D-myo-Inositol 3-phosphate (BioDeep_00000014581)

 

Secondary id: BioDeep_00000171711, BioDeep_00001869620

human metabolite Endogenous


代谢物信息卡片


{[(1R,2S,3R,4R,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphonic acid

化学式: C6H13O9P (260.0297)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(natural_products) 8.9%

分子结构信息

SMILES: C1(C(C(C(C(C1O)O)OP(=O)(O)O)O)O)O
InChI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/t1-,2-,3+,4-,5-,6-/m0/s1

描述信息

D-myo-Inositol 3-phosphate, also known as inositol 3-phosphoric acid, belongs to the class of organic compounds known as inositol phosphates. Inositol phosphates are compounds containing a phosphate group attached to an inositol (or cyclohexanehexol) moiety. D-myo-Inositol 3-phosphate is an extremely weak basic (essentially neutral) compound (based on its pKa). D-myo-Inositol 3-phosphate is involved in the inositol phosphate metabolism and the phosphatidylinositol signalling systems. D-myo-Inositol 3-phosphate is created from D-myo-inositol 3,4-bisphosphate by inositol polyphosphate-4-phosphatase (EC 3.1.3.66) and is converted into myo-inositol by myo-inositol-1(or 4)-monophosphatase (EC 3.1.3.25).
Myo-inositol 1-phosphate is a metabolite of the Inositol phosphate metabolism and the Phosphatidylinositol signaling system. Inositol phosphatases [EC:3.1.3.25] play a crucial role in the phosphatidylinositol signaling pathway; in brain, the expression is substantially higher in the subcortical regions, most prominently in the caudate. The phosphatidylinositol pathway is thought to be modified by lithium, a commonly prescribed medication in treating bipolar disorder. (OMIM 605922) [HMDB]

同义名列表

31 个代谢物同义名

{[(1R,2S,3R,4R,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphonic acid; 1-(Dihydrogen phosphate) DL-myo-inositol; 1D-Myo-inositol 3-monophosphoric acid; 1-(Dihydrogen phosphate) myo-inositol; D-Myo-inositol 3-monophosphoric acid; Myo-inositol 3-monophosphoric acid; 1l-Myo-inositol 1-phosphoric acid; 1D-Myo-inositol 1-phosphoric acid; L-Myo-inositol 1-phosphoric acid; D-Myo-inositol 3-phosphoric acid; 1D-Myo-inositol 3-monophosphate; Inositol 3-monophosphoric acid; D-Myo-inositol 3-monophosphate; Myo-inositol 1-phosphoric acid; Myo-inositol 3-phosphoric acid; Myoinositol 3-phosphoric acid; myo-Inositol 1-monophosphate; Myo-inositol 3-monophosphate; 1D-myo-inositol 3-phosphate; DL-Myo-inositol 1-phosphate; 1l-Myo-inositol 1-phosphate; Inositol 3-phosphoric acid; D-myo-Inositol 3-phosphate; L-Myo-inositol 1-phosphate; Myo-inositol 3-phosphate; myo-Inositol-1-phosphate; myo-Inositol 1-phosphate; Inositol 3-monophosphate; Myoinositol 3-phosphate; Myoinositol 1-phosphate; Inositol 3-phosphate



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(0)

PlantCyc(0)

代谢反应

473 个相关的代谢反应过程信息。

Reactome(51)

BioCyc(3)

WikiPathways(0)

