16-Ketoestradiol (BioDeep_00000009874)

Main id: BioDeep_00000637483

 

human metabolite Endogenous Volatile Flavor Compounds


代谢物信息卡片


(1S,10R,11S,14R,15S)-5,14-dihydroxy-15-methyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-2(7),3,5-trien-13-one

化学式: C18H22O3 (286.15688620000003)
中文名称:
谱图信息: 最多检出来源 Rattus norvegicus(lipidomics) 83.33%

分子结构信息

SMILES: CC12CCC3C(C1CC(=O)C2O)CCC4=C3C=CC(=C4)O
InChI: InChI=1S/C18H22O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-15,17,19,21H,2,4,6-7,9H2,1H3/t13-,14-,15+,17+,18+/m1/s1

描述信息

16-Ketoestradiol is found in the estrogen patch. The estrogen patch is a delivery system for estradiol used as hormone replacement therapy to treat the symptoms of menopause, such as hot flashes and vaginal dryness, and to prevent osteoporosis. Originally marketed as Vivelle (Novartis), it was discontinued in 2003 and reintroduced in a smaller form as Vivelle-Dot. Although the estrogen is given transdermally rather than in the standard oral tablets, the estrogen patch carries similar risks and benefits as more conventional forms of estrogen-only hormone replacement therapy. [HMDB]
16-Ketoestradiol is found in the estrogen patch. The estrogen patch is a delivery system for estradiol used as hormone replacement therapy to treat the symptoms of menopause, such as hot flashes and vaginal dryness, and to prevent osteoporosis. Originally marketed as Vivelle (Novartis), it was discontinued in 2003 and reintroduced in a smaller form as Vivelle-Dot. Although the estrogen is given transdermally rather than in the standard oral tablets, the estrogen patch carries similar risks and benefits as more conventional forms of estrogen-only hormone replacement therapy.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

16 个代谢物同义名

(1S,10R,11S,14R,15S)-5,14-dihydroxy-15-methyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-2(7),3,5-trien-13-one; (17beta)-3,17-Dihydroxyestra-1,3,5(10)-trien-16-one; 16-Ketoestradiol, (17beta)-isomer, 4-(14)C-labeled; 3,17b-Dihydroxyestra-1,3,5(10)-trien-16-one; 1,3,5(10)-Estratriene-3,17b-diol-16-one; 16-Ketoestradiol, (17alpha)-isomer; 16-oxo-17beta-Estradiol; 16-Keto-17b-estradiol; 16-oxo-17b-Estradiol; 16-oxo-17Β-estradiol; 16-Oxoestradiol-17b; 16-Ketoestradiol; SCHEMBL13123065; 16-Oxoestradiol; ST 18:4;O3; 16-Ketoestradiol



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jean-Philippe Emond, Louis Lacombe, Patrick Caron, Véronique Turcotte, David Simonyan, Armen Aprikian, Fred Saad, Michel Carmel, Simone Chevalier, Chantal Guillemette, Eric Lévesque. Urinary oestrogen steroidome as an indicator of the risk of localised prostate cancer progression. British journal of cancer. 2021 07; 125(1):78-84. doi: 10.1038/s41416-021-01376-z. [PMID: 33828256]
  • Karin B Michels, Nadine Binder, Frédérique Courant, Adrian A Franke, Anja Osterhues. Urinary excretion of sex steroid hormone metabolites after consumption of cow milk: a randomized crossover intervention trial. The American journal of clinical nutrition. 2019 02; 109(2):402-410. doi: 10.1093/ajcn/nqy279. [PMID: 30698629]
  • Christopher M Masi, Louise C Hawkley, Xia Xu, Timothy D Veenstra, John T Cacioppo. Serum estrogen metabolites and systolic blood pressure among middle-aged and older women and men. American journal of hypertension. 2009 Nov; 22(11):1148-53. doi: 10.1038/ajh.2009.155. [PMID: 19713943]
  • R T Fowler, M Lever, D J Munster, J D Brown. Kober reaction kinetics and their influence on the design of assays for oestrogens in urine during pregnancy. Clinica chimica acta; international journal of clinical chemistry. 1980 Apr; 103(2):175-81. doi: 10.1016/0009-8981(80)90211-9. [PMID: 7371196]
  • K J RYAN, R A MEIGS, Z PETRO, G MORRISON. ESTROGEN-INDUCED 16-HYDROXYSTEROID DEHYDROGENASE ACTIVITY IN RAT KIDNEY. Science (New York, N.Y.). 1963 Oct; 142(3589):243-4. doi: 10.1126/science.142.3589.243. [PMID: 14057375]
  • L AINSWORTH, R H COMMON. URINARY AND FECAL CONVERSION PRODUCTS OF 16-OXOESTRADIOL-17-BETA-16-C14 IN THE DOMESTIC FOWL. Canadian journal of biochemistry and physiology. 1963 Oct; 41(?):2045-55. doi: NULL. [PMID: 14083972]
  • H F MACRAE, D G DALE, R H COMMON. Formation in vivo of 16-epiestriol and 16-ketoestradiol-17 beta from estriol by the laving hen and occurrence of equol in hen's urine and feces. Canadian journal of biochemistry and physiology. 1960 Jun; 38(?):523-32. doi: . [PMID: 14419643]
  • M LEVITZ, M F ROSEN, G H TWOMBLY. Interconversions of 16-oxygenated estrogens. II. The metabolism of 16-ketoestradiol-17beta-16-C14 in man. Archives of biochemistry and biophysics. 1960 Jun; 88(?):212-5. doi: 10.1016/0003-9861(60)90224-1. [PMID: 14416343]