 Jun; 78(3):709-721. doi:
10.1007/s11418-024-01799-x. [PMID: 38575838] - Yu-Zhu Tan, Hong-Ling Yan, Yun-Yun Liu, Yong-Ming Yan, Li Wang, Ji-Xu Qiao, Jing Wu, Yin Tian, Cheng Peng. Structurally diverse phthalides from fibrous roots of Ligusticum chuanxiong Hort. and their biological activities.
Fitoterapia.
2024 Jun; 175(?):105882. doi:
10.1016/j.fitote.2024.105882. [PMID: 38452906] - Xin-Yu Qi, Guang-Cheng Peng, Qing-Tong Han, Jing Yan, Lu-Zhou Chen, Tian Wang, Lin-Tao Xu, Ming-Jie Liu, Zhen-Peng Xu, Xiao-Ning Wang, Tao Shen. Phthalides from the rhizome of Ligusticum chuanxiong Hort. attenuate diabetic nephropathy in mice.
Journal of ethnopharmacology.
2023 Sep; 319(Pt 2):117247. doi:
10.1016/j.jep.2023.117247. [PMID: 37777028] - Shiqin Cong, Yichun Shi, Guangjun Yu, Feng Zhong, Jingjing Li, Jing Liu, Chanyuan Ye, Zhenghuai Tan, Yong Deng. Discovery of novel 5-(2-hydroxyphenyl)-2-phthalide-3(3H)-pyrazolones as balanced multifunctional agents against Alzheimer's disease.
European journal of medicinal chemistry.
2023 Mar; 250(?):115216. doi:
10.1016/j.ejmech.2023.115216. [PMID: 36857812] - Li-Jun Huang, Xin-Ai Li, Meng-Ying Jin, Wen-Xiu Guo, Li-Rong Lei, Ran Liu, Ming-Zhi Zhang, Da-Le Guo, Dong Wang, Yan Zhou, Yun Deng, Jian-Guang Zhang. Two previously undescribed phthalides from Talaromyces amestolkiae, a symbiotic fungus of Syngnathus acus.
Journal of Asian natural products research.
2023 Feb; 25(2):147-155. doi:
10.1080/10286020.2022.2075738. [PMID: 35582859] - Yan-Yan Ding, Yu Sun, Xiong-Fei Luo, Shao-Yong Zhang, Rui Wang, Zhi-Gang Yang, Jing-Ru Wang, Bao-Qi Zhang, Zhi-Jun Zhang, Yue Ma, Jun-Xia An, Han Zhou, Ying-Qian Liu. Anti-phytopathogenic activity and the mechanisms of phthalides from Angelica sinensis (Oliv.) Diels.
Pest management science.
2023 Jan; ?(?):. doi:
10.1002/ps.7389. [PMID: 36721354] - Lu Huang, Cheng Peng, Li Guo, Rui Feng, Hong-Zhen Shu, Yun-Cai Tian, Qin-Mei Zhou, Liang Xiong. Six pairs of enantiomeric phthalide dimers from the rhizomes of Ligusticum chuanxiong and their absolute configurations and anti-inflammatory activities.
Bioorganic chemistry.
2022 10; 127(?):105970. doi:
10.1016/j.bioorg.2022.105970. [PMID: 35749854] - Liu-Yan Wang, Wen-Yan Li, Hao-Feng Zhou, Xue-Yu Zhao, Xiao-Nian Li, Xing-De Wu, Qin-Shi Zhao. Spiroligustolides A and B: Two pairs of enantiomeric spiro-orthoester-containing phthalide dimers as Cav3.1 calcium channel inhibitors from Ligusticum Chuanxiong Hort.
Bioorganic chemistry.
2022 06; 123(?):105749. doi:
10.1016/j.bioorg.2022.105749. [PMID: 35364556] - Juan Liu, Rui Feng, Ou Dai, Hong Ni, Lu-Si Liu, Hong-Zhen Shu, Yan Lu, Cheng Peng, Liang Xiong. Isoindolines and phthalides from the rhizomes of Ligusticum chuanxiong and their relaxant effects on the uterine smooth muscle.
Phytochemistry.
2022 Jun; 198(?):113159. doi:
10.1016/j.phytochem.2022.113159. [PMID: 35283167] - Zhonglin Guo, Pan Zhou, Hongjian Song, Yuxiu Liu, Jingjing Zhang, Yongqiang Li, Qingmin Wang. Design, Synthesis, and Bioactivities of Phthalide and Coumarin Derivatives Based on the Biosynthesis and Structure Simplification of Gossypol.
Journal of agricultural and food chemistry.
