Creatine (BioDeep_00000001312)

 

Secondary id: BioDeep_00000229636, BioDeep_00000399880

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


[[Amino(imino)methyl](methyl)amino]acetic acid

化学式: C4H9N3O2 (131.0695)
中文名称: 肌肝酸, 肌酸, 无水肌酸
谱图信息: 最多检出来源 Homo sapiens(blood) 18.53%

Reviewed

Last reviewed on 2024-06-29.

Cite this Page

Creatine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/creatine (retrieved 2024-12-23) (BioDeep RN: BioDeep_00000001312). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CN(CC(=O)O)C(=N)N
InChI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9)

描述信息

Creatine, is a naturally occurring non-protein compound. It belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof. Creatine is found in all vertebrates where it facilitates recycling of adenosine triphosphate (ATP). Its primary metabolic role is to combine with a phosphoryl group, via the enzyme creatine kinase, to generate phosphocreatine, which is used to regenerate ATP. Most of the human bodys total creatine and phosphocreatine stores are found in skeletal muscle (95\\\\\%), while the remainder is distributed in the blood, brain, testes, and other tissues. Creatine is not an essential nutrient as it is naturally produced in the human body from the amino acids glycine and arginine, with an additional requirement for methionine to catalyze the transformation of guanidinoacetate to creatine. In the first step of its biosynthesis glycine and arginine are combined by the enzyme arginine:glycine amidinotransferase (AGAT) to form guanidinoacetate, which is then methylated by guanidinoacetate N-methyltransferase (GAMT), using S-adenosyl methionine as the methyl donor. Creatine can also be obtained through the diet at a rate of about 1 gram per day from an omnivorous diet. A cyclic form of creatine, called creatinine, exists in equilibrium with its tautomer and with creatine. Clinically, there are three distinct disorders of creatine metabolism. Deficiencies in the two synthesis enzymes (AGAT and GAMT) can cause L-arginine:glycine amidinotransferase deficiency (caused by variants in AGAT) and guanidinoacetate methyltransferase deficiency (caused by variants in GAMT). Both disorders are inherited in an autosomal recessive manner. A third defect, creatine transporter defect, is caused by mutations in SLC6A8 and inherited in a X-linked manner. Creatine is widely used as a supplement by athletes. Its use can increase maximum power and performance in high-intensity anaerobic repetitive work (periods of work and rest) by 5 to 15\\\\\% (PMID: 24688272). Creatine has no significant effect on aerobic endurance, although it will increase power during short sessions of high-intensity aerobic exercise (PMID: 9662683).
[Spectral] Creatine (exact mass = 131.06948) and L-Aspartate (exact mass = 133.03751) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions.
[Spectral] Creatine (exact mass = 131.06948) and L-Cysteine (exact mass = 121.01975) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions.
Creatine is a essential, non-proteinaceous amino acid found in all animals and in some plants. Creatine is synthesized in the kidney, liver and pancreas from L-arginine, glycine and L-methionine.

Creatine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=57-00-1 (retrieved 2024-06-29) (CAS RN: 57-00-1). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain.
Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain.

同义名列表

41 个代谢物同义名

[[Amino(imino)methyl](methyl)amino]acetic acid; ((Amino(imino)methyl)(methyl)amino)acetic acid; ((Amino(imino)methyl)(methyl)amino)acetate; [[Amino(imino)methyl](methyl)amino]acetate; N-[(e)-AMINO(imino)methyl]-N-methylglycine; 2-[carbamimidoyl(methyl)amino]acetic acid; 2-(N-methylcarbamimidamido)acetic acid; N-(Aminoiminomethyl)-N-methyl-glycine; (N-Methylcarbamimidamido)acetic acid; N-(Aminoiminomethyl)-N-methylglycine; α-Methylguanidino acetic acid; alpha-Methylguanidino acetic acid; (alpha-Methylguanido)acetic acid; (N-Methylcarbamimidamido)acetate; N-Carbamimidoyl-N-methylglycine; Α-methylguanidino acetic acid; a-Methylguanidino acetic acid; alpha-Methylguanidino acetate; (alpha-Methylguanido)acetate; (a-Methylguanido)acetic acid; (Α-methylguanido)acetic acid; Α-methylguanidino acetate; a-Methylguanidino acetate; Methylguanidoacetic acid; (Α-methylguanido)acetate; N-Methyl-N-guanylglycine; (a-Methylguanido)acetate; Methylguanidoacetate; Methylglycocyamine; N-Amidinosarcosine; Creatine,anhydrous; Creatine hydrate; Cosmocair C 100; Phosphagen; Krebiozon; creatine; Kreatin; Creatin; Creatine; Creatine; Creatine



