Fluo-3 (BioDeep_00000008628)
Secondary id: BioDeep_00001876727
human metabolite blood metabolite
代谢物信息卡片
2-{[2-(2-{2-[bis(carboxymethyl)amino]-5-(2,7-dichloro-6-hydroxy-3-oxo-3H-xanthen-9-yl)phenoxy}ethoxy)-4-methylphenyl](carboxymethyl)amino}acetic acid
化学式: C36H30Cl2N2O13 (768.1124870000001)
中文名称: 荧光钙探针FLUO-3
谱图信息:
最多检出来源 Homo sapiens(blood) 22.39%
分子结构信息
SMILES: CC1=CC(=C(C=C1)N(CC(=O)O)CC(=O)O)OCCOC2=C(C=CC(=C2)C3=C4C=C(C(=O)C=C4OC5=CC(=C(C=C53)Cl)O)Cl)N(CC(=O)O)CC(=O)O
InChI: InChI=1S/C36H30Cl2N2O13/c1-18-2-4-24(39(14-32(43)44)15-33(45)46)30(8-18)51-6-7-52-31-9-19(3-5-25(31)40(16-34(47)48)17-35(49)50)36-20-10-22(37)26(41)12-28(20)53-29-13-27(42)23(38)11-21(29)36/h2-5,8-13,41H,6-7,14-17H2,1H3,(H,43,44)(H,45,46)(H,47,48)(H,49,50)
描述信息
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents
D004396 - Coloring Agents > D005456 - Fluorescent Dyes
同义名列表
5 个代谢物同义名
2-{[2-(2-{2-[bis(carboxymethyl)amino]-5-(2,7-dichloro-6-hydroxy-3-oxo-3H-xanthen-9-yl)phenoxy}ethoxy)-4-methylphenyl](carboxymethyl)amino}acetic acid; N-(2-(2-(2-(Bis(carboxymethyl)amino)-5-(2,7-dichloro-6-hydroxy-3-oxo-3H-xanthene-9-yl)phenoxy)ethoxy)-4-methylphenyl)-N-(carboxymethyl)-glycine; Fluo-3-am; fluo 3; Fluo-3
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:5107
- KEGG: C11369
- PubChem: 104978
- HMDB: HMDB0252344
- Metlin: METLIN69018
- ChEMBL: CHEMBL509919
- Wikipedia: Fluo-3
- chemspider: 94730
- CAS: 123632-39-3
- PMhub: MS000022270
- PubChem: 13543
- NIKKAJI: J356.375H
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2009; 24(5-6):407-14. doi:
10.1159/000257433. [PMID: 19910681] - P W L Tas, C Stössel, N Roewer. Inhibition of the histamine-induced Ca2+ influx in primary human endothelial cells (HUVEC) by volatile anaesthetics.
European journal of anaesthesiology.
2008 Dec; 25(12):976-85. doi:
10.1017/s0265021508004778. [PMID: 18631421] - Laszlo Csernoch, Sandrine Pouvreau, Michel Ronjat, Vincent Jacquemond. Voltage-activated elementary calcium release events in isolated mouse skeletal muscle fibers.
The Journal of membrane biology.
2008 Nov; 226(1-3):43-55. doi:
10.1007/s00232-008-9138-0. [PMID: 19015802] - Lillian Cruz-Orengo, Ajay Dhaka, Robert J Heuermann, Timothy J Young, Michael C Montana, Eric J Cavanaugh, Donghee Kim, Gina M Story. Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1.
Molecular pain.
2008 Jul; 4(?):30. doi:
10.1186/1744-8069-4-30. [PMID: 18671867] - Jennifer K Heffron, Timothy S Moerland. Parvalbumin characterization from the euryhaline stingray Dasyatis sabina.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2008 Jul; 150(3):339-46. doi:
10.1016/j.cbpa.2008.04.595. [PMID: 18508399] - Rongfeng Bao, Lawrence M Lifshitz, Richard A Tuft, Karl Bellvé, Kevin E Fogarty, Ronghua ZhuGe. A close association of RyRs with highly dense clusters of Ca2+-activated Cl- channels underlies the activation of STICs by Ca2+ sparks in mouse airway smooth muscle.
The Journal of general physiology.
