Podocaric Acid (BioDeep_00000000870)

 

Secondary id: BioDeep_00000264852

PANOMIX_OTCML-2023 Volatile Flavor Compounds


代谢物信息卡片


(1S,4aS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethylphenanthrene-1-carboxylic acid;(1S,4aS,10aR)-6-hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid

化学式: C17H22O3 (274.15688620000003)
中文名称: 罗汉松酸
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 0.99%

分子结构信息

SMILES: C1CC[C@](C)(C(O)=O)[C@]2([H])CCC3=C([C@]21C)C=C(O)C=C3
InChI: InChI=1S/C17H22O3/c1-16-8-3-9-17(2,15(19)20)14(16)7-5-11-4-6-12(18)10-13(11)16/h4,6,10,14,18H,3,5,7-9H2,1-2H3,(H,19,20)

描述信息

Podocarpic acid is an abietane diterpenoid lacking the isopropyl substituent with an aromatic C-ring and a hydroxy group at the 12-position. It derives from a hydride of a podocarpane.
Podocarpic acid is a natural product found in Podocarpus fasciculus, Nageia wallichiana, and other organisms with data available.
Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a novel TRPA1 activator.

同义名列表

23 个代谢物同义名

(1S,4aS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethylphenanthrene-1-carboxylic acid;(1S,4aS,10aR)-6-hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid; 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethyl-, (1S-(1alpha,4aalpha,10abeta))-; 1-Phenanthrenecarboxylic acid,1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethyl-,(1S,4aS,10aR)-; (1S,4aS,10aR)-6-hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid; (1S,4AS,10aR)-1,2,3,4,4a,9,10,10a-octahydro-6-hydroxy-1,4a-dimethylphenanthrene-1-carboxylic acid; (1S,4aS,10aR)-6-hydroxy-1,4a-dimethyl-1,2,3,4,9,10,10a,4a-octahydrophenanthren ecarboxylic acid; (1S,4aS,10aR)-6-hydroxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylic acid; Podocarpa-8,11,13-trien-16-oic acid, 12-hydroxy- (VAN); 12-hydroxypodocarpa-8,11,13-trien-16-oic acid; Podocarpic acid, 98\\%; PODOCARPIC ACID [MI]; podo-carpic acid; UNII-7K80G5Z96Y; Podocarpic acid; Podocaric Acid; TimTec1_001673; Podocarpicacid; MEGxp0_001903; ACon0_000057; ACon1_002112; 7K80G5Z96Y; Podocarpa-8,11,13-trien-16-oic acid, 12-hydroxy-; Podocarpic acid



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Soumicha Mahdjour, Juan J Guardia, Fernando Rodríguez-Serrano, José Manuel Garrido, Isabel Blancas López-Barajas, Nuria Mut-Salud, Rachid Chahboun, Enrique Alvarez-Manzaneda. Synthesis and antiproliferative activity of podocarpane and totarane derivatives. European journal of medicinal chemistry. 2018 Oct; 158(?):863-873. doi: 10.1016/j.ejmech.2018.09.051. [PMID: 30248657]
  • Elina Karhu, Janne Isojärvi, Pia Vuorela, Leena Hanski, Adyary Fallarero. Identification of Privileged Antichlamydial Natural Products by a Ligand-Based Strategy. Journal of natural products. 2017 10; 80(10):2602-2608. doi: 10.1021/acs.jnatprod.6b01052. [PMID: 29043803]
  • Reiko Tanaka, Harukuni Tokuda, Yoichiro Ezaki. Cancer chemopreventive activity of "rosin" constituents of Pinus spez. and their derivatives in two-stage mouse skin carcinogenesis test. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2008 Nov; 15(11):985-92. doi: 10.1016/j.phymed.2008.02.020. [PMID: 18424098]
  • D J Bennett, E L Carswell, A J Cooke, A S Edwards, O Nimz. Design, structure activity relationships and X-Ray co-crystallography of non-steroidal LXR agonists. Current medicinal chemistry. 2008; 15(2):195-209. doi: 10.2174/092986708783330584. [PMID: 18220775]
  • Hiranthi Jayasuriya, Kithsiri B Herath, John G Ondeyka, Ziqiang Guan, Robert P Borris, Suroojnauth Tiwari, Wil de Jong, Flor Chavez, Jeremy Moss, Dennis W Stevenson, Hans T Beck, Marc Slattery, Nelson Zamora, Marvin Schulman, Aisha Ali, Neelam Sharma, Karen MacNaul, Nancy Hayes, John G Menke, Sheo B Singh. Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources. Journal of natural products. 2005 Aug; 68(8):1247-52. doi: 10.1021/np050182g. [PMID: 16124770]
  • Thanh Lam, Taotao Ling, Chinmay Chowdhury, Ta-Hsiang Chao, F R Bahjat, G K Lloyd, Lyle L Moldawer, Michael A Palladino, Emmanuel A Theodorakis. Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents. Bioorganic & medicinal chemistry letters. 2003 Oct; 13(19):3217-21. doi: 10.1016/s0960-894x(03)00669-3. [PMID: 12951096]
  • A E Fidler, S Zwart, R P Pharis, R J Weston, S B Lawrence, P Jansen, G Elliott, D V Merton. Screening the foods of an endangered parrot, the kakapo (Strigops habroptilus), for oestrogenic activity using a recombinant yeast bioassay. Reproduction, fertility, and development. 2000; 12(3-4):191-9. doi: 10.1071/rd00041. [PMID: 11302429]
  • K A Staschke, S D Hatch, J C Tang, W J Hornback, J E Munroe, J M Colacino, M A Muesing. Inhibition of influenza virus hemagglutinin-mediated membrane fusion by a compound related to podocarpic acid. Virology. 1998 Sep; 248(2):264-74. doi: 10.1006/viro.1998.9273. [PMID: 9721235]
  • T A Söderberg, A Johansson, R Gref. Toxic effects of some conifer resin acids and tea tree oil on human epithelial and fibroblast cells. Toxicology. 1996 Feb; 107(2):99-109. doi: 10.1016/0300-483x(95)03242-8. [PMID: 8599176]
  • A Johansson, B Sunzel, S E Holm, T Söderberg, R Gref. Antimicrobial screening of zinc in the absence or presence of oleoresins and various resin acids. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 1995 Jun; 103(6):419-27. doi: 10.1111/j.1699-0463.1995.tb01127.x. [PMID: 7546644]
  • E J Parish, D H Miles. Investigation of the antitumor activity of podocarpic acid derivatives. Journal of pharmaceutical sciences. 1984 May; 73(5):694-6. doi: 10.1002/jps.2600730528. [PMID: 6737247]
  • H H ZEISS, C E SLIMOWICZ, V Z PASTERNAK. Studies on resin acids; a direct reduction of podocarpic acid. Journal of the American Chemical Society. 1948 May; 70(5):1981. doi: 10.1021/ja01185a525. [PMID: 18861849]