Isovalerate (BioDeep_00000897359)
代谢物信息卡片
Isovalerate
化学式: C5H9O2- (101.0602514)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CC(=O)[O-]
InChI: InChI=1S/C5H10O2/c1-4(2)3-5(6)7/h4H,3H2,1-2H3,(H,6,7)/p-1
描述信息
A branched-chain saturated fatty acid anion that is the conjugate base of isovaleric acid; reported to improve ruminal fermentation and feed digestion in cattle.
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(3)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Elisa Schuh, Sina Cassau, Ahmed R Ismaieel, Regina Stieber, Jürgen Krieger, Bill S Hansson, Silke Sachse, Sonja Bisch-Knaden. Females smell differently: characteristics and significance of the most common olfactory sensilla of female silkmoths.
Proceedings. Biological sciences.
2024 Jan; 291(2015):20232578. doi:
10.1098/rspb.2023.2578. [PMID: 38228178] - Yiming Ni, Liangyin Cai, Xiaojun Gou, Wenjie Li, Mingmei Zhou, Ying Huang. Therapeutic effect of Sanhua decoction on rats with middle cerebral artery occlusion and the associated changes in gut microbiota and short-chain fatty acids.
PloS one.
2024; 19(2):e0298148. doi:
10.1371/journal.pone.0298148. [PMID: 38363776] - Zuren Li, Haodong Bai, Zhendong Bai, Jincai Han, Dingfeng Luo, Lianyang Bai. Multi-omics analysis identifies EcCS4 is negatively regulated in response to phytotoxin isovaleric acid stress in Echinochloa crus-galli.
Pest management science.
2023 Dec; ?(?):. doi:
10.1002/ps.7927. [PMID: 38088480] - Hui Li, Lihan Zhang, Rongshuang Huang, Qian Ren, Fan Guo, Min Shi, Letian Yang, Yang Yu, Liang Ma, Ping Fu. [Sichuan Dark Tea-Based Medicated Dietary Formula Improves Obesity-Induced Renal Lipid Metabolism Disorder in Mice by Remodeling Gut Microbiota and Short-Chain Fatty Acid Metabolism].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2023 Nov; 54(6):1112-1120. doi:
10.12182/20231160208. [PMID: 38162058] - Xiao-Na Huang, Chen-Yang Zhu, Yu-Zhen Li, Chun-Hui Jin. [Weidiao-3 Mixture Improves the Clinical Efficacy of Immunotherapy for Advanced Gastric Cancer by Regulating Intestinal Flora].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.
2023 Aug; 45(4):581-590. doi:
10.3881/j.issn.1000-503x.15496. [PMID: 37654138] - Krzysztof Kowalski, Bogumiła Szponar, Patrycja Bochen, Paulina Żebrowska-Różańska, Łukasz Łaczmański, Jerzy Samochowiec, Błażej Misiak. Altered levels of fecal short-chain fatty acids are associated with subclinical inflammation and worse cognitive performance in patients with schizophrenia.
Journal of psychiatric research.
2023 Jul; 165(?):298-304. doi:
10.1016/j.jpsychires.2023.07.042. [PMID: 37552919] - Hao Lin, Qingqing Guo, Zhiyong Wen, Songlin Tan, Jie Chen, Lijian Lin, Pengcheng Chen, Jianquan He, Jianbo Wen, Ye Chen. The multiple effects of fecal microbiota transplantation on diarrhea-predominant irritable bowel syndrome (IBS-D) patients with anxiety and depression behaviors.
Microbial cell factories.
2021 Dec; 20(1):233. doi:
10.1186/s12934-021-01720-1. [PMID: 34963452] - Lijun Ling, Yunhua Zhao, Yixin Tu, Caiyun Yang, Wenxia Ma, Shenglai Feng, Lu Lu, Ji Zhang. The inhibitory effect of volatile organic compounds produced by Bacillus subtilis CL2 on pathogenic fungi of wolfberry.
Journal of basic microbiology.
2021 Feb; 61(2):110-121. doi:
10.1002/jobm.202000522. [PMID: 33368461] - Paula Cordero-Pérez, Concepción Sánchez-Martínez, Pedro Alberto García-Hernández, Alma L Saucedo. Metabolomics of the diabetic nephropathy: behind the fingerprint of development and progression indicators.
Nefrologia.
2020 Nov; 40(6):585-596. doi:
10.1016/j.nefro.2020.07.002. [PMID: 33036786] - Naoki Nanashima, Maiko Kitajima, Shizuka Takamagi, Miyuki Fujioka, Toshiko Tomisawa. Comparison of Chemical Composition between Kuromoji (Lindera umbellata) Essential Oil and Hydrosol and Determination of the Deodorizing Effect.
