Silica (BioDeep_00000014727)

 

Secondary id: BioDeep_00000619942, BioDeep_00000868413, BioDeep_00001888363

human metabolite


代谢物信息卡片


Silicon(IV) oxide (sio2)

化学式: O2Si (59.966758)
中文名称: Celite® 硅藻土 545, 单分散二氧化硅微球, 硅藻土G, 硅藻土, 石英棉, 石英砂, 细粒砂, 硅胶
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: O=[Si]=O
InChI: InChI=1S/O2Si/c1-3-2

描述信息

Silica, also known as (sio2)n or 380, aerosil, is a member of the class of compounds known as metalloid oxides. Metalloid oxides are inorganic compounds containing an oxygen atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen is a metalloid. Silica is an odorless tasting compound and can be found in a number of food items such as pepper (spice), flaxseed, chicory, and tea, which makes silica a potential biomarker for the consumption of these food products.
Silica is found in barley. The chemical compound silicon dioxide, also known as silica (from the Latin silex), is an oxide of silicon with a chemical formula of SiO2 and has been known for its hardness since antiquity. Silica is most commonly found in nature as sand or quartz, as well as in the cell walls of diatoms. Silica is the most abundant mineral in the Earths crust

同义名列表

30 个代谢物同义名

Silicon(IV) oxide (sio2); Kieselsaeureanhydrid; Diatomaceous Earth; Crystalline silica; Calcined diatomite; Silicic anhydride; Silica, amorphous; Dioxide, silicon; Silicon dioxide; Siliziumdioxid; disilicic acid; Silicon oxide; Silica glass; 380, Aerosil; Cristobalite; Fumed silica; Aerosil 380; silanedione; Quso g-32; Tridymite; g32, Quso; Quso g 32; Quso g32; (SiO2)N; Aerosil; Silica; Quartz; [SiO2]; e551; SiO2



