96574-01-5 (BioDeep_00000865519)
Main id: BioDeep_00000230981
PANOMIX_OTCML-2023
代谢物信息卡片
Benzenepropanoic acid, alpha-((3-(2-(2-(3,4-dihydroxyphenyl)ethenyl)-3,4-dihydroxyphenyl)-1-oxo-2-propenyl)oxy)-3,4-dihydroxy-, (R-(E,E))-
化学式: C26H22O10 (494.1212912)
中文名称: 丹酚酸A
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C=C1CC(C(=O)O)OC(=O)C=CC2=C(C(=C(C=C2)O)O)C=CC3=CC(=C(C=C3)O)O)O)O
InChI: InChI=1S/C26H22O10/c27-18-7-2-14(11-21(18)30)1-6-17-16(4-9-20(29)25(17)33)5-10-24(32)36-23(26(34)35)13-15-3-8-19(28)22(31)12-15/h1-12,23,27-31,33H,13H2,(H,34,35)/b6-1+,10-5+/t23-/m1/s1
描述信息
D004791 - Enzyme Inhibitors > D054328 - Proton Pump Inhibitors
D000970 - Antineoplastic Agents
Salvianolic acid A could protect the blood brain barrier through matrix metallopeptidase 9 (MMP-9) inhibition and anti-inflammation.
Salvianolic acid A could protect the blood brain barrier through matrix metallopeptidase 9 (MMP-9) inhibition and anti-inflammation.
同义名列表
9 个代谢物同义名
Benzenepropanoic acid, alpha-((3-(2-(2-(3,4-dihydroxyphenyl)ethenyl)-3,4-dihydroxyphenyl)-1-oxo-2-propenyl)oxy)-3,4-dihydroxy-, (R-(E,E))-; (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-[2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxy-phenyl]prop-2-enoyl]oxy-propanoic acid; (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-[2-[(E)-2-(3,4-dihydroxyphenyl)vinyl]-3,4-dihydroxyphenyl]-1-oxoprop-2-enoxy]propanoic acid; (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-[2-[(E)-2-(3,4-dihydroxyphenyl)vinyl]-3,4-dihydroxy-phenyl]prop-2-enoyl]oxy-propanoic acid; (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-[2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]prop-2-enoyl]oxypropanoic acid; (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-[2-[(E)-2-(3,4-dihydroxyphenyl)vinyl]-3,4-dihydroxy-phenyl]acryloyl]oxy-propionic acid; Salvianolic acid A; 96574-01-5; C10492
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:9017
- PubChem: 5281793
- DrugBank: DB15246
- ChEMBL: CHEMBL457077
- CAS: 96574-01-5
- medchemexpress: HY-N0318
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ran Yang, Nan Hu, Ting-Yu Liu, Yue Qu, Jie Liu, Jin-Hui Wang, Bao-Feng Yang, Chun-Li Li. Salvianolic acid A provides neuroprotective effects on cerebral ischemia-reperfusion injury in rats via PKA/CREB/c-Fos signaling pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Feb; 124(?):155326. doi:
10.1016/j.phymed.2023.155326. [PMID: 38185068] - Awaguli Dawuti, Shuchan Sun, Ranran Wang, Difei Gong, Ruiqi Liu, Dewen Kong, Tianyi Yuan, Jian Zhou, Yang Lu, Shoubao Wang, Guanhua Du, Lianhua Fang. Salvianolic acid A alleviates heart failure with preserved ejection fraction via regulating TLR/Myd88/TRAF/NF-κB and p38MAPK/CREB signaling pathways.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Dec; 168(?):115837. doi:
10.1016/j.biopha.2023.115837. [PMID: 37931518] - Desheng Yang, Xinyu Xia, Shuhua Xi. Salvianolic acid A attenuates arsenic-induced ferroptosis and kidney injury via HIF-2α/DUOX1/GPX4 and iron homeostasis.
The Science of the total environment.
2023 Oct; 907(?):168073. doi:
10.1016/j.scitotenv.2023.168073. [PMID: 37879473] - Chunliu Wang, Jie Zhou, Shixiang Wang, Yang Liu, Kaihua Long, Tingting Sun, Wenbing Zhi, Yang Yang, Hong Zhang, Ye Zhao, Xiaopu Zheng, Xiaohui Zheng, Ye Li, Pu Jia. Guanxining injection alleviates fibrosis in heart failure mice and regulates SLC7A11/GPX4 axis.
Journal of ethnopharmacology.
2023 Jun; 310(?):116367. doi:
10.1016/j.jep.2023.116367. [PMID: 36914037] - Xiaxia Fan, Lichao Zhang, Xiaoqin La, Jinmiao Tian, Ghani Israr, Aiping Li, Changxin Wu, Yuxuan An, Songtao Li, Xiushan Dong, Zhuoyu Li. Salvianolic acid A attenuates inflammation-mediated atherosclerosis by suppressing GRP78 secretion of endothelial cells.
Journal of ethnopharmacology.
2023 May; 308(?):116219. doi:
10.1016/j.jep.2023.116219. [PMID: 36758912] - Hai-Yang Diao, Wei Zhu, Jie Liu, Sheng Yin, Jin-Hui Wang, Chun-Li Li. Salvianolic Acid A Improves Rat Kidney Injury by Regulating MAPKs and TGF-β1/Smads Signaling Pathways.
Molecules (Basel, Switzerland).