Molecules (Basel, Switzerland).
2020 Sep; 25(18):. doi:
10.3390/molecules25184195. [PMID: 32933154] - Dannielle Kowacich, Eduardo Hatano, Coby Schal, Loganathan Ponnusamy, Charles S Apperson, Tatsiana Shymanovich, Gideon Wasserberg. The egg and larval pheromone dodecanoic acid mediates density-dependent oviposition of Phlebotomus papatasi.
Parasites & vectors.
2020 Jun; 13(1):280. doi:
10.1186/s13071-020-04151-w. [PMID: 32493498] - Jun-Juan Wang, Qi-Min Zhang, Wei-Wei Ni, Xin Zhang, Ying Li, Ai-Li Li, Peng Du, Chun Li, Su-Su Yu. Modulatory effect of Lactobacillus acidophilus KLDS 1.0738 on intestinal short-chain fatty acids metabolism and GPR41/43 expression in β-lactoglobulin-sensitized mice.
Microbiology and immunology.
2019 Aug; 63(8):303-315. doi:
10.1111/1348-0421.12723. [PMID: 31218724] - Jerzy Żuchowski, Łukasz Pecio, Beata Marciniak, Renata Kontek, Anna Stochmal. Unusual isovalerylated flavonoids from the fruit of sea buckthorn (Elaeagnus rhamnoides) grown in Sokółka, Poland.
Phytochemistry.
2019 Jul; 163(?):178-186. doi:
10.1016/j.phytochem.2019.03.001. [PMID: 30952449] - O P Brinda, Deepu Mathew, M R Shylaja, P Sangeetha Davis, K Anita Cherian, P A Valsala. Isovaleric acid and avicequinone-C are Chikungunya virus resistance principles in Glycosmis pentaphylla (Retz.) Correa.
Journal of vector borne diseases.
2019 Apr; 56(2):111-121. doi:
10.4103/0972-9062.263719. [PMID: 31397386] - Rían W Manville, Geoffrey W Abbott. Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket.
Nature communications.
2018 09; 9(1):3845. doi:
10.1038/s41467-018-06339-2. [PMID: 30242262] - Q Liu, C Wang, G Guo, W J Huo, Y L Zhang, C X Pei, S L Zhang, H Wang. Effects of isovalerate supplements on morphology and functional gene expression of rumen mucosa in pre- and post-weaning dairy calves.
Animal : an international journal of animal bioscience.
2018 Mar; 12(3):491-500. doi:
10.1017/s175173111700194x. [PMID: 28766470] - Paul M Ryan, Lis E E London, Trent C Bjorndahl, Rupasri Mandal, Kiera Murphy, Gerald F Fitzgerald, Fergus Shanahan, R Paul Ross, David S Wishart, Noel M Caplice, Catherine Stanton. Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E-/- mice.
Microbiome.
2017 03; 5(1):30. doi:
10.1186/s40168-017-0246-x. [PMID: 28285599] - María L Couce, Luís Aldamiz-Echevarría, María A Bueno, Patricia Barros, Amaya Belanger-Quintana, Javier Blasco, María-Teresa García-Silva, Ana M Márquez-Armenteros, Isidro Vitoria, Inmaculada Vives, Rosa Navarrete, Ana Fernández-Marmiesse, Belén Pérez, Celia Pérez-Cerdá. Genotype and phenotype characterization in a Spanish cohort with isovaleric acidemia.
Journal of human genetics.
2017 Mar; 62(3):355-360. doi:
10.1038/jhg.2016.144. [PMID: 27904153] - Yu V Holota, O O Holubenko, A M Ostapchuk, T M Serhiychuk, L V Zakordonets, G M Tolstanova. Fecal short-chain fatty acids at different time points after ceftriaxone administration in rats.
Ukrainian biochemical journal.
2017 Jan; 89(1):50-8. doi:
10.15407/ubj89.01.050. [PMID: 29236389] - Benjamin Kalbe, Marian Schlimm, Sebastian Wojcik, Stathis Philippou, Désirée Maßberg, Fabian Jansen, Paul Scholz, Hermann Luebbert, Burkhard Ubrig, Sabrina Osterloh, Hanns Hatt. Olfactory signaling components and olfactory receptors are expressed in tubule cells of the human kidney.
Archives of biochemistry and biophysics.