2021 Dec; 69(50):15123-15135. doi:
10.1021/acs.jafc.1c05792. [PMID: 34898208] - Peng-Yi Hu, Ying-Huai Zhong, Jian-Fang Feng, Dong-Xun Li, Ping Deng, Wen-Liu Zhang, Zhi-Qiang Lei, Xue-Mei Liu, Guo-Song Zhang. Pharmacokinetics of five phthalides in volatile oil of Ligusticum sinense Oliv.cv. Chaxiong, and comparison study on physicochemistry and pharmacokinetics after being formulated into solid dispersion and inclusion compound.
BMC complementary medicine and therapies.
2021 Apr; 21(1):129. doi:
10.1186/s12906-021-03289-z. [PMID: 33888111] - Zhongcheng Cao, Qing Song, Guangjun Yu, Zhuoling Liu, Shiqing Cong, Zhenghuai Tan, Yong Deng. Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry.
2021 04; 35(?):116074. doi:
10.1016/j.bmc.2021.116074. [PMID: 33640707] - Ying-Huai Zhong, Jian-Fang Feng, Ming-Yan Xia, Xin-Hua Wei, Qiu-Yan Wu, Dong-Xun Li, Xue-Mei Liu, Guo-Song Zhang. [Pharmacokinetic study on five components in phthalide target areas of Chaxiong and its β-CD inclusion compounds based on UPLC-MS/MS].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2021 Feb; 46(4):972-980. doi:
10.19540/j.cnki.cjcmm.20201012.201. [PMID: 33645104] - Yuyue Qin, Xiaobo Liu, Jing Lin, Jingying Huang, Xiaofei Jiang, Tuxiang Mo, Zhaolong Xu, Jun Li, Ruiyun Yang. Two new phthalide derivatives from the endophytic fungus Penicillium vulpinum isolated from Sophora tonkinensis.
Natural product research.
2021 Feb; 35(3):421-427. doi:
10.1080/14786419.2019.1636237. [PMID: 31274005] - Xin Fang, Qiang Ma, Kai-Xia Zhang, Song-Yun Yao, Yi Feng, Yong-Sheng Jin, Shuang Liang. Synthesis of phthalide derivatives and evaluation on their antiplatelet aggregation and antioxidant activities.
Journal of Asian natural products research.
2020 Dec; 22(12):1176-1187. doi:
10.1080/10286020.2019.1681982. [PMID: 31755304] - Yu-Miao Gan, Dong-Ling Liu, Chu Chen, Wei Duan, Yu-Xin Yang, Jun-Rong Du. Phthalide derivative CD21 alleviates cerebral ischemia-induced neuroinflammation: Involvement of microglial M2 polarization via AMPK activation.
European journal of pharmacology.
2020 Nov; 886(?):173552. doi:
10.1016/j.ejphar.2020.173552. [PMID: 32926919] - Yu Dai, Kunlong Li, Jianglian She, Yanbo Zeng, Hao Wang, Shengrong Liao, Xiuping Lin, Bin Yang, Junfeng Wang, Huaming Tao, Haofu Dai, Xuefeng Zhou, Yonghong Liu. Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus Cochliobolus Lunatus SCSIO41401.
Marine drugs.
2020 Oct; 18(11):. doi:
10.3390/md18110547. [PMID: 33143384] - Aniely Dos Reis Teixeira, Róbson Ricardo Teixeira, Iara Mariana Lellis Ribeiro, Wagner Luiz Pereira, Taise Matte Manhabosco, Ana Carolina Ferreira de Brito, Laser Antônio Machado Oliveira, Katiane de Oliveira Pinto Coelho Nogueira. Association of electroanalytical and spectrophotometric methods to evaluate the antioxidant activity of isobenzofuranone in primary cultures of hippocampal neurons.
Toxicology in vitro : an international journal published in association with BIBRA.
2020 Oct; 68(?):104970. doi:
10.1016/j.tiv.2020.104970. [PMID: 32805376] - Xin Li, Meng-Qi Shi, Chu Chen, Jun-Rong Du. Phthalide derivative CD21 ameliorates ischemic brain injury in a mouse model of global cerebral ischemia: involvement of inhibition of NLRP3.
International immunopharmacology.
2020 Sep; 86(?):106714. doi:
10.1016/j.intimp.2020.106714. [PMID: 32593156] - Mohsen Abbod, Naser Safaie, Khodayar Gholivand, Mohammad Mehrabadi, Mahyar Bonsaii. Mode of action of 3-butylidene phthalide as a competent natural pesticide.
Pesticide biochemistry and physiology.
2020 Mar; 164(?):228-236. doi:
10.1016/j.pestbp.2020.02.003. [PMID: 32284131] - Xiaoqiong Xu, Tiantian Zhu, Tingting Shi, Juan Chen, Ling Jin. Quality suitability regionalization analysis of Angelica sinensis in Gansu, China.
PloS one.