2023 Apr; 28(8):. doi:
10.3390/molecules28083630. [PMID: 37110864] - Di-Fei Gong, Shu-Chan Sun, Ran-Ran Wang, Awaguli Dawuti, De-Wen Kong, Rui-Qi Liu, Li-da Du, Shou-Bao Wang, Yang Lu, Tian-Yi Yuan, Guan-Hua Du, Lian-Hua Fang. Salvianolic acid A improve mitochondrial respiration and cardiac function via inhibiting apoptosis pathway through CRYAB in diabetic cardiomyopathy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Apr; 160(?):114382. doi:
10.1016/j.biopha.2023.114382. [PMID: 36773525] - Shengnan Li, Rong Wang, Fuxing Song, Panpan Chen, Yanqiu Gu, Chun Chen, Yongfang Yuan. Salvianolic acid A suppresses CCl4-induced liver fibrosis through regulating the Nrf2/HO-1, NF-κB/IκBα, p38 MAPK, and JAK1/STAT3 signaling pathways.
Drug and chemical toxicology.
2023 Mar; 46(2):304-313. doi:
10.1080/01480545.2022.2028822. [PMID: 35057680] - Dan Xie, Lijun Song, Dongyang Xiang, Xiangyu Gao, Wenchang Zhao. Salvianolic acid A alleviates atherosclerosis by inhibiting inflammation through Trc8-mediated 3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Feb; 112(?):154694. doi:
10.1016/j.phymed.2023.154694. [PMID: 36804757] - Zhiqiang Ye, Yuyu Liu, Jintong Song, Yin Gao, Haiping Fang, Zilong Hu, Min Zhang, Wenwei Liao, Liao Cui, Yanzhi Liu. Expanding the therapeutic potential of Salvia miltiorrhiza: a review of its pharmacological applications in musculoskeletal diseases.
Frontiers in pharmacology.
2023; 14(?):1276038. doi:
10.3389/fphar.2023.1276038. [PMID: 38116081] - Jialin Sun, Ping Leng, Xiao Li, Qie Guo, Jun Zhao, Yu Liang, Xiaolei Zhang, Xue Yang, Jing Li. Salvianolic acid A promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes through regulation of the AMPK-PGC1α signalling pathway.
Adipocyte.
2022 12; 11(1):562-571. doi:
10.1080/21623945.2022.2116790. [PMID: 36053001] - Lan Yao, Renjie Zhao, Shiyang He, Qi Feng, Yingjin Qiao, Pei Wang, Jun Li. Effects of salvianolic acid A and salvianolic acid B in renal interstitial fibrosis via PDGF-C/PDGFR-α signaling pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Nov; 106(?):154414. doi:
10.1016/j.phymed.2022.154414. [PMID: 36057144] - Ming-Yan Yang, Ze-Yu Song, Hai-Lin Gan, Mei-Hua Zheng, Qian Liu, Xiang-Ting Meng, Tao Pan, Zhen-Yuan Li, Ruo-Xuan Peng, Ke Liu, Hua-Ying Fan. Non-clinical safety evaluation of salvianolic acid A: acute, 4-week intravenous toxicities and genotoxicity evaluations.
BMC pharmacology & toxicology.
2022 10; 23(1):83. doi:
10.1186/s40360-022-00622-1. [PMID: 36289546] - Yi-Ke Lin, Yi-Jun Chen, Jie-Yi Li, Yu-Lin Chen, Dong He, Rui Zuo, Min-Jun Xiao, Dan-Ping Xu, Chao-Yang Zheng, Wei Wang, Rong-Rong He, Yang Chen. Salvianolic acid A from Danhong Injection induces vasorelaxation by Regulating L-type calcium channel in isolated mouse arteries.
Journal of ethnopharmacology.
2022 Oct; 296(?):115431. doi:
10.1016/j.jep.2022.115431. [PMID: 35700852] - Bing Zhang, Ying Zhang, Wenli Dang, Bin Xing, Changxiang Yu, Pan Guo, Jiaxin Pi, Xiuping Deng, Dongli Qi, Zhidong Liu. The anti-tumor and renoprotection study of E-[c(RGDfK)2]/folic acid co-modified nanostructured lipid carrier loaded with doxorubicin hydrochloride/salvianolic acid A.
Journal of nanobiotechnology.
2022 Sep; 20(1):425. doi:
10.1186/s12951-022-01628-x. [PMID: 36153589] - Sen Zhang, De-Wen Kong, Guo-Dong Ma, Cheng-di Liu, Yu-Jiao Yang, Shan Liu, Nan Jiang, Zi-Rong Pan, Wen Zhang, Ling-Lei Kong, Guan-Hua Du. Long-term administration of salvianolic acid A promotes endogenous neurogenesis in ischemic stroke rats through activating Wnt3a/GSK3β/β-catenin signaling pathway.
Acta pharmacologica Sinica.
2022 Sep; 43(9):2212-2225. doi:
10.1038/s41401-021-00844-9. [PMID: 35217812] - Han Li, Ke Zhang, Xiaoya Niu, Nian Wu, Xiaoqin Su, Pengfei Tu, Yunfang Zhao, Yuelin Song. Full collision energy ramp-MS2 spectral features of natural esters: Salvianolic acid A as a case.
Rapid communications in mass spectrometry : RCM.
2022 08; 36(16):e9344. doi:
10.1002/rcm.9344. [PMID: 35737679] - Tingting Ye, Rongrong Chen, Yu Zhou, Juan Zhang, Zhongqin Zhang, Hui Wei, Yan Xu, Yulan Wang, Yinlan Zhang. Salvianolic acid A (Sal A) suppresses malignant progression of glioma and enhances temozolomide (TMZ) sensitivity via repressing transgelin-2 (TAGLN2) mediated phosphatidylinositol-3-kinase (PI3K) / protein kinase B (Akt) pathway.
Bioengineered.
