Vindesine sulfate (BioDeep_00000859019)
Main id: BioDeep_00000395643
PANOMIX_OTCML-2023
代谢物信息卡片
Vindesine sulfate
化学式: C43H57N5O11S (851.3775)
中文名称: 硫酸长春地辛
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)N)O)O)CC)OC)C(=O)OC)O.OS(=O)(=O)O
InChI: /m1./s1
描述信息
D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators
D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents
D000970 - Antineoplastic Agents > D014748 - Vinca Alkaloids
Vindesine sulfate is a potent tubulin inhibitor with an Ki of 0.110 μM. Vindesine sulfate shows anti-proliferation effect in vitro. Vindesine sulfate shows antitumor effect in vivo[1].
同义名列表
2 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:32295
- KEGGdrug: D01769
- PubChem: 43116
- ChEMBL: CHEMBL2105882
- MeSH: Vindesine
- CAS: 59917-39-4
- medchemexpress: HY-129071
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Simin Luo, Xuan Zhang, Xiang Xiao, Wenting Luo, Zixuan Yang, Songqi Tang, Wei Huang. Exploring Potential Biomarkers and Molecular Mechanisms of Ischemic Cardiomyopathy and COVID-19 Comorbidity Based on Bioinformatics and Systems Biology.
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10.1097/00000421-199208000-00015. [PMID: 1325109] - K Furuse, M Fukuoka, H Asamoto, H Niitani, I Kimura, A Sakuma, Y Yamaguchi. [A randomized comparative study of 254-S plus vindesine (VDS) vs. cisplatin (CDDP) plus VDS in patients with advanced non-small cell lung cancer (NSCLC)].
Gan to kagaku ryoho. Cancer & chemotherapy.
1992 Jul; 19(7):1019-26. doi:
. [PMID: 1320846] - Y K Lee, D M Shin. Renal salt wasting in patients treated with high-dose cisplatin, etoposide, and mitomycin in patients with advanced non-small cell lung cancer.
The Korean journal of internal medicine.
1992 Jul; 7(2):118-21. doi:
10.3904/kjim.1992.7.2.118. [PMID: 1339077] - K Miyamoto, S Wakusawa, S Nakamura, K Tajima, H Hidaka. Multidrug resistance in Yoshida rat ascites hepatoma cell lines.
Anticancer research.
1992 May; 12(3):649-53. doi:
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International journal of hematology.
1992 Apr; 55(2):147-55. doi:
NULL. [PMID: 1511164] - S Hayashi, H Ogino, K Ogata, K Yagawa. Hypercoagulopathy induced by chemotherapy in a patient with lung cancer. A possible role for a factor with thrombosis-inducing activity (TIA).
Chest.
1992 Jan; 101(1):277-8. doi:
10.1378/chest.101.1.277. [PMID: 1729088] - Y Saito, K Mori, K Tominaga, K Yokoi, N Miyazawa. Phase II study of cisplatin as a 5-day continuous infusion with vindesine plus recombinant human granulocyte-colony-stimulating factor in the treatment of advanced non-small-cell lung cancer.
Cancer chemotherapy and pharmacology.
1992; 31(2):81-4. doi:
10.1007/bf00685091. [PMID: 1280537] - T Shinkai, K Eguchi, Y Sasaki, T Tamura, Y Ohe, A Kojima, F Oshita, T Miya, H Okamoto, K Iemura. A prognostic-factor risk index in advanced non-small-cell lung cancer treated with cisplatin-containing combination chemotherapy.
Cancer chemotherapy and pharmacology.
1992; 30(1):1-6. doi:
10.1007/bf00686477. [PMID: 1316809] - K Kaito, M Kobayashi, T Katayama, S Ochiai, M Yoshida, H Masuoka, T Shimada, K Nishiwaki, A Saito, R Watanabe. [Pharmacokinetics of BHAC, VP-16 and Ara-C derived from BHAC in a hemodialysed patient with AMMoL].
[Rinsho ketsueki] The Japanese journal of clinical hematology.
1991 Dec; 32(12):1558-63. doi:
NULL. [PMID: 1779456] - A Fujita, Y Inoue, H Sasaki, S Nakajima, K Sekine, R Honda, M Asakawa, A Suzuki. [Cisplatin, ifosfamide and vindesine in the chemotherapy of squamous cell carcinoma of the lung].
