4-Deoxypyridoxine (BioDeep_00000897211)
Volatile Flavor Compounds natural product
代谢物信息卡片
化学式: C8H11NO2 (153.0789746)
中文名称: 4-脱氧吡啶
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C(=NC=C1CO)C)O
InChI: InChI=1S/C8H11NO2/c1-5-7(4-10)3-9-6(2)8(5)11/h3,10-11H,4H2,1-2H3
描述信息
A pyridine ring substituted with methyl groups at positions 2 and 4, a hydroxyl at position 3, and a hydroxymethyl group at position 5.
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D000893 - Anti-Inflammatory Agents
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:65083
- PubChem: 6094
- ChEMBL: CHEMBL3244689
- CAS: 61-67-6
- MetaboLights: MTBLC65083
- LOTUS: LTS0204607
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
9 个相关的物种来源信息
- 2759 - Eukaryota: LTS0204607
- 3310 - Ginkgo: LTS0204607
- 3311 - Ginkgo biloba: 10.1021/JM010868F
- 3311 - Ginkgo biloba: LTS0204607
- 3309 - Ginkgoaceae: LTS0204607
- 29811 - Ginkgoopsida: LTS0204607
- 35493 - Streptophyta: LTS0204607
- 58023 - Tracheophyta: LTS0204607
- 33090 - Viridiplantae: LTS0204607
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Nasr Y A Hemdan, Cynthia Weigel, Christina-Maria Reimann, Markus H Gräler. Modulating sphingosine 1-phosphate signaling with DOP or FTY720 alleviates vascular and immune defects in mouse sepsis.
European journal of immunology.
2016 12; 46(12):2767-2777. doi:
10.1002/eji.201646417
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BioMed research international.
2016; 2016(?):3864193. doi:
10.1155/2016/3864193
. [PMID: 27800491] - Anja Lüth, Corinna Neuber, Burkhard Kleuser. Novel methods for the quantification of (2E)-hexadecenal by liquid chromatography with detection by either ESI QTOF tandem mass spectrometry or fluorescence measurement.
Analytica chimica acta.
2012 Apr; 722(?):70-9. doi:
10.1016/j.aca.2012.01.063
. [PMID: 22444536] - Yosuke Osawa, Ekihiro Seki, Yuzo Kodama, Atsushi Suetsugu, Kouichi Miura, Masayuki Adachi, Hiroyasu Ito, Yoshimune Shiratori, Yoshiko Banno, Jerrold M Olefsky, Masahito Nagaki, Hisataka Moriwaki, David A Brenner, Mitsuru Seishima. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2011 Apr; 25(4):1133-44. doi:
10.1096/fj.10-168351
. [PMID: 21163859] - Evgeny V Berdyshev, Irina Gorshkova, Peter Usatyuk, Satish Kalari, Yutong Zhao, Nigel J Pyne, Susan Pyne, Roger A Sabbadini, Joe G N Garcia, Viswanathan Natarajan. Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase.
PloS one.
2011 Jan; 6(1):e16571. doi:
10.1371/journal.pone.0016571
. [PMID: 21304987] - Francesca Tonelli, Keng Gat Lim, Carolyn Loveridge, Jaclyn Long, Stuart M Pitson, Gabor Tigyi, Robert Bittman, Susan Pyne, Nigel J Pyne. FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
Cellular signalling.
2010 Oct; 22(10):1536-42. doi:
10.1016/j.cellsig.2010.05.022
. [PMID: 20570726] - George F G Allen, Viruna Neergheen, Marcus Oppenheim, Julia C Fitzgerald, Emma Footitt, Keith Hyland, Peter T Clayton, John M Land, Simon J R Heales. Pyridoxal 5'-phosphate deficiency causes a loss of aromatic L-amino acid decarboxylase in patients and human neuroblastoma cells, implications for aromatic L-amino acid decarboxylase and vitamin B(6) deficiency states.
Journal of neurochemistry.
2010 Jul; 114(1):87-96. doi:
10.1111/j.1471-4159.2010.06742.x
. [PMID: 20403077] - Nora Salamon, Cristian Gurgui, Eckhard Leistner, Christel Drewke. Influence of antivitamins ginkgotoxin 5'-phosphate and deoxypyridoxine 5'-phosphate on human pyridoxine 5'-phosphate oxidase.
Planta medica.
