Aflatoxin B2 (BioDeep_00000002612)

Main id: BioDeep_00000404758

Secondary id: BioDeep_00000396805

human metabolite natural product Toxin


代谢物信息卡片


11-methoxy-6,8,19-trioxapentacyclo[10.7.0.0²,⁹.0³,⁷.0¹³,¹⁷]nonadeca-1(12),2(9),10,13(17)-tetraene-16,18-dione

化学式: C17H14O6 (314.0790344)
中文名称: 黄曲霉素B2
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C2C3=C(C(=O)CC3)C(=O)OC2=C4C5CCOC5OC4=C1
InChI: InChI=1S/C17H14O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h6,8,17H,2-5H2,1H3

描述信息

Aflatoxin B2 is a metabolite of Aspergillus flavus and Aspergillus parasiticus (Hugo Vanden Bossche, D.W.R. Mackenzie and G. Cauwenbergh. Aspergillus and Aspergillosis, 1987).
D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins
D009676 - Noxae > D011042 - Poisons > D000348 - Aflatoxins
Metabolite of Aspergillus flavus

同义名列表

8 个代谢物同义名

11-methoxy-6,8,19-trioxapentacyclo[10.7.0.0²,⁹.0³,⁷.0¹³,¹⁷]nonadeca-1(12),2(9),10,13(17)-tetraene-16,18-dione; aflatoxin B2, (6aR-cis)-isomer; Dihydroafflatoxin b1; Dihydroaflatoxine B1; Dihydroaflatoxin B1; aflatoxin B2 alpha; Aflatoxin B2; Aflatoxin B2