Plant Reactome(404)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(14)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Reza Shirzadian-Khorramabad, Taghi Moazzenzadeh, Reza H Sajedi, Hai-Chun Jing, Jacques Hille, Paul P Dijkwel. A mutation in Arabidopsis SAL1 alters its in vitro activity against IP3 and delays developmental leaf senescence in association with lower ROS levels. Plant molecular biology. 2022 Apr; 108(6):549-563. doi: 10.1007/s11103-022-01245-0. [PMID: 35122174]
  • Ishara Perera, Ayaka Fukushima, Tatsuki Akabane, Genki Horiguchi, Saman Seneweera, Naoki Hirotsu. Expression regulation of myo-inositol 3-phosphate synthase 1 (INO1) in determination of phytic acid accumulation in rice grain. Scientific reports. 2019 10; 9(1):14866. doi: 10.1038/s41598-019-51485-2. [PMID: 31619750]
  • Michael Zick, William T Wickner. A distinct tethering step is vital for vacuole membrane fusion. eLife. 2014 Sep; 3(?):e03251. doi: 10.7554/elife.03251. [PMID: 25255215]
  • Stephanus J Ferreira, Uwe Sonnewald. The mode of sucrose degradation in potato tubers determines the fate of assimilate utilization. Frontiers in plant science. 2012; 3(?):23. doi: 10.3389/fpls.2012.00023. [PMID: 22639642]
  • L David Kuykendall, Jonathan Y Shao, John S Hartung. Conservation of gene order and content in the circular chromosomes of 'Candidatus Liberibacter asiaticus' and other Rhizobiales. PloS one. 2012; 7(4):e34673. doi: 10.1371/journal.pone.0034673. [PMID: 22496839]
  • Shingo Sakamoto, Yukichi Fujikawa, Nobukazu Tanaka, Muneharu Esaka. Molecular cloning and characterization of L-galactose-1-phosphate phosphatase from tobacco (Nicotiana tabacum). Bioscience, biotechnology, and biochemistry. 2012; 76(6):1155-62. doi: 10.1271/bbb.110995. [PMID: 22790939]
  • Yushi Ishibashi, Haruka Yamaguchi, Takashi Yuasa, Mari Iwaya-Inoue, Susumu Arima, Shao-Hui Zheng. Hydrogen peroxide spraying alleviates drought stress in soybean plants. Journal of plant physiology. 2011 Sep; 168(13):1562-7. doi: 10.1016/j.jplph.2011.02.003. [PMID: 21377755]
  • Giuseppe Dionisio, Claus K Madsen, Preben B Holm, Karen G Welinder, Malene Jørgensen, Eva Stoger, Elsa Arcalis, Henrik Brinch-Pedersen. Cloning and characterization of purple acid phosphatase phytases from wheat, barley, maize, and rice. Plant physiology. 2011 Jul; 156(3):1087-100. doi: 10.1104/pp.110.164756. [PMID: 21220762]
  • Paula Casati, Mabel Campi, Darren J Morrow, John F Fernandes, Virginia Walbot. Transcriptomic, proteomic and metabolomic analysis of UV-B signaling in maize. BMC genomics. 2011 Jun; 12(?):321. doi: 10.1186/1471-2164-12-321. [PMID: 21679461]
  • Yu Luo, Genji Qin, Jun Zhang, Yuan Liang, Yingqi Song, Meiping Zhao, Tomohiko Tsuge, Takashi Aoyama, Jingjing Liu, Hongya Gu, Li-Jia Qu. D-myo-inositol-3-phosphate affects phosphatidylinositol-mediated endomembrane function in Arabidopsis and is essential for auxin-regulated embryogenesis. The Plant cell. 2011 Apr; 23(4):1352-72. doi: 10.1105/tpc.111.083337. [PMID: 21505066]
  • J Rivandi, J Miyazaki, M Hrmova, M Pallotta, M Tester, N C Collins. A SOS3 homologue maps to HvNax4, a barley locus controlling an environmentally sensitive Na+ exclusion trait. Journal of experimental botany. 2011 Jan; 62(3):1201-16. doi: 10.1093/jxb/erq346. [PMID: 21047983]
  • Paula Casati, Darren J Morrow, John F Fernandes, Virginia Walbot. Rapid Maize Leaf and Immature Ear Responses to UV-B Radiation. Frontiers in plant science. 2011; 2(?):33. doi: 10.3389/fpls.2011.00033. [PMID: 22666224]
  • Mingjun Li, Fengwang Ma, Dong Liang, Juan Li, Yanlei Wang. Ascorbate biosynthesis during early fruit development is the main reason for its accumulation in kiwi. PloS one. 2010 Dec; 5(12):e14281. doi: 10.1371/journal.pone.0014281. [PMID: 21151561]
