Ibuprofen (BioDeep_00000002518)

 

Secondary id: BioDeep_00000397716

natural product human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


2-[4-(2-methylpropyl)phenyl]propanoic acid

化学式: C13H18O2 (206.1306728)
中文名称: 布洛芬
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 15.23%

Reviewed

Last reviewed on 2024-08-14.

Cite this Page

Ibuprofen. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/ibuprofen (retrieved 2024-11-29) (BioDeep RN: BioDeep_00000002518). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC(C)CC1=CC=C(C=C1)C(C)C(=O)O
InChI: InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)

描述信息

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) widely marketed under various trademarks including Act-3, Advil, Brufen, Motrin, Nuprin, and Nurofen. It is used for relief of symptoms of arthritis, primary dysmenorrhoea, and fever; Ibuprofen is an NSAID which is believed to work through inhibition of cyclooxygenase (COX), thus inhibiting prostaglandin synthesis. There are at least 2 variations of cyclooxygenase (COX-1 and COX-2), ibuprofen inhibits both COX-1 and COX-2. It appears that its analgesic, antipyretic, and anti-inflammatory activity are achieved principally through COX-2 inhibition; whereas COX-1 inhibition is responsible for its unwanted effects on platelet aggregation and the GI mucosa. As with other NSAIDs, ibuprofen inhibits platelet aggregation, but is not used therapeutically for this action since it is a minor and reversible effect. -- Wikipedia [HMDB]
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) widely marketed under various trademarks including Act-3, Advil, Brufen, Motrin, Nuprin, and Nurofen. It is used for relief of symptoms of arthritis, primary dysmenorrhoea, and fever; Ibuprofen is an NSAID which is believed to work through inhibition of cyclooxygenase (COX), thus inhibiting prostaglandin synthesis. There are at least 2 variations of cyclooxygenase (COX-1 and COX-2), ibuprofen inhibits both COX-1 and COX-2. It appears that its analgesic, antipyretic, and anti-inflammatory activity are achieved principally through COX-2 inhibition; whereas COX-1 inhibition is responsible for its unwanted effects on platelet aggregation and the GI mucosa. As with other NSAIDs, ibuprofen inhibits platelet aggregation, but is not used therapeutically for this action since it is a minor and reversible effect. -- Wikipedia.
M - Musculo-skeletal system > M02 - Topical products for joint and muscular pain > M02A - Topical products for joint and muscular pain > M02AA - Antiinflammatory preparations, non-steroids for topical use
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AE - Propionic acid derivatives
G - Genito urinary system and sex hormones > G02 - Other gynecologicals > G02C - Other gynecologicals > G02CC - Antiinflammatory products for vaginal administration
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials, DrugBank
R - Respiratory system > R02 - Throat preparations > R02A - Throat preparations
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
C - Cardiovascular system > C01 - Cardiac therapy
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