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

22 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Qing Li, Luyi Jiang, Huan Zhang, Mengmeng Wei, Chu Chu, Jizhong Yan. Modified Magnetic Nanoparticle-Based Solid-Phase Extraction for the Determination of Trace Amounts of Aflatoxins B1 and B₂ in Chinese Patent Medicines: The Use of Fupuganmao Granules as a Case Study. Journal of AOAC International. 2019 May; 102(3):761-766. doi: 10.5740/jaoacint.18-0311. [PMID: 30388968]
  • Samaneh Nabizadeh, Nabi Shariatifar, Esmail Shokoohi, Shahram Shoeibi, Mohsen Gavahian, Yadolah Fakhri, Ali Azari, Amin Mousavi Khaneghah. Prevalence and probabilistic health risk assessment of aflatoxins B1, B2, G1, and G2 in Iranian edible oils. Environmental science and pollution research international. 2018 Dec; 25(35):35562-35570. doi: 10.1007/s11356-018-3510-0. [PMID: 30353428]
  • Salum Mohammed, Joan J E Munissi, Stephen S Nyandoro. Aflatoxins in sunflower seeds and unrefined sunflower oils from Singida, Tanzania. Food additives & contaminants. Part B, Surveillance. 2018 Sep; 11(3):161-166. doi: 10.1080/19393210.2018.1443519. [PMID: 29486657]
  • Hongmei Liu, Anxiang Lu, Hailong Fu, Bingru Li, Meihua Yang, Jihua Wang, Yunxia Luan. Affinity capture of aflatoxin B1 and B2 by aptamer-functionalized magnetic agarose microspheres prior to their determination by HPLC. Mikrochimica acta. 2018 06; 185(7):326. doi: 10.1007/s00604-018-2849-8. [PMID: 29896649]
  • Blake R Rushing, Mustafa I Selim. Structure and Oxidation of Pyrrole Adducts Formed between Aflatoxin B2a and Biological Amines. Chemical research in toxicology. 2017 06; 30(6):1275-1285. doi: 10.1021/acs.chemrestox.7b00002. [PMID: 28514848]
  • Rosa Adriana Ramales-Valderrama, Alma Vázquez-Durán, Abraham Méndez-Albores. Biosorption of B-aflatoxins Using Biomasses Obtained from Formosa Firethorn [Pyracantha koidzumii (Hayata) Rehder]. Toxins. 2016 07; 8(7):. doi: 10.3390/toxins8070218. [PMID: 27420096]
  • Wajiha Iram, Tehmina Anjum, Mazhar Iqbal, Abdul Ghaffar, Mateen Abbas. Mass spectrometric identification and toxicity assessment of degraded products of aflatoxin B1 and B2 by Corymbia citriodora aqueous extracts. Scientific reports. 2015 Oct; 5(?):14672. doi: 10.1038/srep14672. [PMID: 26423838]
  • Sufang Fan, Qiang Li, Xiaoguang Zhang, Xiaobin Cui, Dongsheng Zhang, Yan Zhang. Simultaneous determination of aflatoxin B₁, B₂, G₁, and G₂ in corn powder, edible oil, peanut butter, and soy sauce by liquid chromatography with tandem mass spectrometry utilizing turbulent flow chromatography. Journal of separation science. 2015 May; 38(8):1310-7. doi: 10.1002/jssc.201401376. [PMID: 25683560]
  • Cássia Yumie Kohiyama, Milene Mayumi Yamamoto Ribeiro, Simone Aparecida Galerani Mossini, Erika Bando, Natália da Silva Bomfim, Samuel Botião Nerilo, Gustavo Henrique Oliveira Rocha, Renata Grespan, Jane Martha Graton Mikcha, Miguel Machinski. Antifungal properties and inhibitory effects upon aflatoxin production of Thymus vulgaris L. by Aspergillus flavus Link. Food chemistry. 2015 Apr; 173(?):1006-10. doi: 10.1016/j.foodchem.2014.10.135. [PMID: 25466118]
  • Johannes Gerding, Benedikt Cramer, Hans-Ulrich Humpf. Determination of mycotoxin exposure in Germany using an LC-MS/MS multibiomarker approach. Molecular nutrition & food research. 2014 Dec; 58(12):2358-68. doi: 10.1002/mnfr.201400406. [PMID: 25243722]
  • Sevtap Aydin, Suna Sabuncuoglu, Pinar Erkekoglu, Gönül Sahin, Belma Kocer Giray. Serum aflatoxin levels of the healthy adult population living in the north and south regions of Turkey. Public health nutrition. 2014 Nov; 17(11):2496-504. doi: 10.1017/s1368980013002802. [PMID: 24476808]
  • Jiliang Cao, Shujun Zhou, Weijun Kong, Xiaochi Ma, Meihua Yang, Li Wan, Shihai Yang. Simultaneous determination of aflatoxins B₁, B₂, G₁, G₂ in Fructus Bruceae by high-performance liquid chromatography with online postcolumn photochemical derivatization. Journal of separation science. 2014 Oct; 37(19):2771-8. doi: 10.1002/jssc.201400501. [PMID: 25069411]
