Maltitol (BioDeep_00000017480)

Main id: BioDeep_00000398341

 

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


(2S,3R,4R,5R)-4-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,5,6-pentaol

化学式: C12H24O11 (344.13185539999995)
中文名称: 麦芽糖醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C1C(C(C(C(O1)OC(C(CO)O)C(C(CO)O)O)O)O)O)O
InChI: InChI=1S/C12H24O11/c13-1-4(16)7(18)11(5(17)2-14)23-12-10(21)9(20)8(19)6(3-15)22-12/h4-21H,1-3H2/t4-,5+,6+,7+,8+,9-,10+,11+,12+/m0/s1

描述信息

Maltitol is a sugar alcohol (polyol) used as a sugar substitute. It has 90\\% the sweetness of sugar and nearly identical properties, except for browning. It is used to very easily replace sugar and has less food energy, does not promote tooth decay and has a somewhat lower blood sugar response. Unfortunately, maltitol is well known to cause gastric distress, particularly if consumed in great quantities. Chemically, maltitol is also known as 4-O-alpha-Glucopyranosyl-D-sorbitol. Commercially, it is known under trade names such as Maltisorb and Maltisweet. Due to its slow absorption, excessive consumption of Maltitol can have laxative effect and often can cause gas and/or bloating. Maltitol is particularly demonized regarding gastric side effects because it is so easy for food producers to use it in vast quantities (due to its amazingly sugar-like properties) so consumers often end up consuming far more than they could most other sugar alcohols. While this is a major problem with maltitol, many sugar alcohols are far more likely to cause gastric distress than maltitol when compared gram-for-gram.
Maltitol is an alpha-D-glucoside consisting of D-glucitol having an alpha-D-glucosyl residue attached at the 4-position. Used as a sugar substitute. It has a role as a metabolite, a laxative and a sweetening agent. It is an alpha-D-glucoside and a glycosyl alditol. It is functionally related to an alpha-D-glucose and a D-glucitol.
Maltitol is a natural product found in Lotus filicaulis, Lotus tenuis, and other organisms with data available.
An alpha-D-glucoside consisting of D-glucitol having an alpha-D-glucosyl residue attached at the 4-position. Used as a sugar substitute.
Permitted bulk sweetener for foods

同义名列表

59 个代谢物同义名

(2S,3R,4R,5R)-4-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,5,6-pentaol; (2S,3R,4R,5R)-4-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}hexane-1,2,3,5,6-pentol; (2S,3R,4R,5R)-4-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)hexane-1,2,3,5,6-pentaol; (2S,3R,4R,5R)-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxyhexane-1,2,3,5,6-pentol; (2S,3R,4R,5R)-4-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}hexane-1,2,3,5,6-pentol; (2S,3R,4R,5R)-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,5,6-pentol; Maltitol, Pharmaceutical Secondary Standard; Certified Reference Material; Maltitol, United States Pharmacopeia (USP) Reference Standard; Maltitol, European Pharmacopoeia (EP) Reference Standard; WURCS=2.0/2,2,1/[H2122H][a2122h-1a_1-5]/1-2/a4-b1; 4-O-alpha-delta-Glucopyranosyl-delta-glucitol; delta-4-O-alpha-delta-Glucopyranosylglucitol; 5-17-07-00145 (Beilstein Handbook Reference); Glucitol, 4-O-alpha-D-glucopyranosyl-, D-; D-Glucitol, 4--O-.alpha.-D-glucopyranosyl; alpha-D-glucopyranosyl-(1->4)-D-glucitol; D-Glucitol, 4-O-alpha-D-glucopyranosyl-; 4-O-alpha-D-Glucopyranosyl-D-glucitol; D-4-O-alpha-D-Glucopyranosylglucitol; D-Glucitol, 4-O-a-D-glucopyranosyl-; alpha-D-glucosyl-(1->4)-D-glucitol; 4-O-Α-D-glucopyranosyl-D-glucitol; 4-O-a-D-Glucopyranosyl-D-glucitol; 4-O-a-glucopyranosyl-D-sorbitol; a-D-Glucosyl-(1->4)-D-glucitol; Α-D-glucosyl-(1->4)-D-glucitol; alpha-D-Glcp-(1->4)-D-Glc-ol; alpha-D-Glc-(1->4)-D-Glc-ol; D-Glucopyranosyl-D-glucitol; VQHSOMBJVWLPSR-WUJBLJFYSA-N; Α-D-GLCP-(1->4)-D-GLC-ol; a-D-GLCP-(1->4)-D-GLC-ol; MALTITOL [EP MONOGRAPH]; a-D-GLC-(1->4)-D-GLC-ol; Α-D-GLC-(1->4)-D-GLC-ol; Maltitol (D-Maltitol); Maltitol [BAN:NF]; MALTITOL [USP-RS]; MALTITOL [MART.]; Maltitol, >=98\\%; UNII-D65DG142WK; MALTITOL [INCI]; delta-Maltitol; MALTITOL [FCC]; MALTITOL [II]; Amalty MR 100; Maltitol (NF); Amalti syrup; SMP1_000186; Lycasin hbc; D65DG142WK; D-Maltitol; Maltisorb; Malti Mr; Maltitol; Maltit; Amalty; Malbit; Maltitoll



