1H-Imidazole-4-carboxamide, 5-amino-1-(5-O-phosphono-beta-D-ribofuranosyl)- (BioDeep_00000871834)

Main id: BioDeep_00000002270

 

human metabolite PANOMIX_OTCML-2023 blood metabolite BioNovoGene_Lab2019 Volatile Flavor Compounds natural product


代谢物信息卡片


5-amino-1-{3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl}-1H-imidazole-4-carboximidic acid

化学式: C9H15N4O8P (338.062748)
中文名称: 5-氨基咪唑-4-甲酰胺-1-Β-D-呋喃核糖苷5-一磷酸盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=NC(=C(N1C2C(C(C(O2)COP(=O)(O)O)O)O)N)C(=O)N
InChI: InChI=1S/C9H15N4O8P/c10-7-4(8(11)16)12-2-13(7)9-6(15)5(14)3(21-9)1-20-22(17,18)19/h2-3,5-6,9,14-15H,1,10H2,(H2,11,16)(H2,17,18,19)

描述信息

Produced by the action of brewers yeast on the riboside. The 5-phosphate and its nontoxic salts are potent flavour enhancers of soups, canned foods, beverages, etc [DFC]. Acadesine 5-monophosphate is found in herbs and spices.

同义名列表

8 个代谢物同义名

5-amino-1-{3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl}-1H-imidazole-4-carboximidic acid; 5-amino-1-{3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl}imidazole-4-carboximidic acid; 1H-Imidazole-4-carboxamide, 5-amino-1-(5-O-phosphono-beta-D-ribofuranosyl)-; Acadesine 5-monophosphoric acid; Acadesine 5-monophosphate; Aica ribonucleotide; 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide; 5-Aminoimidazole-4-carboxamide-1-酓-ribofuranosyl 5'-monophosphate



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

26 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Marta Fernández-Galilea, Patricia Pérez-Matute, Pedro L Prieto-Hontoria, J Alfredo Martinez, Maria J Moreno-Aliaga. Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes. Journal of lipid research. 2012 Nov; 53(11):2296-306. doi: 10.1194/jlr.m027086. [PMID: 22941773]
  • Anthony J Cura, Anthony Carruthers. AMP kinase regulation of sugar transport in brain capillary endothelial cells during acute metabolic stress. American journal of physiology. Cell physiology. 2012 Oct; 303(8):C806-14. doi: 10.1152/ajpcell.00437.2011. [PMID: 22763120]
  • Seoung Ju Park, Kyung Sun Lee, So Ri Kim, Han Jung Chae, Wan Hee Yoo, Dong Im Kim, Myoung Shin Jeon, Yong Chul Lee. AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2012 Oct; 61(10):1069-83. doi: 10.1007/s00011-012-0499-6. [PMID: 22692279]
  • Edgar Sepúlveda-García, Mario Rocha-Sosa. The Arabidopsis F-box protein AtFBS1 interacts with 14-3-3 proteins. Plant science : an international journal of experimental plant biology. 2012 Oct; 195(?):36-47. doi: 10.1016/j.plantsci.2012.06.009. [PMID: 22920997]
  • Christina A Shugrue, Martine Alexandre, Alexander Diaz de Villalvilla, Thomas R Kolodecik, Lawrence H Young, Fred S Gorelick, Edwin C Thrower. Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation. American journal of physiology. Gastrointestinal and liver physiology. 2012 Sep; 303(6):G723-32. doi: 10.1152/ajpgi.00082.2012. [PMID: 22821946]
  • Eun Jeong Lee, Minseok Kang, Yeong Shik Kim. Platycodin D inhibits lipogenesis through AMPKα-PPARγ2 in 3T3-L1 cells and modulates fat accumulation in obese mice. Planta medica. 2012 Sep; 78(14):1536-42. doi: 10.1055/s-0032-1315147. [PMID: 22872592]
  • Boubacar Benziane, Marie Björnholm, Sergej Pirkmajer, Reginald L Austin, Olga Kotova, Benoit Viollet, Juleen R Zierath, Alexander V Chibalin. Activation of AMP-activated protein kinase stimulates Na+,K+-ATPase activity in skeletal muscle cells. The Journal of biological chemistry. 2012 Jul; 287(28):23451-63. doi: 10.1074/jbc.m111.331926. [PMID: 22610379]
  • J Lempiäinen, P Finckenberg, J Levijoki, E Mervaala. AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney. British journal of pharmacology. 2012 Jul; 166(6):1905-15. doi: 10.1111/j.1476-5381.2012.01895.x. [PMID: 22324445]
  • Fei-Wang, De-Run Tian, Patrick Tso, Ji-Sheng Han. Diet-induced obese rats exhibit impaired LKB1-AMPK signaling in hypothalamus and adipose tissue. Peptides. 2012 May; 35(1):23-30. doi: 10.1016/j.peptides.2012.02.003. [PMID: 22465622]