2022 05; 13(5):11646-11655. doi:
10.1080/21655979.2022.2070963. [PMID: 35505656] - Ji Zhu, Hang Chen, Yifei Le, Jianan Guo, Zhijun Liu, Xiaobing Dou, Dezhao Lu. Salvianolic acid A regulates pyroptosis of endothelial cells via directly targeting PKM2 and ameliorates diabetic atherosclerosis.
Frontiers in pharmacology.
2022; 13(?):1009229. doi:
10.3389/fphar.2022.1009229. [PMID: 36425580] - Yujiao Yang, Junke Song, NanNan Liu, Guangyi Wei, Shan Liu, Sen Zhang, Nan Jiang, Haiguang Yang, Guanhua Du. Salvianolic acid A relieves cognitive disorder after chronic cerebral ischemia: Involvement of Drd2/Cryab/NF-κB pathway.
Pharmacological research.
2022 01; 175(?):105989. doi:
10.1016/j.phrs.2021.105989. [PMID: 34800628] - Qiang Liu, Cheng-Long Zhu, Hui-Ru Li, Jian Xie, Yu Guo, Peng Li, Zhen-Zhen Zhao, Jia-Feng Wang, Xiao-Ming Deng. Salvianolic Acid A Protects against Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Neutrophil NETosis.
Oxidative medicine and cellular longevity.
2022; 2022(?):7411824. doi:
10.1155/2022/7411824. [PMID: 35910849] - Xin Li, Dong Qi, Meng-Ying Wang, Kai Ji, Qun-Ling Xie, Yu Wang, Shi-Hao Du, Hua-Ying Fan. Salvianolic acid A attenuates steroid resistant nephrotic syndrome through suPAR/uPAR-αvβ3 signaling Inhibition.
Journal of ethnopharmacology.
2021 Oct; 279(?):114351. doi:
10.1016/j.jep.2021.114351. [PMID: 34157324] - Florence Hui Ping Tan, Andrew Chung Jie Ting, Ban Guan Leow, Nazalan Najimudin, Nobumoto Watanabe, Ghows Azzam. Alleviatory effects of Danshen, Salvianolic acid A and Salvianolic acid B on PC12 neuronal cells and Drosophila melanogaster model of Alzheimer's disease.
Journal of ethnopharmacology.
2021 Oct; 279(?):114389. doi:
10.1016/j.jep.2021.114389. [PMID: 34217797] - Guijiang Sun, Xiaomeng Li, Jinxia Wei, Tianpu Zhang, Bo Li, Meiling Chen, Yuming Wang, Kangyin Chen, Yubo Li. Pharmacodynamic substances in Salvia miltiorrhiza for prevention and treatment of hyperlipidemia and coronary heart disease based on lipidomics technology and network pharmacology analysis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Sep; 141(?):111846. doi:
10.1016/j.biopha.2021.111846. [PMID: 34225018] - Yun Ling, Lu Jin, Quanxin Ma, Yu Huang, Qinqin Yang, Minli Chen, Qiyang Shou. Salvianolic acid A alleviated inflammatory response mediated by microglia through inhibiting the activation of TLR2/4 in acute cerebral ischemia-reperfusion.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Jul; 87(?):153569. doi:
10.1016/j.phymed.2021.153569. [PMID: 33985878] - Bei-Bei Ma, Tian-Yu Lou, Yao-Yue Liang, Ting-Ting Wang, Rui-Ji Li, Jin-Hui Liu, Chen-Xiao Wang, Shang-Yue Yu, Yu-Dong Guo, Jing Wang, Zhi-Bin Wang. [Analysis and comparison of metabolic processes of salvianolic acid A and salvianolic acid B in rats based on UHPLC-LTQ-Orbitrap MS technology].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2021 May; 46(9):2276-2286. doi:
10.19540/j.cnki.cjcmm.20200820.201. [PMID: 34047131] - Shiling Hu, Jue Wang, Yongjing Zhang, Haoyun Bai, Cheng Wang, Nan Wang, Langchong He. Three salvianolic acids inhibit 2019-nCoV spike pseudovirus viropexis by binding to both its RBD and receptor ACE2.
Journal of medical virology.
2021 05; 93(5):3143-3151. doi:
10.1002/jmv.26874. [PMID: 33580518] - Jing Wang, Chao Xu, Kunhu Zhang, Jianjun Shi, Zhenyang Liu, Xinxing Wang, Min Guo, Jiannan Lv, Xinmin Ding. Inhibition of ASC enhances the protective role of salvianolic acid A in traumatic brain injury via inhibition of inflammation and recovery of mitochondrial function.
Folia neuropathologica.
2021; 59(1):50-66. doi:
10.5114/fn.2021.105131. [PMID: 33969677] - Hui Zhou, Yang He, Zhong Zheng, Zhiqiang Liu, Fengrui Song, Shu Liu. Quantitative analysis and pharmacokinetic comparison of multiple bioactive components in rat plasma after oral administration of Qi-Shen-Ke-Li formula and its single-herb extracts using ultra-high-performance liquid chromatography-tandem mass spectrometry.
Biomedical chromatography : BMC.
2020 Dec; 34(12):e4959. doi:
10.1002/bmc.4959. [PMID: 32726460] - Mahmoud A A Ibrahim, Alaa H M Abdelrahman, Taha A Hussien, Esraa A A Badr, Tarik A Mohamed, Hesham R El-Seedi, Paul W Pare, Thomas Efferth, Mohamed-Elamir F Hegazy. In silico drug discovery of major metabolites from spices as SARS-CoV-2 main protease inhibitors.
Computers in biology and medicine.