数据库引用编号

52 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

79 个相关的代谢反应过程信息。

Reactome(12)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(3)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(63)

PharmGKB(0)

100 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Eman I Elgizawy, Ghada S Amer, Eman A Ali, Fatma S Alqalashy, Marwa M Ibrahim, Asmaa A Abdel Latif, Anwar M Shaban. Comparing the efficacy of concomitant treatment of resistance exercise and creatine monohydrate versus multiple individual therapies in age related sarcopenia. Scientific reports. 2024 04; 14(1):9798. doi: 10.1038/s41598-024-59884-w. [PMID: 38684784]
  • Gina Mabrey, Majid S Koozehchian, Andrew T Newton, Alireza Naderi, Scott C Forbes, Monoem Haddad. The Effect of Creatine Nitrate and Caffeine Individually or Combined on Exercise Performance and Cognitive Function: A Randomized, Crossover, Double-Blind, Placebo-Controlled Trial. Nutrients. 2024 Mar; 16(6):. doi: 10.3390/nu16060766. [PMID: 38542677]
  • Edgar Willibaldo Allebrandt Neto, Jadyellen Rondon E Silva, Stephanie Figueiredo Santos, Suélem Aparecida de França Lemes, Nair Honda Kawashita, Mayara Peron Pereira. The futile creatine cycle and the synthesis of fatty acids in inguinal white adipose tissue from growing rats, submitted to a hypoprotein-hyperglycidic diet for 15 days. Lipids. 2024 Jan; 59(1):3-12. doi: 10.1002/lipd.12384. [PMID: 38223990]
  • Stacy T Sims, Chad M Kerksick, Abbie E Smith-Ryan, Xanne A K Janse de Jonge, Katie R Hirsch, Shawn M Arent, Susan Joyce Hewlings, Susan M Kleiner, Erik Bustillo, Jaime L Tartar, Valerie G Starratt, Richard B Kreider, Casey Greenwalt, Liliana I Rentería, Michael J Ormsbee, Trisha A VanDusseldorp, Bill I Campbell, Douglas S Kalman, Jose Antonio. International society of sports nutrition position stand: nutritional concerns of the female athlete. Journal of the International Society of Sports Nutrition. 2023 Dec; 20(1):2204066. doi: 10.1080/15502783.2023.2204066. [PMID: 37221858]
  • Limeng Sun, Hu Yan, Ye Zhang. Magnetic resonance spectroscopy (MRS) of multifidus muscle metabolites in chronic low back pain (CLBP). European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 2023 12; 32(12):4397-4404. doi: 10.1007/s00586-023-07933-9. [PMID: 37721604]
  • Fayth M Butler, Jason Utt, Roy O Mathew, Carlos A Casiano, Suzanne Montgomery, Seth A Wiafe, Johanna W Lampe, Gary E Fraser. Plasma metabolomics profiles in Black and White participants of the Adventist Health Study-2 cohort. BMC medicine. 2023 10; 21(1):408. doi: 10.1186/s12916-023-03101-4. [PMID: 37904137]
  • Karrar Imad Abdulsahib Al-Shammari, Sarah Jasim Zamil, Justyna Batkowska. The antioxidative influence of dietary creatine monohydrate and L-carnitine on laying performance, egg quality, ileal microbiota, blood biochemistry, and redox status of stressed laying quails. Poultry science. 2023 Oct; 103(1):103166. doi: 10.1016/j.psj.2023.103166. [PMID: 37939584]
  • Afonso Morgado, Georgios Tsampoukas, Ioannis Sokolakis, Nadja Schoentgen, Ahmet Urkmez, Selcuk Sarikaya. Do "testosterone boosters" really increase serum total testosterone? A systematic review. International journal of impotence research. 2023 Sep; ?(?):. doi: 10.1038/s41443-023-00763-9. [PMID: 37697053]
