Karenzu DK2 (BioDeep_00000863498)
Main id: BioDeep_00000270961
PANOMIX_OTCML-2023
代谢物信息卡片
1,3-di(phenyl)propane-1,3-dione
化学式: C15H12O2 (224.0837252)
中文名称: 二苯甲酰甲烷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)C(=O)CC(=O)C2=CC=CC=C2
InChI: InChI=1S/C15H12O2/c16-14(12-7-3-1-4-8-12)11-15(17)13-9-5-2-6-10-13/h1-10H,11H2
描述信息
Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2[1].
Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2[1].
同义名列表
31 个代谢物同义名
1,3-di(phenyl)propane-1,3-dione; 1,3-Propanedione, 1,3-diphenyl-; 1,3-Diphenylpropane-1,3-dione; 1,3-DIPHENYL-1,3-PROPANEDIONE; .omega.-Benzoylacetophenone; omega-Benzoylacetophenone; Phenyl phenacyl ketone; 2-Benzoylacetophenone; Dibenzoyl-methane; Spectrum3_001950; EINECS 204-398-9; Dibenzoylmethane; Spectrum2_000038; NCGC00095298-02; SPECTRUM1505311; NCGC00095298-01; D33454_ALDRICH; BSPBio_003550; Rhodiastab 83; KBio3_002841; SPBio_000135; BRN 0514910; AIDS-017990; Karenzu DK2; 61346-73-4; AIDS017990; AI3-19022; ST5319429; NSC 6266; 120-46-7; NSC6266
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:75417
- PubChem: 8433
- ChEMBL: CHEMBL371523
- CAS: 120-46-7
- medchemexpress: HY-W009731
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 33090 - Plants: -
- 33090 - 甘草: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Eun Soo Lee, Mi-Hye Kwon, Hong Min Kim, Nami Kim, You Mi Kim, Hyeon Soo Kim, Eun Young Lee, Choon Hee Chung. Dibenzoylmethane ameliorates lipid-induced inflammation and oxidative injury in diabetic nephropathy.
The Journal of endocrinology.
2019 02; 240(2):169-179. doi:
10.1530/joe-18-0206. [PMID: 30475214] - Joo Hyoun Kim, Chae Young Kim, Bobin Kang, Jungil Hong, Hyeon-Son Choi. Dibenzoylmethane Suppresses Lipid Accumulation and Reactive Oxygen Species Production through Regulation of Nuclear Factor (Erythroid-Derived 2)-Like 2 and Insulin Signaling in Adipocytes.
Biological & pharmaceutical bulletin.
2018; 41(5):680-689. doi:
10.1248/bpb.b17-00837. [PMID: 29709906] - Nami Kim, Hong Min Kim, Eun Soo Lee, Jung Ok Lee, Hye Jeong Lee, Soo Kyung Lee, Ji Wook Moon, Ji Hae Kim, Joong Kwan Kim, Su Jin Kim, Sun Hwa Park, Choon Hee Chung, Hyeon Soo Kim. Dibenzoylmethane exerts metabolic activity through regulation of AMP-activated protein kinase (AMPK)-mediated glucose uptake and adipogenesis pathways.
PloS one.
2015; 10(3):e0120104. doi:
10.1371/journal.pone.0120104. [PMID: 25756788] - Marisela D Mancia, Michelle E Reid, Evan S DuBose, James A Campbell, Kimberly M Jackson. Qualitative identification of dibenzoylmethane in licorice root (Glycyrrhiza glabra) using gas chromatography-triple quadrupole mass spectrometry.
Natural product communications.
2014 Jan; 9(1):91-4. doi:
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Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences.
2012 Jun; 44(3):437-43. doi:
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PloS one.
2012; 7(3):e33243. doi:
10.1371/journal.pone.0033243. [PMID: 22432006] - Sabita N Saldanha, Trygve O Tollefsbol. The role of nutraceuticals in chemoprevention and chemotherapy and their clinical outcomes.
Journal of oncology.
2012; 2012(?):192464. doi:
10.1155/2012/192464. [PMID: 22187555] - Jun Xu, Zhihong Sun, Lei Jia, Bo Li, Long Zhao, Xiao Liu, Yufei Ma, Hao Tian, Qin Wang, Weisheng Liu, Yu Tang. Visible light sensitized attapulgite-based lanthanide composites: microstructure, photophysical behaviour and biological application.
Dalton transactions (Cambridge, England : 2003).
2011 Dec; 40(48):12909-16. doi:
10.1039/c1dt11364j. [PMID: 22020653] - Sangeetha Sukumari-Ramesh, J Nicole Bentley, Melissa D Laird, Nagendra Singh, John R Vender, Krishnan M Dhandapani. Dietary phytochemicals induce p53- and caspase-independent cell death in human neuroblastoma cells.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.
2011 Nov; 29(7):701-10. doi:
10.1016/j.ijdevneu.2011.06.002. [PMID: 21704149] - Mireia Marin, Virginie Lhiaubet-Vallet, Cecilia Paris, Minoru Yamaji, Miguel Angel Miranda. Photochemical and photophysical properties of dibenzoylmethane derivatives within protein.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.
2011 Sep; 10(9):1474-9. doi:
10.1039/c1pp05072a. [PMID: 21547313] - Chih-Lung Wu, Ya-Fan Liao, Ying-Cheng Hung, Ko-Hsiu Lu, Hui-Chih Hung, Guang-Yaw Liu. Ornithine decarboxylase prevents dibenzoylmethane-induced apoptosis through repressing reactive oxygen species generation.
Journal of biochemical and molecular toxicology.