  • M F Chen, T T Yang, L R Yeh, H H Chung, Y J Wen, W J Lee, J T Cheng. Activation of imidazoline I-2B receptors by allantoin to increase glucose uptake into C₂C₁₂ cells. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2012 Apr; 44(4):268-72. doi: 10.1055/s-0032-1301898. [PMID: 22351479]
  • Nanthakumar Subramaniam, Mara H Sherman, Renuka Rao, Caroline Wilson, Sally Coulter, Annette R Atkins, Ronald M Evans, Christopher Liddle, Michael Downes. Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/β-catenin signaling. Cancer prevention research (Philadelphia, Pa.). 2012 Apr; 5(4):553-61. doi: 10.1158/1940-6207.capr-12-0053. [PMID: 22406377]
  • Bobby Bhatia, Chad R Potts, Cemile Guldal, SunPhil Choi, Andrey Korshunov, Stefan Pfister, Anna M Kenney, Zaher A Nahlé. Hedgehog-mediated regulation of PPARγ controls metabolic patterns in neural precursors and shh-driven medulloblastoma. Acta neuropathologica. 2012 Apr; 123(4):587-600. doi: 10.1007/s00401-012-0968-6. [PMID: 22407012]
  • Eun-Jeong Jung, Kang-Yo Lee, Byung-Hoon Lee. Proliferating effect of orotic acid through mTORC1 activation mediated by negative regulation of AMPK in SK-Hep1 hepatocellular carcinoma cells. The Journal of toxicological sciences. 2012; 37(4):813-21. doi: 10.2131/jts.37.813. [PMID: 22863860]
  • Seog Hyeon Youn, Jin Sun Lee, Myung Sun Lee, Eun Young Cha, Phuong Thien Thuong, Je Ryong Kim, Eil Sung Chang. Anticancer properties of pomolic acid-induced AMP-activated protein kinase activation in MCF7 human breast cancer cells. Biological & pharmaceutical bulletin. 2012; 35(1):105-10. doi: 10.1248/bpb.35.105. [PMID: 22223345]
  • Andrea Hirsch, Dagmar Hahn, Petra Kempná, Gaby Hofer, Primus E Mullis, Jean-Marc Nuoffer, Christa E Flück. Role of AMP-activated protein kinase on steroid hormone biosynthesis in adrenal NCI-H295R cells. PloS one. 2012; 7(1):e30956. doi: 10.1371/journal.pone.0030956. [PMID: 22295121]
  • Juan-Pablo Idrovo, Weng-Lang Yang, Akihisa Matsuda, Jeffrey Nicastro, Gene F Coppa, Ping Wang. Post-treatment with the combination of 5-aminoimidazole-4-carboxyamide ribonucleoside and carnitine improves renal function after ischemia/reperfusion injury. Shock (Augusta, Ga.). 2012 Jan; 37(1):39-46. doi: 10.1097/shk.0b013e31823185d7. [PMID: 21841537]
  • Joshua D Stone, Avinash Narine, David A Tulis. Inhibition of vascular smooth muscle growth via signaling crosstalk between AMP-activated protein kinase and cAMP-dependent protein kinase. Frontiers in physiology. 2012; 3(?):409. doi: 10.3389/fphys.2012.00409. [PMID: 23112775]
  • Takeo Iwata, Hisaaki Taniguchi, Masamichi Kuwajima, Takako Taniguchi, Yuko Okuda, Akiko Sukeno, Kyoko Ishimoto, Noriko Mizusawa, Katsuhiko Yoshimoto. The action of D-dopachrome tautomerase as an adipokine in adipocyte lipid metabolism. PloS one. 2012; 7(3):e33402. doi: 10.1371/journal.pone.0033402. [PMID: 22428043]
  • John P Fitzgerald, Bijaya Nayak, Karthigayan Shanmugasundaram, William Friedrichs, Sunil Sudarshan, Assaad A Eid, Thomas DeNapoli, Dipen J Parekh, Yves Gorin, Karen Block. Nox4 mediates renal cell carcinoma cell invasion through hypoxia-induced interleukin 6- and 8- production. PloS one. 2012; 7(1):e30712. doi: 10.1371/journal.pone.0030712. [PMID: 22303451]
  • Khang Wei Ong, Annie Hsu, Benny Kwong Huat Tan. Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes. PloS one. 2012; 7(3):e32718. doi: 10.1371/journal.pone.0032718. [PMID: 22412912]
  • Fernanda M Cerqueira, Laura I Brandizzi, Fernanda M Cunha, Francisco R M Laurindo, Alicia J Kowaltowski. Serum from calorie-restricted rats activates vascular cell eNOS through enhanced insulin signaling mediated by adiponectin. PloS one. 2012; 7(2):e31155. doi: 10.1371/journal.pone.0031155. [PMID: 22319612]
