Enison (BioDeep_00000395643)

PANOMIX_OTCML-2023

代谢物信息卡片

3-Carbamoyl-4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine sulfate (1:1) (salt)

化学式: C43H57N5O11S (851.3775)
中文名称: 硫酸长春地辛
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 78.16%

分子结构信息

SMILES: CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)N)O)O)CC)OC)C(=O)OC)O.OS(=O)(=O)O
InChI: /m1./s1

描述信息

Vindesine sulfate is an alkaloid sulfate salt. It has a role as an antineoplastic agent. It is functionally related to a vindesine.
Vindesine Sulfate is the sulfate salt form of Vindesine. Vindesine binds to and stabilizes tubulin, thereby interrupting tubulin polymerization and preventing the formation of the mitotic spindle and cell division; treated cells are unable to undergo mitosis and are arrested in metaphase. This agent also disrupts macromolecular synthesis. (NCI)
Vinblastine derivative with antineoplastic activity against CANCER. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS).
D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators
D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents
D000970 - Antineoplastic Agents > D014748 - Vinca Alkaloids
Vindesine sulfate is a potent tubulin inhibitor with an Ki of 0.110 μM. Vindesine sulfate shows anti-proliferation effect in vitro. Vindesine sulfate shows antitumor effect in vivo[1].

同义名列表

24 个代谢物同义名

3-Carbamoyl-4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine sulfate (1:1) (salt); 3-carbamoyl-O(4)-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine sulfate; Desacetylvinblastine amide sulfate; N-a-Boc-D-2,4-Diaminobutyricacid; VDSDesacetyl Vinblastine amide; Vindesine sulfate salt hydrate; Vindesine sulfate (JAN/USAN); Desacetyl Vinblastine amide; Desacetylvinblastine Amide; Vindesine sulfate- Bio-X; Vindesine sulfate salt; VINDESINE SULFATE(RG); VindesineSulfateSalt; Vindesine (sulfate); Sulfate, Vindesine; Vindesine sulfate; Fildesin (TN); Tox21_113632; Vindesine; Vindesin; Eldisine; Eldesine; FILDESI; Enison

数据库引用编号

7 个数据库交叉引用编号

ChEBI: CHEBI:32295
KEGGdrug: D01769
PubChem: 43116
ChEMBL: CHEMBL2105882
MeSH: Vindesine
CAS: 59917-39-4
medchemexpress: HY-129071

分类词条

吡咯生物碱

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

33090 - Plants: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位		关联基因列表

文献列表

Simin Luo, Xuan Zhang, Xiang Xiao, Wenting Luo, Zixuan Yang, Songqi Tang, Wei Huang. Exploring Potential Biomarkers and Molecular Mechanisms of Ischemic Cardiomyopathy and COVID-19 Comorbidity Based on Bioinformatics and Systems Biology. International journal of molecular sciences. 2023 Mar; 24(7):. doi: 10.3390/ijms24076511. [PMID: 37047484]
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Chenrong Huang, Fan Xia, Ling Xue, Linsheng Liu, Yicong Bian, Zhengming Jin, Liyan Miao. Coadministration of vindesine with high-dose methotrexate therapy increases acute kidney injury via BCRP, MRP2, and OAT1/OAT3. Cancer chemotherapy and pharmacology. 2020 02; 85(2):433-441. doi: 10.1007/s00280-019-03972-6. [PMID: 31691080]
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