2020 11; 126(?):104046. doi:
10.1016/j.compbiomed.2020.104046. [PMID: 33065388] - Rui Zhou, Jinhuan Gao, Changpei Xiang, Zhenming Liu, Yi Zhang, Jingjing Zhang, Hongjun Yang. Salvianolic acid A attenuated myocardial infarction-induced apoptosis and inflammation by activating Trx.
Naunyn-Schmiedeberg's archives of pharmacology.
2020 06; 393(6):991-1002. doi:
10.1007/s00210-019-01766-4. [PMID: 31811327] - Shuang Feng, Hui Cong, Lei Ji. Salvianolic Acid A Exhibits Anti-Inflammatory and Antiarthritic Effects via Inhibiting NF-κB and p38/MAPK Pathways.
Drug design, development and therapy.
2020; 14(?):1771-1778. doi:
10.2147/dddt.s235857. [PMID: 32440102] - Xi Zeng, Xuehong Chen, Huan Qin, Yantao Han, Xiuping Chen, Zhiwu Han, Wenwen Zhao. Preventive effects of a natural anti-inflammatory agent Salvianolic acid A on acute kidney injury in mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2020 Jan; 135(?):110901. doi:
10.1016/j.fct.2019.110901. [PMID: 31654708] - Yalan Wu, Suowen Xu, Xiao Yu Tian. The Effect of Salvianolic Acid on Vascular Protection and Possible Mechanisms.
Oxidative medicine and cellular longevity.
2020; 2020(?):5472096. doi:
10.1155/2020/5472096. [PMID: 33062143] - Chunyang Xu, Biyu Hou, Ping He, Peng Ma, Xinyu Yang, Xiuying Yang, Li Zhang, Guifen Qiang, Wenlan Li, Guanhua Du. Neuroprotective Effect of Salvianolic Acid A against Diabetic Peripheral Neuropathy through Modulation of Nrf2.
Oxidative medicine and cellular longevity.
2020; 2020(?):6431459. doi:
10.1155/2020/6431459. [PMID: 32184918] - Mohamed A Katary, Rafik Abdelsayed, Abdulmohsin Alhashim, Mohamed Abdelhasib, Ahmed A Elmarakby. Salvianolic Acid B Slows the Progression of Breast Cancer Cell Growth via Enhancement of Apoptosis and Reduction of Oxidative Stress, Inflammation, and Angiogenesis.
International journal of molecular sciences.
2019 Nov; 20(22):. doi:
10.3390/ijms20225653. [PMID: 31726654] - Fuqiong Zhou, Linxin Teng, Yu Liu, Yanxia Ma, Weiping Chen, Lei Bi. Elaboration of the Comprehensive Metabolic Profile of Salvianolic Acid A in Vivo and in Vitro Using UFLC-Q/TOF-MS.
Journal of agricultural and food chemistry.
2019 Nov; 67(44):12199-12207. doi:
10.1021/acs.jafc.9b04131. [PMID: 31595753] - Xuekai Wang, Dong Qi, Fenghua Fu, Xin Li, Yue Liu, Kai Ji, Zhenfang Gao, Linlin Kong, Chen Yu, Hua Xie, Guang Yue, Hui Zhu, Ke Liu, Huaying Fan. Therapeutic and antiproteinuric effects of salvianolic acid A in combined with low-dose prednisone in minimal change disease rats: Involvement of PPARγ/Angptl4 and Nrf2/HO-1 pathways.
European journal of pharmacology.
2019 Sep; 858(?):172342. doi:
10.1016/j.ejphar.2019.04.023. [PMID: 31129156] - Hongjin Tang, Fei Ma, Dongsheng Zhao. Integrated multi-spectroscopic and molecular modelling techniques to probe the interaction mechanism between salvianolic acid A and α‑glucosidase.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2019 Jul; 218(?):51-61. doi:
10.1016/j.saa.2019.03.109. [PMID: 30954797] - Yufei Yang, Lichao Zhang, Xiaoqin La, Zhuoyu Li, Hanqing Li, Songjia Guo. Salvianolic acid A inhibits tumor-associated angiogenesis by blocking GRP78 secretion.
Naunyn-Schmiedeberg's archives of pharmacology.
2019 04; 392(4):467-480. doi:
10.1007/s00210-018-1585-2. [PMID: 30560355] - Guangming Zhang, Guanghua Cui, Shuangxi Tong, Qingxian Cao. Salvianolic acid A alleviates the renal damage in rats with chronic renal failure1.
Acta cirurgica brasileira.
2019 Feb; 34(2):e201900204. doi:
10.1590/s0102-8650201900204. [PMID: 30843937] - Ruiying Wang, Jingyi Zhang, Shan Wang, Min Wang, Tianyuan Ye, Yuyang Du, Xueheng Xie, Jingxue Ye, Guibo Sun, Xiaobo Sun. The Cardiotoxicity Induced by Arsenic Trioxide is Alleviated by Salvianolic Acid A via Maintaining Calcium Homeostasis and Inhibiting Endoplasmic Reticulum Stress.
Molecules (Basel, Switzerland).
2019 Feb; 24(3):. doi:
10.3390/molecules24030543. [PMID: 30717322] - Rong Wang, Fuxing Song, Shengnan Li, Bin Wu, Yanqiu Gu, Yongfang Yuan. Salvianolic acid A attenuates CCl4-induced liver fibrosis by regulating the PI3K/AKT/mTOR, Bcl-2/Bax and caspase-3/cleaved caspase-3 signaling pathways.
Drug design, development and therapy.
2019; 13(?):1889-1900. doi:
10.2147/dddt.s194787. [PMID: 31213776] - Hong-Feng Zhang, Jia-Hong Wang, Yan-Li Wang, Cheng Gao, Yan-Ting Gu, Jian Huang, Jin-Hui Wang, Zhou Zhang. Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3β/Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway in 5/6 Nephrectomized Rats.