2020; 15(12):e0243750. doi:
10.1371/journal.pone.0243750. [PMID: 33315941] - Qian Wei, Jianbo Yang, Li Li, Yalun Su, Aiguo Wang. Novel phthalide dimers from the aerial parts of Ligusticum sinense Oliv cv. Chaxiong.
Fitoterapia.
2019 Sep; 137(?):104174. doi:
10.1016/j.fitote.2019.104174. [PMID: 31100437] - Wei Lei, Yan-Fang Deng, Xue-Yan Hu, Jia-Nan Ni, Min Jiang, Gang Bai. Phthalides, senkyunolide A and ligustilide, show immunomodulatory effect in improving atherosclerosis, through inhibiting AP-1 and NF-κB expression.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Sep; 117(?):109074. doi:
10.1016/j.biopha.2019.109074. [PMID: 31177061] - Yan-Ying Liu, Huan Zhao, Jun Xie, Jian Zou, Dan Hu, Liang-Dong Guo, Guo-Dong Chen, Xin-Sheng Yao, Hao Gao. New phthalide derivatives from the Biscogniauxia sp. and their activities.
Fitoterapia.
2019 Sep; 137(?):104184. doi:
10.1016/j.fitote.2019.104184. [PMID: 31145983] - Muhammad Adil, Xiuxia Ren, Byoung Ryong Jeong. Light elicited growth, antioxidant enzymes activities and production of medicinal compounds in callus culture of Cnidium officinale Makino.
Journal of photochemistry and photobiology. B, Biology.
2019 Jul; 196(?):111509. doi:
10.1016/j.jphotobiol.2019.05.006. [PMID: 31128431] - Wei-Hua Yan, Hong-Hong Cao, Shuang Guo, Li-Ya Gu, Wei Hu, Ming Cheng, De-Tao Bai, Jie Chen, Chun-Qin Mao, Lin Li, Tu-Lin Lu. [UPLC fingerprint and multi-components content determination of different processed products of Angelica sinensis].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2019 Jun; 44(12):2499-2510. doi:
10.19540/j.cnki.cjcmm.20190321.311. [PMID: 31359717] - Jian Zou, Guo-Dong Chen, Huan Zhao, Xiao-Xia Wang, Zai-Jun Zhang, Yi-Bo Qu, Rong-Rong He, Kwok-Fai So, Xin-Sheng Yao, Hao Gao. Triangeliphthalides A-D: bioactive phthalide trimers with new skeletons from Angelica sinensis and their production mechanism.
Chemical communications (Cambridge, England).
2019 May; 55(44):6221-6224. doi:
10.1039/c9cc02681a. [PMID: 31080975] - Han Ke, Wei Tong, Rui Xue, Xiaoyan Lu, Xiaohui Fan. Characterization of chemical constituents and identification of absorbed components and metabolites in rat plasma of Fu-Ke-Zai-Zao pills by ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry.
Journal of separation science.
2019 May; 42(10):1842-1852. doi:
10.1002/jssc.201801161. [PMID: 30848561] - Elizeu S Farias, Tamíris A Araújo, Gabriela C Resende, Júlia N D Campos, Mirian F Pimentel, Elson S Alvarenga, Marcelo C Picanço. Toxicity and Sublethal Effects of Phthalides Analogs to Rhyzopertha dominica.
Chemistry & biodiversity.
2019 Mar; 16(3):e1800557. doi:
10.1002/cbdv.201800557. [PMID: 30600913] - Muhammad Adil, Xiuxia Ren, Dong Il Kang, Luc The Thi, Byoung Ryong Jeong. Effect of explant type and plant growth regulators on callus induction, growth and secondary metabolites production in Cnidium officinale Makino.
Molecular biology reports.
2018 Dec; 45(6):1919-1927. doi:
10.1007/s11033-018-4340-3. [PMID: 30187311] - Chengke Zhao, Yuan Jia, Fachuang Lu. Angelica Stem: A Potential Low-Cost Source of Bioactive Phthalides and Phytosterols.
Molecules (Basel, Switzerland).
2018 Nov; 23(12):. doi:
10.3390/molecules23123065. [PMID: 30477097] - Jie-Li Lv, Lai-Bin Zhang, Li-Min Guo. Phthalide dimers from Angelica sinensis and their COX-2 inhibition activity.
Fitoterapia.
2018 Sep; 129(?):102-107. doi:
10.1016/j.fitote.2018.06.016. [PMID: 29935258] - Jakub Pannek, Joanna Gach, Filip Boratyński, Teresa Olejniczak. Antimicrobial activity of extracts and phthalides occurring in Apiaceae plants.
Phytotherapy research : PTR.