  • Jed A Barash, Jeremy D Schmahmann, Zhongcong Xie, Michael H Lev, Georges El Fakhri. Longitudinal Imaging in a Patient With Opioid-associated Amnestic Syndrome. Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology. 2023 09; 36(3):194-197. doi: 10.1097/wnn.0000000000000347. [PMID: 37389894]
  • Luciano A González, Julia G S Carvalho, Bruno C Kuinchtner, Anthony C Dona, Pietro S Baruselli, Michael J D'Occhio. Plasma metabolomics reveals major changes in carbohydrate, lipid, and protein metabolism of abruptly weaned beef calves. Scientific reports. 2023 May; 13(1):8176. doi: 10.1038/s41598-023-35383-2. [PMID: 37210395]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Douglas Janes, Blaine Suehs, Delbert M Gatlin. Dietary creatine and guanidinoacetic acid supplementation have limited effects on hybrid striped bass. Fish physiology and biochemistry. 2023 Apr; ?(?):. doi: 10.1007/s10695-023-01196-3. [PMID: 37069332]
  • M Majdeddin, U Braun, A Lemme, A Golian, H Kermanshahi, S De Smet, J Michiels. Effects of feeding guanidinoacetic acid on oxidative status and creatine metabolism in broilers subjected to chronic cyclic heat stress in the finisher phase. Poultry science. 2023 Mar; 102(6):102653. doi: 10.1016/j.psj.2023.102653. [PMID: 37030259]
  • Yongjie Chen, Yanbin Jiang, Tianyu Cui, Lei Hou, Rong Zhao, Shumin Bo, Liying Zou, Chenghong Yin. Creatine ameliorates high-fat diet-induced obesity by regulation of lipolysis and lipophagy in brown adipose tissue and liver. Biochimie. 2023 Feb; 209(?):85-94. doi: 10.1016/j.biochi.2023.02.004. [PMID: 36773834]
  • Poliana C Marinello, Paola S Cella, Mayra T J Testa, Phillipe B Guirro, Walison Augusto da Silva Brito, Camila S Padilha, Alessandra L Cecchini, Robin P da Silva, José Alberto R Duarte, Rafael Deminice. Creatine supplementation protects against diet-induced non-alcoholic fatty liver but exacerbates alcoholic fatty liver. Life sciences. 2022 Dec; 310(?):121064. doi: 10.1016/j.lfs.2022.121064. [PMID: 36220368]
  • Yongxu Li, Taotao Lu, Wei Wei, Zhicheng Lin, Linlin Ding, Zhaohui Li, Xiehua Xue. Swimming Training Mitigates Neurological Impairment of Intracerebral Haemorrhage in Mice via the Serine-Threonine Kinase/Glycogen Synthase Kinase 3β Signalling Pathway. Neuroscience. 2022 10; 501(?):72-84. doi: 10.1016/j.neuroscience.2022.07.027. [PMID: 35961525]
  • Songyao Kang, Tingting Chen, Zhihui Hao, Xiao Yang, Mingfa Wang, Zhifang Zhang, Sijia Hao, Fengting Lang, Hongxia Hao. Oxymatrine Alleviates Gentamicin-Induced Renal Injury in Rats. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196209. [PMID: 36234739]
  • Qiong Fang, Jing Liu, Lang Chen, Qiaobin Chen, Yan Wang, Zuanfang Li, Wei Fu, Ying Liu. Taurine supplementation improves hippocampal metabolism in immature rats with intrauterine growth restriction (IUGR) through protecting neurons and reducing gliosis. Metabolic brain disease. 2022 08; 37(6):2077-2088. doi: 10.1007/s11011-021-00896-0. [PMID: 35048325]
  • İbrahim Ethem, Ceyhan Hacıoğlu. Effects of perilipin-5 on lipid metabolism and high-sensitivity cardiac troponin I. Revista da Associacao Medica Brasileira (1992). 2022 Aug; 68(8):1011-1016. doi: 10.1590/1806-9282.20211377. [PMID: 36134829]