Gan to kagaku ryoho. Cancer & chemotherapy.
1991 Oct; 18(13):2283-7. doi:
NULL. [PMID: 1929449] - R M Bremnes, E Smeland, L Slørdal, E Wist, J Aarbakke. The effect of vindesine on methotrexate hydroxylation in the rat.
Biochemical pharmacology.
1991 Sep; 42(8):1561-8. doi:
10.1016/0006-2952(91)90425-5. [PMID: 1930283] - M Kawahara, K Furuse, N Kodama, M Yamamoto, K Kubota, M Takada, S Negoro, Y Kusunoki, K Matui, N Takifuji. A randomized study of cisplatin versus cisplatin plus vindesine for non-small cell lung carcinoma.
Cancer.
1991 Aug; 68(4):714-9. doi:
10.1002/1097-0142(19910815)68:4<714::aid-cncr2820680408>3.0.co;2-j. [PMID: 1649683] - T Fukabori, T Nakamura, T Kida, Y Fujita, T Goto, N Hiramori, T Fujii, Y Iwasaki, M Nakagawa. [Syndrome of inappropriate antidiuretic hormone secretion following cisplatinum and vindesine administration in a patient with squamous cell carcinoma of the lung].
Gan to kagaku ryoho. Cancer & chemotherapy.
1991 Jun; 18(7):1213-6. doi:
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
1991 Feb; 9(2):211-9. doi:
10.1200/jco.1991.9.2.211. [PMID: 1703226] - R Kobayashi, H Naito, T Shikano, Y Ishikawa, T Matsumoto, T Tonooka. [Nonoliguric acute renal failure complicated with tumor lysis syndrome in chronic myelocytic leukemia in lymphoid crisis].
[Rinsho ketsueki] The Japanese journal of clinical hematology.
1991 Jan; 32(1):43-6. doi:
NULL. [PMID: 2020116] - T Shinkai, K Eguchi, Y Sasaki, T Tamura, Y Ohe, A Kojima, F Oshita, N Saijo. A randomised clinical trial of vindesine plus cisplatin versus mitomycin plus vindesine and cisplatin in advanced non-small cell lung cancer.
European journal of cancer (Oxford, England : 1990).
1991; 27(5):571-5. doi:
10.1016/0277-5379(91)90220-8. [PMID: 1647183] - C J Twelves, J Goldman, C M Ash, R L Souhami, P G Harper, S G Spiro, D Geddes, J S Tobias. Sequential chemotherapy in good-prognosis patients with small-cell lung cancer.
Cancer chemotherapy and pharmacology.
1991; 28(2):139-41. doi:
10.1007/bf00689704. [PMID: 1647892] - T Nagai, R Koyama, Y Sasagawa, S Matsumoto, Y Niitsu, S Takayama, T Murakami, A Matsuura. Diffuse infiltrating T-cell lymphoma of the colon associated with polyclonal hypergammaglobulinemia and hepatocellular carcinoma: report of a case.
Japanese journal of medicine.
1991 Jan; 30(1):57-63. doi:
10.2169/internalmedicine1962.30.57. [PMID: 1650855] - J P Iredale, L M Hooi, K M Kerr, M F Sudlow, C G Wathen. Vindesine and etoposide chemotherapy in the management of patients with small cell lung cancer and poor prognosis.
Respiration; international review of thoracic diseases.
1991; 58(2):77-80. doi:
10.1159/000195901. [PMID: 1650490] - H J König, W Gutmann, J Weissmüller. Ifosfamide, vindesine and recombinant alpha-interferon combination chemotherapy for metastatic renal cell carcinoma.
Journal of cancer research and clinical oncology.
1991; 117 Suppl 4(?):S221-3. doi:
10.1007/bf01613231. [PMID: 1795011] - S Teramoto, T Nagase, Y Fukuchi, K Ishida, M Yamaoka, T Matsuse, C Jo, H Orimo. [Cisplatin and vinca alkaloid combination chemotherapy of advanced non-small-cell lung cancer in the aged].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics.
1990 Nov; 27(6):680-6. doi:
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
1990 Jul; 8(7):1173-86. doi:
10.1200/jco.1990.8.7.1173. [PMID: 1694235] - H Scherübl, F Raue, R Ziegler. [Combination therapy with adriamycin, cisplatin and vindesine in C cell carcinoma of the thyroid].