2018 Aug; 32(8):1459-1487. doi:
10.1002/ptr.6098. [PMID: 29732627] - Qingqing Zhang, Mengqi Huo, Yanling Zhang, Yanjiang Qiao, Xiaoyan Gao. A strategy to improve the identification reliability of the chemical constituents by high-resolution mass spectrometry-based isomer structure prediction combined with a quantitative structure retention relationship analysis: Phthalide compounds in Chuanxiong as a test case.
Journal of chromatography. A.
2018 Jun; 1552(?):17-28. doi:
10.1016/j.chroma.2018.03.055. [PMID: 29650478] - Nating Zhang, Chen Cheng, Olajide E Olaleye, Yan Sun, Li Li, Yühong Huang, Feifei Du, Junling Yang, Fengqing Wang, Yanhong Shi, Fang Xu, Yanfen Li, Qi Wen, Naixia Zhang, Chuan Li. Pharmacokinetics-Based Identification of Potential Therapeutic Phthalides from XueBiJing, a Chinese Herbal Injection Used in Sepsis Management.
Drug metabolism and disposition: the biological fate of chemicals.
2018 06; 46(6):823-834. doi:
10.1124/dmd.117.079673. [PMID: 29523601] - Wei Wei, Wei Xu, Xiu-Wei Yang. Two new phthalide dimers from the rhizomes of Ligusticum chuanxiong.
Journal of Asian natural products research.
2017 Jul; 19(7):704-711. doi:
10.1080/10286020.2016.1275584. [PMID: 28276766] - Min He, Zhi-Yu Yang, Tian-Biao Yang, Ying Ye, Juan Nie, Yong Hu, Pan Yan. Chemometrics-enhanced one-dimensional/comprehensive two-dimensional gas chromatographic analysis for bioactive terpenoids and phthalides in Chaihu Shugan San essential oils.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 May; 1052(?):158-168. doi:
10.1016/j.jchromb.2017.03.029. [PMID: 28390283] - Alejandra León, Mayela Del-Ángel, José Luis Ávila, Guillermo Delgado. Phthalides: Distribution in Nature, Chemical Reactivity, Synthesis, and Biological Activity.
Progress in the chemistry of organic natural products.
2017 ; 104(?):127-246. doi:
10.1007/978-3-319-45618-8_2. [PMID: 28160212] - Jing-Chang Du, Xiao-Fang Xie, Liang Xiong, Chen Sun, Cheng Peng. [Research progress of chemical constituents and pharmacological activities of essential oil of Ligusticum chuanxiong].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2016 Dec; 41(23):4328-4333. doi:
10.4268/cjcmm20162306. [PMID: 28933107] - Gabriela C Resende, Elson S Alvarenga, Tamíris A de Araújo, Júlia Nd Campos, Marcelo C Pincanço. Toxicity to Diaphania hyalinata, selectivity to non-target species and phytotoxicity of furanones and phthalide analogues.
Pest management science.
2016 Sep; 72(9):1772-7. doi:
10.1002/ps.4210. [PMID: 26679429] - Lai-Bin Zhang, Jie-Li Lv, Jun-Wei Liu. Phthalide Derivatives with Anticoagulation Activities from Angelica sinensis.
Journal of natural products.
2016 07; 79(7):1857-61. doi:
10.1021/acs.jnatprod.6b00080. [PMID: 27400088] - Wen Ma, Weihui Wang, Yan Peng, Qiaoxia Bian, Nannan Wang, David Y-W Lee, Ronghua Dai. Ultra-high performance liquid chromatography with tandem mass spectrometry method for the simultaneous quantitation of five phthalides in rat plasma: Application to a comparative pharmacokinetic study of Huo Luo Xiao Ling Dan and herb-pair extract.
Journal of separation science.
2016 Jun; 39(11):2057-67. doi:
10.1002/jssc.201600023. [PMID: 27062714] - Ming-Ming Zhai, Hai-Tao Niu, Jie Li, Hui Xiao, Yan-Ping Shi, Duo-Long Di, Phillip Crews, Quan-Xiang Wu. Talaromycolides A-C, Novel Phenyl-Substituted Phthalides Isolated from the Green Chinese Onion-Derived Fungus Talaromyces pinophilus AF-02.
Journal of agricultural and food chemistry.
2015 Nov; 63(43):9558-64. doi:
10.1021/acs.jafc.5b04296. [PMID: 26466717] - Meng-Ning Li, Xin Dong, Wen Gao, Xin-Guang Liu, Rui Wang, Ping Li, Hua Yang. Global identification and quantitative analysis of chemical constituents in traditional Chinese medicinal formula Qi-Fu-Yin by ultra-high performance liquid chromatography coupled with mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2015 Oct; 114(?):376-89. doi:
10.1016/j.jpba.2015.05.030. [PMID: 26112926] - Lei Zhang, Dong-Hui Yang, Xin Zhao, Feng Xu, Jing Liang, Qi-Le Zhou, Xiao-Yan Yang, Xiu-Wei Yang. Metabolism of Chuanxiong Rhizoma decoction: Identification of the metabolites in WZS-miniature pig urine.
