Lubiprostone (BioDeep_00000009522)

 

Secondary id: BioDeep_00001880030

human metabolite blood metabolite


代谢物信息卡片


7-[(2R,4aR,5S,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxo-octahydrocyclopenta[b]pyran-5-yl]heptanoic acid

化学式: C20H32F2O5 (390.2218)
中文名称: 鲁比前列素, 鲁比前列酮
谱图信息: 最多检出来源 Homo sapiens(blood) 9.96%

分子结构信息

SMILES: CCCCC(C1(CCC2C(O1)CC(=O)C2CCCCCCC(=O)O)O)(F)F
InChI: InChI=1S/C20H32F2O5/c1-2-3-11-19(21,22)20(26)12-10-15-14(16(23)13-17(15)27-20)8-6-4-5-7-9-18(24)25/h14-15,17,26H,2-13H2,1H3,(H,24,25)/t14-,15+,17+,20+/m0/s1

描述信息

Lubiprostone is a medication used in the management of idiopathic chronic constipation. It is a bicyclic fatty acid (prostaglandin E1 derivative) which acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. These secretions soften the stool, increase motility, and promote spontaneous bowel movements (SBM).
Same as: D04790

同义名列表

8 个代谢物同义名

7-[(2R,4aR,5S,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxo-octahydrocyclopenta[b]pyran-5-yl]heptanoic acid; 7-[2-(1,1-difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-yl]heptanoic acid; 7-[(2R,4AR,5S,7ar)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxo-octahydrocyclopenta[b]pyran-5-yl]heptanoate; Lubiprostone; 0211, SPI; RU-0211; Amitiza; RU-0211



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Sunny Z Hussain, Barrett Labrum, Shadreck Mareya, Stephen Stripling, Robert Clifford. Safety of Lubiprostone in Pediatric Patients With Functional Constipation: A Nonrandomized, Open-Label Trial. Journal of pediatric gastroenterology and nutrition. 2021 11; 73(5):572-578. doi: 10.1097/mpg.0000000000003280. [PMID: 34387619]
  • Takaaki Eguchi, Tetsuya Yoshizaki, Megumi Takagi, Seitaro Ikeoka, Hiroki Hashimura, Norihiro Okamoto, Masanori Matsumoto, Tatsuya Matsuda, Takahiro Miura, Kenji Momose, Takashi Otsuka, Toshiyuki Morisawa, Akihiko Okada. Risk Factors for Adverse Events in Patients with Chronic Constipation Following Lubiprostone Administration. Digestive diseases (Basel, Switzerland). 2021; 39(1):10-15. doi: 10.1159/000508864. [PMID: 32450563]
  • Tsuneo Takenaka, Mikio Zeniya, Soichiro Miura, Takahiro Amano. Symptomatic hyponatremia: a rare but reversible adverse reaction of lubiprostone. BMJ case reports. 2020 Mar; 13(3):. doi: 10.1136/bcr-2019-232438. [PMID: 32188606]
  • Mitsuhide Takeshita, Atsushi Tanaka, Tsukasa Nakamura, Eiichi Sato, Koichi Node. Effect of Lubiprostone on Urinary Protein Excretion: A Report of Two IgA Nephropathy Patients with Chronic Constipation. Internal medicine (Tokyo, Japan). 2019 Nov; 58(22):3255-3259. doi: 10.2169/internalmedicine.3158-19. [PMID: 31292404]
  • Janne P Capra, Sinikka M Eskelinen. MDCK cells are capable of water secretion and reabsorption in response to changes in the ionic environment. Canadian journal of physiology and pharmacology. 2017 Jan; 95(1):72-83. doi: 10.1139/cjpp-2016-0051. [PMID: 27901358]
  • Takayuki Kato, Yasushi Honda, Yusuke Kurita, Akito Iwasaki, Takamitsu Sato, Takaomi Kessoku, Shiori Uchiyama, Yuji Ogawa, Hidenori Ohkubo, Takuma Higurashi, Takeharu Yamanaka, Haruki Usuda, Koichiro Wada, Atsushi Nakajima. Lubiprostone improves intestinal permeability in humans, a novel therapy for the leaky gut: A prospective randomized pilot study in healthy volunteers. PloS one. 2017; 12(4):e0175626. doi: 10.1371/journal.pone.0175626. [PMID: 28410406]
  • Eikan Mishima, Shinji Fukuda, Hisato Shima, Akiyoshi Hirayama, Yasutoshi Akiyama, Yoichi Takeuchi, Noriko N Fukuda, Takehiro Suzuki, Chitose Suzuki, Akinori Yuri, Koichi Kikuchi, Yoshihisa Tomioka, Sadayoshi Ito, Tomoyoshi Soga, Takaaki Abe. Alteration of the Intestinal Environment by Lubiprostone Is Associated with Amelioration of Adenine-Induced CKD. Journal of the American Society of Nephrology : JASN. 2015 Aug; 26(8):1787-94. doi: 10.1681/asn.2014060530. [PMID: 25525179]
  • John Cuppoletti, Anthony T Blikslager, Jayati Chakrabarti, Prashant K Nighot, Danuta H Malinowska. Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular homeostasis after exposure to cell stressors. BMC pharmacology. 2012 May; 12(?):3. doi: 10.1186/1471-2210-12-3. [PMID: 22553939]
  • Anthony J Lembo, John F Johanson, Henry P Parkman, Satish S Rao, Philip B Miner, Ryuji Ueno. Long-term safety and effectiveness of lubiprostone, a chloride channel (ClC-2) activator, in patients with chronic idiopathic constipation. Digestive diseases and sciences. 2011 Sep; 56(9):2639-45. doi: 10.1007/s10620-011-1801-0. [PMID: 21769655]
  • Guijun Fei, Kirsten Raehal, Sumei Liu, Mei-Hua Qu, Xiaohong Sun, Guo-Du Wang, Xi-Yu Wang, Yun Xia, Cullen L Schmid, Laura M Bohn, Jackie D Wood. Lubiprostone reverses the inhibitory action of morphine on intestinal secretion in guinea pig and mouse. The Journal of pharmacology and experimental therapeutics. 2010 Jul; 334(1):333-40. doi: 10.1124/jpet.110.166116. [PMID: 20406855]
  • Marcel J C Bijvelds, Alice G M Bot, Johanna C Escher, Hugo R De Jonge. Activation of intestinal Cl- secretion by lubiprostone requires the cystic fibrosis transmembrane conductance regulator. Gastroenterology. 2009 Sep; 137(3):976-85. doi: 10.1053/j.gastro.2009.05.037. [PMID: 19454284]
  • Richard T Owen. Lubiprostone--a novel treatment for irritable bowel syndrome with constipation. Drugs of today (Barcelona, Spain : 1998). 2008 Sep; 44(9):645-52. doi: 10.1358/dot.2008.44.9.1269852. [PMID: 19137119]
  • Emily M Ambizas, Regina Ginzburg. Lubiprostone: a chloride channel activator for treatment of chronic constipation. The Annals of pharmacotherapy. 2007 Jun; 41(6):957-64. doi: 10.1345/aph.1k047. [PMID: 17519292]
  • E N Nemchinov, O N Ankhimiuk. [Periarteritis nodosa complicated by perirenal hematoma]. Klinicheskaia meditsina. 1975 Jun; 53(6):122-3. doi: NULL. [PMID: 2801]