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jia Ma, Jiaqi Wang, Chenjie Ma, Qian Cai, Shuang Wu, Wenfeng Hu, Jiali Yang, Jing Xue, Juan Chen, Xiaoming Liu. Wnt5a/Ca2+ signaling regulates silica-induced ferroptosis in mouse macrophages by altering ER stress-mediated redox balance. Toxicology. 2023 05; 490(?):153514. doi: 10.1016/j.tox.2023.153514. [PMID: 37075931]
  • Ruimin Ma, Yali Fan, Xiaoxi Huang, Jingwei Wang, Shuang Li, Yuanying Wang, Qiao Ye. Lipid dysregulation associated with progression of silica-induced pulmonary fibrosis. Toxicological sciences : an official journal of the Society of Toxicology. 2023 02; 191(2):296-307. doi: 10.1093/toxsci/kfac124. [PMID: 36477571]
  • Fatma M El-Demerdash, Mohammed A El-Magd, Raghda A El-Sayed. Panax ginseng modulates oxidative stress, DNA damage, apoptosis, and inflammations induced by silicon dioxide nanoparticles in rats. Environmental toxicology. 2021 Jul; 36(7):1362-1374. doi: 10.1002/tox.23132. [PMID: 33749107]
  • Aurica Precupas, Daniela Gheorghe, Alina Botea-Petcu, Anca Ruxandra Leonties, Romica Sandu, Vlad Tudor Popa, Espen Mariussen, El Yamani Naouale, Elise Rundén-Pran, Veronica Dumit, Ying Xue, Mihaela Roxana Cimpan, Maria Dusinska, Andrea Haase, Speranta Tanasescu. Thermodynamic Parameters at Bio-Nano Interface and Nanomaterial Toxicity: A Case Study on BSA Interaction with ZnO, SiO2, and TiO2. Chemical research in toxicology. 2020 08; 33(8):2054-2071. doi: 10.1021/acs.chemrestox.9b00468. [PMID: 32600046]
  • Bonan Zhang, Hong Xu, Yi Zhang, Xue Yi, Guizhen Zhang, Xin Zhang, Dingjie Xu, Xuemin Gao, Shifeng Li, Ying Zhu, Hui Zhang, Zhongqiu Wei, Shumin Li, Lijuan Zhang, Ruimin Wang, Fang Yang. Targeting the RAS axis alleviates silicotic fibrosis and Ang II-induced myofibroblast differentiation via inhibition of the hedgehog signaling pathway. Toxicology letters. 2019 Oct; 313(?):30-41. doi: 10.1016/j.toxlet.2019.05.023. [PMID: 31181250]
  • Zhao-Qiang Zhang, Chun-Zhi Zhang, Bo Shao, Dao-Hua Pang, Gui-Zhi Han, Li Lin. Effects of abnormal expression of fusion and fission genes on the morphology and function of lung macrophage mitochondria in SiO2-induced silicosis fibrosis in rats in vivo. Toxicology letters. 2019 Sep; 312(?):181-187. doi: 10.1016/j.toxlet.2019.04.029. [PMID: 31034866]
  • Gayatri Premshekharan, Kennedy Nguyen, Hongqiao Zhang, Henry Jay Forman, Valerie Jean Leppert. Low dose inflammatory potential of silica particles in human-derived THP-1 macrophage cell culture studies - Mechanism and effects of particle size and iron. Chemico-biological interactions. 2017 Jun; 272(?):160-171. doi: 10.1016/j.cbi.2017.05.004. [PMID: 28512001]
  • Joseph D Latoche, Alexander Chukwuma Ufelle, Fabrizio Fazzi, Koustav Ganguly, George D Leikauf, Cheryl L Fattman. Secreted Phosphoprotein 1 and Sex-Specific Differences in Silica-Induced Pulmonary Fibrosis in Mice. Environmental health perspectives. 2016 08; 124(8):1199-207. doi: 10.1289/ehp.1510335. [PMID: 26955063]
  • Jiali Guo, Tingming Shi, Xiuqing Cui, Yi Rong, Ting Zhou, Zhihong Zhang, Yuewei Liu, Yan Shen, Weihong Chen. Effects of silica exposure on the cardiac and renal inflammatory and fibrotic response and the antagonistic role of interleukin-1 beta in C57BL/6 mice. Archives of toxicology. 2016 Feb; 90(2):247-58. doi: 10.1007/s00204-014-1405-5. [PMID: 25388157]
  • Andreea Iren Serban, Loredana Stanca, Cornelia Sima, Andrea Cristina Staicu, Otilia Zarnescu, Anca Dinischiotu. Complex responses to Si quantum dots accumulation in carp liver tissue: Beyond oxidative stress. Chemico-biological interactions. 2015 Sep; 239(?):56-66. doi: 10.1016/j.cbi.2015.06.015. [PMID: 26079203]
  • Miruna S Stan, Indira Memet, Cornelia Sima, Traian Popescu, Valentin S Teodorescu, Anca Hermenean, Anca Dinischiotu. Si/SiO2 quantum dots cause cytotoxicity in lung cells through redox homeostasis imbalance. Chemico-biological interactions. 2014 Sep; 220(?):102-15. doi: 10.1016/j.cbi.2014.06.020. [PMID: 24992398]
  • Zhonghui Zhu, Gengxia Yang, Yan Wang, Jing Yang, Ai Gao, Piye Niu, Lin Tian. Suppression of thioredoxin system contributes to silica-induced oxidative stress and pulmonary fibrogenesis in rats. Toxicology letters. 2013 Oct; 222(3):289-94. doi: 10.1016/j.toxlet.2013.08.004. [PMID: 23973437]