120 个代谢物同义名

(±)-α-methyl-4-(2-methylpropyl)-benzeneacetic acid; (+-)-alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid; (+-)-alpha-Methyl-4-(2-methylpropyl)benzeneacetate; (+-)-Α-methyl-4-(2-methylpropyl)benzeneacetic acid; (+-)-a-Methyl-4-(2-methylpropyl)benzeneacetic acid; alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid; (+-)-a-Methyl-4-(2-methylpropyl)benzeneacetate; (+-)-Α-methyl-4-(2-methylpropyl)benzeneacetate; 2-[4-(2-methylpropyl)phenyl]propanoic acid; (4-Isobutylphenyl)-alpha-methylacetic acid; (+-)-2-(p-Isobutylphenyl)propionic acid; (4-Isobutylphenyl)-a-methylacetic acid; alpha-(4-Isobutylphenyl)propionic acid; (4-Isobutylphenyl)-alpha-methylacetate; alpha-(p-Isobutylphenyl)propionic acid; (4-Isobutylphenyl)-α-methylacetic acid; alpha-p-Isobutylphenylpropionic acid; (+-)-2-(p-Isobutylphenyl)propionate; a-(p-Isobutylphenyl)propionic acid; a-(4-Isobutylphenyl)propionic acid; alpha-(p-Isobutylphenyl)propionate; alpha-(4-Isobutylphenyl)propionate; (4-Isobutylphenyl)-a-methylacetate; Α-(4-isobutylphenyl)propionic acid; Α-(p-isobutylphenyl)propionic acid; 2-(4-Isobutylphenyl)propanoic acid; (4-Isobutylphenyl)-α-methylacetate; p-Isobutyl-2-phenylpropionic acid; alpha-p-Isobutylphenylpropionate; (+-)-p-Isobutylhydratropic acid; Α-(4-isobutylphenyl)propionate; a-(p-Isobutylphenyl)propionate; a-(4-Isobutylphenyl)propionate; Α-(p-isobutylphenyl)propionate; 2-(4-Isobutylphenyl)propanoate; p-Isobutyl-2-phenylpropionate; Ibuprofen, copper (2+) salt; (+-)-p-Isobutylhydratropate; p-Isobutylhydratropic acid; 4-Isobutylhydratropic acid; Ibuprofen, potassium salt; Ibuprofen, magnesium salt; Salt ibuprofen, magnesium; Magnesium salt ibuprofen; Potassium salt ibuprofen; I.V. solution, ibuprofen; Ibuprofen, aluminum salt; Ibuprofen i.v. solution; Aluminum salt ibuprofen; Ibuprofen, calcium salt; p-Isobutylhydratropate; Ibuprofen, sodium salt; Calcium salt ibuprofen; Ibuprofen, (+-)-isomer; 4-Isobutylhydratropate; Salt ibuprofen, sodium; Sodium salt ibuprofen; Ibuprofen, (R)-isomer; Ibuprofen, (S)-isomer; Ibuprofen, zinc salt; Salt ibuprofen, zinc; (±)-Ibuprofen; Zinc salt ibuprofen; Trauma dolgit gel; Trauma-dolgit gel; TraumaDolgit gel; ibuprofen, (+-)-; (RS)-Ibuprofen; (+-)-Ibuprofen; Ibuprofen-zinc; Ibuprofen zinc; Duralbuprofen; Ibu-attritin; Dolo-dolgit; Pediaprofen; ibuprofen; Butylenin; Ibuprocin; Mynosedin; Salprofen; Dolgirid; Anflagen; Lebrufen; Medipren; Ibumetin; Amibufen; Seclodin; Buburone; Roidenin; Epobron; Suspren; Femadon; Haltran; Apsifen; Nurofen; Tabalon; Inabrin; Lamidon; Trendar; Brufort; Nobgen; Inoven; Ibutid; Dolgin; Bluton; Brufen; Ebufac; Nuprin; Dolgit; Nobfen; Liptan; Motrin; IP 82; Rufen; IP-82; Adran; Advil; Anco; Urem; Ibuprofen