2016 Nov; 610(?):8-15. doi:
10.1016/j.abb.2016.09.017. [PMID: 27693121] - Olga Szczesniak, Knut A Hestad, Jon Fredrik Hanssen, Knut Rudi. Isovaleric acid in stool correlates with human depression.
Nutritional neuroscience.
2016 Sep; 19(7):279-83. doi:
10.1179/1476830515y.0000000007. [PMID: 25710209] - T Ya Vakhitov, N Chalisova, S I Sitkin. EFFECT OF CARBOXYLIC ACIDS OF GUT MICROBIAL ORIGIN ON HOST CELL PROLIFERATION IN ORGANOTYPIC TISSUE CULTURES.
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology.
2016 Jul; 12(12):73-82. doi:
. [PMID: 29889427] - Sonia Blasioli, Enrico Biondi, Devasena Samudrala, Francesco Spinelli, Antonio Cellini, Assunta Bertaccini, Simona M Cristescu, Ilaria Braschi. Identification of volatile markers in potato brown rot and ring rot by combined GC-MS and PTR-MS techniques: study on in vitro and in vivo samples.
Journal of agricultural and food chemistry.
2014 Jan; 62(2):337-47. doi:
10.1021/jf403436t. [PMID: 24313381] - Greta Jakobsdottir, Jens Holst Bjerregaard, Hanne Skovbjerg, Margareta Nyman. Fasting serum concentration of short-chain fatty acids in subjects with microscopic colitis and celiac disease: no difference compared with controls, but between genders.
Scandinavian journal of gastroenterology.
2013 Jun; 48(6):696-701. doi:
10.3109/00365521.2013.786128. [PMID: 23600961] - Mahmoud A Al-Qudah. Chemical composition and antimicrobial activity of the essential oil of Linum pubescens growing wild in Jordan.
Natural product research.
2013; 27(12):1141-4. doi:
10.1080/14786419.2012.715291. [PMID: 22913459] - Yong-Soo Seo, Hyang-Nam Bae, Sung-Hwan Eom, Keun-Sick Lim, In-Hye Yun, Yong-Hyun Chung, Jeong-Min Jeon, Hyun-Woo Kim, Myung-Suk Lee, Yang-Bong Lee, Young-Mog Kim. Removal of off-flavors from sea tangle (Laminaria japonica) extract by fermentation with Aspergillus oryzae.
Bioresource technology.
2012 Oct; 121(?):475-9. doi:
10.1016/j.biortech.2012.07.007. [PMID: 22840201] - Michael D Sharp, Nurdan A Kocaoglu-Vurma, Vaughan Langford, Luis E Rodriguez-Saona, W James Harper. Rapid discrimination and characterization of vanilla bean extracts by attenuated total reflection infrared spectroscopy and selected ion flow tube mass spectrometry.
Journal of food science.
2012 Mar; 77(3):C284-92. doi:
10.1111/j.1750-3841.2011.02544.x. [PMID: 22384952] - Tomás Rezanka, Ales Prell, Jaroslav Spízek, Karel Sigler. Pilot-plant cultivation of Streptomyces griseus producing homologues of nonactin by precursor-directed biosynthesis and their identification by LC/MS-ESI.
The Journal of antibiotics.
2010 Aug; 63(8):524-9. doi:
10.1038/ja.2010.93. [PMID: 20664602] - Bungo Shirouchi, Koji Nagao, Kenta Furuya, Toshiharu Nagai, Kenji Ichioka, Shigeru Tokairin, Yasuhiro Iida, Teruyoshi Yanagita. Physiological functions of iso-type short-chain fatty acid and omega 3 polyunsaturated fatty acids containing oil in obese OLETF rats.
Journal of oleo science.
2010; 59(6):299-305. doi:
10.5650/jos.59.299. [PMID: 20484835] - M L May, M J Quinn, C D Reinhardt, L Murray, M L Gibson, K K Karges, J S Drouillard. Effects of dry-rolled or steam-flaked corn finishing diets with or without twenty-five percent dried distillers grains on ruminal fermentation and apparent total tract digestion.
Journal of animal science.
2009 Nov; 87(11):3630-8. doi:
10.2527/jas.2008-0857. [PMID: 19648506] - Zoey P Zahorodny Duggan, Heather N Koopman, Suzanne M Budge. Distribution and development of the highly specialized lipids in the sound reception systems of dolphins.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology.
2009 Aug; 179(6):783-98. doi:
10.1007/s00360-009-0360-6. [PMID: 19373476] - D T Loots. Abnormal tricarboxylic acid cycle metabolites in isovaleric acidaemia.
Journal of inherited metabolic disease.