Oxidative medicine and cellular longevity.
2019; 2019(?):2853534. doi:
10.1155/2019/2853534. [PMID: 31011401] - Hong-Feng Zhang, Yan-Li Wang, Cheng Gao, Yan-Ting Gu, Jian Huang, Jin-Hui Wang, Jia-Hong Wang, Zhou Zhang. Salvianolic acid A attenuates kidney injury and inflammation by inhibiting NF-κB and p38 MAPK signaling pathways in 5/6 nephrectomized rats.
Acta pharmacologica Sinica.
2018 Dec; 39(12):1855-1864. doi:
10.1038/s41401-018-0026-6. [PMID: 29795135] - Jialin Sun, Junke Song, Wen Zhang, Fanbo Jing, Wen Xu, Ping Leng, Xianghua Quan, Guanhua Du, Zhongguo Sui. Some pharmacokinetic parameters of salvianolic acid A following single-dose oral administration to rats.
Pharmaceutical biology.
2018 Dec; 56(1):399-406. doi:
10.1080/13880209.2018.1491998. [PMID: 30122142] - Qi Wang, Zhenquan Hu, Xixiang Li, Aoli Wang, Hong Wu, Jing Liu, Shugeng Cao, Qingsong Liu. Salviachinensines A-F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal Plant Salvia chinensis.
Journal of natural products.
2018 11; 81(11):2531-2538. doi:
10.1021/acs.jnatprod.8b00638. [PMID: 30370766] - Pradeep Paudel, Su Hui Seong, Yajuan Zhou, Chan Hum Park, Takako Yokozawa, Hyun Ah Jung, Jae Sue Choi. Rosmarinic Acid Derivatives' Inhibition of Glycogen Synthase Kinase-3β Is the Pharmacological Basis of Kangen-Karyu in Alzheimer's Disease.
Molecules (Basel, Switzerland).
2018 Nov; 23(11):. doi:
10.3390/molecules23112919. [PMID: 30413117] - Xue Shi, Yan Zhao, Chunchun Ding, Zhecheng Wang, Anlong Ji, Zhenlu Li, Dongcheng Feng, Yang Li, Dongyan Gao, Junjun Zhou, Xiaofeng Tian, Jihong Yao. Salvianolic acid A alleviates chronic ethanol-induced liver injury via promotion of β-catenin nuclear accumulation by restoring SIRT1 in rats.
Toxicology and applied pharmacology.
2018 07; 350(?):21-31. doi:
10.1016/j.taap.2018.04.036. [PMID: 29729281] - Kai Wang, Qinqin Yang, Quanxin Ma, Bei Wang, Zhengrui Wan, Minli Chen, Liming Wu. Protective Effects of Salvianolic Acid A against Dextran Sodium Sulfate-Induced Acute Colitis in Rats.
Nutrients.
2018 Jun; 10(6):. doi:
10.3390/nu10060791. [PMID: 29921812] - Mei-Juan Xu, Li-Feng Jiang, Ting Wu, Ji-Hong Chu, Yi-Dan Wei, Ji-Ye Aa, Guang-Ji Wang, Hai-Ping Hao, Wen-Zheng Ju, Ping Li. Inhibitory Effects of Danshen components on CYP2C8 and CYP2J2.
Chemico-biological interactions.
2018 Jun; 289(?):15-22. doi:
10.1016/j.cbi.2018.04.011. [PMID: 29689254] - Silin Lü, Jiacheng Deng, Huiying Liu, Bo Liu, Juan Yang, Yutong Miao, Jing Li, Nan Wang, Changtao Jiang, Qingbo Xu, Xian Wang, Juan Feng. PKM2-dependent metabolic reprogramming in CD4+ T cells is crucial for hyperhomocysteinemia-accelerated atherosclerosis.
Journal of molecular medicine (Berlin, Germany).
2018 06; 96(6):585-600. doi:
10.1007/s00109-018-1645-6. [PMID: 29732501] - Xuyang Liu, Zhan-Guo Gao, Yiran Wu, Raymond C Stevens, Kenneth A Jacobson, Suwen Zhao. Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors.
Scientific reports.
2018 05; 8(1):8084. doi:
10.1038/s41598-018-26577-0. [PMID: 29795391] - Chih-Yuan Fang, Ching-Zong Wu, Pei-Ni Chen, Yu-Chao Chang, Chun-Yi Chuang, Chih-Ting Lai, Shun-Fa Yang, Lo-Lin Tsai. Antimetastatic potentials of salvianolic acid A on oral squamous cell carcinoma by targeting MMP-2 and the c-Raf/MEK/ERK pathway.
Environmental toxicology.
2018 May; 33(5):545-554. doi:
10.1002/tox.22542. [PMID: 29385302] - Wen Zhang, Jun-Ke Song, Xue Zhang, Qi-Meng Zhou, Guo-Rong He, Xiao-Na Xu, Yan Rong, Wen-Xia Zhou, Guan-Hua DU. Salvianolic acid A attenuates ischemia reperfusion induced rat brain damage by protecting the blood brain barrier through MMP-9 inhibition and anti-inflammation.
Chinese journal of natural medicines.
2018 Mar; 16(3):184-193. doi:
10.1016/s1875-5364(18)30046-3. [PMID: 29576054] - Yijia Xiang, Shiyong Ye, Changhong Cai, Junchong Chen, Xuyong Zhao, Ning Zhu, Chunlai Zeng. Salvianolic acid a attenuates limb ischemia/reperfusion injury in skeletal muscle of rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jan; 97(?):551-556. doi:
10.1016/j.biopha.2017.10.094. [PMID: 29096356] - Jing-Yi Zhang, Min Wang, Rui-Ying Wang, Xiao Sun, Yu-Yang Du, Jing-Xue Ye, Gui-Bo Sun, Xiao-Bo Sun. Salvianolic Acid A Ameliorates Arsenic Trioxide-Induced Cardiotoxicity Through Decreasing Cardiac Mitochondrial Injury and Promotes Its Anticancer Activity.