Onkologie.
1990 Jun; 13(3):198-202. doi:
10.1159/000216758. [PMID: 2204006] - B Coiffier, S Demolombe, I Tabah. [Vindesine-interferon alpha-2b combination in the treatment of metastases of cancer of the kidney].
Presse medicale (Paris, France : 1983).
1990 May; 19(21):1009. doi:
NULL. [PMID: 2141143] - M Fujii, Y Segawa, S Matsutomo, K Genba. [Phase II study of ifosfamide and vindesine combination of non-small cell lung cancer in elderly patients and patients with reduced renal function].
Gan to kagaku ryoho. Cancer & chemotherapy.
1990 May; 17(5):1021-5. doi:
NULL. [PMID: 2159266] - L J Müller, C M Moorer-van Delft, R Zijl, E W Roubos. Use of snail neurons in developing quantitative ultrastructural parameters for neurotoxic side effects of Vinca antitumor agents.
Cancer research.
1990 Mar; 50(6):1924-8. doi:
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Gan to kagaku ryoho. Cancer & chemotherapy.
1990 Mar; 17(3 Pt 2):429-34. doi:
NULL. [PMID: 2157364] - Y Saito, K Mori, K Tominaga, K Yokoi, N Miyazawa. Phase II study of 5-day continuous infusion of cis-diamminedichloroplatinum(II) in the treatment of non-small-cell lung cancer.
Cancer chemotherapy and pharmacology.
1990; 26(6):389-92. doi:
10.1007/bf02994086. [PMID: 2171793] - R Rahmani, X J Zhou, M Placidi, M Martin, J P Cano. In vivo and in vitro pharmacokinetics and metabolism of vincaalkaloids in rat. I. Vindesine (4-deacetyl-vinblastine 3-carboxyamide).
European journal of drug metabolism and pharmacokinetics.
1990 Jan; 15(1):49-55. doi:
10.1007/bf03190127. [PMID: 2384117] - R Honda, A Fujita, Y Inoue, M Asakawa, A Suzuki. Cisplatin, ifosfamide and vindesine in the chemotherapy of non-small-cell lung cancer: a combination phase II study.
Cancer chemotherapy and pharmacology.
1990; 26(5):373-6. doi:
10.1007/bf02897297. [PMID: 2170045] - H Itoh, A Watanabe, T Ooka, I Shima, M Hayashi. [A case of breast cancer with multiple metastases to the lung and bone responding well to cisplatin and vindesine].
Gan to kagaku ryoho. Cancer & chemotherapy.
1989 Nov; 16(11):3631-4. doi:
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Urology.
1989 Nov; 34(5):281-3. doi:
10.1016/0090-4295(89)90326-9. [PMID: 2815451] - H Ayabe, T Uchikawa, K Kimino, Y Tagawa, K Kawahara, M Tomita. [Pharmacokinetics of cisplatin and vindesine in a patient with chronic renal failure undergoing hemodialysis].
Gan to kagaku ryoho. Cancer & chemotherapy.
1989 Sep; 16(9):3283-5. doi:
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Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics.
1989 Jul; 26(4):329-33. doi:
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Biochemical pharmacology.
1989 Feb; 38(4):641-8. doi:
10.1016/0006-2952(89)90210-4. [PMID: 2917019] - M Naito, K Yusa, T Tsuruo. Steroid hormones inhibit binding of Vinca alkaloid to multidrug resistance related P-glycoprotein.
Biochemical and biophysical research communications.
1989 Feb; 158(3):1066-71. doi:
10.1016/0006-291x(89)92830-1. [PMID: 2563940] - A Hirosawa, H Niitani, K Hayashibara, E Tsuboi. Effects of sodium thiosulfate in combination therapy of cis-dichlorodiammineplatinum and vindesine.
Cancer chemotherapy and pharmacology.
1989; 23(4):255-8. doi:
10.1007/bf00451652. [PMID: 2538252] - C H Ford, V J Richardson, G Tsaltas. Comparison of tetrazolium colorimetric and [3H]-uridine assays for in vitro chemosensitivity testing.
Cancer chemotherapy and pharmacology.
1989; 24(5):295-301. doi:
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