Syringomycin (BioDeep_00000911028)
代谢物信息卡片
Syringomycin
化学式: C53H85ClN14O17 (1224.590535)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCC(CC(=O)NC1COC(=O)C(NC(=O)C(NC(=O)C(=CC)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CO)CCN)CCN)CCCN=C(N)N)CC2=CC=CC=C2)C(C(=O)O)O)C(CCl)O)O
InChI: InChI=1S/C53H85ClN14O17/c1-3-5-6-7-8-9-13-17-30(70)25-39(72)60-37-28-85-52(84)40(38(71)26-54)67-50(81)41(42(73)51(82)83)68-43(74)31(4-2)61-47(78)35(24-29-15-11-10-12-16-29)65-44(75)32(18-14-23-59-53(57)58)62-45(76)33(19-21-55)63-46(77)34(20-22-56)64-48(79)36(27-69)66-49(37)80/h4,10-12,15-16,30,32-38,40-42,69-71,73H,3,5-9,13-14,17-28,55-56H2,1-2H3,(H,60,72)(H,61,78)(H,62,76)(H,63,77)(H,64,79)(H,65,75)(H,66,80)(H,67,81)(H,68,74)(H,82,83)(H4,57,58,59)/b31-4-/t30-,32-,33-,34+,35-,36+,37-,38+,40-,41-,42-/m0/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- M E Carezzano, J P Sotelo, E Primo, E B Reinoso, M F Paletti Rovey, M S Demo, W F Giordano, M de Las M Oliva. Inhibitory effect of Thymus vulgaris and Origanum vulgare essential oils on virulence factors of phytopathogenic Pseudomonas syringae strains.
Plant biology (Stuttgart, Germany).
2017 Jul; 19(4):599-607. doi:
10.1111/plb.12572. [PMID: 28403565] - Vanessa L Vaughn, Dennis C Gross. Characterization of salA, syrF, and syrG Genes and Attendant Regulatory Networks Involved in Plant Pathogenesis by Pseudomonas syringae pv. syringae B728a.
PloS one.
2016; 11(3):e0150234. doi:
10.1371/journal.pone.0150234. [PMID: 26954255] - Kevin L Hockett, Marc T Nishimura, Erick Karlsrud, Kevin Dougherty, David A Baltrus. Pseudomonas syringae CC1557: a highly virulent strain with an unusually small type III effector repertoire that includes a novel effector.
Molecular plant-microbe interactions : MPMI.
2014 Sep; 27(9):923-32. doi:
10.1094/mpmi-11-13-0354-r. [PMID: 24835253] - Poulami Basu Thakur, Vanessa L Vaughn-Diaz, Jessica W Greenwald, Dennis C Gross. Characterization of five ECF sigma factors in the genome of Pseudomonas syringae pv. syringae B728a.
PloS one.
2013; 8(3):e58846. doi:
10.1371/journal.pone.0058846. [PMID: 23516563] - Hye Suk Kong, Daniel P Roberts, Cheryl D Patterson, Sarah A Kuehne, Stephan Heeb, Dilip K Lakshman, John Lydon. Effect of overexpressing rsmA from Pseudomonas aeruginosa on virulence of select phytotoxin-producing strains of P. syringae.
Phytopathology.
2012 Jun; 102(6):575-87. doi:
10.1094/phyto-09-11-0267. [PMID: 22568815] - Gitanjali M Singh, Frédéric H Vaillancourt, Jun Yin, Christopher T Walsh. Characterization of SyrC, an aminoacyltransferase shuttling threonyl and chlorothreonyl residues in the syringomycin biosynthetic assembly line.
Chemistry & biology.
2007 Jan; 14(1):31-40. doi:
10.1016/j.chembiol.2006.11.005. [PMID: 17254950] - Nian Wang, Shi-En Lu, Angela R Records, Dennis C Gross. Characterization of the transcriptional activators SalA and SyrF, Which are required for syringomycin and syringopeptin production by Pseudomonas syringae pv. syringae.
Journal of bacteriology.
2006 May; 188(9):3290-8. doi:
10.1128/jb.188.9.3290-3298.2006. [PMID: 16621822] - Nian Wang, Shi-En Lu, Qingwu Yang, Sing-Hoi Sze, Dennis C Gross. Identification of the syr-syp box in the promoter regions of genes dedicated to syringomycin and syringopeptin production by Pseudomonas syringae pv. syringae B301D.
Journal of bacteriology.
2006 Jan; 188(1):160-8. doi:
10.1128/jb.188.1.160-168.2006. [PMID: 16352832] - Hyojeung Kang, Dennis C Gross. Characterization of a resistance-nodulation-cell division transporter system associated with the syr-syp genomic island of Pseudomonas syringae pv. syringae.
Applied and environmental microbiology.
2005 Sep; 71(9):5056-65. doi:
10.1128/aem.71.9.5056-5065.2005. [PMID: 16151087] - Hans Amrein, Stefan Makart, José Granado, Roshani Shakya, Jana Schneider-Pokorny, Robert Dudler. Functional analysis of genes involved in the synthesis of syringolin A by Pseudomonas syringae pv. syringae B301 D-R.