  • Runsheng Zheng, Hui Xu, Wenli Wang, Ruoting Zhan, Weiwen Chen. Simultaneous determination of aflatoxin B(1), B(2), G(1), G(2), ochratoxin A, and sterigmatocystin in traditional Chinese medicines by LC-MS-MS. Analytical and bioanalytical chemistry. 2014 May; 406(13):3031-9. doi: 10.1007/s00216-014-7750-7. [PMID: 24658469]
  • Run-Sheng Zheng, Hui Xu, Yuan-Xia Peng, Wen-Li Wang, Ruo-Ting Zhan, Wei-Wen Chen. [A high throughput coupled with high performance liquid chromatography-tandem mass spectrometry method for determination of aflatoxin B1, B2, G1, G2 in 10 traditional Chinese medicines]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2014 Jan; 39(2):273-7. doi: ". [PMID: 24761645]
  • Lei Bao, Chengzhu Liang, Mary W Trucksess, Yanli Xu, Ning Lv, Zhenxing Wu, Ping Jing, Fred S Fry. Determination of aflatoxins B1, B2, G1, and G2 in olive oil, peanut oil, and sesame oil using immunoaffinity column cleanup, postcolumn derivatization, and liquid chromatography with fluorescence detection: first action 2013.05. Journal of AOAC International. 2013 Sep; 96(5):1017-8. doi: 10.5740/jaoacint.13-129. [PMID: 24282940]
  • E V Siloto, E F A Oliveira, J R Sartori, V B Fascina, B A B Martins, D R Ledoux, G E Rottinghaus, D R S Sartori. Lipid metabolism of commercial layers fed diets containing aflatoxin, fumonisin, and a binder. Poultry science. 2013 Aug; 92(8):2077-83. doi: 10.3382/ps.2012-02777. [PMID: 23873555]
  • Ke Li, Fen Qiu, Mei Yang, Zhaohai Liang, Haitao Zhou. [Survey of aflatoxins contamination of foodstuffs and edible oil in Shenzhen]. Wei sheng yan jiu = Journal of hygiene research. 2013 Jul; 42(4):610-4. doi: ". [PMID: 24024374]
  • J Yang, F Bai, K Zhang, S Bai, X Peng, X Ding, Y Li, J Zhang, L Zhao. Effects of feeding corn naturally contaminated with aflatoxin B1 and B2 on hepatic functions of broilers. Poultry science. 2012 Nov; 91(11):2792-801. doi: 10.3382/ps.2012-02544. [PMID: 23091134]
  • Xiaomeng Wu, Simin Gao, Jia-Sheng Wang, Hongyan Wang, Yao-Wen Huang, Yiping Zhao. The surface-enhanced Raman spectra of aflatoxins: spectral analysis, density functional theory calculation, detection and differentiation. The Analyst. 2012 Sep; 137(18):4226-34. doi: 10.1039/c2an35378d. [PMID: 22832405]
  • Lina Liu, Hongyu Jin, Lei Sun, Shuangcheng Ma, Ruichao Lin. Determination of aflatoxins in medicinal herbs by high-performance liquid chromatography-tandem mass spectrometry. Phytochemical analysis : PCA. 2012 Sep; 23(5):469-76. doi: 10.1002/pca.2343. [PMID: 22323053]
  • Shen Han, Ying Liu, Meiling Lu, Jianzhong Li, Jinhua Wang. [Determination of five aflatoxins in Chinese patent medicines and medicinal herbs by immunoaffinity extraction coupled with ultra-high performance liquid chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography. 2011 Jul; 29(7):613-7. doi: ". [PMID: 22097786]
  • Lei Bao, Mary W Trucksess, Kevin D White. Determination of aflatoxins B1, B2, G1, and G2 in olive oil, peanut oil, and sesame oil. Journal of AOAC International. 2010 May; 93(3):936-42. doi: 10.1093/jaoac/93.3.936. [PMID: 20629398]
  • Zheng Han, Yunliang Zheng, Lianjun Luan, Zengxuan Cai, Yiping Ren, Yongjiang Wu. An ultra-high-performance liquid chromatography-tandem mass spectrometry method for simultaneous determination of aflatoxins B1, B2, G1, G2, M1 and M2 in traditional Chinese medicines. Analytica chimica acta. 2010 Apr; 664(2):165-71. doi: 10.1016/j.aca.2010.02.009. [PMID: 20363399]
  • D Tang, J C Sauceda, Z Lin, S Ott, E Basova, I Goryacheva, S Biselli, J Lin, R Niessner, D Knopp. Magnetic nanogold microspheres-based lateral-flow immunodipstick for rapid detection of aflatoxin B2 in food. Biosensors & bioelectronics. 2009 Oct; 25(2):514-8. doi: 10.1016/j.bios.2009.07.030. [PMID: 19699076]
  • Robert A Everley, Frederic L Ciner, Dongliang Zhan, Peter F Scholl, John D Groopman, Timothy R Croley. Measurement of aflatoxin and aflatoxin metabolites in urine by liquid chromatography-tandem mass spectrometry. Journal of analytical toxicology. 2007 Apr; 31(3):150-6. doi: 10.1093/jat/31.3.150. [PMID: 17579962]