2008 Jul; 132(1):145-60. doi:
10.1085/jgp.200709933. [PMID: 18591421] - Jong-Hoon Choi, Hae Jo, Jeong Hee Hong, Syng-Ill Lee, Dong Min Shin. Alteration of expression of Ca2+ signaling proteins and adaptation of Ca2+ signaling in SERCA2+/- mouse parotid acini.
Yonsei medical journal.
2008 Apr; 49(2):311-21. doi:
10.3349/ymj.2008.49.2.311. [PMID: 18452270] - Gen-ichiro Arimura, Stefan Garms, Massimo Maffei, Simone Bossi, Birgit Schulze, Margit Leitner, Axel Mithöfer, Wilhelm Boland. Herbivore-induced terpenoid emission in Medicago truncatula: concerted action of jasmonate, ethylene and calcium signaling.
Planta.
2008 Jan; 227(2):453-64. doi:
10.1007/s00425-007-0631-y. [PMID: 17924138] - Michael Föller, Mentor Sopjani, Hasan Mahmud, Florian Lang. Vanadate-induced suicidal erythrocyte death.
Kidney & blood pressure research.
2008; 31(2):87-93. doi:
10.1159/000119704. [PMID: 18319605] - Shu-Jing Wu, Jian-Yong Wu. Extracellular ATP-induced NO production and its dependence on membrane Ca2+ flux in Salvia miltiorrhiza hairy roots.
Journal of experimental botany.
2008; 59(14):4007-16. doi:
10.1093/jxb/ern242. [PMID: 18977749] - Roberta Ribeiro Costa, Wamberto Antonio Varanda. Intracellular calcium changes in mice Leydig cells are dependent on calcium entry through T-type calcium channels.
The Journal of physiology.
2007 Dec; 585(Pt 2):339-49. doi:
10.1113/jphysiol.2007.137950. [PMID: 17932157] - Jing-Jing Wang, Shang-Ming Liu, Rong Chen, Li Li, Xiao-Sun Guo, Bing Xue, Wei-Cheng Hu. A novel effect of lobeline on vascular smooth muscle cell: inhibition of proliferation induced by endothelin-1.
Die Pharmazie.
2007 Aug; 62(8):620-4. doi:
. [PMID: 17867559] - Gang Liu, Lei Dang, Dong Mei Wang. [The influence of elicitor on the distribution pattern of microtubule and the cytosolic calcium in mesophyll protoplast of wheat].
Fen zi xi bao sheng wu xue bao = Journal of molecular cell biology.
2007 Aug; 40(4):205-13. doi:
. [PMID: 17966457] - Jian-Zhong Sheng, Andrew P Braun. Small- and intermediate-conductance Ca2+-activated K+ channels directly control agonist-evoked nitric oxide synthesis in human vascular endothelial cells.
American journal of physiology. Cell physiology.
2007 Jul; 293(1):C458-67. doi:
10.1152/ajpcell.00036.2007. [PMID: 17459950] - Jerry E Johnson, Guy A Perkins, Anand Giddabasappa, Shawntay Chaney, Weimin Xiao, Andrew D White, Joshua M Brown, Jenna Waggoner, Mark H Ellisman, Donald A Fox. Spatiotemporal regulation of ATP and Ca2+ dynamics in vertebrate rod and cone ribbon synapses.
Molecular vision.
2007 Jun; 13(?):887-919. doi:
. [PMID: 17653034] - Marco van der Toorn, Henk F Kauffman, Margaretha van der Deen, Dirk-Jan Slebos, Gerard H Koëter, Rijk O B Gans, Stephan J L Bakker. Cyclosporin A-induced oxidative stress is not the consequence of an increase in mitochondrial membrane potential.
The FEBS journal.
2007 Jun; 274(12):3003-12. doi:
10.1111/j.1742-4658.2007.05827.x. [PMID: 17509081] - Héctor Rojas, Claudia Colina, Magaly Ramos, Gustavo Benaim, Erica H Jaffe, Carlo Caputo, Reinaldo DiPolo. Na+ entry via glutamate transporter activates the reverse Na+/Ca2+ exchange and triggers Ca(i)2+-induced Ca2+ release in rat cerebellar Type-1 astrocytes.
Journal of neurochemistry.