Molecular plant-microbe interactions : MPMI.
2004 Jan; 17(1):90-7. doi:
10.1094/mpmi.2004.17.1.90. [PMID: 14714872] - Shi-En Lu, Jonathan D Soule, Dennis C Gross. Characterization of the argA gene required for arginine biosynthesis and syringomycin production by Pseudomonas syringae pv. syringae.
Applied and environmental microbiology.
2003 Dec; 69(12):7273-80. doi:
10.1128/aem.69.12.7273-7280.2003. [PMID: 14660376] - Shi-En Lu, Brenda K Scholz-Schroeder, Dennis C Gross. Construction of pMEKm12, an expression vector for protein production in Pseudomonas syringae.
FEMS microbiology letters.
2002 Apr; 210(1):115-21. doi:
10.1111/j.1574-6968.2002.tb11169.x. [PMID: 12023087] - Shi-En Lu, Brenda K Scholz-Schroeder, Dennis C Gross. Characterization of the salA, syrF, and syrG regulatory genes located at the right border of the syringomycin gene cluster of Pseudomonas syringae pv. syringae.
Molecular plant-microbe interactions : MPMI.
2002 Jan; 15(1):43-53. doi:
10.1094/mpmi.2002.15.1.43. [PMID: 11843302] - B K Scholz-Schroeder, J D Soule, S E Lu, I Grgurina, D C Gross. A physical map of the syringomycin and syringopeptin gene clusters localized to an approximately 145-kb DNA region of Pseudomonas syringae pv. syringae strain B301D.
Molecular plant-microbe interactions : MPMI.
2001 Dec; 14(12):1426-35. doi:
10.1094/mpmi.2001.14.12.1426. [PMID: 11768538] - B K Scholz-Schroeder, M L Hutchison, I Grgurina, D C Gross. The contribution of syringopeptin and syringomycin to virulence of Pseudomonas syringae pv. syringae strain B301D on the basis of sypA and syrB1 biosynthesis mutant analysis.
Molecular plant-microbe interactions : MPMI.
2001 Mar; 14(3):336-48. doi:
10.1094/mpmi.2001.14.3.336. [PMID: 11277431] - C L Bender, F Alarcón-Chaidez, D C Gross. Pseudomonas syringae phytotoxins: mode of action, regulation, and biosynthesis by peptide and polyketide synthetases.
Microbiology and molecular biology reviews : MMBR.
1999 Jun; 63(2):266-92. doi:
10.1128/mmbr.63.2.266-292.1999. [PMID: 10357851] - M Dalla Serra, G Fagiuoli, P Nordera, I Bernhart, C Della Volpe, D Di Giorgio, A Ballio, G Menestrina. The interaction of lipodepsipeptide toxins from Pseudomonas syringae pv. syringae with biological and model membranes: a comparison of syringotoxin, syringomycin, and two syringopeptins.
Molecular plant-microbe interactions : MPMI.
1999 May; 12(5):391-400. doi:
10.1094/mpmi.1999.12.5.391. [PMID: 10226372] - F P Hu, J M Young, M J Fletcher. Preliminary description of biocidal (syringomycin) activity in fluorescent plant pathogenic Pseudomonas species.
Journal of applied microbiology.
1998 Aug; 85(2):365-71. doi:
10.1046/j.1365-2672.1998.00516.x. [PMID: 9750309] - T Kitten, T G Kinscherf, J L McEvoy, D K Willis. A newly identified regulator is required for virulence and toxin production in Pseudomonas syringae.
Molecular microbiology.
1998 Jun; 28(5):917-29. doi:
10.1046/j.1365-2958.1998.00842.x. [PMID: 9663679] - J H Zhang, N B Quigley, D C Gross. Analysis of the syrP gene, which regulates syringomycin synthesis by Pseudomonas syringae pv. syringae.
Applied and environmental microbiology.
1997 Jul; 63(7):2771-8. doi:
10.1128/aem.63.7.2771-2778.1997. [PMID: 9212424] - M L Hutchison, D C Gross. Lipopeptide phytotoxins produced by Pseudomonas syringae pv. syringae: comparison of the biosurfactant and ion channel-forming activities of syringopeptin and syringomycin.
Molecular plant-microbe interactions : MPMI.
1997 Apr; 10(3):347-54. doi:
10.1094/mpmi.1997.10.3.347. [PMID: 9100379] - A M Feigin, L V Schagina, J Y Takemoto, J H Teeter, J G Brand. The effect of sterols on the sensitivity of membranes to the channel-forming antifungal antibiotic, syringomycin E.
Biochimica et biophysica acta.
1997 Feb; 1324(1):102-10. doi:
10.1016/s0005-2736(96)00214-3. [PMID: 9059503] - A Ballio, F Bossa, L Camoni, D Di Giorgio, M C Flamand, H Maraite, G Nitti, P Pucci, A Scaloni. Structure of fuscopeptins, phytotoxic metabolites of Pseudomonas fuscovaginae.