  • Rasmus Foldbjerg, Jing Wang, Christiane Beer, Kasper Thorsen, Duncan S Sutherland, Herman Autrup. Biological effects induced by BSA-stabilized silica nanoparticles in mammalian cell lines. Chemico-biological interactions. 2013 Jun; 204(1):28-38. doi: 10.1016/j.cbi.2013.04.007. [PMID: 23623845]
  • Teresa Coccini, Elisa Roda, Sergio Barni, Cinzia Signorini, Luigi Manzo. Long-lasting oxidative pulmonary insult in rat after intratracheal instillation of silica nanoparticles doped with cadmium. Toxicology. 2012 Dec; 302(2-3):203-11. doi: 10.1016/j.tox.2012.07.019. [PMID: 22898625]
  • Isabelle Passagne, Marie Morille, Marine Rousset, Igor Pujalté, Béatrice L'azou. Implication of oxidative stress in size-dependent toxicity of silica nanoparticles in kidney cells. Toxicology. 2012 Sep; 299(2-3):112-24. doi: 10.1016/j.tox.2012.05.010. [PMID: 22627296]
  • Javed Ahmad, Maqusood Ahamed, Mohd Javed Akhtar, Salman A Alrokayan, Maqsood A Siddiqui, Javed Musarrat, Abdulaziz A Al-Khedhairy. Apoptosis induction by silica nanoparticles mediated through reactive oxygen species in human liver cell line HepG2. Toxicology and applied pharmacology. 2012 Mar; 259(2):160-8. doi: 10.1016/j.taap.2011.12.020. [PMID: 22245848]
  • Mohd Javed Akhtar, Maqusood Ahamed, Sudhir Kumar, Huma Siddiqui, Govil Patil, Mohd Ashquin, Iqbal Ahmad. Nanotoxicity of pure silica mediated through oxidant generation rather than glutathione depletion in human lung epithelial cells. Toxicology. 2010 Oct; 276(2):95-102. doi: 10.1016/j.tox.2010.07.010. [PMID: 20654680]
  • Yiyi Ye, Jianwen Liu, Jianhe Xu, Lijuan Sun, Mingcang Chen, Minbo Lan. Nano-SiO2 induces apoptosis via activation of p53 and Bax mediated by oxidative stress in human hepatic cell line. Toxicology in vitro : an international journal published in association with BIBRA. 2010 Apr; 24(3):751-8. doi: 10.1016/j.tiv.2010.01.001. [PMID: 20060462]
  • Cinzia Antognelli, Angela Gambelunghe, Chiara Del Buono, Nicola Murgia, Vincenzo N Talesa, Giacomo Muzi. Crystalline silica Min-U-Sil 5 induces oxidative stress in human bronchial epithelial cells BEAS-2B by reducing the efficiency of antiglycation and antioxidant enzymatic defenses. Chemico-biological interactions. 2009 Nov; 182(1):13-21. doi: 10.1016/j.cbi.2009.08.002. [PMID: 19679115]
  • Sonia Scarfì, Mirko Magnone, Chiara Ferraris, Marina Pozzolini, Federica Benvenuto, Umberto Benatti, Marco Giovine. Ascorbic acid pre-treated quartz stimulates TNF-alpha release in RAW 264.7 murine macrophages through ROS production and membrane lipid peroxidation. Respiratory research. 2009 Mar; 10(?):25. doi: 10.1186/1465-9921-10-25. [PMID: 19298665]
  • Mara Ghiazza, Elena Gazzano, Barbara Bonelli, Ivana Fenoglio, Manuela Polimeni, Dario Ghigo, Edoardo Garrone, Bice Fubini. Formation of a vitreous phase at the surface of some commercial diatomaceous earth prevents the onset of oxidative stress effects. Chemical research in toxicology. 2009 Jan; 22(1):136-45. doi: 10.1021/tx800270g. [PMID: 19093746]
  • Hai-ke Du, Shi-xin Wang, Yan Liu, Shi-wu Zhang. [Effect of niacin on nitric oxide synthase expression in rat lung exposed to silica]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 2004 May; 38(3):186-9. doi: . [PMID: 15182488]
  • G Q Shen, E A Ojo-Amaize, M S Agopian, J B Peter. Silicate antibodies in women with silicone breast implants: development of an assay for detection of humoral immunity. Clinical and diagnostic laboratory immunology. 1996 Mar; 3(2):162-6. doi: 10.1128/cdli.3.2.162-166.1996. [PMID: 8991630]
  • Y Zhang, T C Lee, B Guillemin, M C Yu, W N Rom. Enhanced IL-1 beta and tumor necrosis factor-alpha release and messenger RNA expression in macrophages from idiopathic pulmonary fibrosis or after asbestos exposure. Journal of immunology (Baltimore, Md. : 1950). 1993 May; 150(9):4188-96. doi: NULL. [PMID: 8473757]
  • M Nozaki. [Combined use of bucolome and pyrazolone derivatives (1). Pharmacological activities and blood concentration]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1975 Sep; 71(6):609-29. doi: NULL. [PMID: 281]