  • Jinmi Lee, Seok-Woo Hong, Seoung Wan Chae, Dong Hoon Kim, Ji Hun Choi, Ji Cheol Bae, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Sun-Woo Kim, Won-Young Lee. Exendin-4 improves steatohepatitis by increasing Sirt1 expression in high-fat diet-induced obese C57BL/6J mice. PloS one. 2012; 7(2):e31394. doi: 10.1371/journal.pone.0031394. [PMID: 22363635]
  • Carlos R Bueno Júnior, Lucas C Pantaleão, Vanessa A Voltarelli, Luiz Henrique M Bozi, Patricia Chakur Brum, Mayana Zatz. Combined effect of AMPK/PPAR agonists and exercise training in mdx mice functional performance. PloS one. 2012; 7(9):e45699. doi: 10.1371/journal.pone.0045699. [PMID: 23029189]
  • Peter F Mount, Kurt Gleich, Shanna Tam, Scott A Fraser, Suet-Wan Choy, Karen M Dwyer, Bo Lu, Bryce Van Denderen, Günter Fingerle-Rowson, Richard Bucala, Bruce E Kemp, David A Power. The outcome of renal ischemia-reperfusion injury is unchanged in AMPK-β1 deficient mice. PloS one. 2012; 7(1):e29887. doi: 10.1371/journal.pone.0029887. [PMID: 22253816]
  • Neil Auricchio, Izabela Malinowska, Reuben Shaw, Brendan D Manning, David J Kwiatkowski. Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC). PloS one. 2012; 7(2):e31900. doi: 10.1371/journal.pone.0031900. [PMID: 22363765]
  • Meenalakshmi M Mariappan. Signaling mechanisms in the regulation of renal matrix metabolism in diabetes. Experimental diabetes research. 2012; 2012(?):749812. doi: 10.1155/2012/749812. [PMID: 22454628]
  • E Maioli, C Torricelli, G Valacchi. Rottlerin and cancer: novel evidence and mechanisms. TheScientificWorldJournal. 2012; 2012(?):350826. doi: 10.1100/2012/350826. [PMID: 22272173]
  • Joan Smith Sonneborn. Alternative strategy for Alzheimer's disease: stress response triggers. International journal of Alzheimer's disease. 2012; 2012(?):684283. doi: 10.1155/2012/684283. [PMID: 22655213]
  • Yong-Qiang Liu, Xin Cheng, Liang-Xia Guo, Chan Mao, Yi-Jie Chen, Hai-Xia Liu, Qi-Cai Xiao, Sheng Jiang, Zhu-Jun Yao, Guang-Biao Zhou. Identification of an annonaceous acetogenin mimetic, AA005, as an AMPK activator and autophagy inducer in colon cancer cells. PloS one. 2012; 7(10):e47049. doi: 10.1371/journal.pone.0047049. [PMID: 23056575]
  • Mohamed Kodiha, Dennis Ho-Wo-Cheong, Ursula Stochaj. Pharmacological AMP-kinase activators have compartment-specific effects on cell physiology. American journal of physiology. Cell physiology. 2011 Dec; 301(6):C1307-15. doi: 10.1152/ajpcell.00309.2011. [PMID: 21918180]
  • Jianling Xie, Godwin A Ponuwei, Claire E Moore, Gary B Willars, Andrew R Tee, Terence P Herbert. cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity. Cellular signalling. 2011 Dec; 23(12):1927-35. doi: 10.1016/j.cellsig.2011.06.025. [PMID: 21763421]
  • S Guddat, E Solymos, A Orlovius, A Thomas, G Sigmund, H Geyer, M Thevis, W Schänzer. High-throughput screening for various classes of doping agents using a new 'dilute-and-shoot' liquid chromatography-tandem mass spectrometry multi-target approach. Drug testing and analysis. 2011 Nov; 3(11-12):836-50. doi: 10.1002/dta.372. [PMID: 22135086]
  • Yuichi Yokoyama, Kazuhiro Iguchi, Shigeyuki Usui, Kazuyuki Hirano. AMP-activated protein kinase modulates the gene expression of aquaporin 9 via forkhead box a2. Archives of biochemistry and biophysics. 2011 Nov; 515(1-2):80-8. doi: 10.1016/j.abb.2011.08.002. [PMID: 21867676]
  • Mamoru Tanida, Naoki Yamamoto. Central AMP-activated protein kinase affects sympathetic nerve activity in rats. Neuroscience letters. 2011 Oct; 503(3):167-70. doi: 10.1016/j.neulet.2011.08.013. [PMID: 21893163]
  • Marlies Bosselaar, Paul Smits, Luc J C van Loon, Cees J Tack. Intravenous AICAR during hyperinsulinemia induces systemic hemodynamic changes but has no local metabolic effect. Journal of clinical pharmacology. 2011 Oct; 51(10):1449-58. doi: 10.1177/0091270010382912. [PMID: 21148051]