  • Amelia L Parker, Leila Toulabi, Takahiro Oike, Yasuyuki Kanke, Daxeshkumar Patel, Takeshi Tada, Sheryse Taylor, Jessica A Beck, Elise Bowman, Michelle L Reyzer, Donna Butcher, Skyler Kuhn, Gary T Pauly, Kristopher W Krausz, Frank J Gonzalez, S Perwez Hussain, Stefan Ambs, Bríd M Ryan, Xin Wei Wang, Curtis C Harris. Creatine riboside is a cancer cell-derived metabolite associated with arginine auxotrophy. The Journal of clinical investigation. 2022 Jul; 132(14):. doi: 10.1172/jci157410. [PMID: 35838048]
  • Erica N Grodin, Steven J Nieto, Lindsay R Meredith, Elizabeth Burnette, Joseph O'Neill, Jeffry Alger, Edythe D London, Karen Miotto, Christopher J Evans, Michael R Irwin, Lara A Ray. Effects of ibudilast on central and peripheral markers of inflammation in alcohol use disorder: A randomized clinical trial. Addiction biology. 2022 07; 27(4):e13182. doi: 10.1111/adb.13182. [PMID: 35754106]
  • Nhi Thao Tran, Greg M Kowalski, Anna M Muccini, Ilias Nitsos, Nadia Hale, Rod J Snow, David W Walker, Stacey J Ellery. Creatine supplementation reduces the cerebral oxidative and metabolic stress responses to acute in utero hypoxia in the late-gestation fetal sheep. The Journal of physiology. 2022 07; 600(13):3193-3210. doi: 10.1113/jp282840. [PMID: 35587817]
  • Ming Shen, Guangming Yang, Zhehui Chen, Kai Yang, Hui Dong, Chengliang Yin, Yuxuan Cheng, Chunyan Zhang, Fangyan Gu, Yanling Yang, Yaping Tian. Identification of novel variations in SLC6A8 and GAMT genes causing cerebral creatine deficiency syndrome. Clinica chimica acta; international journal of clinical chemistry. 2022 Jul; 532(?):29-36. doi: 10.1016/j.cca.2022.05.006. [PMID: 35588794]
  • Laura Brugnara, Ana Isabel García, Serafín Murillo, Josep Ribalta, Guerau Fernandez, Susanna Marquez, Miguel Angel Rodriguez, Maria Vinaixa, Núria Amigó, Xavier Correig, Susana Kalko, Jaume Pomes, Anna Novials. Muscular carnosine is a marker for cardiorespiratory fitness and cardiometabolic risk factors in men with type 1 diabetes. European journal of applied physiology. 2022 Jun; 122(6):1429-1440. doi: 10.1007/s00421-022-04929-z. [PMID: 35298695]
  • Yi Lu, Peng Zhang, Hongdan Chen, Qingyi Tong, Jia Wang, Qing Li, Cheng Tian, Jian Yang, Senlin Li, Zijun Zhang, Huimin Yuan, Ming Xiang. Cytochalasin Q exerts anti-melanoma effect by inhibiting creatine kinase B. Toxicology and applied pharmacology. 2022 04; 441(?):115971. doi: 10.1016/j.taap.2022.115971. [PMID: 35276125]
  • Victor Augusto Ramos Fernandes, Maria Carolina Delforno, Giovanna Cavalcanti Banov, Mariana Shmayev, Julia Valencio Alves Leandro, Kadu Ferreira Gonçalves Teixeira, Amilton Iatecola, Marcel Fernando Inácio Cardozo, Eduardo José Caldeira, Marcelo Rodrigues da Cunha. Renal, hepatic and muscle effects of creatine supplementation in an older adults experimental model. Clinical nutrition ESPEN. 2022 04; 48(?):464-471. doi: 10.1016/j.clnesp.2021.12.020. [PMID: 35331530]
  • Gouri Rao Passi, Swati Pandey, Akella Radha Rama Devi, Ramesh Konanki, Abhishek Ravindra Jain, Shweta Bhatnagar, Ruchi Tripathi, Vivek Jain. Cerebral creatine deficiency disorders - A clinical, genetic and follow up study from India. Brain & development. 2022 Apr; 44(4):271-280. doi: 10.1016/j.braindev.2021.12.004. [PMID: 34974949]
  • Katie J Sikes, Anna McConnell, Natalie Serkova, Brian Cole, David Frisbie. Untargeted metabolomics analysis identifies creatine, myo-inositol, and lipid pathway modulation in a murine model of tendinopathy. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2022 04; 40(4):965-976. doi: 10.1002/jor.25112. [PMID: 34081345]