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hongjuan Li, Hongmei Yu, Yan Liu, Yi Wang, Hongbo Li, Jinghua Yu. The use of of inulin, maltitol and lecithin as fat replacers and plasticizers in a model reduced-fat mozzarella cheese-like product. Journal of the science of food and agriculture. 2019 Sep; 99(12):5586-5593. doi: 10.1002/jsfa.9835. [PMID: 31152446]
  • Kazumi Hayama, Miki Takahashi, Motofumi Suzuki, Kunio Ezawa, Masatoshi Yamazaki, Taiji Matsukawa, Akinobu Kishi, Nobuya Sato, Shigeru Abe. [Anti-Candida activity of aroma candy and its protective activity against murine oral candidiasis]. Medical mycology journal. 2015; 56(1):J23-9. doi: 10.3314/mmj.56.j23. [PMID: 25855024]
  • F Respondek, C Hilpipre, P Chauveau, M Cazaubiel, D Gendre, C Maudet, A Wagner. Digestive tolerance and postprandial glycaemic and insulinaemic responses after consumption of dairy desserts containing maltitol and fructo-oligosaccharides in adults. European journal of clinical nutrition. 2014 May; 68(5):575-80. doi: 10.1038/ejcn.2014.30. [PMID: 24642779]
  • Kofi Asare-Addo, Barbara R Conway, Mohamed J Hajamohaideen, Waseem Kaialy, Ali Nokhodchi, Hassan Larhrib. Aqueous and hydro-alcoholic media effects on polyols. Colloids and surfaces. B, Biointerfaces. 2013 Nov; 111(?):24-9. doi: 10.1016/j.colsurfb.2013.05.003. [PMID: 23777788]
  • Ana Rodriguez-Mateos, Maria Jose Oruna-Concha, Catherine Kwik-Uribe, Alberto Vidal, Jeremy P E Spencer. Influence of sugar type on the bioavailability of cocoa flavanols. The British journal of nutrition. 2012 Dec; 108(12):2243-50. doi: 10.1017/s0007114512000475. [PMID: 22397837]
  • Hui Sun, Alla Lapidus, Matt Nolan, Susan Lucas, Tijana Glavina Del Rio, Hope Tice, Jan-Fang Cheng, Roxane Tapia, Cliff Han, Lynne Goodwin, Sam Pitluck, Ioanna Pagani, Natalia Ivanova, Konstantinos Mavromatis, Natalia Mikhailova, Amrita Pati, Amy Chen, Krishna Palaniappan, Miriam Land, Loren Hauser, Yun-Juan Chang, Cynthia D Jeffries, Olivier Duplex Ngatchou Djao, Manfred Rohde, Johannes Sikorski, Markus Göker, Tanja Woyke, James Bristow, Jonathan A Eisen, Victor Markowitz, Philip Hugenholtz, Nikos C Kyrpides, Hans-Peter Klenk. Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509). Standards in genomic sciences. 2010 Nov; 3(3):325-36. doi: 10.4056/sigs.1363462. [PMID: 21304737]
  • Phuc Thi Do, Marion Prudent, Ronan Sulpice, Mathilde Causse, Alisdair R Fernie. The influence of fruit load on the tomato pericarp metabolome in a Solanum chmielewskii introgression line population. Plant physiology. 2010 Nov; 154(3):1128-42. doi: 10.1104/pp.110.163030. [PMID: 20841452]
  • Emma Beards, Kieran Tuohy, Glenn Gibson. A human volunteer study to assess the impact of confectionery sweeteners on the gut microbiota composition. The British journal of nutrition. 2010 Sep; 104(5):701-8. doi: 10.1017/s0007114510001078. [PMID: 20370946]
  • Saori Kadoya, Kahori Fujii, Ken-ichi Izutsu, Etsuo Yonemochi, Katsuhide Terada, Chikako Yomota, Toru Kawanishi. Freeze-drying of proteins with glass-forming oligosaccharide-derived sugar alcohols. International journal of pharmaceutics. 2010 Apr; 389(1-2):107-13. doi: 10.1016/j.ijpharm.2010.01.027. [PMID: 20097277]