  • Anita Thyagarajan-Sahu, Brandon Lane, Daniel Sliva. ReishiMax, mushroom based dietary supplement, inhibits adipocyte differentiation, stimulates glucose uptake and activates AMPK. BMC complementary and alternative medicine. 2011 Sep; 11(?):74. doi: 10.1186/1472-6882-11-74. [PMID: 21929808]
  • Eun-Jeong Jung, Sung-Won Kwon, Byung-Hwa Jung, Seon-Hee Oh, Byung-Hoon Lee. Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver. Journal of lipid research. 2011 Sep; 52(9):1617-25. doi: 10.1194/jlr.m015263. [PMID: 21757781]
  • Mandeep P Gaidhu, Andrea Frontini, Steven Hung, Kathryn Pistor, Saverio Cinti, Rolando B Ceddia. Chronic AMP-kinase activation with AICAR reduces adiposity by remodeling adipocyte metabolism and increasing leptin sensitivity. Journal of lipid research. 2011 Sep; 52(9):1702-11. doi: 10.1194/jlr.m015354. [PMID: 21737753]
  • Yanzhuo Ma, Yi Liu, Shaowei Liu, Yan Qu, Rutao Wang, Chenhai Xia, Haifeng Pei, Kun Lian, Tao Yin, Xiaoyan Lu, Lu Sun, Lu Yang, Yanjie Cao, Wayne Bond Lau, Erhe Gao, Haichang Wang, Ling Tao. Dynamic alteration of adiponectin/adiponectin receptor expression and its impact on myocardial ischemia/reperfusion in type 1 diabetic mice. American journal of physiology. Endocrinology and metabolism. 2011 Sep; 301(3):E447-55. doi: 10.1152/ajpendo.00687.2010. [PMID: 21586697]
  • Ruisheng An, Parwinder S Grewal. purL gene expression affects biofilm formation and symbiotic persistence of Photorhabdus temperata in the nematode Heterorhabditis bacteriophora. Microbiology (Reading, England). 2011 Sep; 157(Pt 9):2595-2603. doi: 10.1099/mic.0.048959-0. [PMID: 21700665]
  • Laura K M Steinbusch, Robert W Schwenk, D Margriet Ouwens, Michaela Diamant, Jan F C Glatz, Joost J F P Luiken. Subcellular trafficking of the substrate transporters GLUT4 and CD36 in cardiomyocytes. Cellular and molecular life sciences : CMLS. 2011 Aug; 68(15):2525-38. doi: 10.1007/s00018-011-0690-x. [PMID: 21547502]
  • Amber P Sanchez, JingHong Zhao, Young You, Anne-Emilie Declèves, Maggie Diamond-Stanic, Kumar Sharma. Role of the USF1 transcription factor in diabetic kidney disease. American journal of physiology. Renal physiology. 2011 Aug; 301(2):F271-9. doi: 10.1152/ajprenal.00221.2011. [PMID: 21543418]
  • Jean-Baptiste Menassol, Claire Tautou, Armelle Collet, Didier Chesneau, Didier Lomet, Joëlle Dupont, Benoît Malpaux, Rex J Scaramuzzi. The effect of an intracerebroventricular injection of metformin or AICAR on the plasma concentrations of melatonin in the ewe: potential involvement of AMPK?. BMC neuroscience. 2011 Jul; 12(?):76. doi: 10.1186/1471-2202-12-76. [PMID: 21801416]
  • Jimmy R Thériault, Helen J Palmer, Debra D Pittman. Inhibition of the Unfolded Protein Response by metformin in renal proximal tubular epithelial cells. Biochemical and biophysical research communications. 2011 Jun; 409(3):500-5. doi: 10.1016/j.bbrc.2011.05.034. [PMID: 21600878]
  • José M Cacicedo, Sunun Benjachareonwong, Eva Chou, Norito Yagihashi, Neil B Ruderman, Yasuo Ido. Activation of AMP-activated protein kinase prevents lipotoxicity in retinal pericytes. Investigative ophthalmology & visual science. 2011 Jun; 52(6):3630-9. doi: 10.1167/iovs.10-5784. [PMID: 21345991]
  • Eungseok Kim, Ning-Chun Liu, I-Chen Yu, Hung-Yun Lin, Yi-Fen Lee, Janet D Sparks, Lu-Min Chen, Chawnshang Chang. Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity. Diabetes. 2011 May; 60(5):1493-503. doi: 10.2337/db10-0393. [PMID: 21478464]
  • Erin E Mulvihill, Julia M Assini, Justin K Lee, Emma M Allister, Brian G Sutherland, Julie B Koppes, Cynthia G Sawyez, Jane Y Edwards, Dawn E Telford, Alexandre Charbonneau, Philippe St-Pierre, André Marette, Murray W Huff. Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance. Diabetes. 2011 May; 60(5):1446-57. doi: 10.2337/db10-0589. [PMID: 21471511]
  • Zeqin Lian, Yan Li, Jian Gao, Kai Qu, Jin Li, Linghua Hao, Song Wu, Haibo Zhu. A novel AMPK activator, WS070117, improves lipid metabolism discords in hamsters and HepG2 cells. Lipids in health and disease. 2011 Apr; 10(?):67. doi: 10.1186/1476-511x-10-67. [PMID: 21529359]
