2-Hydroxymyristate (BioDeep_00000901043)
代谢物信息卡片
化学式: C14H27O3- (243.196)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCC(C(=O)[O-])O
InChI: InChI=1S/C14H28O3/c1-2-3-4-5-6-7-8-9-10-11-12-13(15)14(16)17/h13,15H,2-12H2,1H3,(H,16,17)/p-1
描述信息
A 2-hydroxy fatty acid anion that is the conjugate base of 2-hydroxymyristic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.
同义名列表
1 个代谢物同义名
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jiaxuan Chen, Kirill S Lobachev, Brian J Grindel, Mary C Farach-Carson, Sharon L Hyzy, Khairat B El-Baradie, Rene Olivares-Navarrete, Maryam Doroudi, Barbara D Boyan, Zvi Schwartz. Chaperone properties of pdia3 participate in rapid membrane actions of 1α,25-dihydroxyvitamin d3.
Molecular endocrinology (Baltimore, Md.).
2013 Jul; 27(7):1065-77. doi:
10.1210/me.2012-1277. [PMID: 23660595] - Bertrand Boisson, Thierry Meinnel. A continuous assay of myristoyl-CoA:protein N-myristoyltransferase for proteomic analysis.
Analytical biochemistry.
2003 Nov; 322(1):116-23. doi:
10.1016/j.ab.2003.07.007. [PMID: 14705787] - M S Trent, A A Ribeiro, S Lin, R J Cotter, C R Raetz. An inner membrane enzyme in Salmonella and Escherichia coli that transfers 4-amino-4-deoxy-L-arabinose to lipid A: induction on polymyxin-resistant mutants and role of a novel lipid-linked donor.
The Journal of biological chemistry.
2001 Nov; 276(46):43122-31. doi:
10.1074/jbc.m106961200. [PMID: 11535604] - M S Trent, A A Ribeiro, W T Doerrler, S Lin, R J Cotter, C R Raetz. Accumulation of a polyisoprene-linked amino sugar in polymyxin-resistant Salmonella typhimurium and Escherichia coli: structural characterization and transfer to lipid A in the periplasm.
The Journal of biological chemistry.
2001 Nov; 276(46):43132-44. doi:
10.1074/jbc.m106962200. [PMID: 11535605] - Z Zhou, A A Ribeiro, S Lin, R J Cotter, S I Miller, C R Raetz. Lipid A modifications in polymyxin-resistant Salmonella typhimurium: PMRA-dependent 4-amino-4-deoxy-L-arabinose, and phosphoethanolamine incorporation.
The Journal of biological chemistry.
2001 Nov; 276(46):43111-21. doi:
10.1074/jbc.m106960200. [PMID: 11535603] - E B Denner, S Paukner, P Kämpfer, E R Moore, W R Abraham, H J Busse, G Wanner, W Lubitz. Sphingomonas pituitosa sp. nov., an exopolysaccharide-producing bacterium that secretes an unusual type of sphingan.
International journal of systematic and evolutionary microbiology.
2001 May; 51(Pt 3):827-41. doi:
10.1099/00207713-51-3-827. [PMID: 11411704] - C R Raetz. Regulated covalent modifications of lipid A.
Journal of endotoxin research.
2001; 7(1):73-8. doi:
". [PMID: 11521087] - H S Gibbons, S Lin, R J Cotter, C R Raetz. Oxygen requirement for the biosynthesis of the S-2-hydroxymyristate moiety in Salmonella typhimurium lipid A. Function of LpxO, A new Fe2+/alpha-ketoglutarate-dependent dioxygenase homologue.
The Journal of biological chemistry.
2000 Oct; 275(42):32940-9. doi:
10.1074/jbc.m005779200. [PMID: 10903325] - M Ishitani, J Liu, U Halfter, C S Kim, W Shi, J K Zhu. SOS3 function in plant salt tolerance requires N-myristoylation and calcium binding.
The Plant cell.
2000 Sep; 12(9):1667-78. doi:
10.1105/tpc.12.9.1667. [PMID: 11006339] - J S Gunn, R K Ernst, A J McCoy, S I Miller. Constitutive mutations of the Salmonella enterica serovar Typhimurium transcriptional virulence regulator phoP.
Infection and immunity.
2000 Jun; 68(6):3758-62. doi:
10.1128/iai.68.6.3758-3762.2000. [PMID: 10816543] - S M Cordo, N A Candurra, E B Damonte. Myristic acid analogs are inhibitors of Junin virus replication.
Microbes and infection.
1999 Jul; 1(8):609-14. doi:
10.1016/s1286-4579(99)80060-4. [PMID: 10611737] - M J Nadler, M L Harrison, C L Ashendel, J M Cassady, R L Geahlen. Treatment of T cells with 2-hydroxymyristic acid inhibits the myristoylation and alters the stability of p56lck.
Biochemistry.
1993 Sep; 32(35):9250-5. doi:
10.1021/bi00086a034. [PMID: 8103677]