Frontiers in pharmacology.
2018; 9(?):487. doi:
10.3389/fphar.2018.00487. [PMID: 29867492] - Zuokai Zhang, Dong Qi, Xuekai Wang, Zhenfang Gao, Peng Li, Wenbo Liu, Xiao Tian, Yue Liu, Mingyan Yang, Ke Liu, Huaying Fan. Protective effect of Salvianolic acid A on ischaemia-reperfusion acute kidney injury in rats through protecting against peritubular capillary endothelium damages.
Phytotherapy research : PTR.
2018 Jan; 32(1):103-114. doi:
10.1002/ptr.5954. [PMID: 29071768] - Si-Qi Feng, Nan Aa, Jian-Liang Geng, Jing-Qiu Huang, Run-Bin Sun, Chun Ge, Zhi-Jian Yang, Lian-Sheng Wang, Ji-Ye Aa, Guang-Ji Wang. Pharmacokinetic and metabolomic analyses of the neuroprotective effects of salvianolic acid A in a rat ischemic stroke model.
Acta pharmacologica Sinica.
2017 Nov; 38(11):1435-1444. doi:
10.1038/aps.2017.114. [PMID: 28836583] - Jianli Liu, Yu Zhang, Yimeng Hao, Ying Zhao, Yanjiao Li, Rulan Qin, Chongning Lv, Jincai Lu. Chemical composition differentiation of Shen-Shuai-Ning granule between combined decoction and separated decoction using HPLC-DAD-ESI-QTOF-MS.
Biomedical chromatography : BMC.
2017 Sep; 31(9):. doi:
10.1002/bmc.3949. [PMID: 28178753] - Jianqing Zhang, Qinghao Jin, Yanping Deng, Jinjun Hou, Wanying Wu, Dean Guo. New depsides from the roots of Salvia miltiorrhiza and their radical-scavenging capacity and protective effects against H2O2-induced H9c2 cells.
Fitoterapia.
2017 Sep; 121(?):46-52. doi:
10.1016/j.fitote.2017.06.018. [PMID: 28647481] - Shao-Jun Chen, Ming-Chao Cui. Systematic Understanding of the Mechanism of Salvianolic Acid A via Computational Target Fishing.
Molecules (Basel, Switzerland).
2017 Apr; 22(4):. doi:
10.3390/molecules22040644. [PMID: 28420179] - Haidong Wang, Xi Li, Wenting Zhang, Yao Liu, Shijun Wang, Xiaoquan Liu, Hua He. Mechanism-based pharmacokinetic-pharmacodynamic modeling of salvianolic acid A effects on plasma xanthine oxidase activity and uric acid levels in acute myocardial infarction rats.
Xenobiotica; the fate of foreign compounds in biological systems.
2017 Mar; 47(3):208-216. doi:
10.1080/00498254.2016.1180440. [PMID: 27165094] - Ke Mao, Wanting Shu, Qinghua Qiu, Qing Gu, Xingwei Wu. Salvianolic acid A protects retinal pigment epithelium from OX-LDL-induced inflammation in an age-related macular degeneration model.
Discovery medicine.
2017 02; 23(125):129-147. doi:
". [PMID: 28371616] - Yucai Chen, Tianyi Yuan, Huifang Zhang, Yu Yan, Danshu Wang, Lianhua Fang, Yang Lu, Guanhua Du. Activation of Nrf2 Attenuates Pulmonary Vascular Remodeling via Inhibiting Endothelial-to-Mesenchymal Transition: an Insight from a Plant Polyphenol.
International journal of biological sciences.
2017; 13(8):1067-1081. doi:
10.7150/ijbs.20316. [PMID: 28924387] - Tianyi Yuan, Yucai Chen, Huifang Zhang, Lianhua Fang, Guanhua Du. Salvianolic Acid A, a Component of Salvia miltiorrhiza, Attenuates Endothelial-Mesenchymal Transition of HPAECs Induced by Hypoxia.
The American journal of Chinese medicine.
2017; 45(6):1185-1200. doi:
10.1142/s0192415x17500653. [PMID: 28893092] - Biyu Hou, Guifen Qiang, Yuerong Zhao, Xiuying Yang, Xi Chen, Yu Yan, Xiaobo Wang, Chenge Liu, Li Zhang, Guanhua Du. Salvianolic Acid A Protects Against Diabetic Nephropathy through Ameliorating Glomerular Endothelial Dysfunction via Inhibiting AGE-RAGE Signaling.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 44(6):2378-2394. doi:
10.1159/000486154. [PMID: 29262395] - Jing-Yi Zhang, Gui-Bo Sun, Yun Luo, Min Wang, Wei Wang, Yu-Yang Du, Ying-Li Yu, Xiao-Bo Sun. Salvianolic Acid A Protects H9c2 Cells from Arsenic Trioxide-Induced Injury via Inhibition of the MAPK Signaling Pathway.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 41(5):1957-1969. doi:
10.1159/000472409. [PMID: 28391263] - Ke Mao, Wanting Shu, Libin Liu, Qing Gu, Qinghua Qiu, XingWei Wu. Salvianolic Acid A Inhibits OX-LDL Effects on Exacerbating Choroidal Neovascularization via Downregulating CYLD.