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

2 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Alexa Guglielmelli, Caterina M Tone, Eleonora Ragozzino, Federica Ciuchi, Rosa Bartucci. Cholesterol drives enantiospecific effects of ibuprofen in biomimetic membranes. Biochimica et biophysica acta. Biomembranes. 2024 Jun; 1866(5):184334. doi: 10.1016/j.bbamem.2024.184334. [PMID: 38744417]
  • Haneen Ali Abdulrazaq, Abeer I Alwared. Bio-synthesis of TiO2 using grape leaves extract and its application for photocatalytic degradation of ibuprofen from aqueous solution. Environmental technology. 2024 May; 45(13):2493-2505. doi: 10.1080/09593330.2023.2176791. [PMID: 36735351]
  • Anna S Kashnik, Denis S Baranov, Sergei A Dzuba. Spatial Arrangement of the Drug Ibuprofen in a Model Membrane in the Presence of Lipid Rafts. The journal of physical chemistry. B. 2024 Apr; 128(15):3652-3661. doi: 10.1021/acs.jpcb.4c01507. [PMID: 38576273]
  • Menghan Li, Jing Yuan, Zhuoni Liu, Tianxiang Yin, Changjun Peng. Multifunctional Deep Eutectic Solvent-Based Microemulsion for Transdermal Delivery of Artemisinin. Langmuir : the ACS journal of surfaces and colloids. 2024 Mar; 40(10):5098-5105. doi: 10.1021/acs.langmuir.3c02748. [PMID: 38412279]
  • Zhe Li, Xiaosui Luo, Qiong Li, Zhengji Jin, Abid Naeem, Weifeng Zhu, Lihua Chen, Yi Feng, Liangshan Ming. The Fabrication, Drug Loading, and Release Behavior of Porous Mannitol. Molecules (Basel, Switzerland). 2024 Feb; 29(3):. doi: 10.3390/molecules29030715. [PMID: 38338458]
  • Yan Liu, Ming-Wei Liu. A unusual presentation of liver failure caused by Ibuprofen-sustained release capsules: A case report. Medicine. 2024 Jan; 103(4):e36997. doi: 10.1097/md.0000000000036997. [PMID: 38277537]
  • Shiqi Yuan, Yitong Ling, Xiaxuan Huang, Shanyuan Tan, Wanyue Li, Anding Xu, Jun Lyu. Associations between the use of common nonsteroidal anti-inflammatory drugs, genetic susceptibility and dementia in participants with chronic pain: A prospective study based on 194,758 participants from the UK Biobank. Journal of psychiatric research. 2024 01; 169(?):152-159. doi: 10.1016/j.jpsychires.2023.11.030. [PMID: 38039689]
  • Hayam S Ahmed, Enas I A Mohamed, Elham Amin, Abeer S Moawad, Mohamed Sadek Abdel-Bakky, Suliman A Almahmoud, Naglaa Afifi. Phytochemical investigation and anti-inflammatory potential of Atriplex leucoclada Boiss. BMC complementary medicine and therapies. 2023 Dec; 23(1):464. doi: 10.1186/s12906-023-04281-5. [PMID: 38104070]
  • Jiuyan Chen, Qiang Zhang, Weifeng Chen, Usman Farooq, Taotao Lu, Bin Wang, Jinzhi Ni, Huiying Zhang, Zhichong Qi. Mobility of antipyretic drugs with different molecular structures in saturated soil porous media. Environmental science. Processes & impacts. 2023 Dec; 25(12):2092-2101. doi: 10.1039/d3em00358b. [PMID: 37905737]
  • Anna S Kashnik, Olga Yu Selyutina, Denis S Baranov, Nikolay E Polyakov, Sergei A Dzuba. Localization of the ibuprofen molecule in model lipid membranes revealed by spin-label-enhanced NMR relaxation. Biochimica et biophysica acta. Biomembranes. 2023 12; 1865(8):184215. doi: 10.1016/j.bbamem.2023.184215. [PMID: 37633627]
  • Siyi Wu, Jianfeng Zhong, Qiqi Lei, Haoran Song, Shao-Fang Chen, Abdul Qadeer Wahla, Kalpana Bhatt, Shaohua Chen. New roles for Bacillus thuringiensis in the removal of environmental pollutants. Environmental research. 2023 11; 236(Pt 1):116699. doi: 10.1016/j.envres.2023.116699. [PMID: 37481057]
  • Zhiqun Zhang, Xinrui Lou, Luyi Hua, Xinhui Jia, Lili Xu, Min Zhao. Cardiopulmonary Ultrasound-Guided Treatment of Premature Infants with Respiratory Failure and Patent Ductus Arteriosus: A Randomized, Controlled Trial. Indian journal of pediatrics. 2023 11; 90(11):1103-1109. doi: 10.1007/s12098-023-04489-w. [PMID: 36952111]