  • Magali Kitzmann, Louise Lantier, Sophie Hébrard, Jacques Mercier, Marc Foretz, Celine Aguer. Abnormal metabolism flexibility in response to high palmitate concentrations in myotubes derived from obese type 2 diabetic patients. Biochimica et biophysica acta. 2011 Apr; 1812(4):423-30. doi: 10.1016/j.bbadis.2010.12.007. [PMID: 21172433]
  • K V Lobanov, L Errais Lopes, N V Korol'kova, B V Tyaglov, A V Glazunov, R S Shakulov, A S Mironov. Reconstruction of Purine Metabolism in Bacillus subtilis to Obtain the Strain Producer of AICAR: A New Drug with a Wide Range of Therapeutic Applications. Acta naturae. 2011 Apr; 3(2):79-89. doi: . [PMID: 22649686]
  • Yun Wang, Zeyu Wu, Dan Li, Duan Wang, Xiaoming Wang, Xiang Feng, Min Xia. Involvement of oxygen-regulated protein 150 in AMP-activated protein kinase-mediated alleviation of lipid-induced endoplasmic reticulum stress. The Journal of biological chemistry. 2011 Apr; 286(13):11119-31. doi: 10.1074/jbc.m110.203323. [PMID: 21296878]
  • Douglas A Velásquez, Gloria Martínez, Amparo Romero, María J Vázquez, Katia D Boit, Iria G Dopeso-Reyes, Miguel López, Anxo Vidal, Ruben Nogueiras, Carlos Diéguez. The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin. Diabetes. 2011 Apr; 60(4):1177-85. doi: 10.2337/db10-0802. [PMID: 21386086]
  • Jakob G Jespersen, Anders Nedergaard, Søren Reitelseder, Ulla R Mikkelsen, Kasper J Dideriksen, Jakob Agergaard, Frederik Kreiner, Frank C Pott, Peter Schjerling, Michael Kjaer. Activated protein synthesis and suppressed protein breakdown signaling in skeletal muscle of critically ill patients. PloS one. 2011 Mar; 6(3):e18090. doi: 10.1371/journal.pone.0018090. [PMID: 21483870]
  • Jiyoung Yeo, Young-Mi Kang, Su-In Cho, Myeong-Ho Jung. Effects of a multi-herbal extract on type 2 diabetes. Chinese medicine. 2011 Mar; 6(?):10. doi: 10.1186/1749-8546-6-10. [PMID: 21375727]
  • Yumi Takiyama, Tatsuo Harumi, Jun Watanabe, Yukihiro Fujita, Jun Honjo, Norihiko Shimizu, Yuichi Makino, Masakazu Haneda. Tubular injury in a rat model of type 2 diabetes is prevented by metformin: a possible role of HIF-1α expression and oxygen metabolism. Diabetes. 2011 Mar; 60(3):981-92. doi: 10.2337/db10-0655. [PMID: 21282369]
  • Ioana Alesutan, Michael Föller, Mentor Sopjani, Miribane Dërmaku-Sopjani, Christine Zelenak, Henning Fröhlich, Ana Velic, Scott Fraser, Bruce E Kemp, Guiscard Seebohm, Harald Völkl, Florian Lang. Inhibition of the heterotetrameric K+ channel KCNQ1/KCNE1 by the AMP-activated protein kinase. Molecular membrane biology. 2011 Feb; 28(2):79-89. doi: 10.3109/09687688.2010.520037. [PMID: 21231794]
  • Ji-Woong Choi, Jae-Hwan Kim, Sung-Chun Cho, Moon-Kyung Ha, Kye-Yong Song, Hong-Duk Youn, Sang Chul Park. Malondialdehyde inhibits an AMPK-mediated nuclear translocation and repression activity of ALDH2 in transcription. Biochemical and biophysical research communications. 2011 Jan; 404(1):400-6. doi: 10.1016/j.bbrc.2010.11.131. [PMID: 21130747]
  • Anette I Öberg, Kamal Yassin, Robert I Csikasz, Nodi Dehvari, Irina G Shabalina, Dana S Hutchinson, Mona Wilcke, Claes-Göran Östenson, Tore Bengtsson. Shikonin increases glucose uptake in skeletal muscle cells and improves plasma glucose levels in diabetic Goto-Kakizaki rats. PloS one. 2011; 6(7):e22510. doi: 10.1371/journal.pone.0022510. [PMID: 21818330]
  • Xuan Tang, Jingjing Zhuang, Jing Chen, Liang Yu, Lihong Hu, Hualiang Jiang, Xu Shen. Arctigenin efficiently enhanced sedentary mice treadmill endurance. PloS one. 2011; 6(8):e24224. doi: 10.1371/journal.pone.0024224. [PMID: 21887385]
  • Ines Lohse, Patrick Reilly, Kathrin Zaugg. The CPT1C 5'UTR contains a repressing upstream open reading frame that is regulated by cellular energy availability and AMPK. PloS one. 2011; 6(9):e21486. doi: 10.1371/journal.pone.0021486. [PMID: 21961029]