Fitoterapia.
2015 Sep; 105(?):177-86. doi:
10.1016/j.fitote.2015.07.001. [PMID: 26162556] - Hua Guo, Zheng-Hui Li, Tao Feng, Ji-Kai Liu. One new ergostane-type steroid and three new phthalide derivatives from cultures of the basidiomycete Albatrellus confluens.
Journal of Asian natural products research.
2015; 17(2):107-13. doi:
10.1080/10286020.2014.951925. [PMID: 25465923] - Jian Zou, Jun Li, Zu-Yan Wu, Qin Zhao, Gao-Qian Wang, Huan Zhao, Guo-Dong Chen, Xiang Sun, Liang-Dong Guo, Hao Gao. New α-pyrone and phthalide from the Xylariaceae fungus.
Journal of Asian natural products research.
2015; 17(7):705-10. doi:
10.1080/10286020.2015.1054816. [PMID: 26123347] - Weixia Li, Yuping Tang, Yefei Qian, Erxin Shang, Linyan Wang, Li Zhang, Shulan Su, Jin-ao Duan. Comparative analysis of main aromatic acids and phthalides in Angelicae Sinensis Radix, Chuanxiong Rhizoma, and Fo-Shou-San by a validated UHPLC-TQ-MS/MS.
Journal of pharmaceutical and biomedical analysis.
2014 Oct; 99(?):45-50. doi:
10.1016/j.jpba.2014.07.007. [PMID: 25061713] - Ying-Jia Bai, Ming Kong, Jin-Di Xu, Xiao-Lin Zhang, Shan-Shan Zhou, Xiao-Ning Wang, Li-Fang Liu, Song-Lin Li. Effect of different drying methods on the quality of Angelicae Sinensis Radix evaluated through simultaneously determining four types of major bioactive components by high performance liquid chromatography photodiode array detector and ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2014 Jun; 94(?):77-83. doi:
10.1016/j.jpba.2014.01.036. [PMID: 24561333] - C Chen, R L Yang. A phthalide derivative isolated from endophytic fungi Pestalotiopsis photiniae induces G1 cell cycle arrest and apoptosis in human HeLa cells.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2013 Aug; 46(8):643-9. doi:
10.1590/1414-431x20132979. [PMID: 23903687] - Jian Huang, Xiao-Qing Lu, Jin Lu, Guo-Yu Li, Hang-Yu Wang, Li-Hong Li, Rui-Chao Lin, Jin-Hui Wang. Two new phthalides with BuChE inhibitory activity from Ligusticum chuanxiong.
Journal of Asian natural products research.
2013; 15(12):1237-42. doi:
10.1080/10286020.2013.825610. [PMID: 24279751] - Ru Yan, Nga Ling Ko, Bin Ma, Yun Kau Tam, Ge Lin. Metabolic conversion from co-existing ingredient leading to significant systemic exposure of Z-butylidenephthalide, a minor ingredient in Chuanxiong Rhizoma in rats.
Current drug metabolism.
2012 Jun; 13(5):524-34. doi:
10.2174/1389200211209050524. [PMID: 22554277] - Jian Zhong, Federica Pollastro, Jean Prenen, Zhiming Zhu, Giovanni Appendino, Bernd Nilius. Ligustilide: a novel TRPA1 modulator.
Pflugers Archiv : European journal of physiology.
2011 Dec; 462(6):841-9. doi:
10.1007/s00424-011-1021-7. [PMID: 21894528] - Xiao-Long Yang, Su Zhang, Qiong-Bo Hu, Du-Qiang Luo, Yan Zhang. Phthalide derivatives with antifungal activities against the plant pathogens isolated from the liquid culture of Pestalotiopsis photiniae.
The Journal of antibiotics.
2011 Nov; 64(11):723-7. doi:
10.1038/ja.2011.82. [PMID: 21915132] - Xia Ran, Li Ma, Cheng Peng, Hong Zhang, Lu-Ping Qin. Ligusticum chuanxiong Hort: a review of chemistry and pharmacology.
Pharmaceutical biology.
2011 Nov; 49(11):1180-9. doi:
10.3109/13880209.2011.576346. [PMID: 22014266] - Song-Hwa Chae, Soon-Il Kim, Seong-Hum Yeon, Si-Woo Lee, Young-Joon Ahn. Adulticidal activity of phthalides identified in Cnidium officinale rhizome to B- and Q-biotypes of Bemisia tabaci.
Journal of agricultural and food chemistry.