  • Florence Nantaba, John Wasswa, Henrik Kylin, Hindrik Bouwman, Wolf-Ulrich Palm, Klaus Kümmerer. Spatial trends and ecotoxic risk assessment of selected pharmaceuticals in sediments from Lake Victoria, Uganda, East Africa. The Science of the total environment. 2023 Sep; 906(?):167348. doi: 10.1016/j.scitotenv.2023.167348. [PMID: 37769731]
  • Lihui Jiang, Boning Jiang, Juan Xu, Ting Wang. Preparation of pH-responsive oxidized regenerated cellulose hydrogels compounded with nano-ZnO/chitosan/aminocyclodextrin ibuprofen complex for wound dressing. International journal of biological macromolecules. 2023 Aug; 253(Pt 1):126628. doi: 10.1016/j.ijbiomac.2023.126628. [PMID: 37657582]
  • L B Campos, Núñez Aa González, M J Palacio, J P Ferro, P M Castañé, L Ferrari, N A Ossana. Acute and subchronic effects of ibuprofen on the ten spotted live-bearer fish Cnesterodon decemmaculatus (Jenyns, 1842). Chemosphere. 2023 Aug; ?(?):139895. doi: 10.1016/j.chemosphere.2023.139895. [PMID: 37604345]
  • Gerard Esteruelas, Alba Ortiz, Josefina Prat, Estefania Vega, Montserrat Muñoz-Juncosa, Maria Luisa Garcia López, Miren Ettcheto, Antoni Camins, Elena Sánchez-López, Montserrat Pujol. Novel customized age-dependent corneal membranes and interactions with biodegradable nanoparticles loaded with dexibuprofen. Colloids and surfaces. B, Biointerfaces. 2023 Aug; 228(?):113394. doi: 10.1016/j.colsurfb.2023.113394. [PMID: 37301018]
  • Mohammad Ghorbani, Gholamreza Dehghan, Abdollah Allahverdi. Concentration-dependent mechanism of the binding behavior of ibuprofen to the cell membrane: A molecular dynamic simulation study. Journal of molecular graphics & modelling. 2023 Jul; 124(?):108581. doi: 10.1016/j.jmgm.2023.108581. [PMID: 37536233]
  • Thaddeus H Gugu, Geraldine C Agu, Emmanuel M Uronnachi, Salome A Chime. Enhanced anti-inflammatory and ulcerogenicity of Ibuprofen microsphere formulations using Irvingia wombolu fat (IRW) and moringa oil (MO) as co-lipids. BMC complementary medicine and therapies. 2023 Jul; 23(1):249. doi: 10.1186/s12906-023-04036-2. [PMID: 37468938]
  • Chunjing Guo, Min Cao, Ningning Diao, Wenxin Wang, Hongxu Geng, Yanguo Su, Tianying Sun, Xinyue Lu, Ming Kong, Daquan Chen. Novel pH-responsive E-selectin targeting natural polysaccharides hybrid micelles for diabetic nephropathy. Nanomedicine : nanotechnology, biology, and medicine. 2023 Jul; 52(?):102696. doi: 10.1016/j.nano.2023.102696. [PMID: 37394108]
  • Zhang Meijuan, Penglong Yu, Jie Yuan, Tao Yu, Dan Sun. Stomach ulcer caused by mistakenly oral medication of 14,400 mg ibuprofen: A case report. Medicine. 2023 May; 102(20):e33812. doi: 10.1097/md.0000000000033812. [PMID: 37335722]
  • Grace Adebayo-Gege, Zainab Shehu Uthman, Moses Dele Adams, Tarfa Florence, Danazumi Umar Haruna, Ngabea Murtala Audu, Hamidu Jabba Lawan, Ozegbe Queen, Onwuchekwa Chinedu, Ajibola Meraiyebu, Ojo Kafaru. Molecular docking and anti-ulcerative potential of Cucumis (L. Inodorous) on ibuprofen induced gastric ulceration in male wistar animals. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 May; 161(?):114531. doi: 10.1016/j.biopha.2023.114531. [PMID: 36934555]
  • Khuloud A Alibrahim. Adsorption of Ibuprofen as a pharmaceutical pollutant from aqueous phase using zinc oxide nanoparticles: Green synthesis, batch adsorption and biological activities. Journal of molecular recognition : JMR. 2023 Apr; ?(?):e3015. doi: 10.1002/jmr.3015. [PMID: 37021769]
  • Natalia Rojas-Valencia, Sara Gómez, Tommaso Giovannini, Chiara Cappelli, Albeiro Restrepo, Francisco Núñez Zarur. Water Maintains the UV-Vis Spectral Features During the Insertion of Anionic Naproxen and Ibuprofen into Model Cell Membranes. The journal of physical chemistry. B. 2023 Mar; ?(?):. doi: 10.1021/acs.jpcb.2c08332. [PMID: 36877579]