  • Leigh Breen, Andrew Philp, Christopher S Shaw, Asker E Jeukendrup, Keith Baar, Kevin D Tipton. Beneficial effects of resistance exercise on glycemic control are not further improved by protein ingestion. PloS one. 2011; 6(6):e20613. doi: 10.1371/journal.pone.0020613. [PMID: 21701685]
  • Anne Sofie Andreasen, Meghan Kelly, Ronan Martin Griffin Berg, Kirsten Møller, Bente Klarlund Pedersen. Type 2 diabetes is associated with altered NF-κB DNA binding activity, JNK phosphorylation, and AMPK phosphorylation in skeletal muscle after LPS. PloS one. 2011; 6(9):e23999. doi: 10.1371/journal.pone.0023999. [PMID: 21931634]
  • Celine Aguer, Marc Foretz, Louise Lantier, Sophie Hebrard, Benoit Viollet, Jacques Mercier, Magali Kitzmann. Increased FAT/CD36 cycling and lipid accumulation in myotubes derived from obese type 2 diabetic patients. PloS one. 2011; 6(12):e28981. doi: 10.1371/journal.pone.0028981. [PMID: 22194967]
  • David Hauton. Does long-term metformin treatment increase cardiac lipoprotein lipase?. Metabolism: clinical and experimental. 2011 Jan; 60(1):32-42. doi: 10.1016/j.metabol.2009.12.015. [PMID: 20153488]
  • Miki Tadaishi, Shinji Miura, Yuko Kai, Yutaka Kano, Yuichi Oishi, Osamu Ezaki. Skeletal muscle-specific expression of PGC-1α-b, an exercise-responsive isoform, increases exercise capacity and peak oxygen uptake. PloS one. 2011; 6(12):e28290. doi: 10.1371/journal.pone.0028290. [PMID: 22174785]
  • Jørgen Jensen, Per Inge Rustad, Anders Jensen Kolnes, Yu-Chiang Lai. The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise. Frontiers in physiology. 2011; 2(?):112. doi: 10.3389/fphys.2011.00112. [PMID: 22232606]
  • Sergio Polakof, Stéphane Panserat, Paul M Craig, David J Martyres, Elisabeth Plagnes-Juan, Sharareh Savari, Stéphane Aris-Brosou, Thomas W Moon. The metabolic consequences of hepatic AMP-kinase phosphorylation in rainbow trout. PloS one. 2011; 6(5):e20228. doi: 10.1371/journal.pone.0020228. [PMID: 21625448]
  • Eugenia Villa-Cuesta, Joan M Boylan, Marc Tatar, Philip A Gruppuso. Resveratrol inhibits protein translation in hepatic cells. PloS one. 2011; 6(12):e29513. doi: 10.1371/journal.pone.0029513. [PMID: 22242130]
  • Marion Berenguer, Laurène Martinez, Sophie Giorgetti-Peraldi, Yannick Le Marchand-Brustel, Roland Govers. A serum factor induces insulin-independent translocation of GLUT4 to the cell surface which is maintained in insulin resistance. PloS one. 2010 Dec; 5(12):e15560. doi: 10.1371/journal.pone.0015560. [PMID: 21187969]
  • Joshua C Drake, Stephen E Alway, John M Hollander, David L Williamson. AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle. American journal of physiology. Regulatory, integrative and comparative physiology. 2010 Dec; 299(6):R1546-54. doi: 10.1152/ajpregu.00337.2010. [PMID: 20844264]
  • Rodrigo Alzamora, Fan Gong, Christine Rondanino, Jeffrey K Lee, Christy Smolak, Núria M Pastor-Soler, Kenneth R Hallows. AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells. American journal of physiology. Renal physiology. 2010 Dec; 299(6):F1308-19. doi: 10.1152/ajprenal.00423.2010. [PMID: 20861072]
  • Lindsey D Bogachus, Lorraine P Turcotte. Genetic downregulation of AMPK-alpha isoforms uncovers the mechanism by which metformin decreases FA uptake and oxidation in skeletal muscle cells. American journal of physiology. Cell physiology. 2010 Dec; 299(6):C1549-61. doi: 10.1152/ajpcell.00279.2010. [PMID: 20844250]
  • Jennifer Woodard, Sonali Joshi, Benoit Viollet, Nissim Hay, Leonidas C Platanias. AMPK as a therapeutic target in renal cell carcinoma. Cancer biology & therapy. 2010 Dec; 10(11):1168-77. doi: 10.4161/cbt.10.11.13629. [PMID: 20948309]
