3-Mercaptopyruvate (BioDeep_00000897642)
代谢物信息卡片
化学式: C3H3O3S- (118.9803)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 97.66%
分子结构信息
SMILES: C(C(=O)C(=O)[O-])S
InChI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1
描述信息
The conjugate base of 3-mercaptopyruvic acid.
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
8 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(8)
- L-cysteine degradation III:
2-oxoglutarate + cys ⟶ 3-mercaptopyruvate + glt
- L-cysteine degradation III:
2-oxoglutarate + cys ⟶ 3-mercaptopyruvate + glt
- L-cysteine degradation II:
2-oxoglutarate + cys ⟶ 3-mercaptopyruvate + glu
- L-cysteine degradation III:
3-mercaptopyruvate + a reduced thioredoxin ⟶ an oxidized thioredoxin + hydrogen sulfide + pyruvate
- hydrogen sulfide biosynthesis I:
3-mercaptopyruvate ⟶ hydrogen sulfide + pyruvate
- hydrogen sulfide biosynthesis I:
2-oxoglutarate + cys ⟶ 3-mercaptopyruvate + glu
- hydrogen sulfide biosynthesis I:
2-oxoglutarate + cys ⟶ 3-mercaptopyruvate + glt
- hydrogen sulfide biosynthesis I:
2-oxoglutarate + cys ⟶ 3-mercaptopyruvate + glt
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Maher N Ibrahim, Abeer A Khalifa, Dalia A Hemead, Amira Ebrahim Alsemeh, Marwa A Habib. 1,25-Dihydroxycholecalciferol down-regulates 3-mercaptopyruvate sulfur transferase and caspase-3 in rat model of non-alcoholic fatty liver disease.
Journal of molecular histology.
2023 Apr; 54(2):119-134. doi:
10.1007/s10735-023-10118-9
. [PMID: 36930413] - Patrycja Bronowicka-Adamska, Anna Bentke, Małgorzata Lasota, Maria Wróbel. Effect of S-Allyl -L-Cysteine on MCF-7 Cell Line 3-Mercaptopyruvate Sulfurtransferase/Sulfane Sulfur System, Viability and Apoptosis.
International journal of molecular sciences.
2020 Feb; 21(3):. doi:
10.3390/ijms21031090
. [PMID: 32041330] - Michael Gröger, Martin Wepler, Ulrich Wachter, Tamara Merz, Oscar McCook, Sandra Kress, Britta Lukaschewski, Sebastian Hafner, Markus Huber-Lang, Enrico Calzia, Michael Georgieff, Noriyuki Nagahara, Csaba Szabó, Peter Radermacher, Clair Hartmann. The Effects of Genetic 3-Mercaptopyruvate Sulfurtransferase Deficiency in Murine Traumatic-Hemorrhagic Shock.
Shock (Augusta, Ga.).
2019 04; 51(4):472-478. doi:
10.1097/shk.0000000000001165
. [PMID: 29668565] - Norihiro Shibuya. [Production of H2S, H2Sn, and persulfide species (CysSSH and GSSH) by 3-mercaptopyruvate sulfurtransferase].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
2018; 152(5):216-222. doi:
10.1254/fpj.152.216
. [PMID: 30393252] - Saskia Höfler, Christin Lorenz, Tjorven Busch, Mascha Brinkkötter, Takayuki Tohge, Alisdair R Fernie, Hans-Peter Braun, Tatjana M Hildebrandt. Dealing with the sulfur part of cysteine: four enzymatic steps degrade l-cysteine to pyruvate and thiosulfate in Arabidopsis mitochondria.
Physiologia plantarum.
2016 Jul; 157(3):352-66. doi:
10.1111/ppl.12454
. [PMID: 27105581] - Yan Zhang, Jun Yang, Tao Wang, Shao-Gang Wang, Ji-Hong Liu, Chun-Ping Yin, Zhang-Qun Ye. Decreased Endogenous Hydrogen Sulfide Generation in Penile Tissues of Diabetic Rats with Erectile Dysfunction.
The journal of sexual medicine.
2016 Mar; 13(3):350-60. doi:
10.1016/j.jsxm.2016.01.002
. [PMID: 26853047] - Michael W Stutelberg, Joseph K Dzisam, Alexandre R Monteil, Ilona Petrikovics, Gerry R Boss, Steven E Patterson, Gary A Rockwood, Brian A Logue. Simultaneous determination of 3-mercaptopyruvate and cobinamide in plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Jan; 1008(?):181-188. doi:
10.1016/j.jchromb.2015.11.027
. [PMID: 26655110] - Ciro Coletta, Katalin Módis, Bartosz Szczesny, Attila Brunyánszki, Gábor Oláh, Ester C S Rios, Kazunori Yanagi, Akbar Ahmad, Andreas Papapetropoulos, Csaba Szabo. Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia and Restoration by DL-α-Lipoic Acid.
Molecular medicine (Cambridge, Mass.).
2015 Feb; 21(?):1-14. doi:
10.2119/molmed.2015.00035
. [PMID: 25715337] - Michael W Stutelberg, Chakravarthy V Vinnakota, Brendan L Mitchell, Alexandre R Monteil, Steven E Patterson, Brian A Logue. Determination of 3-mercaptopyruvate in rabbit plasma by high performance liquid chromatography tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Feb; 949-950(?):94-8. doi:
10.1016/j.jchromb.2014.01.006
. [PMID: 24480329] - Yong-Sheng Ren, Sheng-Ying Wu, Xing-Jun Wang, Fang Yu, Jing Zhao, Chao-Shu Tang, Jing-Ping Ouyang, Bin Geng. Multiple hemodynamic effects of endogenous hydrogen sulfide on central nervous system in rats.
Chinese medical journal.
2011 Nov; 124(21):3468-75. doi:
. [PMID: 22340160]
- D A Wing, S I Baskin. Modifiers of mercaptopyruvate sulfurtransferase catalyzed conversion of cyanide to thiocyanate in vitro.
Journal of biochemical toxicology.
1992; 7(2):65-72. doi:
10.1002/jbt.2570070203
. [PMID: 1404244] - H M Mousa, R H Davis. Alternative sulphur donors for detoxification of cyanide in the chicken.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.
1991; 99(3):309-15. doi:
10.1016/0742-8413(91)90247-q
. [PMID: 1685401] - J Mårtensson, L Nilsson, B Sörbo. The decarboxylation of 3-mercaptopyruvate to 2-mercaptoacetate.
FEBS letters.
1984 Oct; 176(2):334-6. doi:
10.1016/0014-5793(84)81191-6
. [PMID: 6489522] - S Kiguchi. Metabolism of 3-mercaptopyruvate in rat tissues.
Acta medica Okayama.
1983 Apr; 37(2):85-91. doi:
10.18926/amo/32415
. [PMID: 6869067] - U Hannestad, J Mårtensson, R Sjödahl, B Sörbo. 3-mercaptolactate cysteine disulfiduria: biochemical studies on affected and unaffected members of a family.
Biochemical medicine.
1981 Aug; 26(1):106-14. doi:
10.1016/0006-2944(81)90035-1
. [PMID: 6945862] - R Jarabak. 3-Mercaptopyruvate sulfurtransferase.
Methods in enzymology.
1981; 77(?):291-7. doi:
10.1016/s0076-6879(81)77040-x
. [PMID: 6948992] - . .
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. [PMID: 10601861]