  • Barbara Kasprzyk-Hordern, Natalie Sims, Kata Farkas, Kishore Jagadeesan, Kathryn Proctor, Matthew J Wade, Davey L Jones. Wastewater-based epidemiology for comprehensive community health diagnostics in a national surveillance study: Mining biochemical markers in wastewater. Journal of hazardous materials. 2023 Feb; 450(?):130989. doi: 10.1016/j.jhazmat.2023.130989. [PMID: 36848844]
  • Ashokkumar Sibiya, Jeyaraj Jeyavani, Manoharan Saravanan, Mohammed F Albeshr, Marcello Nicoletti, Marimuthu Govindarajan, Baskaralingam Vaseeharan. Response of hepatic biochemical parameters and neurotoxicity to carbamazepine and ibuprofen in Oreochromis mossambicus. Fish physiology and biochemistry. 2023 Jan; ?(?):. doi: 10.1007/s10695-023-01172-x. [PMID: 36717424]
  • Dinesh Nyavanandi, Sagar Narala, Preethi Mandati, Abdullah Alzahrani, Praveen Kolimi, Ahmed Almotairy, Michael A Repka. Twin Screw Melt Granulation: Alternative Approach for Improving Solubility and Permeability of a Non-steroidal Anti-inflammatory Drug Ibuprofen. AAPS PharmSciTech. 2023 Jan; 24(1):47. doi: 10.1208/s12249-023-02512-z. [PMID: 36703024]
  • Márton Pápai, Tibor Benedek, András Táncsics, Till L V Bornemann, Julia Plewka, Alexander J Probst, Daood Hussein, Gergely Maróti, Ofir Menashe, Balázs Kriszt. Selective enrichment, identification, and isolation of diclofenac, ibuprofen, and carbamazepine degrading bacteria from a groundwater biofilm. Environmental science and pollution research international. 2023 Jan; ?(?):. doi: 10.1007/s11356-022-24975-6. [PMID: 36690856]
  • Nolan V Chalifoux, Emmanuelle M Butty, Katie D Mauro, Rachel B Moyle, Caryn M Ehrhardt, James B Robertson, Mary A Labato, Christine A Culler, Leonel A Londoño, Alessio Vigani, Yu Ueda, Steven E Suter, Alex M Lynch. Outcomes of 434 dogs with non-steroidal anti-inflammatory drug toxicosis treated with fluid therapy, lipid emulsion, or therapeutic plasma exchange. Journal of veterinary internal medicine. 2023 Jan; 37(1):161-172. doi: 10.1111/jvim.16603. [PMID: 36453531]
  • H Skubatz. Nonsteroidal anti-inflammatory drugs as antipyretics and modulators of a molecular clock(s) in the appendix of Sauromatum venosum inflorescence. Plant biology (Stuttgart, Germany). 2023 Jan; 25(1):152-160. doi: 10.1111/plb.13466. [PMID: 36074072]
  • Ramatu Idris Sha'aba, Mathias Ahii Chia, Yisa Abraham Gana, Abdullahi Bala Alhassan, Ibrahim Madu Katsallah Gadzama. The growth, biochemical composition, and antioxidant response of Microcystis and Chlorella are influenced by Ibuprofen. Environmental science and pollution research international. 2023 Jan; 30(5):13118-13131. doi: 10.1007/s11356-022-22837-9. [PMID: 36123556]
  • Wenhao Xu, Jinli Yang, Xiangyang Gu, Wenjing Su, Faxiang Pu, Zhangfu Xie, Kongliang Jin, Weike Su, Lichan Mao. Mechanochemical prepared ibuprofen-Polygonatum sibiricum polysaccharide drug delivery system for enhanced bioactivity with reduced renal injury induced by NSAIDs. Drug delivery. 2022 Dec; 29(1):351-363. doi: 10.1080/10717544.2022.2026533. [PMID: 35049408]
  • Nagesh Kishan Panchal, Purushotham Swarnalatha, Sabina Evan Prince. Trichopus zeylanicus ameliorates ibuprofen inebriated hepatotoxicity and enteropathy: an insight into its modulatory impact on pro/anti-inflammatory cytokines and apoptotic signaling pathways. Inflammopharmacology. 2022 Dec; 30(6):2229-2242. doi: 10.1007/s10787-022-01052-5. [PMID: 36008576]
  • Linyi Li, Danqing Zheng, Xinyi Gu, Chengju Sun, Yankun Liu, Wenbo Dong, Yanlin Wu. Mechanism of the improved Fe(III)/persulfate reaction by gallic acid for ibuprofen degradation. Environmental pollution (Barking, Essex : 1987). 2022 Dec; 314(?):120318. doi: 10.1016/j.envpol.2022.120318. [PMID: 36183876]