  • Tomas Jelenik, Martin Rossmeisl, Ondrej Kuda, Zuzana Macek Jilkova, Dasa Medrikova, Vladimir Kus, Michal Hensler, Petra Janovska, Ivan Miksik, Marcin Baranowski, Jan Gorski, Sophie Hébrard, Thomas E Jensen, Pavel Flachs, Simon Hawley, Benoit Viollet, Jan Kopecky. AMP-activated protein kinase α2 subunit is required for the preservation of hepatic insulin sensitivity by n-3 polyunsaturated fatty acids. Diabetes. 2010 Nov; 59(11):2737-46. doi: 10.2337/db09-1716. [PMID: 20693347]
  • A Nerstedt, A Johansson, C X Andersson, E Cansby, U Smith, M Mahlapuu. AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3). Diabetologia. 2010 Nov; 53(11):2406-16. doi: 10.1007/s00125-010-1856-z. [PMID: 20652679]
  • Hyun-Kyong Kim, Byung-Soo Youn, Mi-Seon Shin, Churl Namkoong, Kyeong Han Park, Ja Hyun Baik, Jae Bum Kim, Joong-Yeol Park, Ki-Up Lee, Young-Bum Kim, Min-Seon Kim. Hypothalamic Angptl4/Fiaf is a novel regulator of food intake and body weight. Diabetes. 2010 Nov; 59(11):2772-80. doi: 10.2337/db10-0145. [PMID: 20798332]
  • Dan Li, Duan Wang, Yun Wang, Wenhua Ling, Xiang Feng, Min Xia. Adenosine monophosphate-activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice. The Journal of biological chemistry. 2010 Oct; 285(43):33499-33509. doi: 10.1074/jbc.m110.159772. [PMID: 20713354]
  • Erik C Johnson, Nevzat Kazgan, Colin A Bretz, Lawrence J Forsberg, Clare E Hector, Ryan J Worthen, Rob Onyenwoke, Jay E Brenman. Altered metabolism and persistent starvation behaviors caused by reduced AMPK function in Drosophila. PloS one. 2010 Sep; 5(9):. doi: 10.1371/journal.pone.0012799. [PMID: 20862213]
  • Xiao Xiao Tang, Hao Chen, Sidney Yu, Li Zhang, Michael J Caplan, Hsiao Chang Chan. Lymphocytes accelerate epithelial tight junction assembly: role of AMP-activated protein kinase (AMPK). PloS one. 2010 Aug; 5(8):e12343. doi: 10.1371/journal.pone.0012343. [PMID: 20808811]
  • Anand Rotte, Venkanna Pasham, Melanie Eichenmüller, Madhuri Bhandaru, Michael Föller, Florian Lang. Upregulation of Na+/H+ exchanger by the AMP-activated protein kinase. Biochemical and biophysical research communications. 2010 Aug; 398(4):677-82. doi: 10.1016/j.bbrc.2010.06.135. [PMID: 20609358]
  • Emiliano Panieri, Gabriele Toietta, Marina Mele, Valentina Labate, Sofia Chiatamone Ranieri, Salvatore Fusco, Valentina Tesori, Annalisa Antonini, Giuseppe Maulucci, Marco De Spirito, Tommaso Galeotti, Giovambattista Pani. Nutrient withdrawal rescues growth factor-deprived cells from mTOR-dependent damage. Aging. 2010 Aug; 2(8):487-503. doi: 10.18632/aging.100183. [PMID: 20739737]
  • David Akhavan, Timothy F Cloughesy, Paul S Mischel. mTOR signaling in glioblastoma: lessons learned from bench to bedside. Neuro-oncology. 2010 Aug; 12(8):882-9. doi: 10.1093/neuonc/noq052. [PMID: 20472883]
  • Mandeep P Gaidhu, Robert L S Perry, Fawad Noor, Rolando B Ceddia. Disruption of AMPKalpha1 signaling prevents AICAR-induced inhibition of AS160/TBC1D4 phosphorylation and glucose uptake in primary rat adipocytes. Molecular endocrinology (Baltimore, Md.). 2010 Jul; 24(7):1434-40. doi: 10.1210/me.2009-0502. [PMID: 20501641]
  • Seung-Beom Hong, HyoungBin Oh, Vladimir A Valera, Jaime Stull, Duy-Tan Ngo, Masaya Baba, Maria J Merino, W Marston Linehan, Laura S Schmidt. Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling. Molecular cancer. 2010 Jun; 9(?):160. doi: 10.1186/1476-4598-9-160. [PMID: 20573232]
  • Dan Yang Huang, Huanhuan Gao, Krishna M Boini, Hartmut Osswald, Bernd Nürnberg, Florian Lang. In vivo stimulation of AMP-activated protein kinase enhanced tubuloglomerular feedback but reduced tubular sodium transport during high dietary NaCl intake. Pflugers Archiv : European journal of physiology. 2010 Jun; 460(1):187-96. doi: 10.1007/s00424-010-0803-7. [PMID: 20349193]
  • Benjamin T Bikman, Donghai Zheng, Melissa A Reed, Robert C Hickner, Joseph A Houmard, G Lynis Dohm. Lipid-induced insulin resistance is prevented in lean and obese myotubes by AICAR treatment. American journal of physiology. Regulatory, integrative and comparative physiology. 2010 Jun; 298(6):R1692-9. doi: 10.1152/ajpregu.00190.2009. [PMID: 20393162]