  • Marina Korn, Tanja Gärtner, Alexander Erban, Joachim Kopka, Joachim Selbig, Dirk K Hincha. Predicting Arabidopsis freezing tolerance and heterosis in freezing tolerance from metabolite composition. Molecular plant. 2010 Jan; 3(1):224-35. doi: 10.1093/mp/ssp105. [PMID: 20026477]
  • David P Livingston, Dirk K Hincha, Arnd G Heyer. Fructan and its relationship to abiotic stress tolerance in plants. Cellular and molecular life sciences : CMLS. 2009 Jul; 66(13):2007-23. doi: 10.1007/s00018-009-0002-x. [PMID: 19290476]
  • Carla Antonio, Tony Larson, Alison Gilday, Ian Graham, Ed Bergström, Jane Thomas-Oates. Hydrophilic interaction chromatography/electrospray mass spectrometry analysis of carbohydrate-related metabolites from Arabidopsis thaliana leaf tissue. Rapid communications in mass spectrometry : RCM. 2008 May; 22(9):1399-407. doi: 10.1002/rcm.3519. [PMID: 18384194]
  • S Nakamura, R Hongo, K Moji, T Oku. Suppressive effect of partially hydrolyzed guar gum on transitory diarrhea induced by ingestion of maltitol and lactitol in healthy humans. European journal of clinical nutrition. 2007 Sep; 61(9):1086-93. doi: 10.1038/sj.ejcn.1602623. [PMID: 17251924]
  • J Quílez, M Bulló, J Salas-Salvadó. Improved postprandial response and feeling of satiety after consumption of low-calorie muffins with maltitol and high-amylose corn starch. Journal of food science. 2007 Aug; 72(6):S407-11. doi: 10.1111/j.1750-3841.2007.00408.x. [PMID: 17995698]
  • Kenta Yamamoto, Hiraku Onishi, Akihiko Ito, Yoshiharu Machida. In vitro and in vivo evaluation of medicinal carbon granules and tablet on the adsorption of acetaminophen. International journal of pharmaceutics. 2007 Jan; 328(2):105-11. doi: 10.1016/j.ijpharm.2006.07.053. [PMID: 16942843]
  • E Söderling, S Karjalainen, M Lille, J Maukonen, M Saarela, K Autio. The effect of liquorice extract-containing starch gel on the amount and microbial composition of plaque. Clinical oral investigations. 2006 Jun; 10(2):108-13. doi: 10.1007/s00784-006-0040-9. [PMID: 16523267]
  • Eva Arrigoni, Fred Brouns, Renato Amadò. Human gut microbiota does not ferment erythritol. The British journal of nutrition. 2005 Nov; 94(5):643-6. doi: 10.1079/bjn20051546. [PMID: 16277764]
  • Patchana Asvarujanon, Satoshi Ishizuka, Hiroshi Hara. Promotive effects of non-digestible disaccharides on rat mineral absorption depend on the type of saccharide. Nutrition (Burbank, Los Angeles County, Calif.). 2005 Oct; 21(10):1025-35. doi: 10.1016/j.nut.2005.02.011. [PMID: 16157240]
  • T Tomo, T Shibata, M Nasu, K Shibata, G Izumi, K Sofue. Evaluation of several saccharides as osmotic agent for peritoneal dialysate. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. 2000 Nov; 20(6):727-33. doi: 10.1177/089686080002000625. [PMID: 11216567]
  • M Fukahori, H Sakurai, S Akatsu, M Negishi, H Sato, T Goda, S Takase. Enhanced absorption of calcium after oral administration of maltitol in the rat intestine. The Journal of pharmacy and pharmacology. 1998 Nov; 50(11):1227-32. doi: 10.1111/j.2042-7158.1998.tb03338.x. [PMID: 9877307]
  • T Goda, K Kishi, I Ezawa, S Takase. The maltitol-induced increase in intestinal calcium transport increases the calcium content and breaking force of femoral bone in weanling rats. The Journal of nutrition. 1998 Nov; 128(11):2028-31. doi: 10.1093/jn/128.11.2028. [PMID: 9808660]
