11beta,17beta-Dihydroxy-4-androsten-3-one (BioDeep_00000014795)

Main id: BioDeep_00000016688

 

human metabolite Endogenous


代谢物信息卡片


(1S,2R,10S,11S,14S,15S,17S)-14,17-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one

化学式: C19H28O3 (304.2038)
中文名称: 11beta-羟基睾酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4O)C)O
InChI: InChI=1S/C19H28O3/c1-18-8-7-12(20)9-11(18)3-4-13-14-5-6-16(22)19(14,2)10-15(21)17(13)18/h9,13-17,21-22H,3-8,10H2,1-2H3/t13-,14-,15-,16-,17+,18-,19-/m0/s1

描述信息

This compound belongs to the family of Androgens and Derivatives. These are hydroxylated C19 steroid hormones. They are known to favour the development of masculine characteristics. They also show profound effects on scalp and body hair in humans.

同义名列表

24 个代谢物同义名

(1S,2R,10S,11S,14S,15S,17S)-14,17-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one; 11-Hydroxytestosterone, (9beta,10alpha,11alpha,17beta)-isomer; 11-Hydroxytestosterone, (9beta,10alpha,11beta,17beta)-isomer; (11beta,17beta)-11,17-Dihydroxyandrost-4-en-3-one; 11-Hydroxytestosterone, (11alpha,17beta)-isomer; Androst-4-en-3-one,11,17-dihydroxy-, (11b,17b)-; 11β,17β-Dihydroxy-4-androsten-3-one; (11Β,17β)-11,17-dihydroxyandrost-4-en-3-one; (11b,17b)-11,17-Dihydroxyandrost-4-en-3-one; 11beta,17beta-Dihydroxyandrost-4-ene-3-one; 11beta,17beta-Dihydroxy-4-androsten-3-one; 11Β,17β-dihydroxyandrost-4-ene-3-one; 11b,17b-Dihydroxyandrost-4-ene-3-one; 11b,17b-Dihydroxy-4-androsten-3-one; 11Β,17β-dihydroxy-4-androsten-3-one; 11β-Hydroxytestosterone; 11 alpha-Hydroxytestosterone; 11 beta-Hydroxytestosterone; 11beta-Hydroxytestosterone; 11b-Hydroxytestosterone; 11α-hydroxytestosterone; 11Β-hydroxytestosterone; 11-Hydroxytestosterone; 11beta,17beta-Dihydroxy-4-androsten-3-one



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Patrick Caron, Véronique Turcotte, Chantal Guillemette. A quantitative analysis of total and free 11-oxygenated androgens and its application to human serum and plasma specimens using liquid-chromatography tandem mass spectrometry. Journal of chromatography. A. 2021 Aug; 1650(?):462228. doi: 10.1016/j.chroma.2021.462228. [PMID: 34090133]
  • Michael W O'Reilly, Punith Kempegowda, Carl Jenkinson, Angela E Taylor, Jonathan L Quanson, Karl-Heinz Storbeck, Wiebke Arlt. 11-Oxygenated C19 Steroids Are the Predominant Androgens in Polycystic Ovary Syndrome. The Journal of clinical endocrinology and metabolism. 2017 03; 102(3):840-848. doi: 10.1210/jc.2016-3285. [PMID: 27901631]
  • R K Brantley, J C Wingfield, A H Bass. Sex steroid levels in Porichthys notatus, a fish with alternative reproductive tactics, and a review of the hormonal bases for male dimorphism among teleost fishes. Hormones and behavior. 1993 Sep; 27(3):332-47. doi: 10.1006/hbeh.1993.1025. [PMID: 8225257]
  • I Mayer, B Borg, R Schulz. Seasonal changes in and effect of castration/androgen replacement on the plasma levels of five androgens in the male three-spined stickleback, Gasterosteus aculeatus L. General and comparative endocrinology. 1990 Jul; 79(1):23-30. doi: 10.1016/0016-6480(90)90084-y. [PMID: 2354778]
  • D E Kime, L O Larsen. Effect of gonadectomy and hypophysectomy on plasma steroid levels in male and female lampreys (Lampetra fluviatilis, L.). General and comparative endocrinology. 1987 Nov; 68(2):189-96. doi: 10.1016/0016-6480(87)90028-1. [PMID: 2962897]
  • R C Cochran. Serum androgens during the annual reproductive cycle of the male mummichog, Fundulus heteroclitus. General and comparative endocrinology. 1987 Jan; 65(1):141-8. doi: 10.1016/0016-6480(87)90233-4. [PMID: 3803896]
  • S T Chan, W S Yeung. A new method for the simultaneous determination of androstenedione, testosterone, 11-oxotestosterone and 11 beta-OH-testosterone in fish plasma using combined techniques of Celite chromatography and radioimmunoassay. Journal of steroid biochemistry. 1986 Dec; 25(6):1013-21. doi: 10.1016/0022-4731(86)90338-9. [PMID: 3795949]
  • R Schulz. In vitro metabolism of steroid hormones in the liver and in blood cells of male rainbow trout (Salmo gairdneri Richardson). General and comparative endocrinology. 1986 Nov; 64(2):312-9. doi: 10.1016/0016-6480(86)90019-5. [PMID: 3557096]
  • R Schlaghecke, H K Kley, H L Krüskemper. The measurement of 11 beta, 17 beta-dihydroxy-4-androsten-3-one (11 beta-hydroxytestosterone) by radioimmunoassay in human plasma. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie. 1986 Aug; 24(8):577-81. doi: 10.1515/cclm.1986.24.8.577. [PMID: 3760788]
  • P M Rosenblum, L Yamada, I P Callard, G V Callard. Validation of radioimmunoassay systems for the measurement of 11-keto- and 11 beta-hydroxytestosterone in teleost blood. Comparative biochemistry and physiology. B, Comparative biochemistry. 1985; 82(4):659-65. doi: 10.1016/0305-0491(85)90504-8. [PMID: 4092434]
  • D E Kime, M Hyder. The effect of temperature and gonadotropin on testicular steroidogenesis in Sarotherodon (Tilapia) mossambicus in vitro. General and comparative endocrinology. 1983 Apr; 50(1):105-15. doi: 10.1016/0016-6480(83)90247-2. [PMID: 6852519]