Heptachlor exo-epoxide (BioDeep_00000009829)

 

Secondary id: BioDeep_00001873597

human metabolite blood metabolite


代谢物信息卡片


1,6,8,9,10,11,11-heptachloro-4-oxatetracyclo[6.2.1.0²,⁷.0³,⁵]undec-9-ene

化学式: C10H5Cl7O (385.816009)
中文名称: 外环氧七氯
谱图信息: 最多检出来源 Homo sapiens(blood) 85.71%

分子结构信息

SMILES: C12C(C(C3C1O3)Cl)C4(C(=C(C2(C4(Cl)Cl)Cl)Cl)Cl)Cl
InChI: InChI=1S/C10H5Cl7O/c11-3-1-2(4-5(3)18-4)9(15)7(13)6(12)8(1,14)10(9,16)17/h1-5H

描述信息

D010575 - Pesticides > D007306 - Insecticides
D016573 - Agrochemicals

同义名列表

5 个代谢物同义名

1,6,8,9,10,11,11-heptachloro-4-oxatetracyclo[6.2.1.0²,⁷.0³,⁵]undec-9-ene; Heptachlor epoxide [Isomer B]; Heptachlor exo-epoxide; Epoxide, heptachlor; HEPTACHLOR EPOXIDE



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Israel Castro-Ramirez, Diana Olivia Rocha-Amador, Tania Ruiz-Vera, Jorge Alejandro Alegría-Torres, Gustavo Cruz-Jiménez, Israel Enciso-Donis, Rogelio Costilla-Salazar. Environmental and biological monitoring of organochlorine pesticides in the city of Salamanca, Mexico. Environmental geochemistry and health. 2022 Sep; ?(?):. doi: 10.1007/s10653-022-01368-9. [PMID: 36066703]
  • Se-A Kim, Yu-Mi Lee, Ho-Won Lee, David R Jacobs, Duk-Hee Lee. Greater cognitive decline with aging among elders with high serum concentrations of organochlorine pesticides. PloS one. 2015; 10(6):e0130623. doi: 10.1371/journal.pone.0130623. [PMID: 26107947]
  • Ulrike Luderer, James S Kesner, Julie M Fuller, Edward F Krieg, Juliana W Meadows, Simone L Tramma, Haiou Yang, Dean Baker. Effects of gestational and lactational exposure to heptachlor epoxide on age at puberty and reproductive function in men and women. Environmental research. 2013 Feb; 121(?):84-94. doi: 10.1016/j.envres.2012.11.001. [PMID: 23194642]
  • Rong Xu, Jianwei Wu, Yougang Liu, Runhuai Zhao, Bo Chen, Meihua Yang, Jun Chen. Analysis of pesticide residues using the Quick Easy Cheap Effective Rugged and Safe (QuEChERS) pesticide multiresidue method in traditional Chinese medicine by gas chromatography with electron capture detection. Chemosphere. 2011 Aug; 84(7):908-12. doi: 10.1016/j.chemosphere.2011.06.013. [PMID: 21741067]
  • Hiroyuki Kojima, Fumihiro Sata, Shinji Takeuchi, Tatsuya Sueyoshi, Tadanori Nagai. Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. Toxicology. 2011 Feb; 280(3):77-87. doi: 10.1016/j.tox.2010.11.008. [PMID: 21115097]
  • Jian Xue, Lili Hao, Fei Peng. Residues of 18 organochlorine pesticides in 30 traditional Chinese medicines. Chemosphere. 2008 Apr; 71(6):1051-5. doi: 10.1016/j.chemosphere.2007.11.014. [PMID: 18160094]
  • Frank H Pierik, Mark A Klebanoff, John W Brock, Matthew P Longnecker. Maternal pregnancy serum level of heptachlor epoxide, hexachlorobenzene, and beta-hexachlorocyclohexane and risk of cryptorchidism in offspring. Environmental research. 2007 Nov; 105(3):364-9. doi: 10.1016/j.envres.2007.04.005. [PMID: 17532317]
  • Patrick S Y Wong, Fumio Matsumura. Serum free BG-1 cell proliferation assay: a sensitive method for determining organochlorine pesticide estrogen receptor activation at the nanomolar range. Toxicology in vitro : an international journal published in association with BIBRA. 2006 Apr; 20(3):382-94. doi: 10.1016/j.tiv.2005.08.016. [PMID: 16242299]
  • Mark E Hansen, Isaac N Pessah, Fumio Matsumura. Heptachlor epoxide induces a non-capacitative type of Ca2+ entry and immediate early gene expression in mouse hepatoma cells. Toxicology. 2006 Mar; 220(2-3):218-31. doi: 10.1016/j.tox.2006.01.006. [PMID: 16469423]
  • Richard A Cassidy, George M Vaughan, Basil A Pruitt, Arthur D Mason. Xenoestrogens: do they lower survival after thermal injury?. Archives of environmental health. 2003 Sep; 58(9):597-604. doi: NULL. [PMID: 15369279]
  • Louis J Guillette, Peter M Vonier, John A McLachlan. Affinity of the alligator estrogen receptor for serum pesticide contaminants. Toxicology. 2002 Dec; 181-182(?):151-4. doi: 10.1016/s0300-483x(02)00272-x. [PMID: 12505301]
  • Wim J M Hegeman, Remi W P M Laane. Enantiomeric enrichment of chiral pesticides in the environment. Reviews of environmental contamination and toxicology. 2002; 173(?):85-116. doi: NULL. [PMID: 11776751]
  • E van Wyk, H Bouwman, H van der Bank, G H Verdoorn, D Hofmann. Persistent organochlorine pesticides detected in blood and tissue samples of vultures from different localities in South Africa. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2001 Jul; 129(3):243-64. doi: 10.1016/s1532-0456(01)90201-7. [PMID: 11461840]