2011 Aug; 59(15):8193-8. doi:
10.1021/jf201927t. [PMID: 21728333] - Chang-Yin Li, Lian-Wen Qi, Ping Li. Correlative analysis of metabolite profiling of Danggui Buxue Tang in rat biological fluids by rapid resolution LC-TOF/MS.
Journal of pharmaceutical and biomedical analysis.
2011 Apr; 55(1):146-60. doi:
10.1016/j.jpba.2010.12.034. [PMID: 21277133] - Xue Qiao, Jian Han, Man Xu, Zi-chuan Zhang, Min Ye, Guan Ye, De-an Guo. Metabolic profiling of GuanXin II prescription based on metabolic fingerprinting and chemical analysis.
Journal of pharmaceutical and biomedical analysis.
2011 Mar; 54(4):789-98. doi:
10.1016/j.jpba.2010.10.017. [PMID: 21094011] - Ismiarni Komala, Takuya Ito, Fumihiro Nagashima, Yasuyuki Yagi, Yoshinori Asakawa. Cytotoxic bibenzyls, and germacrane- and pinguisane-type sesquiterpenoids from Indonesian, Tahitian and Japanese liverworts.
Natural product communications.
2011 Mar; 6(3):303-9. doi:
". [PMID: 21485264] - Chinwendum Stephenie Alaribe, Francis Shode, Herbert A B Coker, Gloria Ayoola, Adesegun Sunday, Nisha Singh, Silva Iwuanyanwu. Antimicrobial activities of hexane extract and decussatin from stembark extract of Ficus congensis.
International journal of molecular sciences.
2011; 12(4):2750-6. doi:
10.3390/ijms12042750. [PMID: 21731468] - Mohammed Rabbani, Seyed Ebrahim Sajjadi, Masoud Sadeghi. Chemical composition of the essential oil from kelussia odoratissima Mozaff. and the evaluation of its sedative and anxiolytic effects in mice.
Clinics (Sao Paulo, Brazil).
2011; 66(5):843-8. doi:
10.1590/s1807-59322011000500022. [PMID: 21789390] - Léia Cecilia de Lima Fávaro, Fernando Lucas de Melo, Carlos Ivan Aguilar-Vildoso, Welington Luiz Araújo. Polyphasic analysis of intraspecific diversity in Epicoccum nigrum warrants reclassification into separate species.
PloS one.
2011; 6(8):e14828. doi:
10.1371/journal.pone.0014828. [PMID: 21853017] - Yuping Tang, Min Zhu, Sheng Yu, Yongqing Hua, Jin-Ao Duan, Shulan Su, Xu Zhang, Yin Lu, Anwei Ding. Identification and comparative quantification of bio-active phthalides in essential oils from si-wu-tang, fo-shou-san, radix angelica and rhizoma chuanxiong.
Molecules (Basel, Switzerland).
2010 Jan; 15(1):341-51. doi:
10.3390/molecules15010341. [PMID: 20110895] - Anita S Bassey, Jude E Okokon, Emmanuel I Etim, Francis U Umoh, Emmanuel Bassey. Evaluation of the in vivo antimalarial activity of ethanolic leaf and stembark extracts of Anthocleista djalonensis.
Indian journal of pharmacology.
2009 Dec; 41(6):258-61. doi:
10.4103/0253-7613.59924. [PMID: 20407556] - Xin-Liang Chang, Zhi-Yong Jiang, Yun-Bao Ma, Xue-Mei Zhang, Karl W K Tsim, Ji-Jun Chen. Two new compounds from the roots of Ligusticum chuanxiong.
Journal of Asian natural products research.
2009 Sep; 11(9):805-10. doi:
10.1080/10286020903071068. [PMID: 20183328] - Yong Zhou, Brian Taylor, Thomas J Smith, Zhong-Ping Liu, Malcolm Clench, Noel W Davies, K D Rainsford. A novel compound from celery seed with a bactericidal effect against Helicobacter pylori.
The Journal of pharmacy and pharmacology.
2009 Aug; 61(8):1067-77. doi:
10.1211/jpp/61.08.0011. [PMID: 19703351] - Chang-Yin Li, Lian-Wen Qi, Ping Li, Xiao-Dong Wen, Yan-Fei Zhu, E-Hu Liu, Zhen Gong, Xiao-Lin Yang, Mei-Ting Ren, Yan-Jing Li, Xiao-Xiao Ge. Identification of metabolites of Danggui Buxue Tang in rat urine by liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2009 Jul; 23(13):1977-88. doi:
10.1002/rcm.4110. [PMID: 19504482] - Jonathan Sperry, Jimmy J P Sejberg, Frank M Stiemke, Margaret A Brimble. Biomimetic studies towards the cardinalins: synthesis of (+)-ventiloquinone L and an unusual dimerisation.
Organic & biomolecular chemistry.