2011 Sep; 25(5):312-9. doi:
10.1002/jbt.20391. [PMID: 21523861] - Wen Lin, Jin-Liern Hong, Guoxiang Shen, Rachel T Wu, Yuwen Wang, Mou-Tuan Huang, Harold L Newmark, Qingrong Huang, Tin Oo Khor, Tycho Heimbach, Ah-Ng Kong. Pharmacokinetics of dietary cancer chemopreventive compound dibenzoylmethane in rats and the impact of nanoemulsion and genetic knockout of Nrf2 on its disposition.
Biopharmaceutics & drug disposition.
2011 Mar; 32(2):65-75. doi:
10.1002/bdd.734. [PMID: 21341276] - Rika Murakami, Masayuki Uchida, Osamu Hori, Nobuyasu Matsuura, Tominari Choshi, Satoshi Hibino, Masashi Yamada. Efficacy of dibenzoylmethane derivatives in protecting against endoplasmic reticulum stress and inhibiting nuclear factor kappa B on dextran sulfate sodium induced colitis in mice.
Biological & pharmaceutical bulletin.
2010; 33(12):2029-32. doi:
10.1248/bpb.33.2029. [PMID: 21139246] - Beatrice E Bachmeier, Cristina M Iancu, Peter H Killian, Emanuel Kronski, Valentina Mirisola, Giovanna Angelini, Marianne Jochum, Andreas G Nerlich, Ulrich Pfeffer. Overexpression of the ATP binding cassette gene ABCA1 determines resistance to Curcumin in M14 melanoma cells.
Molecular cancer.
2009 Dec; 8(?):129. doi:
10.1186/1476-4598-8-129. [PMID: 20030852] - Neil Sidell, Lijuan Hao, Marzia Pasquali, J David McDonald. Carcinogenic effects in a phenylketonuria mouse model.
PloS one.
2009; 4(1):e4292. doi:
10.1371/journal.pone.0004292. [PMID: 19172175] - Preetha Anand, Ajaikumar B Kunnumakkara, Ajaikumar B Kunnumakara, Chitra Sundaram, Kuzhuvelil B Harikumar, Sheeja T Tharakan, Oiki S Lai, Bokyung Sung, Bharat B Aggarwal. Cancer is a preventable disease that requires major lifestyle changes.
Pharmaceutical research.
2008 Sep; 25(9):2097-116. doi:
10.1007/s11095-008-9661-9. [PMID: 18626751] - Shahab Shariati, Yadollah Yamini, Mohammadreza Khalili Zanjani. Simultaneous preconcentration and determination of U(VI), Th(IV), Zr(IV) and Hf(IV) ions in aqueous samples using micelle-mediated extraction coupled to inductively coupled plasma-optical emission spectrometry.
Journal of hazardous materials.
2008 Aug; 156(1-3):583-90. doi:
10.1016/j.jhazmat.2007.12.061. [PMID: 18243548] - Guoxiang Shen, Jin-Liern Hong, Ah-Ng Tony Kong. Development and validation of an HPLC method for the determination of dibenzoylmethane in rat plasma and its application to the pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jun; 852(1-2):56-61. doi:
10.1016/j.jchromb.2006.12.042. [PMID: 17236826] - Bettina Ebert, Albrecht Seidel, Alfonso Lampen. Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.
Toxicological sciences : an official journal of the Society of Toxicology.
2007 Apr; 96(2):227-36. doi:
10.1093/toxsci/kfl147. [PMID: 17077187] - Federico Gómez-Garibay, Oswaldo Téllez-Valdez, Gregorio Moreno-Torres, José S Calderón. Flavonoids from Tephrosia major. A new prenyl-beta-hydroxychalcone.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2002 Jul; 57(7-8):579-83. doi:
10.1515/znc-2002-7-805. [PMID: 12240979] - Cecília T T Blatt, Daniel Chávez, Heebyung Chai, James G Graham, Fernando Cabieses, Norman R Farnsworth, Geoffrey A Cordell, John M Pezzuto, A Douglas Kinghorn. Cytotoxic flavonoids from the stem bark of Lonchocarpus aff. fluvialis.
Phytotherapy research : PTR.
2002 Jun; 16(4):320-5. doi:
10.1002/ptr.889. [PMID: 12112286] - A W Abu-Qare, M B Abou-Donia. Determination of depleted uranium, pyridostigmine bromide and its metabolite in plasma and urine following combined administration in rats.
Journal of pharmaceutical and biomedical analysis.
2001 Sep; 26(2):281-9. doi:
10.1016/s0731-7085(01)00403-4. [PMID: 11470205] - C C Lin, C T Ho, M T Huang. Mechanistic studies on the inhibitory action of dietary dibenzoylmethane, a beta-diketone analogue of curcumin, on 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis.
Proceedings of the National Science Council, Republic of China. Part B, Life sciences.
2001 Jul; 25(3):158-65. doi:
NULL. [PMID: 11480771] - E Damiani, P Carloni, C Biondi, L Greci. Increased oxidative modification of albumin when illuminated in vitro in the presence of a common sunscreen ingredient: protection by nitroxide radicals.
Free radical biology & medicine.
2000 Jan; 28(2):193-201. doi:
10.1016/s0891-5849(99)00221-x. [PMID: 11281286] - E Damiani, L Greci, R Parsons, J Knowland. Nitroxide radicals protect DNA from damage when illuminated in vitro in the presence of dibenzoylmethane and a common sunscreen ingredient.
Free radical biology & medicine.
1999 Apr; 26(7-8):809-16. doi:
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