  • Viresh Mohanlall, Bharti Odhav. Biocontrol of aflatoxins B1, B2, G1, G2, and fumonisin B1 with 6,7-dimethoxycoumarin, a phytoalexin from Citrus sinensis. Journal of food protection. 2006 Sep; 69(9):2224-9. doi: 10.4315/0362-028x-69.9.2224. [PMID: 16995528]
  • Kathleen D'Ovidio, Mary Trucksess, Carol Weaver, Erin Horn, Marla McIntosh, George Bean. Aflatoxins in ginseng roots. Food additives and contaminants. 2006 Feb; 23(2):174-80. doi: 10.1080/02652030500442524. [PMID: 16449060]
  • Xue-hui Zhang, Jian-min Chen. [HPLC analysis of alfatoxins in medicinal herb extracts by immunoaffinity column cleanup and post-column bromination]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2005 Feb; 30(3):182-4. doi: ". [PMID: 15719633]
  • Cinzia Tozzi, Laura Anfossi, Claudio Baggiani, Cristina Giovannoli, Gianfranco Giraudi. A combinatorial approach to obtain affinity media with binding properties towards the aflatoxins. Analytical and bioanalytical chemistry. 2003 Apr; 375(8):994-9. doi: 10.1007/s00216-003-1754-z. [PMID: 12733009]
  • E Gonçalez, J D Felicio, M M Pinto. Biflavonoids inhibit the production of aflatoxin by Aspergillus flavus. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2001 Nov; 34(11):1453-6. doi: 10.1590/s0100-879x2001001100013. [PMID: 11668356]
  • S E Lee, B C Campbell. In vitro metabolism of aflatoxin B1 by larvae of navel orangeworm, Amyelois transitella (Walker) (Insecta, Lepidoptera, Pyralidae) and codling moth, Cydia pomonella (L.) (Insecta, Lepidoptera, Tortricidae). Archives of insect biochemistry and physiology. 2000 Dec; 45(4):166-74. doi: 10.1002/1520-6327(200012)45:4<166::aid-arch4>3.0.co;2-8. [PMID: 11223936]
  • Y M Diop, B Ndiaye, M Fall, A Diouf, A Sall, M Ciss, D Ba. [Aflatoxin contamination level in artisanal and industrial peanut butter food in Dakar (Senegal)]. Dakar medical. 2000; 45(2):134-7. doi: ". [PMID: 15779168]
  • B Ndiaye, Y M Diop, A Diouf, M Fall, C Thiaw, A Thiam, O Barry, M Ciss, D Ba. [Measurement and levels of aflatoxins in small-scale pressed peanut oil prepared in the Diourbel and Kaolack regions of Senegal]. Dakar medical. 1999; 44(2):202-5. doi: ". [PMID: 11957285]
  • A Kussak, B Andersson, K Andersson. Immunoaffinity column clean-up for the high-performance liquid chromatographic determination of aflatoxins B1, B2, G1, G2, M1 and Q1 in urine. Journal of chromatography. B, Biomedical applications. 1995 Oct; 672(2):253-9. doi: 10.1016/0378-4347(95)00227-a. [PMID: 8581131]
  • D M Wilson, J K King. Production of aflatoxins B1, B2, G1, and G2 in pure and mixed cultures of Aspergillus parasiticus and Aspergillus flavus. Food additives and contaminants. 1995 May; 12(3):521-5. doi: 10.1080/02652039509374339. [PMID: 7664952]
  • M A Gabal, S A Hegazi, N Hassanin. Aflatoxin production by Aspergillus flavus field isolates. Veterinary and human toxicology. 1994 Dec; 36(6):519-21. doi: ". [PMID: 7900269]
  • S S Sahay, T Prasad. The occurrence of aflatoxins in mustard and mustard products. Food additives and contaminants. 1990 Jul; 7(4):509-13. doi: 10.1080/02652039009373912. [PMID: 2118457]
  • G Zhang, F S Chu. Production and characterization of antibodies cross-reactive with major aflatoxins. Experientia. 1989 Feb; 45(2):182-4. doi: 10.1007/bf01954869. [PMID: 2493390]
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  • J D Groopman, L J Trudel, P R Donahue, A Marshak-Rothstein, G N Wogan. High-affinity monoclonal antibodies for aflatoxins and their application to solid-phase immunoassays. Proceedings of the National Academy of Sciences of the United States of America. 1984 Dec; 81(24):7728-31. doi: 10.1073/pnas.81.24.7728. [PMID: 6440143]
  • S M Lamplugh. Comparison of three methods for the extraction of aflatoxins from human serum in combination with a high-performance liquid chromatographic assay. Journal of chromatography. 1983 Apr; 273(2):442-8. doi: 10.1016/s0378-4347(00)80968-8. [PMID: 6408106]