2007 Mar; 100(5):1188-202. doi:
10.1111/j.1471-4159.2006.04303.x. [PMID: 17316398] - C Jung, A V Zima, P Szentesi, I Jona, L A Blatter, E Niggli. Ca2+ release from the sarcoplasmic reticulum activated by the low affinity Ca2+ chelator TPEN in ventricular myocytes.
Cell calcium.
2007 Feb; 41(2):187-94. doi:
10.1016/j.ceca.2006.06.009. [PMID: 16920191] - Min-Gui Zhao, Qiu-Ying Tian, Wen-Hao Zhang. Ethylene activates a plasma membrane Ca(2+)-permeable channel in tobacco suspension cells.
The New phytologist.
2007; 174(3):507-515. doi:
10.1111/j.1469-8137.2007.02037.x. [PMID: 17447907] - Viera Bohácová, Zdena Sulová, Ima Dovinová, Eva Poláková, Miroslav Barancík, Branislav Uhrík, Jozef Orlický, Albert Breier. L1210 cells cultivated under the selection pressure of doxorubicin or vincristine express common mechanisms of multidrug resistance based on the overexpression of P-glycoprotein.
Toxicology in vitro : an international journal published in association with BIBRA.
2006 Dec; 20(8):1560-8. doi:
10.1016/j.tiv.2006.07.011. [PMID: 16962737] - Marina Sedova, Elena N Dedkova, Lothar A Blatter. Integration of rapid cytosolic Ca2+ signals by mitochondria in cat ventricular myocytes.
American journal of physiology. Cell physiology.
2006 Nov; 291(5):C840-50. doi:
10.1152/ajpcell.00619.2005. [PMID: 16723510] - Linshan Shang, Jincheng Liu, Qingjun Zhu, Ling Zhao, Yuxin Feng, Xuping Wang, Weipeng Cao, Hua Xin. Gypenosides protect primary cultures of rat cortical cells against oxidative neurotoxicity.
Brain research.
2006 Aug; 1102(1):163-74. doi:
10.1016/j.brainres.2006.05.035. [PMID: 16806111] - Lingan Kong, Mao Wang, Qinli Wang, Xiaohua Wang, Jinxing Lin. Protein phosphatases 1 and 2A and the regulation of calcium uptake and pollen tube development in Picea wilsonii.
Tree physiology.
2006 Aug; 26(8):1001-12. doi:
10.1093/treephys/26.8.1001. [PMID: 16651249] - Guanghui Yu, Jiangong Liang, Zhike He, Mengxiang Sun. Quantum dot-mediated detection of gamma-aminobutyric acid binding sites on the surface of living pollen protoplasts in tobacco.
Chemistry & biology.
2006 Jul; 13(7):723-31. doi:
10.1016/j.chembiol.2006.05.007. [PMID: 16873020] - Jose Miguel Vicencio, Cristian Ibarra, Manuel Estrada, Mario Chiong, Dagoberto Soto, Valentina Parra, Guillermo Diaz-Araya, Enrique Jaimovich, Sergio Lavandero. Testosterone induces an intracellular calcium increase by a nongenomic mechanism in cultured rat cardiac myocytes.
Endocrinology.
2006 Mar; 147(3):1386-95. doi:
10.1210/en.2005-1139. [PMID: 16339199] - Vladimír Pucovský, Thomas B Bolton. Localisation, function and composition of primary Ca(2+) spark discharge region in isolated smooth muscle cells from guinea-pig mesenteric arteries.
Cell calcium.
2006 Feb; 39(2):113-29. doi:
10.1016/j.ceca.2005.10.002. [PMID: 16297446] - Ming-en Xu, Shang-zhi Xiao, Yong-hong Sun, Yang Ou-Yang, Xiao-xiang Zheng. Effects of astragaloside IV on pathogenesis of metabolic syndrome in vitro.
Acta pharmacologica Sinica.
2006 Feb; 27(2):229-36. doi:
10.1111/j.1745-7254.2006.00243.x. [PMID: 16412274] - Kenneth Wong, Xuebin Li, Yongqiang Ma. Paraformaldehyde induces elevation of intracellular calcium and phosphatidylserine externalization in platelets.
Thrombosis research.
2006; 117(5):537-42. doi:
10.1016/j.thromres.2005.04.030. [PMID: 15951006] - Li Shao, L Trevor Young, Jun-Feng Wang. Chronic treatment with mood stabilizers lithium and valproate prevents excitotoxicity by inhibiting oxidative stress in rat cerebral cortical cells.