Oxidative medicine and cellular longevity.
2017; 2017(?):6210694. doi:
10.1155/2017/6210694. [PMID: 29081889] - Huaizhi Li, Yan Cheng, Hongjing Dong, Xiao Wang, Jia Li, Qianshan Gao. Preparation of salvianolic acid A by the degradation reaction of salvianolic acid B in subcritical water integrated with pH-zone-refining counter-current chromatography.
Journal of chromatography. A.
2016 Oct; 1468(?):42-48. doi:
10.1016/j.chroma.2016.09.039. [PMID: 27670752] - Fei-Yan Chen, Lei Bi, Lei Qian, Jing Gao, Yu-Cui Jiang, Wei-Ping Chen. [Identification of multidrug resistance gene MDR1 associated microRNA of salvianolic acid A reversal in lung cancer].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2016 Sep; 41(17):3279-3284. doi:
10.4268/cjcmm20161726. [PMID: 28920383] - Yu-Cai Chen, Tian-Yi Yuan, Hui-Fang Zhang, Dan-Shu Wang, Yu Yan, Zi-Ran Niu, Yi-Huang Lin, Lian-Hua Fang, Guan-Hua Du. Salvianolic acid A attenuates vascular remodeling in a pulmonary arterial hypertension rat model.
Acta pharmacologica Sinica.
2016 Jun; 37(6):772-82. doi:
10.1038/aps.2016.22. [PMID: 27180980] - Lei Li, Jian-Xun Ren, Zhi-Rong Lin, Yue Shi, Yan-Lei Ma, Jian-Xun Liu. [Effect of salvianolic acid A on anesthetized canine experimental myocardial infarction].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2016 Mar; 41(5):910-916. doi:
10.4268/cjcmm20160525. [PMID: 28875648] - Fukang Teng, Ying Yin, Yajun Cui, Yanping Deng, Defang Li, Kenka Cho, Ge Zhang, Aiping Lu, Wanying Wu, Min Yang, Xuan Liu, De-an Guo, Jun Yin, Baohong Jiang. Salvianolic acid A inhibits endothelial dysfunction and vascular remodeling in spontaneously hypertensive rats.
Life sciences.
2016 Jan; 144(?):86-93. doi:
10.1016/j.lfs.2015.06.010. [PMID: 26135625] - Ling Li, Tongda Xu, Yinping Du, Defeng Pan, Wanling Wu, Hong Zhu, Yanbin Zhang, Dongye Li. Salvianolic Acid A Attenuates Cell Apoptosis, Oxidative Stress, Akt and NF-κB Activation in Angiotensin-II Induced Murine Peritoneal Macrophages.
Current pharmaceutical biotechnology.
2016; 17(3):283-90. doi:
10.2174/138920101703160206150535. [PMID: 26873077] - Shi-tang Ma, Hao Yu, Xiao-lin Zhang, You-yi Xiong. [Potency Material Bases of Xuebijing Formula and Its Multi-target Effects on Sepsis].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2015 Nov; 35(11):1351-5. doi:
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Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2015 Oct; 35(5):564-70. doi:
10.1016/s0254-6272(15)30140-0. [PMID: 26591687] - Jun-ke Song, Wen Zhang, Wei-ku Zhang, Zhang-ying Feng, Tao Xie, Guan-Hua Du. [Pharmacokinetics of salvianolic acid A after single intravenous administration in Rhesus monkey].
Yao xue xue bao = Acta pharmaceutica Sinica.
2015 Sep; 50(9):1142-7. doi:
NULL. [PMID: 26757551] - Xiaojing Yan, Zequn Jiang, Lei Bi, Ye Yang, Weiping Chen. Salvianolic acid A attenuates TNF-α- and D-GalN-induced ER stress-mediated and mitochondrial-dependent apoptosis by modulating Bax/Bcl-2 ratio and calcium release in hepatocyte LO2 cells.
Naunyn-Schmiedeberg's archives of pharmacology.
2015 Aug; 388(8):817-30. doi:
10.1007/s00210-015-1116-3. [PMID: 25943027] - Hua-Ying Fan, Ming-Yan Yang, Dong Qi, Zuo-Kai Zhang, Lin Zhu, Xiu-Xin Shang-Guan, Ke Liu, Hui Xu, Xin Che. Salvianolic acid A as a multifunctional agent ameliorates doxorubicin-induced nephropathy in rats.
Scientific reports.
2015 Jul; 5(?):12273. doi:
10.1038/srep12273. [PMID: 26194431] - Hongli Luo, Weijun Kong, Yichen Hu, Ping Chen, Xiaoru Wu, Li Wan, Meihua Yang. Quality evaluation of Salvia miltiorrhiza Bge. by ultra high performance liquid chromatography with photodiode array detection and chemical fingerprinting coupled with chemometric analysis.
Journal of separation science.
2015 May; 38(9):1544-51. doi:
10.1002/jssc.201401430. [PMID: 25708915] - Jian-Ping Dai, Dan-Xia Zhu, Jiang-Tao Sheng, Xiao-Xuan Chen, Wei-Zhong Li, Ge-Fei Wang, Kang-Sheng Li, Yun Su. Inhibition of Tanshinone IIA, salvianolic acid A and salvianolic acid B on Areca nut extract-induced oral submucous fibrosis in vitro.
Molecules (Basel, Switzerland).
2015 Apr; 20(4):6794-807. doi:
10.3390/molecules20046794. [PMID: 25884554] - Xin-cai Zhang, Jin-qin Chen, Bo Li. Salvianolic acid A suppresses CCL-20 expression in TNF-α-treated macrophages and ApoE-deficient mice.
Journal of cardiovascular pharmacology.