  • G Livesey, I T Johnson, J M Gee, T Smith, W E Lee, K A Hillan, J Meyer, S C Turner. 'Determination' of sugar alcohol and Polydextrose absorption in humans by the breath hydrogen (H2) technique: the stoichiometry of hydrogen production and the interaction between carbohydrates assessed in vivo and in vitro. European journal of clinical nutrition. 1993 Jun; 47(6):419-30. doi: NULL. [PMID: 8365383]
  • T Oku, M Akiba, M H Lee, S J Moon, N Hosoya. Metabolic fate of ingested [14C]-maltitol in man. Journal of nutritional science and vitaminology. 1991 Oct; 37(5):529-44. doi: 10.3177/jnsv.37.529. [PMID: 1802977]
  • K Shima, T Suda, K Nishimoto, S Yoshimoto. Relationship between molecular structures of sugars and their ability to stimulate the release of glucagon-like peptide-1 from canine ileal loops. Acta endocrinologica. 1990 Oct; 123(4):464-70. doi: 10.1530/acta.0.1230464. [PMID: 2239092]
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  • X Z Zhang, G W Meijer, A C Beynen. Dietary maltitol causes increased serum and liver cholesterol concentrations in rats. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. 1990; 60(3):296-7. doi: NULL. [PMID: 2276888]
  • P Würsch, B Koellreutter, F Gétaz, M J Arnaud. Metabolism of maltitol by conventional rats and mice and germ-free mice, and comparative digestibility between maltitol and sorbitol in germ-free mice. The British journal of nutrition. 1990 Jan; 63(1):7-15. doi: 10.1079/bjn19900087. [PMID: 2107869]
  • J P Felber, L Tappy, D Vouillamoz, J P Randin, E Jéquier. Comparative study of maltitol and sucrose by means of continuous indirect calorimetry. JPEN. Journal of parenteral and enteral nutrition. 1987 May; 11(3):250-4. doi: 10.1177/0148607187011003250. [PMID: 3298708]
  • A Secchi, A E Pontiroli, L Cammelli, A Bizzi, M Cini, G Pozza. Effects of oral administration of maltitol on plasma glucose, plasma sorbitol, and serum insulin levels in man. Klinische Wochenschrift. 1986 Mar; 64(6):265-9. doi: 10.1007/bf01711933. [PMID: 3520129]
  • V Barzanti, M Maranesi. [Influence of maltitol on lipid metabolism: fatty acid composition of the heart and brain of the rat]. Bollettino della Societa italiana di biologia sperimentale. 1984 Nov; 60(11):2091-7. doi: ". [PMID: 6525264]
  • M Maranesi, V Barzanti, P Gentili, G Carenini. Nutritional studies on maltitol. Part 2: Effect on lipid metabolism and fatty acid composition of different rat tissues. Acta vitaminologica et enzymologica. 1984; 6(1):11-5. doi: ". [PMID: 6464929]
  • H J Zunft, J Schulze, H Gärtner, F K Grütte. Digestion of maltitol in man, rat, and rabbit. Annals of nutrition & metabolism. 1983; 27(6):470-6. doi: 10.1159/000176721. [PMID: 6651223]
  • R Lian-Loh, G G Birch, M E Coates. The metabolism of maltitol in the rat. The British journal of nutrition. 1982 Nov; 48(3):477-81. doi: 10.1079/bjn19820133. [PMID: 7171535]
  • H H Rennhard, J R Bianchine. Metabolism and caloric utilization of orally administered maltitol-14C in rat, dog, and man. Journal of agricultural and food chemistry. 1976 Mar; 24(2):287-9. doi: 10.1021/jf60204a030. [PMID: 1254807]