  • Gregory C Bogdanis, Mary E Nevill, George Aphamis, Pinelopi S Stavrinou, David G Jenkins, Christoforos D Giannaki, Henryk K A Lakomy, Clyde Williams. Effects of Oral Creatine Supplementation on Power Output during Repeated Treadmill Sprinting. Nutrients. 2022 Mar; 14(6):. doi: 10.3390/nu14061140. [PMID: 35334797]
  • Thaysa Mara Gazzotto Neves, Estefania Simoes, Maria Concepcíon García Otaduy, Elie Leal de Barros Calfat, Pâmela Bertolazzi, Naomi Antunes da Costa, Fábio Luís de Souza Duran, Joanna Correia-Lima, Maria da Graça Morais Martin, Marília Cerqueira Leite Seelander, Victor Henrique Oyamada Otani, Thais Zélia Dos Santos Otani, Daniel Augusto Corrêa Vasques, Geraldo Busatto Filho, Cristiane Kochi, Ricardo Riyoiti Uchida. Inverse Association Between Hypothalamic N-Acetyl Aspartate/Creatine Ratio and Indices of Body Mass in Adolescents with Obesity. The Journal of nutrition. 2022 03; 152(3):663-670. doi: 10.1093/jn/nxab415. [PMID: 34888674]
  • Ryuta Jomura, Shin-Ichi Akanuma, Masanori Tachikawa, Ken-Ichi Hosoya. SLC6A and SLC16A family of transporters: Contribution to transport of creatine and creatine precursors in creatine biosynthesis and distribution. Biochimica et biophysica acta. Biomembranes. 2022 03; 1864(3):183840. doi: 10.1016/j.bbamem.2021.183840. [PMID: 34921896]
  • Denise Schrama, Cláudia Raposo de Magalhães, Marco Cerqueira, Raquel Carrilho, Ana Paula Farinha, Ana M Rosa da Costa, Amparo Gonçalves, Annette Kuehn, Dominique Revets, Sébastien Planchon, Sofia Engrola, Pedro M Rodrigues. Effect of creatine and EDTA supplemented diets on European seabass (Dicentrarchus labrax) allergenicity, fish muscle quality and omics fingerprint. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 2022 03; 41(?):100941. doi: 10.1016/j.cbd.2021.100941. [PMID: 34814088]
  • Robin P da Silva. The Dietary Supplement Creatyl-l-Leucine Does Not Bioaccumulate in Muscle, Brain or Plasma and Is Not a Significant Bioavailable Source of Creatine. Nutrients. 2022 Feb; 14(3):. doi: 10.3390/nu14030701. [PMID: 35277060]
  • Adrian Post, Daan Kremer, J Casper Swarte, Sara Sokooti, Fabian A Vogelpohl, Dion Groothof, Ido P Kema, Erwin Garcia, Margery A Connelly, Theo Wallimann, Robin P F Dullaart, Casper F M Franssen, Stephan J L Bakker. Plasma creatine concentration is associated with incident hypertension in a cohort enriched for the presence of high urinary albumin concentration: the Prevention of Renal and Vascular Endstage Disease study. Journal of hypertension. 2022 02; 40(2):229-239. doi: 10.1097/hjh.0000000000002996. [PMID: 34371517]
  • Salwan Maqdasy, Simon Lecoutre, Gianluca Renzi, Scott Frendo-Cumbo, David Rizo-Roca, Thomas Moritz, Marta Juvany, Ondrej Hodek, Hui Gao, Morgane Couchet, Michael Witting, Alastair Kerr, Martin O Bergo, Robin P Choudhury, Myriam Aouadi, Juleen R Zierath, Anna Krook, Niklas Mejhert, Mikael Rydén. Impaired phosphocreatine metabolism in white adipocytes promotes inflammation. Nature metabolism. 2022 02; 4(2):190-202. doi: 10.1038/s42255-022-00525-9. [PMID: 35165448]
  • Laurence Kay, Lucia Potenza, Isabelle Hininger-Favier, Hubert Roth, Stéphane Attia, Cindy Tellier, Christian Zuppinger, Cinzia Calcabrini, Piero Sestili, Theo Wallimann, Uwe Schlattner, Malgorzata Tokarska-Schlattner. Supplementing Soy-Based Diet with Creatine in Rats: Implications for Cardiac Cell Signaling and Response to Doxorubicin. Nutrients. 2022 Jan; 14(3):. doi: 10.3390/nu14030583. [PMID: 35276943]
