108-59-8 (BioDeep_00000868663)
Main id: BioDeep_00000397453
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C5H8O4 (132.0422568)
中文名称: 丙二酸二甲酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC(=O)CC(=O)OC
InChI: InChI=1S/C5H8O4/c1-8-4(6)3-5(7)9-2/h3H2,1-2H3
描述信息
Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis[1].
Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH). Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis[1].
同义名列表
18 个代谢物同义名
PROPANEDIOIC ACID,DIMETHYL ESTER (MALONIC ACID,DIMETHYL ESTER); InChI=1\C5H8O4\c1-8-4(6)3-5(7)9-2\h3H2,1-2H; Propanedioic acid, dimethyl ester; propanedioic acid dimethyl ester; MALONIC ACID, DIMETHYL ESTER; Malonic Acid Dimethyl Ester; Dimethyl 1,3-propanedioate; Dimethyl propanedioate; Dimethyl malonate; EINECS 203-597-8; 136441_ALDRICH; 241040_ALDRICH; ZINC00388229; NCI60_005924; 63380_FLUKA; CCRIS 8981; NSC620046; 108-59-8
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 7943
- ChEMBL: CHEMBL1986332
- CAS: 75238-25-4
- CAS: 108-59-8
- medchemexpress: HY-Y1787
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 33090 - Plants: -
- 33090 - 苦楝皮: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- José Luiz Portela, Matheus Chimelo Bianchini, Aline Augusti Boligon, Murilo Ricardo Sigal Carriço, Rafael Roehrs, Félix Alexandre Antunes Soares, Marcelo Gomes de Gomes, Waseem Hassan, Robson Luiz Puntel. Ilex paraguariensis Attenuates Changes in Mortality, Behavioral and Biochemical Parameters Associated to Methyl Malonate or Malonate Exposure in Drosophila melanogaster.
Neurochemical research.
2019 Sep; 44(9):2202-2214. doi:
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International journal of nanomedicine.
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Cell.
2016 Oct; 167(2):457-470.e13. doi:
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American journal of medical genetics. Part A.
2015 Oct; 167A(10):2300-5. doi:
10.1002/ajmg.a.37147
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The Indian journal of medical research.
2011 Oct; 134(?):432-9. doi:
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Chemistry Central journal.
2011 Jun; 5(1):33. doi:
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Nutrition journal.
2011 May; 10(?):56. doi:
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Physiologia plantarum.
2011 Mar; 141(3):251-64. doi:
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Basic & clinical pharmacology & toxicology.
2009 Sep; 105(3):156-66. doi:
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European journal of clinical nutrition.
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Pediatric blood & cancer.
2007 Oct; 49(5):754-8. doi:
10.1002/pbc.20720
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The clinical respiratory journal.
2007 Jul; 1(1):23-9. doi:
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Acta obstetricia et gynecologica Scandinavica.
2007; 86(2):145-50. doi:
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Clinical chemistry and laboratory medicine.
2006; 44(1):123-4. doi:
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. [PMID: 16375598] - Terry Kind, Joseph Levy, Margaret Lee, Shipra Kaicker, John F Nicholson, Steven A Kane. Cobalamin C disease presenting as hemolytic-uremic syndrome in the neonatal period.
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2002 May; 24(4):327-9. doi:
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Revista de neurologia.
2001 Jul; 33(2):101-11. doi:
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Journal of inherited metabolic disease.
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American journal of hematology.
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Archives of disease in childhood.
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Biokhimiia (Moscow, Russia).
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The Biochemical journal.
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Lancet (London, England).
1988 May; 1(8594):1078-9. doi:
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Clinica chimica acta; international journal of clinical chemistry.
1987 Jun; 165(2-3):197-204. doi:
10.1016/0009-8981(87)90163-x
. [PMID: 3652445] - D Watkins, D S Rosenblatt. Failure of lysosomal release of vitamin B12: a new complementation group causing methylmalonic aciduria (cblF).
American journal of human genetics.
1986 Sep; 39(3):404-8. doi:
. [PMID: 3766542]
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Pediatrics.
1986 Jul; 78(1):51-4. doi:
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. [PMID: 3725502] - C H McMurray, W J Blanchflower, D A Rice, M McLoughlin. Sensitive and specific gas chromatographic method for the determination of methylmalonic acid in the plasma and urine of ruminants.
Journal of chromatography.
1986 May; 378(1):201-7. doi:
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1984 May; 11(5):236-41. doi:
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1983 Nov; 749(1):1-8. doi:
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The Journal of biological chemistry.
1983 Sep; 258(18):11415-21. doi:
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