dinor-Levomethadyl acetate (BioDeep_00000011338)

 

Secondary id: BioDeep_00001886186

human metabolite Endogenous blood metabolite Volatile Flavor Compounds


代谢物信息卡片


1 alpha-Acetyldinormethadol, hydrochloride, (S-(r*,r*))-isomer

化学式: C21H27NO2 (325.2041682)
中文名称:
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.38%

分子结构信息

SMILES: CCC(OC(C)=O)C(CC(C)N)(C1=CC=CC=C1)C1=CC=CC=C1
InChI: InChI=1S/C21H27NO2/c1-4-20(24-17(3)23)21(15-16(2)22,18-11-7-5-8-12-18)19-13-9-6-10-14-19/h5-14,16,20H,4,15,22H2,1-3H3

描述信息

dinor-Levomethadyl acetate is a metabolite of levomethadyl acetate. Levacetylmethadol, levomethadyl acetate, Orlaam (trade name) or levo-α-acetylmethadol (LAAM) is a synthetic opioid similar in structure to methadone. It has a long duration of action due to its active metabolites. (Wikipedia)

同义名列表

16 个代谢物同义名

1 alpha-Acetyldinormethadol, hydrochloride, (S-(r*,r*))-isomer; 1 alpha-Acetyldinormethadol maleate, (r*,r*)-(+-)-isomer; 1 alpha-Acetyldinormethadol maleate, (S-(r*,r*))-isomer; 1 alpha-Acetyldinormethadol, (-)-(S-(r*,r*))-isomer; 1 alpha-Acetyldinormethadol, (R-(r*,r*))-isomer; 6-amino-4,4-diphenylheptan-3-yl acetate; 1 alpha-Acetyldinormethadol maleate; L-alpha-Acetyl-N,N-dinormethadol; Dinor-levomethadyl acetic acid; L-alpha-Dinoracetylmethadol; 1 alpha-Acetyldinormethadol; dinor-Levomethadyl acetate; Dinor-laam; DinorLAAM; DNLAAM; L-alpha-Acetyl-N,N-dinormethadol



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Evan D Kharasch, Dale Whittington, Christine Hoffer, Kevin Krudys, Keith Craig, Paolo Vicini, Pam Sheffels, Bojan Lalovic. Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies. Clinical pharmacokinetics. 2005; 44(7):731-51. doi: 10.2165/00003088-200544070-00005. [PMID: 15966756]
  • Wei Huang, Paul A Bemis, Matthew H Slawson, David E Moody. Determination of l-alpha-acetylmethadol (LAAM), norLAAM, and dinorLAAM in clinical and in vitro samples using liquid chromatography with electrospray ionization and tandem mass spectrometry. Journal of pharmaceutical sciences. 2003 Jan; 92(1):10-20. doi: 10.1002/jps.10263. [PMID: 12486677]
  • D G Wilkins, A S Valdez, G G Krueger, D E Rollins. Quantitative analysis of l-alpha-acetylmethadol, l-alpha-acetyl-N-normethadol, and l-alpha-acetyl-N,N-dinormethadol in human hair by positive ion chemical ionization mass spectrometry. Journal of analytical toxicology. 1997 Oct; 21(6):420-6. doi: 10.1093/jat/21.6.420. [PMID: 9323520]
  • D E Moody, D J Crouch, C O Sakashita, M E Alburges, K Minear, J E Schulthies, R L Foltz. A gas chromatographic-positive ion chemical ionization-mass spectrometric method for the determination of I-alpha-acetylmethadol (LAAM), norLAAM, and dinorLAAM in plasma, urine, and tissue. Journal of analytical toxicology. 1995 Oct; 19(6):343-51. doi: 10.1093/jat/19.6.343. [PMID: 8926727]
  • B F Thomas, A R Jeffcoat, M W Myers, J M Mathews, C E Cook. Determination of l-alpha-acetylmethadol, l-alpha-noracetylmethadol and l-alpha-dinoracetylmethadol in plasma by gas chromatography-mass spectrometry. Journal of chromatography. B, Biomedical applications. 1994 May; 655(2):201-11. doi: 10.1016/0378-4347(94)00097-2. [PMID: 8081466]
  • K Verebey, A DePace, S J Mulé. Quantitation of l-alpha-acetylmethadol and its metabolites in human serum by capillary gas-liquid chromatography and nitrogen detection. Journal of chromatography. 1985 Oct; 343(2):339-48. doi: 10.1016/s0378-4347(00)84602-2. [PMID: 4066875]
  • L Lichtblau, B S Finkle, S B Sparber. Cumulation of active metabolites of levo-alpha-acetylmethadol in the rat fetus and neonate. Life sciences. 1982 Jan; 30(3):307-12. doi: 10.1016/0024-3205(82)90513-6. [PMID: 7070211]
  • F L Tse, P G Welling. Pharmacokinetics of acetylmethadols I: gas-liquid chromatographic determination of L-alpha-acetylmethadol and its major metabolites in plasma. Biopharmaceutics & drug disposition. 1980 Apr; 1(4):203-9. doi: 10.1002/bdd.2510010408. [PMID: 7448349]
  • R M Kater, N Carulli, F L Iber. Differences in the rate of ethanol metabolism in recently drinking alcoholic and nondrinking subjects. The American journal of clinical nutrition. 1969 Dec; 22(12):1608-17. doi: 10.1093/ajcn/22.12.1608. [PMID: 5362487]