Mikamycin B (BioDeep_00000008760)

 

Secondary id: BioDeep_00000897348, BioDeep_00001872263

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


N-(3-{[4-(dimethylamino)phenyl]methyl}-12-ethyl-4,16-dimethyl-2,5,11,14,18,21,24-heptaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentaazatricyclo[20.4.0.0⁶,¹⁰]hexacosan-15-yl)-3-hydroxypyridine-2-carboxamide

化学式: C45H54N8O10 (866.3962704)
中文名称: 维及霉素B
谱图信息: 最多检出来源 Homo sapiens(blood) 98.68%

分子结构信息

SMILES: C1C(=O)C[C@@H]2N(C1)C(=O)[C@H](N(C(=O)[C@H]1N(C(=O)[C@@H](NC(=O)[C@H]([C@H](OC(=O)[C@@H](NC2=O)c2ccccc2)C)NC(=O)c2c(cccn2)O)CC)CCC1)C)Cc1ccc(cc1)N(C)C
InChI: InChI=1S/C45H54N8O10/c1-6-31-42(59)52-22-11-14-32(52)43(60)51(5)34(24-27-16-18-29(19-17-27)50(3)4)44(61)53-23-20-30(54)25-33(53)39(56)49-37(28-12-8-7-9-13-28)45(62)63-26(2)36(40(57)47-31)48-41(58)38-35(55)15-10-21-46-38/h7-10,12-13,15-19,21,26,31-34,36-37,55H,6,11,14,20,22-25H2,1-5H3,(H,47,57)(H,48,58)(H,49,56)

描述信息

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D025361 - Streptogramins
Pristinamycin IA (Mikamycin B) is a cycle-peptidic macrolactone antibiotic. Pristinamycin IA is a substrate of P-glycoprotein and inhibits its function. Pristinamycin IA is active against StaphyloEoccus and Srreptococcus[1].

同义名列表

18 个代谢物同义名

N-(3-{[4-(dimethylamino)phenyl]methyl}-12-ethyl-4,16-dimethyl-2,5,11,14,18,21,24-heptaoxo-19-phenyl-17-oxa-1,4,10,13,20-pentaazatricyclo[20.4.0.0⁶,¹⁰]hexacosan-15-yl)-3-hydroxypyridine-2-carboxamide; 4-(4-(Dimethylamino)-N-methyl-L-phenylalanine)virginiamycin S1; 4-[4-(Dimethylamino)-N-methyl-L-phenylalanine]virginiamycin S1; Antibiotic PA 114B1; Vernamycin b alpha; Antibiotic PA 114B; Vernamycin Balpha; pristinamycin IA; Virginiamycin B; Streptogramin B; Vernamycin b a; Vernamycin b α; Osteogrycin b; Synergistin b; Mikamycin IA; Mikamycin B; NSC 92554; PA 114B



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Alicia G Beukers, Rahat Zaheer, Noriko Goji, Kingsley K Amoako, Alexandre V Chaves, Michael P Ward, Tim A McAllister. Comparative genomics of Enterococcus spp. isolated from bovine feces. BMC microbiology. 2017 03; 17(1):52. doi: 10.1186/s12866-017-0962-1. [PMID: 28270110]
  • Patricia Alba, Fabiola Feltrin, Gessica Cordaro, María Concepción Porrero, Britta Kraushaar, María Angeles Argudín, Suvi Nykäsenoja, Monica Monaco, Marc Stegger, Frank M Aarestrup, Patrick Butaye, Alessia Franco, Antonio Battisti. Livestock-Associated Methicillin Resistant and Methicillin Susceptible Staphylococcus aureus Sequence Type (CC)1 in European Farmed Animals: High Genetic Relatedness of Isolates from Italian Cattle Herds and Humans. PloS one. 2015; 10(8):e0137143. doi: 10.1371/journal.pone.0137143. [PMID: 26322785]
  • D Marosevic, D Cervinkova, H Vlkova, P Videnska, V Babak, Z Jaglic. In vivo spread of macrolide-lincosamide-streptogramin B (MLSB) resistance--a model study in chickens. Veterinary microbiology. 2014 Jul; 171(3-4):388-96. doi: 10.1016/j.vetmic.2013.12.017. [PMID: 24467930]
  • Lei Dai, Cong-Ming Wu, Ming-Gui Wang, Yang Wang, Yu Wang, Si-Yang Huang, Li-Ning Xia, Bei-Bei Li, Jian-Zhong Shen. First report of the multidrug resistance gene cfr and the phenicol resistance gene fexA in a Bacillus strain from swine feces. Antimicrobial agents and chemotherapy. 2010 Sep; 54(9):3953-5. doi: 10.1128/aac.00169-10. [PMID: 20585133]
  • Amani D Politano, Robert G Sawyer. NXL-103, a combination of flopristin and linopristin, for the potential treatment of bacterial infections including community-acquired pneumonia and MRSA. Current opinion in investigational drugs (London, England : 2000). 2010 Feb; 11(2):225-36. doi: . [PMID: 20112172]
  • Zhi Zhou, Lutgarde Raskin, Julie L Zilles. Macrolide resistance in microorganisms at antimicrobial-free Swine farms. Applied and environmental microbiology. 2009 Sep; 75(18):5814-20. doi: 10.1128/aem.00977-09. [PMID: 19633121]
  • J Chen, F L Fluharty, N St-Pierre, M Morrison, Z Yu. Technical note: Occurrence in fecal microbiota of genes conferring resistance to both macrolide-lincosamide-streptogramin B and tetracyclines concomitant with feeding of beef cattle with tylosin. Journal of animal science. 2008 Sep; 86(9):2385-91. doi: 10.2527/jas.2007-0705. [PMID: 18469042]