  • Anthony J Cura, Anthony Carruthers. Acute modulation of sugar transport in brain capillary endothelial cell cultures during activation of the metabolic stress pathway. The Journal of biological chemistry. 2010 May; 285(20):15430-15439. doi: 10.1074/jbc.m110.110593. [PMID: 20231288]
  • S Samuel Yang, Oswaldo Valdés-López, Wayne W Xu, Bruna Bucciarelli, John W Gronwald, Georgina Hernández, Carroll P Vance. Transcript profiling of common bean (Phaseolus vulgaris L.) using the GeneChip Soybean Genome Array: optimizing analysis by masking biased probes. BMC plant biology. 2010 May; 10(?):85. doi: 10.1186/1471-2229-10-85. [PMID: 20459672]
  • Jin Hee Jung, Jeong Ok Lee, Ji Hae Kim, Soo Kyung Lee, Ga Young You, Sun Hwa Park, Ji Man Park, Eung-Kyun Kim, Pann-Ghill Suh, Jin Kyung An, Hyeon Soo Kim. Quercetin suppresses HeLa cell viability via AMPK-induced HSP70 and EGFR down-regulation. Journal of cellular physiology. 2010 May; 223(2):408-14. doi: 10.1002/jcp.22049. [PMID: 20082303]
  • Andreas Thomas, Simon Beuck, Jens Christian Eickhoff, Sven Guddat, Oliver Krug, Matthias Kamber, Wilhelm Schänzer, Mario Thevis. Quantification of urinary AICAR concentrations as a matter of doping controls. Analytical and bioanalytical chemistry. 2010 Apr; 396(8):2899-908. doi: 10.1007/s00216-010-3560-8. [PMID: 20225061]
  • Chi Bun Chan, Xia Liu, Dae Young Jung, John Y Jun, Hongbo R Luo, Jason K Kim, Keqiang Ye. Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance. Diabetes. 2010 Apr; 59(4):883-93. doi: 10.2337/db09-1404. [PMID: 20068140]
  • LiYong Chen, FuRong Wang, XiangLan Sun, Jing Zhou, Ling Gao, YuLian Jiao, XiaoLei Hou, Cheng Yong Qin, JiaJun Zhao. Chronic ethanol feeding impairs AMPK and MEF2 expression and is associated with GLUT4 decrease in rat myocardium. Experimental & molecular medicine. 2010 Mar; 42(3):205-15. doi: 10.3858/emm.2010.42.3.021. [PMID: 20164678]
  • Bei-Ying Qiu, Nigel Turner, Yuan-Yuan Li, Min Gu, Meng-Wei Huang, Fang Wu, Tao Pang, Fa-Jun Nan, Ji-Ming Ye, Jing-Ya Li, Jia Li. High-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice. Diabetes. 2010 Jan; 59(1):256-65. doi: 10.2337/db09-0223. [PMID: 19833880]
  • Armineh Zohrabian. Clinical and economic considerations of antiobesity treatment: a review of orlistat. ClinicoEconomics and outcomes research : CEOR. 2010; 2(?):63-74. doi: 10.2147/ceor.s5101. [PMID: 21935315]
  • Marcia J Abbott, Arthur M Edelman, Lorraine P Turcotte. CaMKK is an upstream signal of AMP-activated protein kinase in regulation of substrate metabolism in contracting skeletal muscle. American journal of physiology. Regulatory, integrative and comparative physiology. 2009 Dec; 297(6):R1724-32. doi: 10.1152/ajpregu.00179.2009. [PMID: 19812359]
  • Yassine Sakar, Corinne Nazaret, Philippe Lettéron, Amal Ait Omar, Mathilde Avenati, Benoît Viollet, Robert Ducroc, André Bado. Positive regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents. PloS one. 2009 Nov; 4(11):e7935. doi: 10.1371/journal.pone.0007935. [PMID: 19956534]
  • Kwangmi Kim, Lin Wang, Inkyu Hwang. Acute inhibition of selected membrane-proximal mouse T cell receptor signaling by mitochondrial antagonists. PloS one. 2009 Nov; 4(11):e7738. doi: 10.1371/journal.pone.0007738. [PMID: 19901985]
  • Tyisha Williams, Lawrence J Forsberg, Benoit Viollet, Jay E Brenman. Basal autophagy induction without AMP-activated protein kinase under low glucose conditions. Autophagy. 2009 Nov; 5(8):1155-65. doi: 10.4161/auto.5.8.10090. [PMID: 19844161]
  • Hakam Alkhateeb, Adrian Chabowski, Jan F C Glatz, Brendon Gurd, Joost J F P Luiken, Arend Bonen. Restoring AS160 phosphorylation rescues skeletal muscle insulin resistance and fatty acid oxidation while not reducing intramuscular lipids. American journal of physiology. Endocrinology and metabolism. 2009 Nov; 297(5):E1056-66. doi: 10.1152/ajpendo.90908.2008. [PMID: 19724017]