Avizafone (BioDeep_00000008829)

   


代谢物信息卡片


(2S)-2,6-diamino-N-[2-(2-benzoyl-4-chloro-N-methylanilino)-2-oxoethyl]hexanamide

化学式: C22H27ClN4O3 (430.1771582)
中文名称: 阿维扎封
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN(C(=O)CNC(=O)C(N)CCCCN)c1ccc(Cl)cc1C(=O)c1ccccc1
InChI: InChI=1S/C22H27ClN4O3/c1-27(20(28)14-26-22(30)18(25)9-5-6-12-24)19-11-10-16(23)13-17(19)21(29)15-7-3-2-4-8-15/h2-4,7-8,10-11,13,18H,5-6,9,12,14,24-25H2,1H3,(H,26,30)/t18-/m0/s1

描述信息

C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent

同义名列表

4 个代谢物同义名

(2S)-2,6-diamino-N-[2-(2-benzoyl-4-chloro-N-methylanilino)-2-oxoethyl]hexanamide; Avizafone; LDZ; BCP13760



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Davin Rautiola, Patricia D Maglalang, Narsihmulu Cheryala, Kathryn M Nelson, Gunda I Georg, Jared M Fine, Aleta L Svitak, Katherine A Faltesek, Leah R Hanson, Usha Mishra, Lisa D Coles, James C Cloyd, Ronald A Siegel. Intranasal Coadministration of a Diazepam Prodrug with a Converting Enzyme Results in Rapid Absorption of Diazepam in Rats. The Journal of pharmacology and experimental therapeutics. 2019 09; 370(3):796-805. doi: 10.1124/jpet.118.255943. [PMID: 30837282]
  • M E Price, C L Whitmore, J E H Tattersall, A C Green, H Rice. Efficacy of the antinicotinic compound MB327 against soman poisoning - Importance of experimental end point. Toxicology letters. 2018 Sep; 293(?):167-171. doi: 10.1016/j.toxlet.2017.11.006. [PMID: 29127032]
  • Mamta Kapoor, Narsihmulu Cheryala, Davin Rautiola, Gunda I Georg, James C Cloyd, Ronald A Siegel. Chirally Pure Prodrugs and Their Converting Enzymes Lead to High Supersaturation and Rapid Transcellular Permeation of Benzodiazepines. Journal of pharmaceutical sciences. 2016 08; 105(8):2365-71. doi: 10.1016/j.xphs.2016.05.011. [PMID: 27342435]
  • Matthew E Price, Cerys J Docx, Helen Rice, Sarah J Fairhall, Sarah J C Poole, Michael Bird, Luke Whiley, Daniel P Flint, A Christopher Green, Christopher M Timperley, John E H Tattersall. Pharmacokinetic profile and quantitation of protection against soman poisoning by the antinicotinic compound MB327 in the guinea-pig. Toxicology letters. 2016 Feb; 244(?):154-160. doi: 10.1016/j.toxlet.2015.08.013. [PMID: 26325216]
  • Mamta Kapoor, Tate Winter, Lev Lis, Gunda I Georg, Ronald A Siegel. Rapid delivery of diazepam from supersaturated solutions prepared using prodrug/enzyme mixtures: toward intranasal treatment of seizure emergencies. The AAPS journal. 2014 May; 16(3):577-85. doi: 10.1208/s12248-014-9596-5. [PMID: 24700272]
  • Helen Mumford, Cerys J Docx, Matthew E Price, A Christopher Green, John E H Tattersall, Stuart J Armstrong. Human plasma-derived BuChE as a stoichiometric bioscavenger for treatment of nerve agent poisoning. Chemico-biological interactions. 2013 Mar; 203(1):160-6. doi: 10.1016/j.cbi.2012.08.018. [PMID: 22981459]
  • C Abbara, J M Rousseau, A Turcant, G Lallement, E Comets, I Bardot, P Clair, B Diquet. Bioavailability of diazepam after intramuscular injection of its water-soluble prodrug alone or with atropine-pralidoxime in healthy volunteers. British journal of pharmacology. 2009 Aug; 157(8):1390-7. doi: 10.1111/j.1476-5381.2009.00330.x. [PMID: 19681868]
  • Chadi Abbara, Isabelle Bardot, Annie Cailleux, Guy Lallement, Anne Le Bouil, Alain Turcant, Pascal Clair, Bertrand Diquet. High-performance liquid chromatography coupled with electrospray tandem mass spectrometry (LC/MS/MS) method for the simultaneous determination of diazepam, atropine and pralidoxime in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Oct; 874(1-2):42-50. doi: 10.1016/j.jchromb.2008.08.027. [PMID: 18805073]
  • L Taysse, J-H Calvet, J Buée, D Christin, S Delamanche, P Breton. Comparative efficacy of diazepam and avizafone against sarin-induced neuropathology and respiratory failure in guinea pigs: influence of atropine dose. Toxicology. 2003 Jun; 188(2-3):197-209. doi: 10.1016/s0300-483x(03)00086-6. [PMID: 12767691]
  • G Lallement, F Renault, D Baubichon, M Peoc'h, M F Burckhart, M Galonnier, D Clarençon, N Jourdil. Compared efficacy of diazepam or avizafone to prevent soman-induced electroencephalographic disturbances and neuropathology in primates: relationship to plasmatic benzodiazepine pharmacokinetics. Archives of toxicology. 2000 Oct; 74(8):480-6. doi: 10.1007/s002040000146. [PMID: 11097386]
  • B Karlsson, B Lindgren, E Millquist, M Sandberg, A Sellström. On the use of diazepam and pro-diazepam (2-benzoyl-4-chloro-N-methyl-N-lysylglycin anilide), as adjunct antidotes in the treatment of organophosphorus intoxication in the guinea-pig. The Journal of pharmacy and pharmacology. 1990 Apr; 42(4):247-51. doi: 10.1111/j.2042-7158.1990.tb05401.x. [PMID: 1974291]