2009 Jun; 7(12):2599-603. doi:
10.1039/b905077a. [PMID: 19503935] - Xuelei Xin, Yi Yang, Jie Zhong, Haji Akber Aisa, Hanqing Wang. Preparative isolation and purification of isobenzofuranone derivatives and saponins from seeds of Nigella glandulifera Freyn by high-speed counter-current chromatography combined with gel filtration.
Journal of chromatography. A.
2009 May; 1216(19):4258-62. doi:
10.1016/j.chroma.2009.03.050. [PMID: 19344906] - M Nurul Islam, Hye Hyun Yoo, Chung-Ki Sung, Mi-sook Dong, Young In Park, Changbae Jin, Dong-Hyun Kim. Simultaneous determination of phenolic acids and phthalide compounds by liquid chromatography for quality assessment of Rhizoma cnidii.
Journal of AOAC International.
2009 Mar; 92(2):375-81. doi:
. [PMID: 19485194] - Hui Lv, Gulnar Sabir, Bahargul Kungurhan, Yongqiang Liu, Haji Akber Aisa. New phthalide glycosides from Helichrysum arenarium (L.) Moench.
Journal of Asian natural products research.
2009; 11(4):352-6. doi:
10.1080/10286020902819772. [PMID: 19431016] - B Tuetun, W Choochote, Y Pongpaibul, A Junkum, D Kanjanapothi, U Chaithong, A Jitpakdi, D Riyong, B Pitasawat. Celery-based topical repellents as a potential natural alternative for personal protection against mosquitoes.
Parasitology research.
2008 Dec; 104(1):107-15. doi:
10.1007/s00436-008-1167-1. [PMID: 18766378] - Li-Wei Xu, Ming-Ying Shang, Jun Li, Xiao-Mei Li, Li-Qiang Meng, Shao-Qing Cai. [Analysis of principal composition of ethyl acetate part in Huangqi Danggui decoction by HPLC-ESI-TOF-MS].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2008 Nov; 33(21):2508-12. doi:
". [PMID: 19149261] - Winnie Lai Ting Kan, Chi Hin Cho, John A Rudd, Ge Lin. Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells.
Journal of ethnopharmacology.
2008 Oct; 120(1):36-43. doi:
10.1016/j.jep.2008.07.027. [PMID: 18718517] - Tsung-Hsien Chou, Ih-Sheng Chen, Tsong-Long Hwang, Tai-Chi Wang, Tzong-Huei Lee, Lin-Yang Cheng, Ya-Chih Chang, Jui-Ying Cho, Jih-Jung Chen. Phthalides from Pittosporum illicioides var. illicioides with inhibitory activity on superoxide generation and elastase release by neutrophils.
Journal of natural products.
2008 Oct; 71(10):1692-5. doi:
10.1021/np8004503. [PMID: 18817445] - Andreas Schinkovitz, Samuel M Pro, Matthew Main, Shao-Nong Chen, Birgit U Jaki, David C Lankin, Guido F Pauli. Dynamic nature of the ligustilide complex.
Journal of natural products.
2008 Sep; 71(9):1604-11. doi:
10.1021/np800137n. [PMID: 18781813] - Lian-Wen Qi, Xiao-Dong Wen, Jun Cao, Chang-Yin Li, Ping Li, Ling Yi, Yu-Xia Wang, Xiao-Lan Cheng, Xiao-Xiao Ge. Rapid and sensitive screening and characterization of phenolic acids, phthalides, saponins and isoflavonoids in Danggui Buxue Tang by rapid resolution liquid chromatography/diode-array detection coupled with time-of-flight mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2008 Aug; 22(16):2493-509. doi:
10.1002/rcm.3638. [PMID: 18651584] - Songlin Li, Quanbin Han, Chunfeng Qiao, Jingzheng Song, Chuen Lung Cheng, Hongxi Xu. Chemical markers for the quality control of herbal medicines: an overview.
Chinese medicine.
2008 Jun; 3(?):7. doi:
10.1186/1749-8546-3-7. [PMID: 18588699] - Ting-Fang Lee, Yun-Lian Lin, Yi-Tsau Huang. Studies on antiproliferative effects of phthalides from Ligusticum chuanxiong in hepatic stellate cells.
Planta medica.
2007 Jun; 73(6):527-34. doi:
10.1055/s-2007-981520. [PMID: 17520522] - John J Beck, Shen-Chieh Chou. The structural diversity of phthalides from the Apiaceae.
Journal of natural products.
2007 May; 70(5):891-900. doi:
10.1021/np0605586. [PMID: 17477571] - Tao Yi, Kelvin Sze-Yin Leung, Guang-Hua Lu, Hao Zhang. Comparative analysis of Ligusticum chuanxiong and related umbelliferous medicinal plants by high performance liquid chromatography-electrospray ionization mass spectrometry.