  • Elin Thysell, Izabella Surowiec, Emma Hörnberg, Sead Crnalic, Anders Widmark, Annika I Johansson, Pär Stattin, Anders Bergh, Thomas Moritz, Henrik Antti, Pernilla Wikström. Metabolomic characterization of human prostate cancer bone metastases reveals increased levels of cholesterol. PloS one. 2010 Dec; 5(12):e14175. doi: 10.1371/journal.pone.0014175. [PMID: 21151972]
  • David M Mutch, Jens C Fuhrmann, Dietrich Rein, Jan C Wiemer, Jean-Luc Bouillot, Christine Poitou, Karine Clément. Metabolite profiling identifies candidate markers reflecting the clinical adaptations associated with Roux-en-Y gastric bypass surgery. PloS one. 2009 Nov; 4(11):e7905. doi: 10.1371/journal.pone.0007905. [PMID: 19936240]
  • Yi Huang, Liang Chen, Liping Wang, Kannan Vijayan, Sieu Phan, Ziying Liu, Lianglu Wan, Andrew Ross, Daoquan Xiang, Raju Datla, Youlian Pan, Jitao Zou. Probing the endosperm gene expression landscape in Brassica napus. BMC genomics. 2009 Jun; 10(?):256. doi: 10.1186/1471-2164-10-256. [PMID: 19490642]
  • Elitsa A Ananieva, Glenda E Gillaspy, Amanda Ely, Ryan N Burnette, F Les Erickson. Interaction of the WD40 domain of a myoinositol polyphosphate 5-phosphatase with SnRK1 links inositol, sugar, and stress signaling. Plant physiology. 2008 Dec; 148(4):1868-82. doi: 10.1104/pp.108.130575. [PMID: 18931139]
  • Wenyan Zhang, Hope A Gruszewski, Boris I Chevone, Craig L Nessler. An Arabidopsis purple acid phosphatase with phytase activity increases foliar ascorbate. Plant physiology. 2008 Feb; 146(2):431-40. doi: 10.1104/pp.107.109934. [PMID: 18065557]
  • Bhadra Gunesekera, Javad Torabinejad, Jamille Robinson, Glenda E Gillaspy. Inositol polyphosphate 5-phosphatases 1 and 2 are required for regulating seedling growth. Plant physiology. 2007 Mar; 143(3):1408-17. doi: 10.1104/pp.106.089474. [PMID: 17237190]
  • Dong-Jae Jun, Jong-Hee Lee, Bo-Hwa Choi, Tae-Kyung Koh, Dae-Cheong Ha, Min-Woo Jeong, Kyong-Tai Kim. Sphingosine-1-phosphate modulates both lipolysis and leptin production in differentiated rat white adipocytes. Endocrinology. 2006 Dec; 147(12):5835-44. doi: 10.1210/en.2006-0579. [PMID: 16973728]
  • Aline C S Nunes, Giovanni R Vianna, Florencia Cuneo, Jaime Amaya-Farfán, Guy de Capdeville, Elíbio L Rech, Francisco J L Aragão. RNAi-mediated silencing of the myo-inositol-1-phosphate synthase gene (GmMIPS1) in transgenic soybean inhibited seed development and reduced phytate content. Planta. 2006 Jun; 224(1):125-32. doi: 10.1007/s00425-005-0201-0. [PMID: 16395584]
  • A Sajidan, A Farouk, R Greiner, P Jungblut, E-C Müller, R Borriss. Molecular and physiological characterisation of a 3-phytase from soil bacterium Klebsiella sp. ASR1. Applied microbiology and biotechnology. 2004 Jul; 65(1):110-8. doi: 10.1007/s00253-003-1530-1. [PMID: 14727093]
  • Theodore R Chauvin, Michael D Griswold. Characterization of the expression and regulation of genes necessary for myo-inositol biosynthesis and transport in the seminiferous epithelium. Biology of reproduction. 2004 Mar; 70(3):744-51. doi: 10.1095/biolreprod.103.022731. [PMID: 14613899]
  • Hiroaki Komatsu, Jan Westerman, Gerry T Snoek, Theodore F Taraschi, Nathan Janes. Effects of D-myo-inositol 1-phosphate on the transfer function of phosphatidylinositol transfer protein alpha. Journal of liposome research. 2004; 14(3-4):141-53. doi: 10.1081/lpr-200029889. [PMID: 15676123]
  • Brian Faurskov, Henning F Bjerregaard. Evidence for cadmium mobilization of intracellular calcium through a divalent cation receptor in renal distal epithelial A6 cells. Pflugers Archiv : European journal of physiology. 2002 Oct; 445(1):40-50. doi: 10.1007/s00424-002-0912-z. [PMID: 12397385]
  • . . . . doi: . [PMID: 17068342]
  • . . . . doi: . [PMID: 15918884]