Biological psychiatry.
2005 Dec; 58(11):879-84. doi:
10.1016/j.biopsych.2005.04.052. [PMID: 16005436] - Jan-Zhong Sheng, Dianna Wang, Andrew P Braun. DAF-FM (4-amino-5-methylamino-2',7'-difluorofluorescein) diacetate detects impairment of agonist-stimulated nitric oxide synthesis by elevated glucose in human vascular endothelial cells: reversal by vitamin C and L-sepiapterin.
The Journal of pharmacology and experimental therapeutics.
2005 Nov; 315(2):931-40. doi:
10.1124/jpet.105.087932. [PMID: 16093274] - Paloma Alonso-Magdalena, Ouahiba Laribi, Ana B Ropero, Esther Fuentes, Cristina Ripoll, Bernat Soria, Angel Nadal. Low doses of bisphenol A and diethylstilbestrol impair Ca2+ signals in pancreatic alpha-cells through a nonclassical membrane estrogen receptor within intact islets of Langerhans.
Environmental health perspectives.
2005 Aug; 113(8):969-77. doi:
10.1289/ehp.8002. [PMID: 16079065] - Joseph Cuschieri, Eileen Bulger, Iris Garcia, Ronald V Maier. Oxidative-induced calcium mobilization is dependent on annexin VI release from lipid rafts.
Surgery.
2005 Aug; 138(2):158-64. doi:
10.1016/j.surg.2005.03.018. [PMID: 16153422] - Xin Liu, Wu Liang Shi, Shu Qiu Zhang, Cheng Hou Lou. [Calcium involved in the signaling pathway of jasmonic acid induced stomatal closure of Vicia faba L].
Shi yan sheng wu xue bao.
2005 Aug; 38(4):297-302. doi:
". [PMID: 16231695] - Qing Li, Yukio Kato, Yoshimichi Sai, Teruko Imai, Akira Tsuji. Multidrug resistance-associated protein 1 functions as an efflux pump of xenobiotics in the skin.
Pharmaceutical research.
2005 Jun; 22(6):842-6. doi:
10.1007/s11095-005-4576-1. [PMID: 15948026] - Yan-jing Chen, Jian-dong Li, Qi-fu Huang. [Effects of Panax notoginseng saponins on rat cardiomyocytes apoptosis induced by angiotengin II in vitro].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2005 May; 30(10):778-81. doi:
". [PMID: 16075720] - Noritaka Nakamichi, Hirotaka Oikawa, Yuki Kambe, Yu Ohno, Yukio Yoneda. [A mechanism for modulation of N-methyl-D-aspartate receptor channels by free ferrous ions in cultured rat cortical neurons].
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology.
2005 Apr; 25(2):105-13. doi:
NULL. [PMID: 16220660] - Ying Huang, Ya-Lin Huang, Sun Zhang, Yi-Chun Zhu, Tai Yao. Estradiol acutely attenuates glutamate-induced calcium overload in primarily cultured rat hippocampal neurons through a membrane receptor-dependent mechanism.
Brain research.
2004 Nov; 1026(2):254-60. doi:
10.1016/j.brainres.2004.08.038. [PMID: 15488487] - Hui Zou, Lawrence M Lifshitz, Richard A Tuft, Kevin E Fogarty, Joshua J Singer. Using total fluorescence increase (signal mass) to determine the Ca2+ current underlying localized Ca2+ events.
The Journal of general physiology.
2004 Sep; 124(3):259-72. doi:
10.1085/jgp.200409066. [PMID: 15337821] - Hui Zou, Lawrence M Lifshitz, Richard A Tuft, Kevin E Fogarty, Joshua J Singer. Imaging calcium entering the cytosol through a single opening of plasma membrane ion channels: SCCaFTs--fundamental calcium events.
Cell calcium.
2004 Jun; 35(6):523-33. doi:
10.1016/j.ceca.2004.01.019. [PMID: 15110142] - Jody A White, Peter F Blackmore, Karl H Schoenbach, Stephen J Beebe. Stimulation of capacitative calcium entry in HL-60 cells by nanosecond pulsed electric fields.
The Journal of biological chemistry.
2004 May; 279(22):22964-72. doi:
10.1074/jbc.m311135200. [PMID: 15026420]