Tauro-beta-muricholic acid (BioDeep_00000895847)

   

Bile acids


代谢物信息卡片


Tauro-beta-muricholic acid

化学式: C26H45NO7S (515.291658)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C1(CCC3C2C(C(C4C3(CCC(C4)O)C)O)O)C
InChI: InChI=1S/C26H45NO7S/c1-15(4-7-21(29)27-12-13-35(32,33)34)17-5-6-18-22-19(9-11-25(17,18)2)26(3)10-8-16(28)14-20(26)23(30)24(22)31/h15-20,22-24,28,30-31H,4-14H2,1-3H3,(H,27,29)(H,32,33,34)/t15-,16-,17-,18+,19+,20+,22+,23+,24-,25-,26-/m1/s1

描述信息

D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts
A bile acid taurine conjugate derived from beta-muricholic acid.
D005765 - Gastrointestinal Agents > D002793 - Cholic Acids

同义名列表

1 个代谢物同义名

Tauro-beta-muricholic acid



数据库引用编号

5 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

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INOH(0)

PlantCyc(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Zhifu Xie, Haowen Jiang, Wei Liu, Xinwen Zhang, Dakai Chen, Shuimei Sun, Chendong Zhou, Jia Liu, Sheng Bao, Xiachang Wang, Yinan Zhang, Jia Li, Lihong Hu, Jingya Li. The triterpenoid sapogenin (2α-OH-Protopanoxadiol) ameliorates metabolic syndrome via the intestinal FXR/GLP-1 axis through gut microbiota remodelling. Cell death & disease. 2020 09; 11(9):770. doi: 10.1038/s41419-020-02974-0. [PMID: 32943612]
  • Yongtao Xiao, Kejun Zhou, Ying Lu, Weihui Yan, Wei Cai, Ying Wang. Administration of antibiotics contributes to cholestasis in pediatric patients with intestinal failure via the alteration of FXR signaling. Experimental & molecular medicine. 2018 11; 50(12):1-14. doi: 10.1038/s12276-018-0181-3. [PMID: 30504803]
  • Evelyn Zöhrer, Katharina Meinel, Günter Fauler, Victor Aguiriano Moser, Theresa Greimel, Joachim Zobl, Axel Schlagenhauf, Jörg Jahnel. Neonatal sepsis leads to early rise of rare serum bile acid tauro-omega-muricholic acid (TOMCA). Pediatric research. 2018 07; 84(1):66-70. doi: 10.1038/s41390-018-0007-y. [PMID: 29795204]
  • Dong-Sheng Zhao, Li-Long Jiang, Ya-Xi Fan, Lei-Chi Dong, Jiang Ma, Xin Dong, Xiao-Jun Xu, Ping Li, Hui-Jun Li. Identification of urine tauro-β-muricholic acid as a promising biomarker in Polygoni Multiflori Radix-induced hepatotoxicity by targeted metabolomics of bile acids. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2017 Oct; 108(Pt B):532-542. doi: 10.1016/j.fct.2017.02.030. [PMID: 28237774]
  • Annika Wahlström, Petia Kovatcheva-Datchary, Marcus Ståhlman, Muhammad-Tanweer Khan, Fredrik Bäckhed, Hanns-Ulrich Marschall. Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota. Journal of lipid research. 2017 02; 58(2):412-419. doi: 10.1194/jlr.m072819. [PMID: 27956475]
  • Michael DiMarzio, Brigida Rusconi, Neela H Yennawar, Mark Eppinger, Andrew D Patterson, Edward G Dudley. Identification of a mouse Lactobacillus johnsonii strain with deconjugase activity against the FXR antagonist T-β-MCA. PloS one. 2017; 12(9):e0183564. doi: 10.1371/journal.pone.0183564. [PMID: 28910295]
  • Daniël A Lionarons, Michal Heger, Rowan F van Golen, Lindy K Alles, Vincent A van der Mark, Jaap J Kloek, Dirk R de Waart, Hendrik A Marsman, Henny Rusch, Joanne Verheij, Ulrich Beuers, Coen C Paulusma, Thomas M van Gulik. Simple steatosis sensitizes cholestatic rats to liver injury and dysregulates bile salt synthesis and transport. Scientific reports. 2016 08; 6(?):31829. doi: 10.1038/srep31829. [PMID: 27535001]
  • K E R Gooijert, R Havinga, H Wolters, R Wang, V Ling, S Tazuma, H J Verkade. The mechanism of increased biliary lipid secretion in mice with genetic inactivation of bile salt export pump. American journal of physiology. Gastrointestinal and liver physiology. 2015 Mar; 308(5):G450-7. doi: 10.1152/ajpgi.00391.2014. [PMID: 25552583]
  • Yunpeng Qi, Changtao Jiang, Jie Cheng, Kristopher W Krausz, Tiangang Li, Jessica M Ferrell, Frank J Gonzalez, John Y L Chiang. Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice. Biochimica et biophysica acta. 2015 Jan; 1851(1):19-29. doi: 10.1016/j.bbalip.2014.04.008. [PMID: 24796972]
  • Fei Li, Changtao Jiang, Kristopher W Krausz, Yunfei Li, Istvan Albert, Haiping Hao, Kristin M Fabre, James B Mitchell, Andrew D Patterson, Frank J Gonzalez. Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity. Nature communications. 2013; 4(?):2384. doi: 10.1038/ncomms3384. [PMID: 24064762]
  • Juan C García-Cañaveras, M Teresa Donato, José V Castell, Agustín Lahoz. Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method. Journal of lipid research. 2012 Oct; 53(10):2231-2241. doi: 10.1194/jlr.d028803. [PMID: 22822028]
  • K Uchida, T Satoh, S Narushima, K Itoh, H Takase, K Kuruma, H Nakao, N Yamaga, K Yamada. Transformation of bile acids and sterols by clostridia (fusiform bacteria) in Wistar rats. Lipids. 1999 Mar; 34(3):269-73. doi: 10.1007/s11745-999-0363-y. [PMID: 10230721]
  • K Kitani, S Kanai, Y Sato, M Ohta. Tauro alpha-muricholate is as effective as tauro beta-muricholate and tauroursodeoxycholate in preventing taurochenodeoxycholate-induced liver damage in the rat. Hepatology (Baltimore, Md.). 1994 Apr; 19(4):1007-12. doi: . [PMID: 8138240]
  • M B Thompson, D G Davis, R W Morris. Taurine conjugate of 3 alpha,6 beta,7 beta-trihydroxy-5 beta,22-cholen-24-oic acid (tauro-delta 22-beta-muricholate): the major bile acid in the serum of female rats treated with alpha-naphthylisothiocyanate and its secretion by liver slices. Journal of lipid research. 1993 Apr; 34(4):553-61. doi: NULL. [PMID: 8496661]
  • D G Davis, M B Thompson. Nuclear magnetic resonance identification of the taurine conjugate of 3 alpha,6 beta,7 beta-trihydroxy-5 beta,22-cholen-24-oic acid (tauro-delta 22-beta-muricholate) in the serum of female rats treated with alpha-naphthylisothiocyanate. Journal of lipid research. 1993 Apr; 34(4):651-61. doi: NULL. [PMID: 8388431]