2009 Jun; 32(3):403-11. doi:
10.1007/s10545-009-1071-6. [PMID: 19343532] - Yun Weng, Tienyi Theresa Hsu, Jing Zhao, Stefanie Nishimura, Gerald G Fuller, James M Sonner. Isovaleric, methylmalonic, and propionic acid decrease anesthetic EC50 in tadpoles, modulate glycine receptor function, and interact with the lipid 1,2-dipalmitoyl-Sn-glycero-3-phosphocholine.
Anesthesia and analgesia.
2009 May; 108(5):1538-45. doi:
10.1213/ane.0b013e31819cd964. [PMID: 19372333] - T Atsumi, K Tonosaki, S Fujisawa. Salivary free radical-scavenging activity is affected by physical and mental activities.
Oral diseases.
2008 Sep; 14(6):490-6. doi:
10.1111/j.1601-0825.2007.01406.x. [PMID: 18826379] - Alexandre F Solano, Guilhian Leipnitz, Giorgia M De Bortoli, Bianca Seminotti, Alexandre U Amaral, Carolina G Fernandes, Alexandra S Latini, Carlos S Dutra-Filho, Moacir Wajner. Induction of oxidative stress by the metabolites accumulating in isovaleric acidemia in brain cortex of young rats.
Free radical research.
2008 Aug; 42(8):707-15. doi:
10.1080/10715760802311179. [PMID: 18661426] - Dominika Bal, Anna Kraska-Dziadecka, Wanda Gradowska, Adam Gryff-Keller. Investigation of a wide spectrum of inherited metabolic disorders by 13C NMR spectroscopy.
Acta biochimica Polonica.
2008; 55(1):107-18. doi:
10.18388/abp.2008_3103. [PMID: 18217108] - D T Loots, L J Mienie, E Erasmus. Amino-acid depletion induced by abnormal amino-acid conjugation and protein restriction in isovaleric acidemia.
European journal of clinical nutrition.
2007 Nov; 61(11):1323-7. doi:
10.1038/sj.ejcn.1602648. [PMID: 17299485] - Tang-Chia Chung, Mei-Chyn Chao, Hsin-Lung Wu. A sensitive liquid chromatographic method for the analysis of isovaleric and valeric acids in urine as fluorescent derivatives.
Journal of chromatography. A.
2007 Jul; 1156(1-2):259-63. doi:
10.1016/j.chroma.2007.03.009. [PMID: 17374376] - César A J Ribeiro, Fabrício Balestro, Vanessa Grando, Moacir Wajner. Isovaleric acid reduces Na+, K+-ATPase activity in synaptic membranes from cerebral cortex of young rats.
Cellular and molecular neurobiology.
2007 Jun; 27(4):529-40. doi:
10.1007/s10571-007-9143-3. [PMID: 17394058] - Gregory Kaler, David M Truong, Derina E Sweeney, Darren W Logan, Megha Nagle, Wei Wu, Satish A Eraly, Sanjay K Nigam. Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions.
Biochemical and biophysical research communications.
2006 Dec; 351(4):872-6. doi:
10.1016/j.bbrc.2006.10.136. [PMID: 17094945] - Carlo Dionisi-Vici, Federica Deodato, Wulf Röschinger, William Rhead, Bridget Wilcken. 'Classical' organic acidurias, propionic aciduria, methylmalonic aciduria and isovaleric aciduria: long-term outcome and effects of expanded newborn screening using tandem mass spectrometry.
Journal of inherited metabolic disease.
2006 Apr; 29(2-3):383-9. doi:
10.1007/s10545-006-0278-z. [PMID: 16763906] - Michael Klocke, Kerstin Mundt, Christine Idler, Joseph McEniry, Padraig O'Kiely, Susanne Barth. Monitoring Lactobacillus plantarum in grass silages with the aid of 16S rDNA-based quantitative real-time PCR assays.
Systematic and applied microbiology.
2006 Jan; 29(1):49-58. doi:
10.1016/j.syapm.2005.06.001. [PMID: 16423656] - Du Toit Loots, Elardus Erasmus, Lodewyk J Mienie. Identification of 19 new metabolites induced by abnormal amino acid conjugation in isovaleric acidemia.
Clinical chemistry.
2005 Aug; 51(8):1510-2. doi:
10.1373/clinchem.2005.048421. [PMID: 16040844] - Man-Jeong Paik, Hong-Jin Lee, Kyoung-Rae Kim. Simultaneous retention index analysis of urinary amino acids and carboxylic acids for graphic recognition of abnormal state.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Jul; 821(1):94-104. doi:
10.1016/j.jchromb.2005.04.011. [PMID: 15894518] - Lian-shu Han, Xiao-lan Gao, Jun Ye, Wen-juan Qiu, Xue-fan Gu. [Application of tandem mass spectrometry in diagnosis of organic acidemias].