FEBS letters.
1996 Mar; 381(3):213-6. doi:
10.1016/0014-5793(96)00043-9. [PMID: 8601458] - A M Feigin, J Y Takemoto, R Wangspa, J H Teeter, J G Brand. Properties of voltage-gated ion channels formed by syringomycin E in planar lipid bilayers.
The Journal of membrane biology.
1996 Jan; 149(1):41-7. doi:
10.1007/s002329900005. [PMID: 8825527] - F C Adetuyi, A Isogai, D Di Giorgio, A Ballio, J Y Takemoto. Saprophytic Pseudomonas syringae strain M1 of wheat produces cyclic lipodepsipeptides.
FEMS microbiology letters.
1995 Aug; 131(1):63-7. doi:
10.1016/0378-1097(95)00236-x. [PMID: 7557311] - M L Hutchison, M A Tester, D C Gross. Role of biosurfactant and ion channel-forming activities of syringomycin in transmembrane ion flux: a model for the mechanism of action in the plant-pathogen interaction.
Molecular plant-microbe interactions : MPMI.
1995 Jul; 8(4):610-20. doi:
10.1094/mpmi-8-0610. [PMID: 8589416] - J H Zhang, N B Quigley, D C Gross. Analysis of the syrB and syrC genes of Pseudomonas syringae pv. syringae indicates that syringomycin is synthesized by a thiotemplate mechanism.
Journal of bacteriology.
1995 Jul; 177(14):4009-20. doi:
10.1128/jb.177.14.4009-4020.1995. [PMID: 7608074] - J J Rich, T G Kinscherf, T Kitten, D K Willis. Genetic evidence that the gacA gene encodes the cognate response regulator for the lemA sensor in Pseudomonas syringae.
Journal of bacteriology.
1994 Dec; 176(24):7468-75. doi:
10.1128/jb.176.24.7468-7475.1994. [PMID: 8002569] - M Mazzola, F F White. A mutation in the indole-3-acetic acid biosynthesis pathway of Pseudomonas syringae pv. syringae affects growth in Phaseolus vulgaris and syringomycin production.
Journal of bacteriology.
1994 Mar; 176(5):1374-82. doi:
10.1128/jb.176.5.1374-1382.1994. [PMID: 8113177] - D K Willis, J J Rich, T G Kinscherf, T Kitten. Genetic regulation in plant pathogenic pseudomonads.
Genetic engineering.
1994; 16(?):167-93. doi:
". [PMID: 7765196] - N B Quigley, D C Gross. Syringomycin production among strains of Pseudomonas syringae pv. syringae: conservation of the syrB and syrD genes and activation of phytotoxin production by plant signal molecules.
Molecular plant-microbe interactions : MPMI.
1994 Jan; 7(1):78-90. doi:
10.1094/mpmi-7-0078. [PMID: 7909458] - J Y Takemoto, Y Yu, S D Stock, T Miyakawa. Yeast genes involved in growth inhibition by Pseudomonas syringae pv. syringae syringomycin family lipodepsipeptides.
FEMS microbiology letters.
1993 Dec; 114(3):339-42. doi:
10.1111/j.1574-6968.1993.tb06595.x. [PMID: 8288110] - N B Quigley, Y Y Mo, D C Gross. SyrD is required for syringomycin production by Pseudomonas syringae pathovar syringae and is related to a family of ATP-binding secretion proteins.
Molecular microbiology.
1993 Aug; 9(4):787-801. doi:
10.1111/j.1365-2958.1993.tb01738.x. [PMID: 8231810] - Y Y Mo, D C Gross. Plant signal molecules activate the syrB gene, which is required for syringomycin production by Pseudomonas syringae pv. syringae.
Journal of bacteriology.
1991 Sep; 173(18):5784-92. doi:
10.1128/jb.173.18.5784-5792.1991. [PMID: 1885550] - K Hiraga, H Tahara, N Taguchi, E Tsuchiya, S Fukui, T Miyakawa. Inhibition of membrane Ca2(+)-ATPase of Saccharomyces cerevisiae by mating pheromone alpha-factor in vitro.
Journal of general microbiology.
1991 Jan; 137(1):1-4. doi:
10.1099/00221287-137-1-1. [PMID: 1828496] - G W Xu, D C Gross. Physical and functional analyses of the syrA and syrB genes involved in syringomycin production by Pseudomonas syringae pv. syringae.
Journal of bacteriology.
1988 Dec; 170(12):5680-8. doi:
10.1128/jb.170.12.5680-5688.1988. [PMID: 2848010] - L Zhang, J Y Takemoto. Mechanism of action of Pseudomonas syringae phytotoxin, syringomycin. Interaction with the plasma membrane of wild-type and respiratory-deficient strains of Saccharomyces cerevisiae.
Biochimica et biophysica acta.
1986 Sep; 861(1):201-4. doi:
10.1016/0005-2736(86)90581-x. [PMID: 3530326]