  • R J Smialowicz, W C Williams, C B Copeland, M W Harris, D Overstreet, B J Davis, R E Chapin. The effects of perinatal/juvenile heptachlor exposure on adult immune and reproductive system function in rats. Toxicological sciences : an official journal of the Society of Toxicology. 2001 May; 61(1):164-75. doi: 10.1093/toxsci/61.1.164. [PMID: 11294987]
  • M E Hansen, F Matsumura. Down-regulation of particulate protein kinase Cepsilon and up-regulation of nuclear activator protein-1 DNA binding in liver following in vivo exposure of B6C3F1 male mice to heptachlor epoxide. Journal of biochemical and molecular toxicology. 2001; 15(1):1-14. doi: 10.1002/1099-0461(2001)15:1<1::aid-jbt1>3.0.co;2-0. [PMID: 11170310]
  • T M O'Hara, M M Krahn, D Boyd, P R Becker, L M Philo. Organochlorine contaminant levels in Eskimo harvested bowhead whales of arctic Alaska. Journal of wildlife diseases. 1999 Oct; 35(4):741-52. doi: 10.7589/0090-3558-35.4.741. [PMID: 10574534]
  • G W Miller, M L Kirby, A I Levey, J R Bloomquist. Heptachlor alters expression and function of dopamine transporters. Neurotoxicology. 1999 Aug; 20(4):631-7. doi: . [PMID: 10499361]
  • D F Matesic, H L Rupp, W J Bonney, R J Ruch, J E Trosko. Changes in gap-junction permeability, phosphorylation, and number mediated by phorbol ester and non-phorbol-ester tumor promoters in rat liver epithelial cells. Molecular carcinogenesis. 1994 Aug; 10(4):226-36. doi: 10.1002/mc.2940100407. [PMID: 8068183]
  • G Singh, A Dowman, F R Higginson, I G Fenton. Translocation of aged cyclodiene insecticide residues from soil into forage crops and pastures at various growth stages under field conditions. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 1992 Dec; 27(6):711-28. doi: 10.1080/03601239209372808. [PMID: 1460243]
  • H Mussalo-Rauhamaa, H Pyysalo, K Antervo. Heptachlor, heptachlor epoxide, and other chlordane compounds in Finnish plywood workers. Archives of environmental health. 1991 Nov; 46(6):340-6. doi: 10.1080/00039896.1991.9934400. [PMID: 1772258]
  • D B Baker, S Loo, J Barker. Evaluation of human exposure to the heptachlor epoxide contamination of milk in Hawaii. Hawaii medical journal. 1991 Mar; 50(3):108-12, 118. doi: NULL. [PMID: 2061027]
  • P A Stehr-Green, V W Burse, J C Wohlleb. Persistence of heptachlor in serum of people consuming contaminated dairy products. Lancet (London, England). 1988 Sep; 2(8610):570-1. doi: 10.1016/s0140-6736(88)92694-3. [PMID: 2900953]
  • R Murphy, C Harvey. Residues and metabolites of selected persistent halogenated hydrocarbons in blood specimens from a general population survey. Environmental health perspectives. 1985 May; 60(?):115-20. doi: 10.1289/ehp.8560115. [PMID: 2411534]
  • D R Clark, R K LaVal, M D Tuttle. Estimating pesticide burdens of bats from guano analyses. Bulletin of environmental contamination and toxicology. 1982 Aug; 29(2):214-20. doi: 10.1007/bf01606153. [PMID: 7126909]
  • G G Caldwell, S B Cannon, C B Pratt, R D Arthur. Serum pesticide levels in patients with childhood colorectal carcinoma. Cancer. 1981 Aug; 48(3):774-8. doi: 10.1002/1097-0142(19810801)48:3<774::aid-cncr2820480319>3.0.co;2-t. [PMID: 6166364]
  • M Feroz, M A Khan. Metabolism of 14C-heptachlor in goldfish (Carassius auratus). Archives of environmental contamination and toxicology. 1979; 8(5):519-31. doi: 10.1007/bf01055033. [PMID: 539836]
  • K Bencze, G Wildbrett. [Investigations on the influence of insecticides on autoxidation processes. X. Formation of peroxides from octadecenic acid methylester in the presence of water and chlorinated hydrocarbon insecticides (author's transl)]. Zeitschrift fur Lebensmittel-Untersuchung und -Forschung. 1975 Aug; 158(5):265-72. doi: 10.1007/bf01525474. [PMID: 1227164]
  • K Bencze, G Wildbrett. [Investigations on the influence of insecticides on autoxidation processes. XI. Formation of secondary metabolites from octadecenic acid methyl ester in the presence of water and chlorinated hydrocarbon insecticides (author's transl)]. Zeitschrift fur Lebensmittel-Untersuchung und -Forschung. 1975 Aug; 158(5):273-8. doi: 10.1007/bf01525475. [PMID: 1227165]
  • C H Walker, A C Craven, M Kurukgy. The metabolism of organochlorine compound by microsomal enzymes of the shag (Phalacrocorax aristotelis). Environmental physiology & biochemistry. 1975; 5(1):58-64. doi: . [PMID: 1140184]
  • R F Reidinger, D G Crabtree. Organochlorine residues in golden eagles, United States--March 1964-July 1971. Pesticides monitoring journal. 1974 Jun; 8(1):37-43. doi: NULL. [PMID: 4216005]