Zhonghua er ke za zhi = Chinese journal of pediatrics.
2005 May; 43(5):325-30. doi:
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Analytical chemistry.
2005 Mar; 77(5):1282-9. doi:
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Journal of inherited metabolic disease.
2005; 28(4):457-65. doi:
10.1007/s10545-005-0457-3. [PMID: 15902548] - Chang-Ching Wei, Wei-De Lin, Fuu-Jen Tsai, Jer-Yuarn Wu, Ching-Tien Peng, Chang-Hai Tsai. Isovaleric acidemia diagnosed promptly by tandem mass spectrometry: report of one case.
Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi.
2004 Jul; 45(4):236-8. doi:
. [PMID: 15624372] - Ayten Sagiroglu, Azmi Telefoncu. Immobilization of lipases on different carriers and their use in synthesis of pentyl isovalerates.
Preparative biochemistry & biotechnology.
2004 May; 34(2):169-78. doi:
10.1081/pb-120030875. [PMID: 15195711] - S C Gardner, U Varanasi. Isovaleric acid accumulation in odontocete melon during development.
Die Naturwissenschaften.
2003 Nov; 90(11):528-31. doi:
10.1007/s00114-003-0472-x. [PMID: 14610653] - M T Gabler, A J Heinrichs. Altering soluble and potentially rumen degradable protein for prepubertal Holstein heifers.
Journal of dairy science.
2003 Jun; 86(6):2122-30. doi:
10.3168/jds.s0022-0302(03)73802-8. [PMID: 12836949] - H Ogier de Baulny, J M Saudubray. Branched-chain organic acidurias.
Seminars in neonatology : SN.
2002 Feb; 7(1):65-74. doi:
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Veterinary and human toxicology.
2001 Aug; 43(4):216-8. doi:
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Molecular genetics and metabolism.
2000 Apr; 69(4):302-11. doi:
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The Southeast Asian journal of tropical medicine and public health.
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Rapid communications in mass spectrometry : RCM.
1999; 13(4):279-84. doi:
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Journal of inherited metabolic disease.
1998 Aug; 21(6):624-30. doi:
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Journal of inherited metabolic disease.
1998 Apr; 21(2):136-40. doi:
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Harefuah.
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The Journal of pediatrics.
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The Tohoku journal of experimental medicine.
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Journal of chromatography. B, Biomedical applications.
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Journal of chromatography. B, Biomedical applications.
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Chemical senses.
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Prenatal diagnosis.
1995 Jun; 15(6):527-33. doi:
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Pediatric research.
1994 Aug; 36(2):182-6. doi:
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Pediatric research.
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Pediatric research.
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Proceedings of the National Academy of Sciences of the United States of America.
1991 Mar; 88(6):2366-9. doi:
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1990 Nov; 68(11):3821-31. doi:
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The British journal of dermatology.
1990 Jun; 122(6):771-6. doi:
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1989 Apr; 72(4):942-9. doi:
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Archiv fur experimentelle Veterinarmedizin.
1989 Jan; 43(1):81-96. doi:
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Clinical chemistry.
1989 Jan; 35(1):74-6. doi:
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Rapid communications in mass spectrometry : RCM.
1988 Dec; 2(12):269-72. doi:
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Archives of pathology & laboratory medicine.
1988 Nov; 112(11):1133-9. doi:
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1988 Jul; 24(1):9-13. doi:
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1987 May; 109(5):566-70. doi:
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The International journal of pediatric nephrology.
1986 Apr; 7(2):95-8. doi:
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Clinica chimica acta; international journal of clinical chemistry.
1986 Mar; 155(2):167-72. doi:
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1986 Mar; 40(2):183-94. doi:
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1986 Mar; 40(2):195-205. doi:
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Pediatric research.
1986 Mar; 20(3):222-6. doi:
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European journal of pediatrics.
1986 Feb; 144(5):451-6. doi:
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1986 Feb; 1(1):38-40. doi:
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1985 May; 341(1):1-10. doi:
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1985 Jan; 39(1):10-24. doi:
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1984 Dec; 74(6):2290-5. doi:
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Clinica chimica acta; international journal of clinical chemistry.
1984 Apr; 138(3):333-6. doi:
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1984 Feb; 37(2):117-9. doi:
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