2014 Oct; 64(4):318-25. doi:
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Journal of ethnopharmacology.
2014 Sep; 155(3):1589-96. doi:
10.1016/j.jep.2014.07.049. [PMID: 25102244] - Yu Fu, Hua-Yan Mo, Wen Gao, Jia-Ying Hong, Jun Lu, Ping Li, Jun Chen. Affinity selection-based two-dimensional chromatography coupled with high-performance liquid chromatography-mass spectrometry for discovering xanthine oxidase inhibitors from Radix Salviae Miltiorrhizae.
Analytical and bioanalytical chemistry.
2014 Aug; 406(20):4987-95. doi:
10.1007/s00216-014-7902-9. [PMID: 24866714] - Hongrui Xia, Longru Sun, Hongxiang Lou, M Mukhlesur Rahman. Conversion of salvianolic acid B into salvianolic acid A in tissues of Radix Salviae Miltiorrhizae using high temperature, high pressure and high humidity.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2014 May; 21(6):906-11. doi:
10.1016/j.phymed.2014.01.005. [PMID: 24548723] - Sheng-Min Liu, Zhi-Hong Yang, Xiao-Bo Sun. [Simultaneous determination of six Salvia miltiorrhiza gradients in rat plasma and brain by LC-MS/MS].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2014 May; 39(9):1704-8. doi:
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Bioorganic & medicinal chemistry letters.
2014 Feb; 24(3):708-16. doi:
10.1016/j.bmcl.2013.12.042. [PMID: 24393583] - Yu-Juan Li, Chang-Ling Duan, Jian-Xun Liu. Salvianolic acid A promotes the acceleration of neovascularization in the ischemic rat myocardium and the functions of endothelial progenitor cells.
Journal of ethnopharmacology.
2014; 151(1):218-27. doi:
10.1016/j.jep.2013.10.019. [PMID: 24189032] - Yuan-Feng Yao, Chang-Song Wang, Jianjun Qiao, Guang-Rong Zhao. Metabolic engineering of Escherichia coli for production of salvianic acid A via an artificial biosynthetic pathway.
Metabolic engineering.
2013 Sep; 19(?):79-87. doi:
10.1016/j.ymben.2013.06.001. [PMID: 23774671] - Ying Ying Cao, Ling Wang, Hu Ge, Xi Lin Lu, Zhong Pei, Qiong Gu, Jun Xu. Salvianolic acid A, a polyphenolic derivative from Salvia miltiorrhiza bunge, as a multifunctional agent for the treatment of Alzheimer's disease.
Molecular diversity.
2013 Aug; 17(3):515-24. doi:
10.1007/s11030-013-9452-z. [PMID: 23703159] - Jialin Sun, Li Zhang, Junke Song, Shuo Tian, Chao Huang, Zhangying Feng, Yang Lv, Guanhua Du. Pharmacokinetic study of salvianolic acid A in beagle dog after oral administration by a liquid chromatography-mass spectrometry method: a study on bioavailability and dose proportionality.
Journal of ethnopharmacology.
2013 Jul; 148(2):617-23. doi:
10.1016/j.jep.2013.05.013. [PMID: 23707334] - Hua He, Xi Li, Haidong Wang, Wenting Zhang, Huiyong Jiang, Shijun Wang, Linhua Yuan, Yao Liu, Xiaoquan Liu. Effects of salvianolic acid A on plasma and tissue dimethylarginine levels in a rat model of myocardial infarction.
Journal of cardiovascular pharmacology.
2013 Jun; 61(6):482-8. doi:
10.1097/fjc.0b013e3182893fd5. [PMID: 23429591] - Bao Wang, Jian-xun Liu, Hong-xu Meng, Cheng-ren Lin. Blocking effect of salvianolic acid A on calcium channels in isolated rat ventricular myocytes.
Chinese journal of integrative medicine.
2012 May; 18(5):366-70. doi:
10.1007/s11655-011-0707-1. [PMID: 21526366] - Dan Yang, Ping Xie, Zhihua Liu. Ischemia/reperfusion-induced MKP-3 impairs endothelial NO formation via inactivation of ERK1/2 pathway.
PloS one.
2012; 7(7):e42076. doi:
10.1371/journal.pone.0042076. [PMID: 22848708] - Huanjun Pan, Dongye Li, Fang Fang, Dan Chen, Lingling Qi, Ruiqu Zhang, Tongda Xu, Hong Sun. Salvianolic acid A demonstrates cardioprotective effects in rat hearts and cardiomyocytes after ischemia/reperfusion injury.
Journal of cardiovascular pharmacology.
2011 Nov; 58(5):535-42. doi:
10.1097/fjc.0b013e31822de355. [PMID: 21795988] - Xiu-Ying Yang, Gui-Fen Qiang, Li Zhang, Xiao-Ming Zhu, Shou-Bao Wang, Lan Sun, Hai-Guang Yang, Guan-Hua Du. Salvianolic acid A protects against vascular endothelial dysfunction in high-fat diet fed and streptozotocin-induced diabetic rats.
Journal of Asian natural products research.
2011 Oct; 13(10):884-94. doi:
10.1080/10286020.2011.598457. [PMID: 21972802] - Li Zhang, Weiku Zhang, Ying Zhao, Xiuying Yang, Lianhua Fang, Shoubao Wang, Lili Shi, Xiaoyan Yu, Subo Wang, Haiguang Yang, Jialin Sun, Shuo Tian, Guanhua Du. [Research progress of salvianolic acid A].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2011 Oct; 36(19):2603-9. doi:
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Fitoterapia.
2011 Sep; 82(6):883-8. doi:
10.1016/j.fitote.2011.04.015. [PMID: 21575691]