Planta medica.
2007 Apr; 73(4):392-8. doi:
10.1055/s-2007-967139. [PMID: 17372865] - Shixin Deng, Shao-Nong Chen, Jian Lu, Zaijie Jim Wang, Dejan Nikolic, Richard B van Breemen, Bernard D Santarsiero, Andrew Mesecar, Harry H S Fong, Norman R Farnsworth, Guido F Pauli. GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels.
Phytochemical analysis : PCA.
2006 Nov; 17(6):398-405. doi:
10.1002/pca.937. [PMID: 17144247] - Fan Yang, Yuan-sheng Xiao, Fei-fang Zhang, Xing-ya Xue, Qing Xu, Xin-miao Liang. [High performance liquid chromatography-mass spectrometry analysis of radix Angelica sciensis].
Yao xue xue bao = Acta pharmaceutica Sinica.
2006 Nov; 41(11):1078-83. doi:
". [PMID: 17262951] - Yoshiko Kurobayashi, Emi Kouno, Akira Fujita, Yasujiro Morimitsu, Kikue Kubota. Potent odorants characterize the aroma quality of leaves and stalks in raw and boiled celery.
Bioscience, biotechnology, and biochemistry.
2006 Apr; 70(4):958-65. doi:
10.1271/bbb.70.958. [PMID: 16636464] - Tao Yi, Kelvin Sze-Yin Leung, Guang-Hua Lu, Kelvin Chan, Hao Zhang. Simultaneous qualitative and quantitative analyses of the major constituents in the rhizome of Ligusticum Chuanxiong using HPLC-DAD-MS.
Chemical & pharmaceutical bulletin.
2006 Feb; 54(2):255-9. doi:
10.1248/cpb.54.255. [PMID: 16462078] - Li Liu, Zhi-Qiang Ning, Song Shan, Kun Zhang, Tuo Deng, Xian-Ping Lu, Yi-Yu Cheng. Phthalide Lactones from Ligusticum chuanxiong inhibit lipopolysaccharide-induced TNF-alpha production and TNF-alpha-mediated NF-kappaB Activation.
Planta medica.
2005 Sep; 71(9):808-13. doi:
10.1055/s-2005-871231. [PMID: 16206033] - Toshihiko Tsukamoto, Yukio Ishikawa, Mitsuo Miyazawa. Larvicidal and adulticidal activity of alkylphthalide derivatives from rhizome of Cnidium officinale against Drosophila melanogaster.
Journal of agricultural and food chemistry.
2005 Jul; 53(14):5549-53. doi:
10.1021/jf050110v. [PMID: 15998112] - Masashi Kosaka, Satoshi Sekiguchi, Junpei Naito, Makoto Uemura, Shunsuke Kuwahara, Masataka Watanabe, Nobuyuki Harada, Kunio Hiroi. Synthesis of enantiopure phthalides including 3-butylphthalide, a fragrance component of celery oil, and determination of their absolute configurations.
Chirality.
2005 May; 17(4):218-32. doi:
10.1002/chir.20156. [PMID: 15830406] - Dong-min Su, Shi-shan Yu, Hai-lin Qin. [New dimeric phthalide derivative from Angelica sinensis].
Yao xue xue bao = Acta pharmaceutica Sinica.
2005 Feb; 40(2):141-4. doi:
". [PMID: 15875670] - S Zschocke, I Klaiber, R Bauer, B Vogler. HPLC-coupled spectroscopic techniques (UV, MS, NMR) for the structure elucidation of phthalides in Ligusticum chuanxiong.
Molecular diversity.
2005; 9(1-3):33-9. doi:
10.1007/s11030-005-1305-y. [PMID: 15789549] - Junichi Kitajima, Toru Ishikawa, Mitsuru Satoh. Polar constituents of celery seed.
Phytochemistry.
2003 Nov; 64(5):1003-11. doi:
10.1016/s0031-9422(03)00461-8. [PMID: 14561518] - Ahmed Abdel-Lateff, Katja M Fisch, Anthony D Wright, Gabriele M König. A new antioxidant isobenzofuranone derivative from the algicolous marine fungus Epicoccum sp.
Planta medica.
2003 Sep; 69(9):831-4. doi:
10.1055/s-2003-43209. [PMID: 14598209] - Gary Strobel, Eugene Ford, Jeerepun Worapong, James K Harper, Atta M Arif, David M Grant, Peter C W Fung, Raymond Ming Wah Chau. Isopestacin, an isobenzofuranone from Pestalotiopsis microspora, possessing antifungal and antioxidant activities.
Phytochemistry.
2002 May; 60(2):179-83. doi:
10.1016/s0031-9422(02)00062-6. [PMID: 12009322]