  • Nara Lins Meira Quintão, Jaqueline Pavesi Reis, Larissa Benvenutti, Roberta Nunes, Fernanda Capitanio Goldoni, Manuela Somensi Cozer, Priscila de Souza, Rita de Cássia Melo Vilhena de Andrade Fonseca da Silva, Jessica Melato, Carlos Rafael Vaz, Juliana Cristina Pereira Whitaker, Flavia Werner Jesuíno, Mariana Couto Costa, Maria Verônica Dávila Pastor, Angela Malheiros, Christiane Meyre-Silva, José Roberto Santin. Involvement of a neutrophil-mast cell axis in the effects of Piper malacophyllum (C. PESL) C. DC extract and its isolated compounds in a mouse model of dysmenorrhoea. Inflammopharmacology. 2022 Dec; 30(6):2489-2504. doi: 10.1007/s10787-022-01032-9. [PMID: 35867292]
  • Tommaso Cai, Luca Gallelli, Erika Cione, Paolo Verze, Alessandro Palmieri, Vincenzo Mirone, Gernot Bonkat, Florian M Wagenlehner, Truls E Bjerklund Johansen. The efficacy and tolerability of pollen extract in combination with hyaluronic acid and vitamins in the management of patients affected by chronic prostatitis/chronic pelvic pain syndrome: a 26 weeks, randomized, controlled, single-blinded, phase III study. Minerva urology and nephrology. 2022 Dec; 74(6):780-788. doi: 10.23736/s2724-6051.21.04141-2. [PMID: 33781014]
  • Halina Falfushynska, Dmytro Poznanskyi, Nadiia Kasianchuk, Oksana Horyn, Oksana Bodnar. Multimarker Responses of Zebrafish to the Effect of Ibuprofen and Gemfibrozil in Environmentally Relevant Concentrations. Bulletin of environmental contamination and toxicology. 2022 Dec; 109(6):1010-1017. doi: 10.1007/s00128-022-03607-2. [PMID: 36074127]
  • Valentina I Merkus, Christina Sommer, Esther Smollich, Bernd Sures, Torsten C Schmidt. Acute ecotoxicological effects on daphnids and green algae caused by the ozonation of ibuprofen. The Science of the total environment. 2022 Nov; 847(?):157611. doi: 10.1016/j.scitotenv.2022.157611. [PMID: 35896135]
  • Hadis Goodarzi, Fatemeh Valizadeh, Fatemeh Ghasemi, Farzad Ebrahimzade, Seyedeh Hanieh Seifosadat, Bahram Delfan, Nadereh Taee. Comparing the effect of body wash with marshmallow plant and lukewarm water on reducing the temperature of febrile children: a randomized clinical trial. BMC complementary medicine and therapies. 2022 Nov; 22(1):293. doi: 10.1186/s12906-022-03762-3. [PMID: 36369081]
  • Naveen Chand, Surindra Suthar, Kapil Kumar, Vineet Singh. Removal of pharmaceuticals by vertical flow constructed wetland with different configurations: Effect of inlet load and biochar addition in the substrate. Chemosphere. 2022 Nov; 307(Pt 2):135975. doi: 10.1016/j.chemosphere.2022.135975. [PMID: 35944676]
  • Xiaoqing Ma, Guihua Duan, Hongfeng Chen, Ping Tang, Shunyu Su, Zhaoxia Wei, Jing Yang. Characterization of infected process and primary mechanism in rice Acuce defense against rice blast fungus, Magnaporthe oryzae. Plant molecular biology. 2022 Oct; 110(3):219-234. doi: 10.1007/s11103-022-01296-3. [PMID: 35759052]
  • Vaikunthavasan Thiruchenthooran, Marta Świtalska, Lorena Bonilla, Marta Espina, Maria Luisa García, Joanna Wietrzyk, Elena Sánchez-López, Anna Gliszczyńska. Novel Strategies against Cancer: Dexibuprofen-Loaded Nanostructured Lipid Carriers. International journal of molecular sciences. 2022 Sep; 23(19):. doi: 10.3390/ijms231911310. [PMID: 36232614]
  • Maria Eduarda Pierri, Lucas Morés, Gabrieli Bernardi, Eduardo Carasek. Multiclass determination of endocrine disruptors in urine by hollow fiber microporous membrane and liquid chromatography. Analytical biochemistry. 2022 09; 652(?):114725. doi: 10.1016/j.ab.2022.114725. [PMID: 35597269]
  • Yuhang Xu, Ye Cai, Yun Meng, Long Wu, Jingbao Chen, Wenxuan Cao, Xiaoqin Chu. Liposome and microemulsion loaded with ibuprofen: from preparation to mechanism of drug transport. Journal of microencapsulation. 2022 Sep; 39(6):539-551. doi: 10.1080/02652048.2022.2131920. [PMID: 36190415]
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