O-Methylsterigmatocystin (BioDeep_00000005284)

human metabolite Endogenous Volatile Flavor Compounds natural product

代谢物信息卡片

11,15-dimethoxy-6,8,20-trioxapentacyclo[10.8.0.0²,⁹.0³,⁷.0¹⁴,¹⁹]icosa-1(12),2(9),4,10,14,16,18-heptaen-13-one

化学式: C19H14O6 (338.0790344)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(natural_products) 0.13%

分子结构信息

SMILES: c1c2c(c3c(c1OC)c(=O)c1c(o3)cccc1OC)[C@H]1[C@@H](O2)OC=C1
InChI: InChI=1S/C19H14O6/c1-21-10-4-3-5-11-15(10)17(20)16-12(22-2)8-13-14(18(16)24-11)9-6-7-23-19(9)25-13/h3-9,19H,1-2H3

描述信息

O-Methylsterigmatocystin is a mycotoxin of Aspergillus flavu
D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins

同义名列表

10 个代谢物同义名

11,15-dimethoxy-6,8,20-trioxapentacyclo[10.8.0.0²,⁹.0³,⁷.0¹⁴,¹⁹]icosa-1(12),2(9),4,10,14,16,18-heptaen-13-one; Sterigmatocystin, O-methyl- (6ci); Sterigmatocystin, O-methyl-(6CI); 7-O-Methylsterigmatocystin; 8-O-Methylsterigmatocystin; O-Methyl-sterigmatocystin; 6,7-Dimethoxyfuroxanthone; O-Methyl sterigmatocystin; O-Methylsterigmatocystin; O-Methylsterigmatocystin

数据库引用编号

17 个数据库交叉引用编号

ChEBI: CHEBI:18171
KEGG: C03686
PubChem: 10871462
PubChem: 104940
HMDB: HMDB0030589
Metlin: METLIN41024
KNApSAcK: C00023634
foodb: FDB002482
chemspider: 9046743
CAS: 17878-69-2
PMhub: MS000018039
PubChem: 6461
LipidMAPS: LMPK10000003
3DMET: B00623
NIKKAJI: J86.123E
KNApSAcK: 18171
LOTUS: LTS0043318

分类词条

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

aflatoxins B1 and G1 biosynthesis: 8-O-methylsterigmatocystin + H⁺ + NADPH + O₂ ⟶ CO₂ + H₂O + NADP⁺ + aflatoxin B₁ + methanol
aflatoxins B1 and G1 biosynthesis: 8-O-methylsterigmatocystin + O₂ + a reduced [NADPH-hemoprotein reductase] ⟶ CO₂ + H₂O + MeOH + aflatoxin B₁ + an oxidized [NADPH-hemoprotein reductase]

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

17 个相关的物种来源信息

4890 - Ascomycota: LTS0043318
1131492 - Aspergillaceae: LTS0043318
5052 - Aspergillus: LTS0043318
5059 - Aspergillus flavus:
5059 - Aspergillus flavus: LTS0043318
5067 - Aspergillus parasiticus:
5067 - Aspergillus parasiticus: LTS0043318
35718 - Chaetomiaceae: LTS0043318
5149 - Chaetomium: LTS0043318
1934365 - Collariella: LTS0043318
1934374 - Collariella virescens: 10.1248/CPB.28.2428
2759 - Eukaryota: LTS0043318
147545 - Eurotiomycetes: LTS0043318
4751 - Fungi: LTS0043318
9606 - Homo sapiens: -
147550 - Sordariomycetes: LTS0043318
28568 - Trichocomaceae: LTS0043318

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Rodrigo A Olarte, Carolyn J Worthington, Bruce W Horn, Geromy G Moore, Rakhi Singh, James T Monacell, Joe W Dorner, Eric A Stone, De-Yu Xie, Ignazio Carbone. Enhanced diversity and aflatoxigenicity in interspecific hybrids of Aspergillus flavus and Aspergillus parasiticus. Molecular ecology. 2015 Apr; 24(8):1889-909. doi: 10.1111/mec.13153. [PMID: 25773520]
R Prieto, C P Woloshuk. ord1, an oxidoreductase gene responsible for conversion of O-methylsterigmatocystin to aflatoxin in Aspergillus flavus. Applied and environmental microbiology. 1997 May; 63(5):1661-6. doi: 10.1128/aem.63.5.1661-1666.1997. [PMID: 9143099]
R Prieto, G L Yousibova, C P Woloshuk. Identification of aflatoxin biosynthesis genes by genetic complementation in an Aspergillus flavus mutant lacking the aflatoxin gene cluster. Applied and environmental microbiology. 1996 Oct; 62(10):3567-71. doi: 10.1128/aem.62.10.3567-3571.1996. [PMID: 8967772]
D P Hsieh. Biological reactive intermediates of bisfuranoid mycotoxins. The Journal of toxicological sciences. 1990 Dec; 15 Suppl 4(?):152-8. doi: 10.2131/jts.15.supplementiv_152. [PMID: 2129232]