  • Meline Gomes Gonçalves, Matheus Anselmo Medeiros, Licyanne Ingrid Carvalho de Lemos, Lucia de Fátima Campos Pedrosa, Pedro Paulo de Andrade Santos, Bento João Abreu, João Paulo Matos Santos Lima. Effects of Creatine Supplementation on Histopathological and Biochemical Parameters in the Kidney and Pancreas of Streptozotocin-Induced Diabetic Rats. Nutrients. 2022 Jan; 14(3):. doi: 10.3390/nu14030431. [PMID: 35276790]
  • Kang Mao, Guwei Lu, Yanjiao Li, Yitian Zang, Xianghui Zhao, Qinghua Qiu, Mingren Qu, Kehui Ouyang. Effects of rumen-protected creatine pyruvate on blood biochemical parameters and rumen fluid characteristics in transported beef cattle. BMC veterinary research. 2022 Jan; 18(1):35. doi: 10.1186/s12917-021-03134-y. [PMID: 35033088]
  • Shiqi Zhang, Changjiang Zang, Jun Pan, Chen Ma, Caidie Wang, Xiaobin Li, Wenjie Cai, Kailun Yang. Effects of dietary guanidinoacetic acid on growth performance, guanidinoacetic acid absorption and creatine metabolism of lambs. PloS one. 2022; 17(3):e0264864. doi: 10.1371/journal.pone.0264864. [PMID: 35275964]
  • Xuefei Lin, Yongfang Liu, Yizhen Chen, Xiaodan Huang, Jundu Li, Yuansheng Hou, Miaoying Shen, Zaoqiang Lin, Ronglin Zhang, Haifeng Yang, Songlin Hong, Xusheng Liu, Chuan Zou. Prediction of prognosis in immunoglobulin a nephropathy patients with focal crescent by machine learning. PloS one. 2022; 17(3):e0265017. doi: 10.1371/journal.pone.0265017. [PMID: 35263356]
  • M V Matveeva, Yu G Samoilova, D A Kudlay. [Blood pressure variability and brain neuroimaging in patients with type 2 diabetes]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2022; 122(5):90-96. doi: 10.17116/jnevro202212205190. [PMID: 35611906]
  • Simon Franz, Gisela Skopp, Frank Musshoff. The effect of creatine ingestion on urinary creatinine concentration: Does supplementation mask a heavy dilution?. Drug testing and analysis. 2022 Jan; 14(1):162-168. doi: 10.1002/dta.3165. [PMID: 34559477]
  • Ye Sun, Ling Kong, Ai-Hua Zhang, Ying Han, Hui Sun, Guang-Li Yan, Xi-Jun Wang. A Hypothesis From Metabolomics Analysis of Diabetic Retinopathy: Arginine-Creatine Metabolic Pathway May Be a New Treatment Strategy for Diabetic Retinopathy. Frontiers in endocrinology. 2022; 13(?):858012. doi: 10.3389/fendo.2022.858012. [PMID: 35399942]
  • Satoshi Yamaguchi, Takayuki Hamano, Tatsufumi Oka, Yohei Doi, Sachio Kajimoto, Yusuke Sakaguchi, Akira Suzuki, Yoshitaka Isaka. Low-grade proteinuria and atherosclerotic cardiovascular disease: A transition study of patients with diabetic kidney disease. PloS one. 2022; 17(2):e0264568. doi: 10.1371/journal.pone.0264568. [PMID: 35213636]
  • M V Matveeva, Y G Samoilova, D A Kudlay. [Blood pressure variability and neuroplasticity in patients with type 2 diabetes mellitus]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2022; 122(3):78-84. doi: 10.17116/jnevro202212203178. [PMID: 35394724]
  • Sergej M Ostojic. Safety of Dietary Guanidinoacetic Acid: A Villain of a Good Guy?. Nutrients. 2021 Dec; 14(1):. doi: 10.3390/nu14010075. [PMID: 35010949]
  • Ajith Cherian, K P Divya. Cerebral creatine deficiency: Black cat in the coal cellar. Acta neurologica Belgica. 2021 Dec; 121(6):1859-1861. doi: 10.1007/s13760-020-01437-9. [PMID: 32681499]
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