2009 May; 75(6):563-7. doi:
10.1055/s-0029-1185482
. [PMID: 19288402] - M D Mostaqul Huq, Nien-Pei Tsai, Ya-Ping Lin, LeeAnn Higgins, Li-Na Wei. Vitamin B6 conjugation to nuclear corepressor RIP140 and its role in gene regulation.
Nature chemical biology.
2007 Mar; 3(3):161-5. doi:
10.1038/nchembio861
. [PMID: 17277785] - Hong Chen, Kangsen Mai, Wenbing Zhang, Zhiguo Liufu, Wei Xu, Beiping Tan. Effects of dietary pyridoxine on immune responses in abalone, Haliotis discus hannai Ino.
Fish & shellfish immunology.
2005 Sep; 19(3):241-52. doi:
10.1016/j.fsi.2004.12.006
. [PMID: 15820125] - Stavros Frydas, Nicolaos Papaioannou, Marcella Reale, Renato C Barbacane, Pio Conti. MCP-1 and MIP-2 response in Trichinella spiralis infected mice treated with 4-deoxypyridoxine (4-DPD).
Immunology letters.
2002 Aug; 83(1):31-7. doi:
10.1016/s0165-2478(02)00045-7
. [PMID: 12057852] - S J Chang. Vitamin B6 antagonists alter the function and ultrastructure of mice endothelial cells.
Journal of nutritional science and vitaminology.
2000 Aug; 46(4):149-53. doi:
10.3177/jnsv.46.149
. [PMID: 11185649] - S Frydas, M Reale, D Vacalis, R C Barbacane, F C Placido, I Cataldo, M Di Gioacchino, E Karagouni, E Dotsika, G Anogiannakis, A Trakatellis, P Conti. IgG, IgG1 and IgM response in Trichinella spiralis-infected mice treated with 4-deoxypirydoxine or fed a Vitamin B6-deficient diet.
Molecular and cellular biochemistry.
1999 Apr; 194(1-2):47-52. doi:
10.1023/a:1006996603605
. [PMID: 10391123] - S Frydas, E Karagouni, E Dotsika, M Reale, R C Barbacane, I Vlemmas, G Anogianakis, A Trakatellis, P Conti. Generation of TNF alpha, IFN gamma, IL-6, IL-4 and IL-10 in mouse serum from trichinellosis: effect of the anti-inflammatory compound 4-deoxypyridoxine (4-DPD).
Immunology letters.
1996 Mar; 49(3):179-84. doi:
10.1016/0165-2478(96)02501-1
. [PMID: 8739314] - S Fridas, A Trakatellis, E Karagouni, E Dotsika, C Himonas, P Conti. 4-Deoxypyridoxine inhibits chronic granuloma formation induced by potassium permanganate in vivo.
Molecular and cellular biochemistry.
1994 Jul; 136(1):59-63. doi:
10.1007/bf00931605
. [PMID: 7854332] - S P Coburn, J D Mahuren, B S Wostmann, D L Snyder, D W Townsend. Role of intestinal microflora in the metabolism of vitamin B-6 and 4'-deoxypyridoxine examined using germfree guinea pigs and rats.
The Journal of nutrition.
1989 Feb; 119(2):181-8. doi:
10.1093/jn/119.2.181
. [PMID: 2918389] - J L Hoover-Plow, Y N Sinha. The effects of vitamin B6 deprivation with 4-deoxypyridoxine in meal-fed rats.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1985 Feb; 178(2):234-9. doi:
10.3181/00379727-178-42004
. [PMID: 3969381] - A K Chatterjee, U Sadhu, B B Dalal, T Chatterjee. Studies on certain drug-metabolizing enzymes in deoxypyridoxine-treated rats.
Japanese journal of pharmacology.
1984 Apr; 34(4):367-73. doi:
10.1254/jjp.34.367
. [PMID: 6727075] - S P Coburn, J D Mahuren, W E Schaltenbrand, B S Wostmann, D Madsen. Effects of vitamin B-6 deficiency and 4'- deoxypyridoxine on pyridoxal phosphate concentrations, pyridoxine kinase and other aspects of metabolism in the rat.
The Journal of nutrition.
1981 Feb; 111(2):391-8. doi:
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. [PMID: 6257871] - R J Roberts. Bacterial diseases of farmed fishes.
Society for Applied Bacteriology symposium series.
1976; 4(?):55-62. doi:
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